1.02010-04-08 22:04:32 UTC2019-11-26 02:54:40 UTCFDB000362EstradiolGrowth promoter for livestock. Permitted in the USA
Estradiol (E2 or 17?-estradiol, also oestradiol) is a sex hormone. Estradiol is found in common bean and pomegranate.(+)-3,17b-Estradiol(+)-3,17beta-Estradiol(17b)-Estra-1,3,5(10)-triene-3,17-diol(17beta)-Estra-1,3,5(10)-triene-3,17-diol(17beta)-Estra-1(10),2,4-triene-3,17-diol(17β)-estra-1,3,5(10)-triene-3,17-diol1,3,5-Estratriene-3,17-beta-diol1,3,5-Estratriene-3,17β-diol1,3,5,(10)-Estratrien-3,17β-diol13b-Methyl-1,3,5(10)-gonatriene-3,17b-ol17-beta-Estra-1,3,5(10)-triene-3,17-diol17-beta-Estradiol17-beta-Oestra-1,3,5(10)-triene-3,17-diol17-beta-OH-Estradiol17-beta-OH-Oestradiol17β-Estra-1,3,5(10)-triene-3,17-diol17β-Estradiol17β-Oestra-1,3,5(10)-triene-3,17-diol17β-Oestradiol17b Oestradiol17b-Estra-1,3,5(10)-triene-3,17-diol17b-Estradiol17b-Oestradiol17beta Oestradiol17beta-Estra-1,3,5(10)-triene-3,17-diol17beta-Estradiol17beta-Oestra-1,3,5(10)-triene-3,17-diol17beta-Oestradiol17β oestradiol17β-estra-1,3,5(10)-triene-3,17-diol17β-estradiol17β-oestradiol3,17-β-Oestradiol3,17-beta-Dihydroxy-1,3,5(10)-oestratriene3,17-beta-Dihydroxyestra-1,3,5(10)-triene3,17-beta-Dihydroxyoestra-1,3,5-triene3,17-beta-Estradiol3,17-beta-Oestradiol3,17-Epidihydroxyestratriene3,17β-Dihydroxy-1, 3,5(10)-oestratriene3,17β-Dihydroxy-1,3,5(10)-estratriene3,17β-Dihydroxy-1,3,5(10)-oestratriene3,17β-Dihydroxyestra-1,3,5-triene3,17β-Dihydroxyestra-1,3,5(10)-triene3,17β-Dihydroxyoestra-1,3,5-triene3,17β-Estradiol3,17b-Dihydroxyestra-1,3,5(10)-triene3,17b-Estradiol3,17beta-Dihydroxyestra-1,3,5-triene3,17beta-Dihydroxyestra-1,3,5(10)-triene3,17beta-Dihydroxyoestra-1,3,5-triene3,17beta-EstradiolAerodiolAgofollinAltradAmnestrogenAquadiolb-EstradiolBardiolbeta-Estradiolcis-Estradiolcis-OestradiolClimadermClimaraCompudoseCorpagenD-3,17-beta-EstradiolD-3,17-beta-OestradiolD-3,17β-EstradiolD-3,17β-OestradiolD-3,17beta-EstradiolD-3,17beta-OestradiolD-EstradiolD-Oestradioldelta-Estradioldelta-OestradiolDermestrildihydro-TheelinDihydrofollicular hormoneDihydrofolliculinDihydromenformonDihydrotheelinDihydroxyestrinDimenformonDiogynDiogynetsDivigelEncoreEpiestriol 50Estra-1,3,5(10)-triene-3,17b-diolEstraceEstraderm ttsEstradiol-17-betaEstradiol-17bEstradiol-17betaEstradiol-17βEstradiol, INN, USANEstradotEstraldineEstring vaginal ringEstroclimEstroclim 50EstrogelEstrogel hbfEstroviteEvorelFemestralFemogenFollicyclinGelestraGinosedolGynergonGynoestrylLamdiolMacrodiolMenorestNordicolOesclimOestergonOestra-1,3,5(10)-triene-3,17-beta-diolOestra-1,3,5(10)-triene-3,17β-diolOestra-1,3,5(10)-triene-3,17b-diolOestra-1,3,5(10)-triene-3,17beta-diolOestradiolOestradiol, BANOestrogelOestroglandolOvahormonOvasterolOvastevolOvocyclinOvocylinPerlatanolPrimofolProfoliolProfoliol bProgynonProgynon dhSandrena 1SyndiolSystenVivelleZumenonβ-estradiolC18H24O2272.382272.177630012(1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-triene-5,14-diol(1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-triene-5,14-diol50-28-2[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])C=C(O)C=C3InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1VOXZDWNPVJITMN-ZBRFXRBCSA-N belongs to the class of organic compounds known as estrogens and derivatives. These are steroids with a structure containing a 3-hydroxylated estrane.Estrogens and derivativesOrganic compoundsLipids and lipid-like moleculesSteroids and steroid derivativesEstrane steroidsAromatic homopolycyclic compounds1-hydroxy-2-unsubstituted benzenoids17-hydroxysteroids3-hydroxysteroidsCyclic alcohols and derivativesHydrocarbon derivativesPhenanthrenes and derivativesSecondary alcoholsTetralins1-hydroxy-2-unsubstituted benzenoid17-hydroxysteroid3-hydroxysteroidAlcoholAromatic homopolycyclic compoundBenzenoidCyclic alcoholEstrogen-skeletonHydrocarbon derivativeHydroxysteroidOrganic oxygen compoundOrganooxygen compoundPhenanthreneSecondary alcoholTetralin17beta-hydroxy steroidC18 steroids (estrogens) and derivativesC18 steroids (estrogens) and derivativesEstrane and derivativesEstrogensestradiolSolidlogp3.57logs-4.11solubility2.13e-02 g/lmelting_pointMp 178°logp3.75pka_strongest_acidic10.33pka_strongest_basic-0.88iupac(1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-triene-5,14-diolaverage_mass272.382mono_mass272.177630012smiles[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])C=C(O)C=C3formulaC18H24O2inchiInChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1inchikeyVOXZDWNPVJITMN-ZBRFXRBCSA-Npolar_surface_area40.46refractivity79.9polarizability32.12rotatable_bond_count0acceptor_count2donor_count2physiological_charge0formal_charge0Androgen and Estrogen MetabolismSMP00068map00150Specdb::NmrTwoD1171Specdb::NmrOneD1112Specdb::EiMs847Specdb::CMs2067Specdb::CMs14708Specdb::CMs27518Specdb::CMs27727Specdb::CMs28720Specdb::CMs29608Specdb::CMs31026Specdb::CMs37323Specdb::CMs174888Specdb::CMs1051648Specdb::CMs1051650Specdb::CMs1051652Specdb::CMs1051653Specdb::CMs1051655Specdb::MsMs230Specdb::MsMs231Specdb::MsMs232Specdb::MsMs3101Specdb::MsMs3102Specdb::MsMs3103Specdb::MsMs3104Specdb::MsMs250644Specdb::MsMs250645Specdb::MsMs250646Specdb::MsMs270582Specdb::MsMs270583Specdb::MsMs270584Specdb::MsMs439749Specdb::MsMs449067Specdb::MsMs449068Specdb::MsMs449069Specdb::MsMs449070Specdb::MsMs2240159Specdb::MsMs2240739Specdb::MsMs2240967Specdb::MsMs2241572Specdb::MsMs2244287Specdb::MsMs2244939Specdb::MsMs2245052HMDB0015116469EST#<Reference:0x0000555676225bd8>#<Reference:0x0000555676225840>#<Reference:0x00005556762255e8>#<Reference:0x0000555676225098>#<Reference:0x0000555676224ee0>#<Reference:0x0000555676224cb0>#<Reference:0x0000555676224a80>#<Reference:0x0000555676224878>#<Reference:0x0000555676224670>#<Reference:0x0000555676224468>#<Reference:0x00005556762242b0>#<Reference:0x0000555676224058>#<Reference:0x0000555676223ef0>#<Reference:0x0000555676223c98>#<Reference:0x00005556762239c8>#<Reference:0x0000555676223748>#<Reference:0x0000555676223568>#<Reference:0x0000555676223310>#<Reference:0x0000555676223108>#<Reference:0x0000555676222f50>#<Reference:0x0000555676222d70>#<Reference:0x0000555676222b18>#<Reference:0x0000555676222960>#<Reference:0x0000555676222780>#<Reference:0x0000555676222550>#<Reference:0x00005556762222f8>#<Reference:0x00005556762220f0>#<Reference:0x0000555676221e98>#<Reference:0x0000555676221ad8>#<Reference:0x0000555676221808>#<Reference:0x0000555676221510>AnatidaeType 1specificAnatidae8830BeefaloType 1specificBos taurus X Bison bison297284BisonType 1specificBison bison9901BuffaloType 1specificBubalus bubalis89462Cattle (Beef, Veal)Type 1specificBos taurus9913ChickenType 1specificGallus gallus9031Columbidae (Dove, Pigeon)Type 1specificColumbidae8930Common beanType 1specificPhaseolus vulgaris3885DeerType 1specificCervidae9850Domestic goatType 1specificCapra aegagrus hircus9925Domestic pigType 1specificSus scrofa domestica9825ElkType 1specificCervus canadensis1574408EmuType 1specificDromaius novaehollandiae8790European rabbitType 1specificOryctolagus9984Greylag gooseType 1specificAnser anser8843Guinea henType 1specificNumida meleagris8996HorseType 1specificEquus caballus9796Mallard duckType 1specificAnas platyrhynchos8839Milk (Cow)Type 2specific0.0001320.001180.00000147uMMountain hareType 1specificLepus timidus62621Mule deerType 1specificOdocoileus9871OstrichType 1specificStruthio camelus8801PheasantType 1specificPhasianus colchicus9054PomegranateType 1specificPunica granatum22663QuailType 1specificPhasianidae9005RabbitType 1specificLeporidae9979Rock ptarmiganType 1specificLagopus muta64668Sheep (Mutton, Lamb)Type 1specificOvis aries9940SquabType 1specificColumba8931TurkeyType 1specificMeleagris gallopavo9103Velvet duckType 1specificMelanitta fusca371864Wild boarType 1specificSus scrofa9823Cytochrome P450 2D6Q6NWU0CYP2D6Cytochrome P450, family 1, subfamily A, polypeptide 1A0N0X8CYP1A1Estrogen receptorP03372ESR1Estrogen receptor betaQ92731ESR2Nuclear receptor subfamily 1 group I member 2O75469NR1I2Sex hormone-binding globulinP04278SHBGUDP-glucuronosyltransferase 1-1P22309UGT1A1UDP-glucuronosyltransferase 1-10Q9HAW8UGT1A10UDP-glucuronosyltransferase 1-3P35503UGT1A3UDP-glucuronosyltransferase 1-4P22310UGT1A4UDP-glucuronosyltransferase 1-5P35504UGT1A5UDP-glucuronosyltransferase 1-6P19224UGT1A6UDP-glucuronosyltransferase 1-7Q9HAW7UGT1A7UDP-glucuronosyltransferase 1-8Q9HAW9UGT1A8UDP-glucuronosyltransferase 1-9O60656UGT1A9UDP-glucuronosyltransferase 2A1Q9Y4X1UGT2A1UDP-glucuronosyltransferase 2A3Q6UWM9UGT2A3UDP-glucuronosyltransferase 2B10P36537UGT2B10UDP-glucuronosyltransferase 2B11O75310UGT2B11UDP-glucuronosyltransferase 2B15P54855UGT2B15UDP-glucuronosyltransferase 2B17O75795UGT2B17UDP-glucuronosyltransferase 2B28Q9BY64UGT2B28UDP-glucuronosyltransferase 2B4P06133UGT2B4UDP-glucuronosyltransferase 2B7P16662UGT2B7carcinogenic762A role played by a chemical compound which is known to induce a process of carcinogenesis by corrupting normal cellular pathways, leading to the acquistion of tumoral capabilities.estrogenic922topoisomerase-I inhibitor1368A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA.