FDB003908 (Ammonia) FDB030683 (ATP) FDB031004 (Mg2+) FDB030900 (H2O) FDB029221 (Fe3+) FDB003729 (Zinc) FDB016251 (Iron)
- FDB016251 (Iron)
- Gemcitabine Action Pathway
- gemcitabine enters the cell via sodium nucleoside co-transporters (slc29a1, slc28a1, and slc28a3), where it acts through multiple mechanisms to produce a cytotoxic effect. gemcitabine is phosphorylated into gemcitabine monophosphate by deoxycytidine kinase, which is then subsequently phosphorylated into the diphosphate and triphosphate nucleotides by ump-cmp kinase and nucleoside diphosphate kinase respectively.
- Parent Term
- Biochemical pathway
- Parent Definition
- A linked series of chemical reactions that occur in a defined order within or between organism cells, and lead to a known function or end product.
- Other Compounds Mapped to 'Gemcitabine Action Pathway'