1.0 2010-04-08 22:04:59 UTC 2019-11-26 02:56:30 UTC FDB001475 D-Arabitol D-Arabitol is a polyol. Polyols are sugar alcohols linked to the pentose phosphate pathway (PPP). They are classified on the basis of the number of carbon atoms. Polyols occur in body fluids. A patient with leukoencephalopathy and peripheral neuropathy has been identified as suffering from ribose-5-phosphate isomerase (RPI) deficiency, a defect in the PPP. In this disorder, highly elevated concentrations of the C5 polyols such as D-arabitol are found in body fluids. In addition, transaldolase deficiency, another defect in the PPP, has been diagnosed in a patient with mainly liver problems among others had increased concentrations of polyols, mainly D-arabitol. So far, the pathophysiological role of polyols is relatively unknown. It is thought that D-arabitol is a metabolic end-product in humans. The strong brain-CSF-plasma gradient of polyols in the patient with RPI deficiency suggested a primary metabolic disorder. The mechanisms of brain and neuronal damage in RPI deficiency remain to be elucidated. A neurotoxic effect due to accumulation of the polyols may play a role. D-Arabitol is a product of the enzyme D-arabinitol 4-dehydrogenase (EC 1.1.1.11) in the Pentose and glucuronate interconversion pathway. (PMID: 16435225, J Inherit Metab Dis. 2005;28(6):1181-3). Arabinitol Arabinitol, d- Arabitol Arabitol, (d) Arabitol, d- D-(+)-arabinitol D-(+)-arabitol D-arabinitol D-arabinol D-lyxitol C5H12O5 152.1458 152.068473494 pentane-1,2,3,4,5-pentol 1,2,3,4,5-pentahydroxypentane 488-82-4 OCC(O)C(O)C(O)CO InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2 HEBKCHPVOIAQTA-UHFFFAOYSA-N belongs to the class of organic compounds known as sugar alcohols. These are hydrogenated forms of carbohydrate in which the carbonyl group (aldehyde or ketone, reducing sugar) has been reduced to a primary or secondary hydroxyl group. Sugar alcohols Organic compounds Organic oxygen compounds Organooxygen compounds Carbohydrates and carbohydrate conjugates Aliphatic acyclic compounds Hydrocarbon derivatives Monosaccharides Polyols Primary alcohols Secondary alcohols Alcohol Aliphatic acyclic compound Hydrocarbon derivative Monosaccharide Polyol Primary alcohol Secondary alcohol Sugar alcohol a sugar alcohol Solid logp -2.53 ALOGPS logs 0.64 ALOGPS solubility 6.64e+02 g/l ALOGPS melting_point 101-104 oC logp -3.1 ChemAxon pka_strongest_acidic 12.76 ChemAxon pka_strongest_basic -3 ChemAxon iupac pentane-1,2,3,4,5-pentol ChemAxon average_mass 152.1458 ChemAxon mono_mass 152.068473494 ChemAxon smiles OCC(O)C(O)C(O)CO ChemAxon formula C5H12O5 ChemAxon inchi InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2 ChemAxon inchikey HEBKCHPVOIAQTA-UHFFFAOYSA-N ChemAxon polar_surface_area 101.15 ChemAxon refractivity 32.44 ChemAxon polarizability 14.42 ChemAxon rotatable_bond_count 4 ChemAxon acceptor_count 5 ChemAxon donor_count 5 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Specdb::EiMs 1902 Specdb::NmrTwoD 1369 Specdb::NmrOneD 1424 Specdb::NmrOneD 4279 Specdb::NmrOneD 4682 Specdb::CMs 20730 Specdb::CMs 37628 Specdb::MsMs 794 Specdb::MsMs 795 Specdb::MsMs 796 Specdb::MsMs 20273 Specdb::MsMs 20274 Specdb::MsMs 20275 Specdb::MsMs 21824 Specdb::MsMs 21825 Specdb::MsMs 21826 Specdb::MsMs 439762 Specdb::MsMs 440177 Specdb::MsMs 440180 Specdb::MsMs 449888 Specdb::MsMs 449889 Specdb::MsMs 449890 Specdb::MsMs 449891 HMDB00568 18333 #<Reference:0x000055ce30692310> #<Reference:0x000055ce30692068> Anatidae Type 1 specific Anatidae 8830 Avocado Type 1 specific Persea americana 3435 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Mallard duck Type 1 specific Anas platyrhynchos 8839 Milk (Cow) Type 2 specific Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Red wine Type 2 71.5 71.5 71.5 mg/100 g Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 White wine Type 2 36.0 36.0 36.0 mg/100 g Wild boar Type 1 specific Sus scrofa 9823