1.0 2010-04-08 22:09:14 UTC 2018-05-28 23:28:45 UTC FDB010662 Sulfadiazine Antibacterial agent. It is used in some countries for control of bacterial disease in farmed fish. Not approved for aquacultural use in the USA Sulfadiazine is a sulfonamide antibiotic.; Sulfadiazine is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of <i>p</i>-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus. <IMG SRC="/ncidb2/images/delta.gif" WIDTH=12 HEIGHT=14>zina 2-(4-Aminobenzenesulfonamido)pyrimidine 2-Sulfanilamido-pyrimidine 2-Sulfanilamidopyridine 2-Sulfanilamidopyrimidin 2-Sulfanilamidopyrimidine 2-Sulfanilylaminopyrimidine 2-Sulfapyrimidine 2-Sulphanilamidopyrimidine 2-Sulphanilylaminopyrimidine 4-Amino-N-(2-pyrimidinyl)benzenesulfonamide 4-amino-N-(pyrimidin-2-yl)benzenesulfonamide 4-Amino-N-2-pyrimidinyl- benzenesulfonamide 4-Amino-N-2-pyrimidinyl-benzenesulfonamide 4-Amino-N-2-pyrimidinylbenzenesulfonamide 4-Amino-N-2-pyrimidinylbenzenesulfonamide, 9CI 4-amino-N-2-Pyrimidinylbenzenesulphonamide 4-amino-N-pyrimidin-2-ylbenzenesulfonamide Adiazin Adiazine Benzenesulfonamide, 4-amino-N-2-pyrimidinyl- Coco-Diazine Cocodiazine Codiazine Cremodiazine Cremotres CRL-8131 & Sulfadiazine Debenal Deltazina Di-azo-mul Diazin Diazolone Diazovit Eskadiazine Honey diazine Lipo-diazine Lipo-levazine Liquadiazine Metha-meridiazine Microsulfon Mixture of sulfadiazine, sulfamerazine, and sulfamethazine N'-(2-Pyrimidinyl)sulfanilamide, 8CI N(1)-2-pyrimidinylsulfanilamide N(1)-2-Pyrimidinylsulphanilamide N(1)-2-pyrimidylsulfanilamide N(1)-2-Pyrimidylsulphanilamide N(sup 1)-2-Pyrimidinylsulfanilamide N(sup1)-2-Pyrimidinylsulfanilamide N(sup1)-2-Pyrimidylsulfanilamide N1-(Pyrimidin-2-yl)sulfanilamide N1-2-Pyrimidinylsulfanilamide N1-2-Pyrimidylsulfanilamide Neazine Neotrizine Palatrize Pecta-diazine, suspension Piridisir Pirimal Pyrimal Pyrimidine, 2-sulfanilamido- Quadetts Quadramoid rBPI21 & Sulfa Sanodiazine SDA Sodium sulfadiazine Solfadiazina Solfadiazina [dcit] Spofadrizine Sterazine Sulfacombin Sulfadiazene Sulfadiazin Sulfadiazina Sulfadiazine (jan/usp/inn) Sulfadiazine (TN) Sulfadiazine [usan:inn:jan] Sulfadiazinum Sulfanilamide, N(sup 1)-2-pyrimidinyl- Sulfanilamide, N1-2-pyrimidinyl- Sulfanilamide, N1-2-pyrimidinyl- (8CI) Sulfanilamide, N1-2(1H)-pyrimidinylidene- Sulfanilamidopyrimidine Sulfapirimidin Sulfapyrimidin Sulfapyrimidin (german) Sulfapyrimidine Sulfatryl Sulfazin Sulfazin (Russian pharmaceutical) Sulfazin (russian) Sulfazine Sulfolex Sulfonamide duplex Sulfonamides duplex Sulfonsol Sulfose Sulphadiazina Sulphadiazine Sulphadiazine e Sulphadiazine, BAN Sulphadiazinum Sulphapyrimidine Terfonyl Theradiazine Thi-di-mer Tri-sulfameth Trifonamide Triple sulfas Trisem Trisulfapyrimidine, oral suspension Truozine Zinc sulfadiazine C10H10N4O2S 250.277 250.052446274 4-amino-N-(pyrimidin-2-yl)benzene-1-sulfonamide sulfadiazine 68-35-9 NC1=CC=C(C=C1)S(=O)(=O)NC1=NC=CC=N1 InChI=1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14) SEEPANYCNGTZFQ-UHFFFAOYSA-N belongs to the class of organic compounds known as aminobenzenesulfonamides. These are organic compounds containing a benzenesulfonamide moiety with an amine group attached to the benzene ring. Aminobenzenesulfonamides Organic compounds Benzenoids Benzene and substituted derivatives Benzenesulfonamides Aromatic heteromonocyclic compounds Aminosulfonyl compounds Aniline and substituted anilines Azacyclic compounds Benzenesulfonyl compounds Heteroaromatic compounds Hydrocarbon derivatives Organic oxides Organopnictogen compounds Organosulfonamides Primary amines Pyrimidines and pyrimidine derivatives Amine Aminobenzenesulfonamide Aminosulfonyl compound Aniline or substituted anilines Aromatic heteromonocyclic compound Azacycle Benzenesulfonyl group Heteroaromatic compound Hydrocarbon derivative Organic nitrogen compound Organic oxide Organic oxygen compound Organic sulfonic acid or derivatives Organoheterocyclic compound Organonitrogen compound Organopnictogen compound Organosulfonic acid amide Organosulfonic acid or derivatives Organosulfur compound Primary amine Pyrimidine Sulfonyl pyrimidines substituted aniline sulfonamide sulfonamide antibiotic Solid logp 0.25 ALOGPS logs -2.62 ALOGPS solubility 6.01e-01 g/l ALOGPS melting_point Mp 255-256° dec. logp 0.39 ChemAxon pka_strongest_acidic 6.99 ChemAxon pka_strongest_basic 2.01 ChemAxon iupac 4-amino-N-(pyrimidin-2-yl)benzene-1-sulfonamide ChemAxon average_mass 250.277 ChemAxon mono_mass 250.052446274 ChemAxon smiles NC1=CC=C(C=C1)S(=O)(=O)NC1=NC=CC=N1 ChemAxon formula C10H10N4O2S ChemAxon inchi InChI=1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14) ChemAxon inchikey SEEPANYCNGTZFQ-UHFFFAOYSA-N ChemAxon polar_surface_area 97.97 ChemAxon refractivity 64.2 ChemAxon polarizability 24.39 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 5 ChemAxon donor_count 2 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon Specdb::CMs 24208 Specdb::CMs 135547 Specdb::CMs 143281 Specdb::MsMs 62208 Specdb::MsMs 62209 Specdb::MsMs 62210 Specdb::MsMs 118884 Specdb::MsMs 118885 Specdb::MsMs 118886 Specdb::MsMs 440732 Specdb::MsMs 440733 Specdb::MsMs 440734 Specdb::MsMs 440735 Specdb::MsMs 441615 Specdb::MsMs 441616 Specdb::MsMs 441617 Specdb::MsMs 441618 Specdb::MsMs 441619 Specdb::MsMs 441620 Specdb::MsMs 441621 Specdb::MsMs 441622 Specdb::MsMs 441623 Specdb::MsMs 441624 Specdb::MsMs 441625 Specdb::MsMs 441626 Specdb::MsMs 441627 Specdb::MsMs 441628 Specdb::MsMs 2226621 HMDB14503 9328