Record Information
Creation date2010-04-08 22:09:20 UTC
Update date2018-01-23 19:12:07 UTC
Primary IDFDB010856
Secondary Accession NumbersNot Available
Chemical Information
FooDB NameRhein
DescriptionPresent in Rheum palmatum (Chinese rhubarb). Rhein is found in dock, green vegetables, and garden rhubarb.
CAS Number478-43-3
1,8-Dihydroxy-3-carboxyl anthraquinoneHMDB
1,8-Dihydroxyanthraquinone-3-carboxylic acidHMDB
4, 5-Dihydroxyanthraquinone-2-carboxylic acidHMDB
4,5-Dihydroxy-2-anthraquinonecarboxylic acidHMDB
9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid, 9ciHMDB
9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthroic acidHMDB
Cassic acidHMDB
Chrysazin-3-carboxylic acidHMDB
Dipropionyl rheinHMDB
Rhein (1,8-dihydroxy-3-carboxyl anthraquinone)HMDB
Rhubarb yellowHMDB
4,5-Dihydroxyanthraquinone-2-carboxylic acidHMDB
1,8-dihydroxy-3-carboxyl anthraquinonebiospider
2-Anthroic acid, 9,10-dihydro-4,5-dihydroxy-9, 10-dioxo-biospider
2-Anthroic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-biospider
9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid, 9CIdb_source
9,10-dihydro-4,5-Dihydroxy-9,10-dioxo-2-anthroic acidHMDB
Predicted Properties
Water Solubility0.21 g/LALOGPS
pKa (Strongest Acidic)3.4ChemAxon
pKa (Strongest Basic)-4.4ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area111.9 ŲChemAxon
Rotatable Bond Count1ChemAxon
Refractivity72.37 m³·mol⁻¹ChemAxon
Polarizability26.62 ųChemAxon
Number of Rings3ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Chemical FormulaC15H8O6
IUPAC name4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid
InChI IdentifierInChI=1S/C15H8O6/c16-9-3-1-2-7-11(9)14(19)12-8(13(7)18)4-6(15(20)21)5-10(12)17/h1-5,16-17H,(H,20,21)
Isomeric SMILESOC(=O)C1=CC2=C(C(O)=C1)C(=O)C1=C(C=CC=C1O)C2=O
Average Molecular Weight284.2204
Monoisotopic Molecular Weight284.032087988
Description belongs to the class of organic compounds known as anthracenecarboxylic acids. These are organic compounds containing a carboxylic acid group attached to an anthracene ring system.
KingdomOrganic compounds
Super ClassBenzenoids
Sub ClassAnthracenecarboxylic acids and derivatives
Direct ParentAnthracenecarboxylic acids
Alternative Parents
  • Anthracene carboxylic acid
  • 9,10-anthraquinone
  • Anthraquinone
  • 2-naphthalenecarboxylic acid
  • 2-naphthalenecarboxylic acid or derivatives
  • Hydroxybenzoic acid
  • Aryl ketone
  • 1-hydroxy-4-unsubstituted benzenoid
  • 1-hydroxy-2-unsubstituted benzenoid
  • Vinylogous acid
  • Ketone
  • Monocarboxylic acid or derivatives
  • Carboxylic acid
  • Carboxylic acid derivative
  • Organic oxygen compound
  • Hydrocarbon derivative
  • Organic oxide
  • Organooxygen compound
  • Aromatic homopolycyclic compound
Molecular FrameworkAromatic homopolycyclic compounds
External Descriptors
OntologyShould have ontology for this compound
Physico-Chemical Properties - Experimental
Physico-Chemical Properties - Experimental
Physical stateNot Available
Physical DescriptionNot Available
Mass CompositionC 63.39%; H 2.84%; O 33.77%DFC
Melting PointMp 321° (310°)DFC
Boiling PointNot Available
Experimental Water SolubilityNot Available
Experimental logPNot Available
Experimental pKaNot Available
Isoelectric pointNot Available
ChargeNot Available
Optical RotationNot Available
Spectroscopic UV Data425 () (EtOH) (Berdy)DFC
DensityNot Available
Refractive IndexNot Available
Spectrum TypeDescriptionSplash Key
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positivesplash10-07cv-0590000000-afcf37d77e69652177f2View in MoNA
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (3 TMS) - 70eV, Positivesplash10-024r-4102900000-c5b546456fd0d7644f8aView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , negativesplash10-001i-0090000000-9ac3e7791e49a21d3f7eView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , negativesplash10-000i-0090000000-8a0c3c4f77482fc05626View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , negativesplash10-000i-0190000000-a217257577bda56ddeb9View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , negativesplash10-001i-0950000000-f5cac5a3a6c78fc4ed85View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , negativesplash10-001i-0910000000-4671892dc0bcf7214bc0View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , negativesplash10-000i-0090000000-5f27d9cb7d81c2b3da8dView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , negativesplash10-000i-0190000000-87c468c6073faf9e5faeView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , negativesplash10-001i-0920000000-0b0038f124d8c1494117View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , positivesplash10-000i-0090000000-a2294fd7666d75dbcbd0View in MoNA
LC-MS/MSLC-MS/MS Spectrum - , positivesplash10-052u-0890000000-5f1951e9414e26b22db9View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-00kr-0090000000-6163d091b67836bcff63View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-014r-0190000000-bd5d0494f66cd7d5828cView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-00rl-2290000000-33f58cc10ba47d1b818aView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-001i-0090000000-05c98e64e03e092b3975View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0019-0090000000-ec4cf61d964a40527521View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-00ku-4390000000-5d5e000d8c2e171dd309View in MoNA
ChemSpider ID9762
KEGG Compound IDC10401
Pubchem Compound ID10168
Pubchem Substance IDNot Available
ChEBI IDNot Available
Phenol-Explorer IDNot Available
DrugBank IDNot Available
CRC / DFC (Dictionary of Food Compounds) IDFQW20-U:FQW20-U
EAFUS IDNot Available
BIGG IDNot Available
KNApSAcK IDC00002861
Flavornet IDNot Available
GoodScent IDNot Available
SuperScent IDNot Available
Wikipedia IDNot Available
Phenol-Explorer Metabolite IDNot Available
Duplicate IDSNot Available
Old DFC IDSNot Available
Associated Foods
FoodContent Range AverageReference
Biological Effects and Interactions
Health Effects / Bioactivities
anti bacterial33282 A substance that kills or slows the growth of bacteria.DUKE
anti carcinomic35610 A substance that inhibits or prevents the proliferation of neoplasms.DUKE
anti cariogenic52217 Any substance introduced into a living organism with therapeutic or diagnostic purpose.DUKE
anti cytomegalovirus22587 A substance that destroys or inhibits replication of viruses.DUKE
anti neoplastic35610 A substance that inhibits or prevents the proliferation of neoplasms.DUKE
anti plaqueDUKE
anti septic33281 A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.DUKE
antitumor35610 A substance that inhibits or prevents the proliferation of neoplasms.DUKE
anti viral22587 A substance that destroys or inhibits replication of viruses.DUKE
calcium antagonist48706 Substance that attaches to and blocks cell receptors that normally bind naturally occurring substances.DUKE
cathartic75325 Any substance that accelerates defecation. Compare with laxatives, which are substances that ease defecation (usually by softening faeces). A substance can be both a laxative and a cathartic.DUKE
cytotoxic52209 A role played by the molecular entity or part thereof which causes the development of a pathological process.DUKE
fungicide24127 A substance used to destroy fungal pests.DUKE
pesticide25944 Strictly, a substance intended to kill pests. In common usage, any substance used for controlling, preventing, or destroying animal, microbiological or plant pests.DUKE
proteinase inhibitor37670 A compound which inhibits or antagonizes the biosynthesis or actions of proteases (endopeptidases).DUKE
purgative50503 An agent that produces a soft formed stool, and relaxes and loosens the bowels, typically used over a protracted period, to relieve constipation. Compare with cathartic, which is a substance that accelerates defecation. A substances can be both a laxative and a cathartic.DUKE
EnzymesNot Available
PathwaysNot Available
MetabolismNot Available
BiosynthesisNot Available
Organoleptic Properties
FlavoursNot Available
MSDSNot Available
Synthesis ReferenceNot Available
General ReferenceNot Available
Content Reference— Duke, James. 'Dr. Duke's Phytochemical and Ethnobotanical Databases. United States Department of Agriculture.' Agricultural Research Service, Accessed April 27 (2004).
— Shinbo, Y., et al. 'KNApSAcK: a comprehensive species-metabolite relationship database.' Plant Metabolomics. Springer Berlin Heidelberg, 2006. 165-181.