1.02010-04-08 22:09:09 UTC2019-11-26 03:03:40 UTCFDB010505N-(2-Hydroxybenzoyl)glycineConstituent of milk
Salicyluric acid is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction:; acyl-CoA + glycine < -- > CoA + N-acylglycine; The induction of the salicyluric acid formation is one of the saturable pathways of salicylate elimination.; The formation of the methyl ester of salicyluric acid is observed during the quantitation of salicyluric acid and other salicylate metabolites in urine by high-pressure liquid chromatography. This methyl ester formation causes artificially low values for salicyluric acid and high values for salicylic acid.; (PMID: 6101164, 6857178). N-(2-Hydroxybenzoyl)glycine is found in milk and milk products.((2-hydroxybenzoyl)amino)acetic acid(2-hydroxybenzamido)acetic acid(2-Hydroxybenzoyl)glycine[(2-Hydroxybenzoyl)amino]acetate[(2-Hydroxybenzoyl)amino]acetic acid2-Hydroxybenzamidoacetic acid2-hydroxybenzoylaminoacetate2-hydroxybenzoylaminoacetic acid2-Hydroxybenzoylglycine2-Hydroxyhippurate2-Hydroxyhippuric acidGlycine, N-(2-hydroxybenzoyl)-Glycine, N-(2-hydroxybenzoyl)- (9CI)Glycine, n-salicyloyl-Hippuric acid, o-hydroxy-N-(2-Hydroxybenzoyl)-glycineN-o-hydroxybenzoylglycineN-salicyloylglycineO-hydroxy-hippurateO-hydroxy-hippuric acidO-HydroxyhippateO-Hydroxyhippic acidO-hydroxyhippurateO-hydroxyhippuric acido-Hydroxyhippuric acid, 8CIOrtho-hydroxyhippurateOrtho-hydroxyhippuric acidSalicylglycineSalicyloylaminoacetic acidSalicyloylglycineSalicylurateSalicyluric acidC9H9NO4195.1721195.0531577812-[(2-hydroxyphenyl)formamido]acetic acidsalicyluric acid487-54-7OC(=O)CNC(=O)C1=CC=CC=C1OInChI=1S/C9H9NO4/c11-7-4-2-1-3-6(7)9(14)10-5-8(12)13/h1-4,11H,5H2,(H,10,14)(H,12,13)ONJSZLXSECQROL-UHFFFAOYSA-N belongs to the class of organic compounds known as hippuric acids. Hippuric acids are compounds containing hippuric acid, which consists of a of a benzoyl group linked to the N-terminal of a glycine.Hippuric acidsOrganic compoundsBenzenoidsBenzene and substituted derivativesBenzoic acids and derivativesAromatic homomonocyclic compounds1-hydroxy-2-unsubstituted benzenoids1-hydroxy-4-unsubstituted benzenoidsBenzoyl derivativesCarbonyl compoundsCarboxylic acidsHydrocarbon derivativesMonocarboxylic acids and derivativesN-acyl-alpha amino acidsOrganic oxidesOrganonitrogen compoundsOrganopnictogen compoundsSalicylamidesSecondary carboxylic acid amidesVinylogous acids1-hydroxy-2-unsubstituted benzenoid1-hydroxy-4-unsubstituted benzenoidAlpha-amino acid or derivativesAromatic homomonocyclic compoundBenzoylCarbonyl groupCarboxamide groupCarboxylic acidCarboxylic acid derivativeHippuric acidHydrocarbon derivativeMonocarboxylic acid or derivativesN-acyl-alpha amino acid or derivativesN-acyl-alpha-amino acidOrganic nitrogen compoundOrganic oxideOrganic oxygen compoundOrganonitrogen compoundOrganooxygen compoundOrganopnictogen compoundPhenolSalicylamideSalicylic acid or derivativesSecondary carboxylic acid amideVinylogous acidN-acyl-amino acidN-acylglycineSolidlogp0.51logs-1.68solubility4.04e+00 g/lmelting_pointMp 170-172°logp0.87pka_strongest_acidic3.27pka_strongest_basic-1.9iupac2-[(2-hydroxyphenyl)formamido]acetic acidaverage_mass195.1721mono_mass195.053157781smilesOC(=O)CNC(=O)C1=CC=CC=C1OformulaC9H9NO4inchiInChI=1S/C9H9NO4/c11-7-4-2-1-3-6(7)9(14)10-5-8(12)13/h1-4,11H,5H2,(H,10,14)(H,12,13)inchikeyONJSZLXSECQROL-UHFFFAOYSA-Npolar_surface_area86.63refractivity48.1polarizability18.4rotatable_bond_count3acceptor_count4donor_count3physiological_charge-1formal_charge0Specdb::NmrOneD1562Specdb::NmrTwoD1504Specdb::MsIr899Specdb::MsIr900Specdb::MsIr901Specdb::MsMs1184Specdb::MsMs1185Specdb::MsMs1186Specdb::MsMs4710Specdb::MsMs4711Specdb::MsMs4712Specdb::MsMs4713Specdb::MsMs4714Specdb::MsMs179112Specdb::MsMs179113Specdb::MsMs179114Specdb::MsMs181437Specdb::MsMs181438Specdb::MsMs181439Specdb::MsMs437826Specdb::MsMs437827Specdb::MsMs437828Specdb::MsMs437829Specdb::MsMs437830Specdb::MsMs438669Specdb::MsMs2236282Specdb::MsMs2237086Specdb::MsMs2239223Specdb::MsMs2240355Specdb::MsMs2241330Specdb::CMs1677Specdb::CMs1773Specdb::CMs2926Specdb::CMs31243Specdb::CMs31244Specdb::CMs32055Specdb::CMs32056Specdb::CMs37795Specdb::CMs174819Specdb::CMs1079237Specdb::CMs1079239Specdb::CMs1079241Specdb::CMs1079242Specdb::CMs1079244Specdb::CMs1079245Specdb::CMs1079247Specdb::CMs1079249Specdb::CMs1079251Specdb::CMs1079253Specdb::CMs1079254HMDB008409008#<Reference:0x0000555674d851b0>#<Reference:0x0000555674d84fd0>#<Reference:0x0000555674d84d00>#<Reference:0x0000555674d84ad0>#<Reference:0x0000555674d84828>#<Reference:0x0000555674d84558>#<Reference:0x0000555674d842d8>#<Reference:0x0000555674d840d0>#<Reference:0x0000555674d83e50>#<Reference:0x0000555674d83810>#<Reference:0x0000555674d83450>#<Reference:0x0000555674d83180>AnatidaeType 1specificAnatidae8830BeefaloType 1specificBos taurus X Bison bison297284BisonType 1specificBison bison9901BuffaloType 1specificBubalus bubalis89462Cattle (Beef, Veal)Type 1specificBos taurus9913ChickenType 1specificGallus gallus9031Columbidae (Dove, Pigeon)Type 1specificColumbidae8930DeerType 1specificCervidae9850Domestic goatType 1specificCapra aegagrus hircus9925Domestic pigType 1specificSus scrofa domestica9825ElkType 1specificCervus canadensis1574408EmuType 1specificDromaius novaehollandiae8790European rabbitType 1specificOryctolagus9984Greylag gooseType 1specificAnser anser8843Guinea henType 1specificNumida meleagris8996HorseType 1specificEquus caballus9796Mallard duckType 1specificAnas platyrhynchos8839Milk (Cow)Type 2specificMilk and milk productsUnknowngenericMountain hareType 1specificLepus timidus62621Mule deerType 1specificOdocoileus9871OstrichType 1specificStruthio camelus8801PheasantType 1specificPhasianus colchicus9054QuailType 1specificPhasianidae9005RabbitType 1specificLeporidae9979Rock ptarmiganType 1specificLagopus muta64668Sheep (Mutton, Lamb)Type 1specificOvis aries9940SquabType 1specificColumba8931TurkeyType 1specificMeleagris gallopavo9103Velvet duckType 1specificMelanitta fusca371864Wild boarType 1specificSus scrofa9823Glycine N-acyltransferaseQ6IB77GLYATGlycine N-acyltransferase-like protein 1Q969I3GLYATL1Glycine N-acyltransferase-like protein 2Q8WU03GLYATL2Glycine N-acyltransferase-like protein 3Q5SZD4GLYATL3