Record Information
Version1.0
Creation date2010-04-08 22:09:53 UTC
Update date2018-05-29 18:27:53 UTC
Primary IDFDB011904
Secondary Accession NumbersNot Available
Chemical Information
FooDB NameQuercetin
DescriptionQuercetin is isolated from many plants, especially fruits, such as Helichrysum, Euphorbia and Karwinskia spp. Present in the Solanaceae, Rhamnaceae, Passifloraceae and many other families. For example detected in almost all studied Umbelliferae. Nutriceutical with antiinflammatory props. and a positive influence on the blood lipid profile. Found in a wide variety of foods especially apples, bee pollen, blackcurrants, capers, cocoa, cranberries, dock leaves, elderberries, fennel, lovage, red onions, ancho peppers, dill weed and tarragon.
CAS Number117-39-5
Structure
Thumb
Synonyms
SynonymSource
2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-oneChEBI
3,3',4',5,7-PentahydroxyflavoneChEBI
3,5,7,3',4'-PentahydroxyflavoneChEBI
SophoretinChEBI
XanthaurineChEBI
3,3',4,5,7-PentahydroxyflavoneKegg
2-(3,4-Dihydroxy-phenyl)-3,5,7-trihydroxy-chromen-4-oneHMDB
3',4',5,7-Tetrahydroxyflavan-3-olHMDB
3',4',5,7-Tetrahydroxyflavon-3-olHMDB
3,4',5,5',7-Pentahydroxy-flavoneHMDB
3,5,7-Trihydroxy-2-(3,4-dihydroxyphenyl)-4H-chromen-4-ONHMDB
Flavin meletinHMDB
MeletinHMDB
Quercetin dihydrateHMDB
QuercetolHMDB
QuertinHMDB
DikvertinHMDB
2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one, 9CIdb_source
2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-onebiospider
2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxychromen-4-onebiospider
3,5,7-Trihydroxy-2-(3,4-dihydroxyphenyl)-4H-chromen-4-onHMDB
3,5,7-Trihydroxy-2-(3,4-dihydroxyphenyl)-4H-chromen-4-onebiospider
3',4',5,7-Tetrahydroxyflavonoldb_source
Flavone, 3,4',5,5',7-pentahydroxy-biospider
Quercetindb_source
Quercetinebiospider
Quercitinbiospider
Quertinebiospider
Predicted Properties
PropertyValueSource
Water Solubility0.26 g/LALOGPS
logP1.81ALOGPS
logP2.16ChemAxon
logS-3.1ALOGPS
pKa (Strongest Acidic)6.38ChemAxon
pKa (Strongest Basic)-4ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area127.45 ŲChemAxon
Rotatable Bond Count1ChemAxon
Refractivity76.86 m³·mol⁻¹ChemAxon
Polarizability28.54 ųChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Chemical FormulaC15H10O7
IUPAC name2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one
InChI IdentifierInChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H
InChI KeyREFJWTPEDVJJIY-UHFFFAOYSA-N
Isomeric SMILESOC1=CC2=C(C(O)=C1)C(=O)C(O)=C(O2)C1=CC=C(O)C(O)=C1
Average Molecular Weight302.2357
Monoisotopic Molecular Weight302.042652674
Classification
Description belongs to the class of organic compounds known as flavonols. Flavonols are compounds that contain a flavone (2-phenyl-1-benzopyran-4-one) backbone carrying a hydroxyl group at the 3-position.
KingdomOrganic compounds
Super ClassPhenylpropanoids and polyketides
ClassFlavonoids
Sub ClassFlavones
Direct ParentFlavonols
Alternative Parents
Substituents
  • 3-hydroxyflavone
  • 3'-hydroxyflavonoid
  • 3-hydroxyflavonoid
  • 4'-hydroxyflavonoid
  • 5-hydroxyflavonoid
  • 7-hydroxyflavonoid
  • Hydroxyflavonoid
  • Chromone
  • Benzopyran
  • 1-benzopyran
  • Catechol
  • 1-hydroxy-4-unsubstituted benzenoid
  • 1-hydroxy-2-unsubstituted benzenoid
  • Phenol
  • Pyranone
  • Benzenoid
  • Monocyclic benzene moiety
  • Pyran
  • Heteroaromatic compound
  • Vinylogous acid
  • Oxacycle
  • Organoheterocyclic compound
  • Polyol
  • Organic oxide
  • Organic oxygen compound
  • Hydrocarbon derivative
  • Organooxygen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
Disposition

Route of exposure:

Source:

Biological location:

Role

Industrial application:

Foods
  • Cocoa and cocoa products
  • Grains:

    Nuts and legumes:

    Fruits and vegetables:

    Fats and oils:

    Beverages:

    Physico-Chemical Properties - Experimental
    Physico-Chemical Properties - Experimental
    PropertyValueReference
    Physical stateSolid
    Physical DescriptionNot Available
    Mass CompositionC 59.61%; H 3.33%; O 37.06%DFC
    Melting PointMp 313-314° dec.DFC
    Boiling PointNot Available
    Experimental Water Solubility0.06 mg/mL at 16 oCSEIDELL,A (1941)
    Experimental logPNot Available
    Experimental pKaNot Available
    Isoelectric pointNot Available
    ChargeNot Available
    Optical RotationNot Available
    Spectroscopic UV Data375 (e 20900) (EtOH) (Berdy)DFC
    DensityNot Available
    Refractive IndexNot Available
    Spectra
    Spectra
    Spectrum TypeDescriptionSplash KeyView
    GC-MSGC-MS Spectrum - GC-MS (5 TMS)splash10-0bt9-2611390000-f8e98c928a7ed82acda4JSpectraViewer | MoNA
    GC-MSGC-MS Spectrum - GC-MS (Non-derivatized)splash10-0bt9-2611390000-f8e98c928a7ed82acda4JSpectraViewer | MoNA
    Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positivesplash10-0079-0591000000-2a146657da898ec9322eJSpectraViewer
    Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (5 TMS) - 70eV, Positivesplash10-00l2-2093078000-1de46637305246feffd2JSpectraViewer
    LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-0udi-0009000000-d4689b76f41c73487399JSpectraViewer | MoNA
    LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-0udi-0967000000-613e61ec0c69ed0ee630JSpectraViewer | MoNA
    LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-0uy0-5910000000-ee816015eec26c8621b1JSpectraViewer | MoNA
    LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) 5V, Positivesplash10-0udi-0009000000-ec1cab852ed9f9f78fa4JSpectraViewer | MoNA
    LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negativesplash10-0udi-1907000000-6f36df2733dadae380c2JSpectraViewer | MoNA
    LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negativesplash10-0udi-0309000000-976a99c106ceca16d73bJSpectraViewer | MoNA
    LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negativesplash10-0pi0-1900000000-b2e286366d41e47dd8fcJSpectraViewer | MoNA
    LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negativesplash10-0udi-0209000000-e891863ec110aeb660b0JSpectraViewer | MoNA
    LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positivesplash10-0udi-0940000000-aa52db00c1defe3ccf75JSpectraViewer | MoNA
    LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positivesplash10-0udi-0219000000-5ef285c4b6bfd220b8b1JSpectraViewer | MoNA
    LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positivesplash10-0udi-0219000000-547c83bb70e7da007d6cJSpectraViewer | MoNA
    LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negativesplash10-0udi-1907000000-a59602c09f66e9656068JSpectraViewer | MoNA
    LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITTOF (LCMS-IT-TOF) , Positivesplash10-0udi-0009000000-4416f39adf6c9b919bfaJSpectraViewer | MoNA
    LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITTOF (LCMS-IT-TOF) , Negativesplash10-0udi-0019000000-eb14ec62fc2fb2f1da88JSpectraViewer | MoNA
    LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITTOF (LCMS-IT-TOF) , Negativesplash10-0ufr-0910000000-0730bca525c17aac75c5JSpectraViewer | MoNA
    LC-MS/MSLC-MS/MS Spectrum - ESI-TOF 10V, Negativesplash10-004i-0030290000-06238e4a98a4daad3265JSpectraViewer | MoNA
    LC-MS/MSLC-MS/MS Spectrum - ESI-TOF , Negativesplash10-0udi-0039008002-9df3edfb34deb15f8474JSpectraViewer | MoNA
    LC-MS/MSLC-MS/MS Spectrum - ESI-TOF 10V, Negativesplash10-0udi-0039008002-9df3edfb34deb15f8474JSpectraViewer | MoNA
    LC-MS/MSLC-MS/MS Spectrum - ESI-TOF 20V, Negativesplash10-0uka-0193000000-3325ca1a080730a9c0bfJSpectraViewer | MoNA
    Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0udi-0019000000-ee8570ac70818e8939bbJSpectraViewer
    Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0udi-0279000000-71b5db7ef8322cc8b9e9JSpectraViewer
    Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0zg0-7960000000-7edbb229853a642749acJSpectraViewer
    Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0udi-0009000000-21580b9d8394d2eea3a5JSpectraViewer
    Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0udi-0239000000-b77fcb9c0ce11dc515bfJSpectraViewer
    Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0apr-5940000000-0590bdee504c5ed6ba36JSpectraViewer
    1D NMR1H NMR SpectrumNot AvailableJSpectraViewer
    2D NMR[1H,13C] 2D NMR SpectrumNot AvailableJSpectraViewer
    ChemSpider ID4444051
    ChEMBL IDCHEMBL50
    KEGG Compound IDC00389
    Pubchem Compound ID5280343
    Pubchem Substance IDNot Available
    ChEBI IDNot Available
    Phenol-Explorer ID291
    DrugBank IDDB04216
    HMDB IDHMDB05794
    CRC / DFC (Dictionary of Food Compounds) IDHBR39-C:HBR39-C
    EAFUS IDNot Available
    Dr. Duke IDQUERCETIN
    BIGG IDNot Available
    KNApSAcK IDC00004631
    HET IDQUE
    Food Biomarker OntologyNot Available
    VMH IDNot Available
    Flavornet IDNot Available
    GoodScent IDNot Available
    SuperScent IDNot Available
    Wikipedia IDQuercetin
    Phenol-Explorer Metabolite ID291
    Duplicate IDSNot Available
    Old DFC IDSNot Available
    Associated Foods
    FoodContent Range AverageReference
    FoodReference
    Biological Effects and Interactions
    Health Effects / Bioactivities
    DescriptorIDDefinitionReference
    11beta-hydroxysteroid-dehydrogenase inhibitor23924 A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.DUKE
    5-lipoxygenase inhibitor23924 A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.DUKE
    aldehyde-oxidase inhibitor23924 A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.DUKE
    aldose reductase inhibitor48550 An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of aldehyde reductase (EC 1.1.1.21).DUKE
    allelochemicDUKE
    allergenic50904 A chemical compound which causes the onset of an allergic reaction by interacting with any of the molecular pathways involved in an allergy.DUKE
    analgesic35480 An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms.DUKE
    anti aflatoxin35222 A substance that diminishes the rate of a chemical reaction.DUKE
    anti aggregantDUKE
    anti aging52217 Any substance introduced into a living organism with therapeutic or diagnostic purpose.DUKE
    anti allergic50857 A drug used to treat allergic reactions.DUKE
    anti Alzheimeran52217 Any substance introduced into a living organism with therapeutic or diagnostic purpose.DUKE
    anti anaphylactic52217 Any substance introduced into a living organism with therapeutic or diagnostic purpose.DUKE
    anti angiogenic48422 An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.DUKE
    anti arthritic52217 Any substance introduced into a living organism with therapeutic or diagnostic purpose.DUKE
    anti asthmatic49167 A drug used to treat asthma.DUKE
    anti atherosclerotic38070 A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres.DUKE
    anti bacterial33282 A substance that kills or slows the growth of bacteria.DUKE
    anti carcinomic35610 A substance that inhibits or prevents the proliferation of neoplasms.DUKE
    anti cariogenic52217 Any substance introduced into a living organism with therapeutic or diagnostic purpose.DUKE
    anti cataract52217 Any substance introduced into a living organism with therapeutic or diagnostic purpose.DUKE
    anti colitic52217 Any substance introduced into a living organism with therapeutic or diagnostic purpose.DUKE
    anti complementaryDUKE
    anti Crohn's52217 Any substance introduced into a living organism with therapeutic or diagnostic purpose.DUKE
    anti cystiticDUKE
    anti depressant52217 Any substance introduced into a living organism with therapeutic or diagnostic purpose.DUKE
    anti dermatitic50177 A drug used to treat or prevent skin disorders or for the routine care of skin.DUKE
    anti diabetic52217 Any substance introduced into a living organism with therapeutic or diagnostic purpose.DUKE
    anti elastase23924 A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.DUKE
    anti encephalitic52217 Any substance introduced into a living organism with therapeutic or diagnostic purpose.DUKE
    anti escherichicDUKE
    anti estrogenic35222 A substance that diminishes the rate of a chemical reaction.DUKE
    anti feedantDUKE
    anti fibrosarcomicDUKE
    anti flu22587 A substance that destroys or inhibits replication of viruses.DUKE
    anti gastricDUKE
    anti gonadotropicDUKE
    anti glucose-tolerance-factorDUKE
    anti hepatotoxic62868 Any compound that is able to prevent damage to the liver.DUKE
    anti herpetic22587 A substance that destroys or inhibits replication of viruses.DUKE
    anti histaminic37956 Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists.DUKE
    anti HIV22587 A substance that destroys or inhibits replication of viruses.DUKE
    anti hydrophobicDUKE
    anti hypertensive52217 Any substance introduced into a living organism with therapeutic or diagnostic purpose.DUKE
    anti inflammatory35472 A substance that reduces or suppresses inflammation.DUKE
    anti leishmanic33281 A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.DUKE
    anti leukemic35610 A substance that inhibits or prevents the proliferation of neoplasms.DUKE
    anti leukotriene35222 A substance that diminishes the rate of a chemical reaction.DUKE
    anti lipoperoxidantDUKE
    anti malarial33281 A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.DUKE
    anti melanomic35610 A substance that inhibits or prevents the proliferation of neoplasms.DUKE
    anti metastatic35610 A substance that inhibits or prevents the proliferation of neoplasms.DUKE
    anti mutagenicDUKE
    anti myocarditic38070 A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres.DUKE
    anti nitrosaminicDUKE
    anti nociceptive35470 A class of drugs producing both physiological and psychological effects through a variety of mechanisms involving the central nervous system.DUKE
    antioxidant22586 A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides. In European countries, E-numbers for permitted antioxidant food additives are from E 300 to E 324.DUKE
    anti pancreatitic52217 Any substance introduced into a living organism with therapeutic or diagnostic purpose.DUKE
    anti periodontalDUKE
    anti peristalticDUKE
    anti permeabilityDUKE
    anti peroxidantDUKE
    anti pharyngiticDUKE
    anti plaqueDUKE
    anti plasmodial33281 A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.DUKE
    anti premenstrual syndrome52217 Any substance introduced into a living organism with therapeutic or diagnostic purpose.DUKE
    anti podriacDUKE
    anti polio22587 A substance that destroys or inhibits replication of viruses.DUKE
    anti proliferantDUKE
    anti prostanoidDUKE
    anti prostatiticDUKE
    anti psoriac52217 Any substance introduced into a living organism with therapeutic or diagnostic purpose.DUKE
    anti radicularDUKE
    anti spasmodic52217 Any substance introduced into a living organism with therapeutic or diagnostic purpose.DUKE
    anti streptococcic33282 A substance that kills or slows the growth of bacteria.DUKE
    anti thiaminDUKE
    anti thrombic50248 Drug that acts on blood and blood-forming organs and those that affect the hemostatic system.DUKE
    anti trypanosomic33281 A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.DUKE
    antitumor35610 A substance that inhibits or prevents the proliferation of neoplasms.DUKE
    antitumor promoter35610 A substance that inhibits or prevents the proliferation of neoplasms.DUKE
    anti ulcer49201 One of various classes of drugs with different action mechanisms used to treat or ameliorate peptic ulcer or irritation of the gastrointestinal tract.DUKE
    anti viral22587 A substance that destroys or inhibits replication of viruses.DUKE
    apoptoticDUKE
    ATPase inhibitor23924 A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.DUKE
    bacteristat33282 A substance that kills or slows the growth of bacteria.DUKE
    bradycardiac38070 A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres.DUKE
    calmodulin antagonist48706 Substance that attaches to and blocks cell receptors that normally bind naturally occurring substances.DUKE
    cAMP-phosphodiesterase inhibitor23924 A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.DUKE
    cancer preventive35610 A substance that inhibits or prevents the proliferation of neoplasms.DUKE
    candidicideDUKE
    capillariprotectiveDUKE
    carcinogenic50903 A role played by a chemical compound which is known to induce a process of carcinogenesis by corrupting normal cellular pathways, leading to the acquistion of tumoral capabilities.DUKE
    catabolicDUKE
    catechol O-methyltransferase inhibitor48406 An EC 2.1.1.* (methyltransferase) inhibitor that interferes with the action of catechol O-methyltransferase (EC 2.1.1.6).DUKE
    copper chelator38161 A ligand with two or more separate binding sites that can bind to a single metallic central atom, forming a chelate.DUKE
    cyclooxygenase-2 inhibitor50629 A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 2.DUKE
    cyclooxygenase inhibitor35544 A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes.DUKE
    cytochrome-P450-1A2 inhibitor50183 An enzyme inhibitor that interferes with the activity of cytochrome P450 involved in catalysis of organic substances.DUKE
    cytochrome-p450 inducerDUKE
    cytochrome-P450 inhibitor50183 An enzyme inhibitor that interferes with the activity of cytochrome P450 involved in catalysis of organic substances.DUKE
    cytotoxic52209 A role played by the molecular entity or part thereof which causes the development of a pathological process.DUKE
    deiodinase inhibitor23924 A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.DUKE
    diaphoreticDUKE
    differentiatorDUKE
    estrogenicDUKE
    fungicide24127 A substance used to destroy fungal pests.DUKE
    glucosyl-transferase inhibitor23924 A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.DUKE
    hemostatDUKE
    hepatomagenicDUKE
    hepatoprotective62868 Any compound that is able to prevent damage to the liver.DUKE
    HIV-reverse-transcriptase inhibitor23924 A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.DUKE
    hypoglycemic35526 A drug which lowers the blood glucose level.DUKE
    iNOS inhibitor23924 A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.DUKE
    inotropicDUKE
    insulinogenicDUKE
    juvabionalDUKE
    larvistatDUKE
    lipoxygenase inhibitor35856 A compound or agent that combines with lipoxygenase and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of the icosanoid products hydroxyicosatetraenoic acid and various leukotrienes.DUKE
    monoamine-oxidase-A inhibitor23924 A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.DUKE
    mast-cell stabilizerDUKE
    metalloproteinase inhibitor50664 DUKE
    matrix-metalloproteinase-9 inhibitor50664 DUKE
    mutagenicDUKE
    NADPH-oxidase inhibitor50423 An EC 1.6.3.* (oxidoreductase acting on NADH or NADPH with oxygen as acceptor) inhibitor that interferes with the action of NAD(P)H oxidase (H2O2-forming), EC 1.6.3.1.DUKE
    neutral-endopeptidase inhibitor59107 Any EC 3.4.* (hydrolases acting on peptide bond) inhibitor that interferes with the activity of a metalloendopeptidase (EC 3.4.24.*).DUKE
    neuroprotective63726 Any compound that can be used for the treatment of neurodegenerative disorders.DUKE
    NF-kappa-B inhibitor35222 A substance that diminishes the rate of a chemical reaction.DUKE
    nitric-oxide inhibitor35222 A substance that diminishes the rate of a chemical reaction.DUKE
    nitric-oxide-synthase inhibitor23924 A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.DUKE
    ornithine-decarboxylase inhibitor23924 A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.DUKE
    pesticide25944 Strictly, a substance intended to kill pests. In common usage, any substance used for controlling, preventing, or destroying animal, microbiological or plant pests.DUKE
    prostaglandin-E2 inhibitor35222 A substance that diminishes the rate of a chemical reaction.DUKE
    phospholipase inhibitor23924 A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.DUKE
    protein kinase C inhibitor37700 An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of protein kinase C (EC 2.7.11.13).DUKE
    plasmodicideDUKE
    proliferantDUKE
    prostaglandin synthesis inhibitor35222 A substance that diminishes the rate of a chemical reaction.DUKE
    protein-tyrosine-kinase inhibitor23924 A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.DUKE
    quinone-reductase inducerDUKE
    teratologicDUKE
    TNF-alpha inhibitor35222 A substance that diminishes the rate of a chemical reaction.DUKE
    topoisomerase-II inhibitor50750 A topoisomerase inhibitor that inhibits DNA topoisomerase (ATP-hydrolysing), EC 5.99.1.3 (topoisomerase II), which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands.DUKE
    topoisomerase-I inhibitor50276 A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA.DUKE
    tumorigenic50903 A role played by a chemical compound which is known to induce a process of carcinogenesis by corrupting normal cellular pathways, leading to the acquistion of tumoral capabilities.DUKE
    tyrosinase inhibitor59997 Any EC 1.14.18.* (oxidoreductase acting on paired donors, miscellaneous compound as one donor, incorporating 1 atom of oxygen) inhibitor that interferes with the action of tyrosinase (monophenol monooxygenase), EC 1.14.18.1, an enzyme that catalyses the oxidation of phenols (such as tyrosine) and is widespread in plants and animals.DUKE
    tyrosine-kinase inhibitor23924 A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.DUKE
    vasodilator35620 A drug used to cause dilation of the blood vessels.DUKE
    VEGF inhibitor35222 A substance that diminishes the rate of a chemical reaction.DUKE
    xanthine oxidase inhibitor35634 An EC 1.17.3.* (oxidoreductase acting on CH or CH2 with oxygen as acceptor) inhibitor that interferes with the action of xanthine oxidase (EC 1.17.3.2).DUKE
    protein kinase inhibitor37699 An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of protein kinases.CHEBI
    EnzymesNot Available
    PathwaysNot Available
    MetabolismNot Available
    BiosynthesisNot Available
    Organoleptic Properties
    Flavours
    FlavorCitations
    bitter
    1. Ayana Wiener, Marina Shudler, Anat Levit, Masha Y. Niv. BitterDB: a database of bitter compounds. Nucleic Acids Res 2012, 40(Database issue):D413-419. DOI:10.1093/nar/gkr755
    Files
    MSDSshow
    References
    Synthesis ReferenceNot Available
    General ReferenceNot Available
    Content Reference— Rothwell JA, Pérez-Jiménez J, Neveu V, Medina-Ramon A, M'Hiri N, Garcia Lobato P, Manach C, Knox K, Eisner R, Wishart D, Scalbert A. (2013) Phenol-Explorer 3.0: a major update of the Phenol-Explorer database to incorporate data on the effects of food processing on polyphenol content. Database, 10.1093/database/bat070.
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