1.0 2010-04-08 22:06:41 UTC 2025-11-18 22:59:13 UTC FDB005421 Methylguanidine Methylguanidine (MG) is a guanidine compound deriving from protein catabolism. It is also a product of putrefaction. Methylguanidine is a suspected uraemic toxin that accumulates in renal failure, however it also exhibits anti-inflammatory effects. Methylguanidine is synthesized from creatinine concomitant with the synthesis of hydrogen peroxide from endogenous substrates in peroxisomes. Recent evidence suggests that methylguanidine significantly inhibits iNOS activity and TNF- release. This means that methylguandine can attenuate the degree of inflammation and tissue damage associated with endotoxic shock. Methylguanidine is found in loquat and apple. 1-methylguanidine Guanidine, methyl- Methylguanidin Methylguanidine MGX Monomethyl guanidin Monomethylguanidine N-methylguanidine N1-Methylguanidine C2H7N3 73.0971 73.063997239 N-methylguanidine methylguanidine 471-29-4 CNC(N)=N InChI=1S/C2H7N3/c1-5-2(3)4/h1H3,(H4,3,4,5) CHJJGSNFBQVOTG-UHFFFAOYSA-N belongs to the class of organic compounds known as guanidines. Guanidines are compounds containing a guanidine moiety, with the general structure (R1R2N)(R3R4N)C=N-R5. Guanidines Organic compounds Organic nitrogen compounds Organonitrogen compounds Guanidines Aliphatic acyclic compounds Carboximidamides Hydrocarbon derivatives Imines Organopnictogen compounds Aliphatic acyclic compound Carboximidamide Guanidine Hydrocarbon derivative Imine Organopnictogen compound guanidines logp -1.33 ALOGPS logs -0.67 ALOGPS solubility 1.57e+01 g/l ALOGPS logp -0.96 ChemAxon pka_strongest_basic 12.78 ChemAxon iupac N-methylguanidine ChemAxon average_mass 73.0971 ChemAxon mono_mass 73.063997239 ChemAxon smiles CNC(N)=N ChemAxon formula C2H7N3 ChemAxon inchi InChI=1S/C2H7N3/c1-5-2(3)4/h1H3,(H4,3,4,5) ChemAxon inchikey CHJJGSNFBQVOTG-UHFFFAOYSA-N ChemAxon polar_surface_area 61.9 ChemAxon refractivity 30.63 ChemAxon polarizability 7.57 ChemAxon rotatable_bond_count 0 ChemAxon acceptor_count 3 ChemAxon donor_count 3 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon Specdb::CMs 19658 Specdb::CMs 134635 Specdb::CMs 142369 Specdb::MsIr 1308 Specdb::MsIr 1309 Specdb::MsIr 1310 Specdb::EiMs 249 Specdb::NmrTwoD 1663 Specdb::NmrOneD 1722 Specdb::NmrOneD 148020 Specdb::NmrOneD 148021 Specdb::NmrOneD 148022 Specdb::NmrOneD 148023 Specdb::NmrOneD 148024 Specdb::NmrOneD 148025 Specdb::NmrOneD 148026 Specdb::NmrOneD 148027 Specdb::NmrOneD 148028 Specdb::NmrOneD 148029 Specdb::NmrOneD 148030 Specdb::NmrOneD 148031 Specdb::NmrOneD 148032 Specdb::NmrOneD 148033 Specdb::NmrOneD 148034 Specdb::NmrOneD 148035 Specdb::NmrOneD 148036 Specdb::NmrOneD 148037 Specdb::NmrOneD 148038 Specdb::NmrOneD 148039 Specdb::MsMs 1622 Specdb::MsMs 1623 Specdb::MsMs 1624 Specdb::MsMs 309742 Specdb::MsMs 309743 Specdb::MsMs 309744 Specdb::MsMs 354247 Specdb::MsMs 354248 Specdb::MsMs 354249 Specdb::MsMs 451898 Specdb::MsMs 2231090 Specdb::MsMs 2231349 Specdb::MsMs 2232874 Specdb::MsMs 2233095 Specdb::MsMs 2252571 Specdb::MsMs 2253902 Specdb::MsMs 2254624 Specdb::MsMs 2255960 Specdb::MsMs 2256550 Specdb::MsMs 2258032 Specdb::MsMs 2258576 Specdb::MsMs 2260007 Specdb::MsMs 2451202 Specdb::MsMs 2451203 Specdb::MsMs 2451204 HMDB01522 16628 Anatidae Type 1 specific Anatidae 8830 Apple Type 1 specific Malus pumila 283210 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Loquat Type 1 specific Eriobotrya japonica 32224 Mallard duck Type 1 specific Anas platyrhynchos 8839 Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 Wild boar Type 1 specific Sus scrofa 9823