1.0 2010-04-08 22:05:21 UTC 2019-11-26 02:57:22 UTC FDB002369 Amoxycillin Potential contaminant in cow's milk arising from its veterinary use Amoxicillin (INN), formerly amoxycillin (BAN), is a moderate-spectrum, bacteriolytic, ?-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. It is usually the drug of choice within the class because it is better absorbed, following oral administration, than other ?-lactam antibiotics.; Amoxicillin in trihydrate form is available as capsules, chewable and dispersable tablets plus syrup and pediatric suspension for oral use, and as the sodium salt for intravenous administration. It is one of the most common antibiotics prescribed for children, and the liquid forms are helpful where the patient might find it difficult to take tablets or capsules. It has three ionizable groups. A once daily dosing form (Moxatag) was approved by the American FDA in January 2008.; Amoxicillin is a moderate-spectrum antibiotic active against a wide range of Gram-positive, and a limited range of Gram-negative organisms. It is usually the drug of choice within the class because it is better absorbed, following oral administration, than other beta-lactam antibiotics. Amoxicillin is susceptible to degradation by β-lactamase-producing bacteria, and so may be given with clavulanic acid to increase its susceptability. The incidence of β-lactamase-producing resistant organisms, including <i>E. coli</i>, appears to be increasing. Amoxicillin is sometimes combined with clavulanic acid, a β-lactamase inhibitor, to increase the spectrum of action against Gram-negative organisms, and to overcome bacterial antibiotic resistance mediated through β-lactamase production.; Amoxicillin is one of the semi-synthetic penicillins discovered by Beecham scientists. The patent for amoxicillin has expired, thus amoxicillin is marketed under many trade names including: Actimoxi, Alphamox, AMK, Amoksibos, Amoxiclav Sandoz, Amoxidal, Amoxil, Amoxin, Amoksiklav, Amoxibiotic, Amoxicilina, Apo-Amoxi, Augmentin, Bactox, Betalaktam, Cilamox, Curam, Dedoxil, Dispermox, Duomox, E-Mox (250mg and 500 mg), Enhancin, Gimalxina, Geramox, Hiconcil, Isimoxin, Klavox, Lamoxy, Moxatag, Moxilen, Moxypen, Moxyvit, Nobactam, Novamoxin, Ospamox, Panklav, Pamoxicillin, Panamox, Polymox, Samthongcillin, Clamoxyl, Senox, Sinacilin, Trimox, Tolodina, Wymox, Yucla, Zerrsox and Zimox. Amoxycillin is found in milk and milk products. α-amino-p-hydroxybenzylpenicillin 6-(a-Amino-4-hydroxyphenylacetamido)penicillanic acid 6-(D-(-)-p-Hydroxy-alpha-aminobenzyl)penicillin 6-(p-hydroxy-alpha-aminophenylacetamido)penicillanic acid 6-[[Amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 9CI Almodan Alpha-amino-p-hydroxybenzylpenicillin Amix Amoclen Amolin Amopen Amopenixin Amoram Amox 250 Cap 250mg Amox 500 Cap 500mg Amox S 125 Sus 125mg/5ml Amox S 250 Sus 250mg/5ml Amoxi Amoxi-mast Amoxicaps Amoxicilina Amoxicillin Amoxicillin (anhydrous) Amoxicillin (inn) Amoxicillin (TN) Amoxicillin and clavulanate potassium Amoxicillin anhydrous Amoxicillin pediatric Amoxicillin trihydrate Amoxicillin(usan) Amoxicilline Amoxicilline [inn] Amoxicillinum Amoxid Amoxiden Amoxil Amoxivet Amoxycillin Amoxycillin trihydrate Amoxycillin, BAN Amoxymed AMPC Amrit Anemolin Apo-amoxi Apo-Amoxi Cap 250mg Apo-Amoxi Cap 500mg Apo-Amoxi Pwr for Susp 125mg/5ml Apo-Amoxi Pwr for Susp 250mg/5ml Apo-amoxi sugar free Aspenil AUGMENTIN '125' AUGMENTIN '200' AUGMENTIN '250' AUGMENTIN '400' AUGMENTIN '500' AUGMENTIN '875' AUGMENTIN ES-600 Biomox Bristamox BRL 2333 Cemoxin Clamoxyl Clamoxyl (SKB) D-(-)-α-amino-p-hydroxybenzyl penicillin D-(-)-α-amino-p-hydroxybenzylpenicillin D-(-)-alpha-amino-P-Hydroxybenzyl penicillin D-(-)-alpha-amino-p-hydroxybenzylpenicillin D-(α-amino-p-hydroxybenzyl)penicillin D-(alpha-amino-P-Hydroxybenzyl)penicillin D-2-Amino-2-(4-hydroxyphenyl)acetamidopenicillanic acid D-amoxicillin Delacillin Dispermox Efpenix Flemoxin Galenamox Gen-Amoxicillin 250mg Gen-Amoxicillin 500mg Hiconcil Histocillin Hydroxyampicillin Ibiamox Imacillin Larotid Metafarma capsules Metifarma capsules Moxacin Moxal Moxatag Novamoxin Cap 250mg Novamoxin Cap 500mg Novamoxin Sus 125mg/5ml Novamoxin Sus 250mg/5ml Nu-Amoxi Cap 250mg Nu-Amoxi Cap 500mg Nu-Amoxi Sus 125/5ml Nu-Amoxi Sus 250mg/5ml Ospamox P-hydroxyampicillin PHL-amoxicillin Piramox PMS-amoxicillin Polymox Prevpac Pro Amox Pwr for Oral Susp 125mg/5ml Pro Amox-250 Cap 250mg Pro Amox-500 Cap 500mg Pro-Amox-250 Orl Sus 250mg/5ml r-Hydroxyampicillin Rimoxallin Robamox Sauracillin Sawamox PM Sumox Trimox Unicillin Utimox Vetramox Wymox C16H19N3O5S 365.404 365.104541423 6-[2-amino-2-(4-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid amoxil 26787-78-0 CC1(C)SC2C(NC(=O)C(N)C3=CC=C(O)C=C3)C(=O)N2C1C(O)=O InChI=1S/C16H19N3O5S/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24) LSQZJLSUYDQPKJ-UHFFFAOYSA-N belongs to the class of organic compounds known as heteroaromatic compounds. Heteroaromatic compounds are compounds containing an aromatic ring where a carbon atom is linked to an hetero atom. Heteroaromatic compounds Organic compounds Organoheterocyclic compounds Heteroaromatic compounds Aromatic heteromonocyclic compounds Furans Hydrocarbon derivatives Organic disulfides Organooxygen compounds Oxacyclic compounds Sulfenyl compounds Aromatic heteromonocyclic compound Furan Heteroaromatic compound Hydrocarbon derivative Organic disulfide Organic oxygen compound Organooxygen compound Organosulfur compound Oxacycle Sulfenyl compound logp 0.75 ALOGPS logs -2.58 ALOGPS solubility 9.58e-01 g/l ALOGPS logp -2.3 ChemAxon pka_strongest_acidic 3.23 ChemAxon pka_strongest_basic 7.43 ChemAxon iupac 6-[2-amino-2-(4-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid ChemAxon average_mass 365.404 ChemAxon mono_mass 365.104541423 ChemAxon smiles CC1(C)SC2C(NC(=O)C(N)C3=CC=C(O)C=C3)C(=O)N2C1C(O)=O ChemAxon formula C16H19N3O5S ChemAxon inchi InChI=1S/C16H19N3O5S/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24) ChemAxon inchikey LSQZJLSUYDQPKJ-UHFFFAOYSA-N ChemAxon polar_surface_area 132.96 ChemAxon refractivity 89.5 ChemAxon polarizability 35.22 ChemAxon rotatable_bond_count 4 ChemAxon acceptor_count 6 ChemAxon donor_count 4 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Specdb::NmrOneD 181921 Specdb::NmrOneD 181922 Specdb::NmrOneD 181923 Specdb::NmrOneD 181924 Specdb::NmrOneD 181925 Specdb::NmrOneD 181926 Specdb::NmrOneD 181927 Specdb::NmrOneD 181928 Specdb::NmrOneD 181929 Specdb::NmrOneD 181930 Specdb::NmrOneD 181931 Specdb::NmrOneD 181932 Specdb::NmrOneD 181933 Specdb::NmrOneD 181934 Specdb::NmrOneD 181935 Specdb::NmrOneD 181936 Specdb::NmrOneD 181937 Specdb::NmrOneD 181938 Specdb::NmrOneD 181939 Specdb::NmrOneD 181940 Specdb::MsMs 295735 Specdb::MsMs 295736 Specdb::MsMs 295737 Specdb::MsMs 336829 Specdb::MsMs 336830 Specdb::MsMs 336831 Specdb::MsMs 3391360 Specdb::MsMs 3391361 Specdb::MsMs 3391362 Specdb::MsMs 3391363 Specdb::MsMs 3391364 Specdb::MsMs 3391365 Specdb::CMs 13488 Specdb::CMs 41965 Specdb::CMs 122384 Specdb::CMs 805923 Specdb::CMs 805924 Specdb::CMs 805925 Specdb::CMs 805926 Specdb::CMs 805927 Specdb::CMs 805928 Specdb::CMs 805929 Specdb::CMs 805930 Specdb::CMs 805931 Specdb::CMs 805932 Specdb::CMs 805933 Specdb::CMs 805934 Specdb::CMs 805935 Specdb::CMs 805936 Specdb::CMs 805937 Specdb::CMs 805938 Specdb::CMs 805939 Specdb::CMs 805940 Specdb::CMs 805941 Specdb::CMs 805942 Specdb::CMs 805943 HMDB30500 2676 #<Reference:0x000055ce30c2e738> #<Reference:0x000055ce30c2e580> #<Reference:0x000055ce30c2e378> Milk (Cow) Type 2 specific 0.052 0.052 0.052 uM Milk and milk products Unknown generic