Record Information
Version1.0
Creation date2010-04-08 22:10:11 UTC
Update date2018-05-28 23:37:13 UTC
Primary IDFDB012474
Secondary Accession NumbersNot Available
Chemical Information
FooDB NameXanthotoxin
DescriptionPresent in celery, especies the outer leaves, and other common grocery vegetables. Implicated in photodermatitis among grocery workers. Isolated from Aegle marmelos (bael) Methoxsalen (marketed under the trade name Oxsoralen) is a drug used to treat psoriasis, eczema, vitiligo, and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight. Methoxsalen modifies the way skin cells receive the UVA radiation, allegedly clearing up the disease. The dosage comes in 10mg tablets, which are taken in the amount of 30mg 75 minutes before a PUVA light treatment. The substance is also present in bergamot oil which is used in many perfumes and aromatherapy oils.; Methoxsalen selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of Methoxsalen-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.; Patients with high blood pressure or a history of liver problems are at risk for inflammation and irreparable damage to both liver and skin. The eyes must be protected from UVA radiation. Side effects include nausea, headaches, dizziness, and in rare cases insomnia. When Eau de Cologne was made, it became a popular perfume. It contained bergamot oil as one of its components. Ladies wearing the perfume on places where the skin was radiated by the sun, noticed that their skin turned brownish at those spots. This is due to the phototoxic effects of methoxsalen present in the bergamot oil. The methoxsalen was removed, and most modern formulations of perfumes containing bergamot are de-methoxsalenised. Xanthotoxin is found in many foods, some of which are parsley, wild celery, dill, and angelica.
CAS Number298-81-7
Structure
Thumb
Synonyms
SynonymSource
6-Hydroxy-7-methoxy-5-benzofuranacrylic acid delta-lactoneChEBI
8-Methoxy-2',3',6,7-furocoumarinChEBI
8-Methoxy-4',5':6,7-furocoumarinChEBI
8-Methoxy-[furano-3'.2':6.7-coumarin]ChEBI
8-MethoxyfuranocoumarinChEBI
8-MethoxypsoralenChEBI
8-MOPChEBI
8-MPChEBI
9-Methoxy-7H-furo[3,2-g][1]benzopyran-7-oneChEBI
MeladinineChEBI
MeloxineChEBI
O-MethylxanthotoxolChEBI
OxsoralenChEBI
Ultra mopChEBI
UvadexChEBI
XanthotoxinChEBI
6-Hydroxy-7-methoxy-5-benzofuranacrylate delta-lactoneGenerator
6-Hydroxy-7-methoxy-5-benzofuranacrylate δ-lactoneGenerator
6-Hydroxy-7-methoxy-5-benzofuranacrylic acid δ-lactoneGenerator
MethoxalenHMDB
XanthotoxineHMDB
XanthoxinHMDB
ZanthotoxinHMDB
8 MOPHMDB
Chinoin brand OF methoxsalenHMDB
DermoxHMDB
GeroxalenHMDB
ICN brand 2 OF methoxsalenHMDB
Methoxsalen mex-america brandHMDB
Oxsoralen ultraHMDB
Oxsoralen-ultraHMDB
8 MethoxypsoralenHMDB
AmmoidinHMDB
DB Brand OF methoxsalenHMDB
DeltasoralenHMDB
MeladininaHMDB
Methoxsalen Delta brandHMDB
Mex-america brand OF methoxsalenHMDB
MéladinineHMDB
Sanofi-synthelabo brand OF methoxsalenHMDB
8MOPHMDB
Boehringer ingelheim brand OF methoxsalenHMDB
Galderma brand OF methoxsalenHMDB
Methoxa-domeHMDB
Methoxsalen canderm brandHMDB
Methoxsalen chinoin brandHMDB
Methoxsalen dermatech brandHMDB
Methoxsalen sanofi-synthelabo brandHMDB
PuvalenHMDB
Sanofi synthelabo brand OF methoxsalenHMDB
UltramopHMDB
Canderm brand OF methoxsalenHMDB
Delta Brand OF methoxsalenHMDB
Dermatech brand OF methoxsalenHMDB
ICN brand 1 OF methoxsalenHMDB
ICN brand 3 OF methoxsalenHMDB
Methoxa domeHMDB
Mex america brand OF methoxsalenHMDB
6-hydroxy-7-methoxy-5-benzofuranacrylic acid delta-lactonebiospider
7-Furocoumarinbiospider
7H-Furo(3,2-g)(1)benzopyran-7-one, 9-methoxy-biospider
7H-Furo[3,2-g][1]benzopyran-7-one, 9-methoxy-biospider
8-Methoxybiospider
8-Methoxy-(furano-3'.2':6.7-coumarin)biospider
8-Methoxy-2',3',6, 7-furocoumarinbiospider
8-Methoxy-4',5',6,7-furocoumarinbiospider
8-Methoxy-6,7-furanocoumarinbiospider
8-Methoxy(furano-3'.2':6.7-coumarin)biospider
8-Methoxypsoralen with ultraviolet A therapybiospider
8-Methoxypsoralenebiospider
9-(methyloxy)-7H-furo[3,2-g]chromen-7-onebiospider
9-metho xy-7H-furo(3,2-g)benzopyran-7-onebiospider
9-Methoxy-7H-furo(3,2-g)(1)benzopyran-7-onebiospider
9-Methoxy-7H-furo(3,2-g)benzopyran-7-onebiospider
9-Methoxy-7H-furo[3,2-g][1]benzopyran-7-one, 9CI, 8CIdb_source
9-Methoxy-7H-furo[3,2-g]chromen-7-onebiospider
9-Methoxyfuro(3,2-g)chromen-7-onebiospider
9-Methoxyfuro[3,2-g][1]benzopyran-7-onebiospider
9-Methoxyfuro[3,2-g]chromen-7-onedb_source
9-Methoxypsoralendb_source
Ammodinbiospider
Boehringer ingelheim brand of methoxsalenbiospider
Canderm brand of methoxsalenbiospider
Chinoin brand of methoxsalenbiospider
DB brand of methoxsalenbiospider
Delta brand of methoxsalenbiospider
Dermatech brand of methoxsalenbiospider
Galderma brand of methoxsalenbiospider
ICN Brand 1 of Methoxsalenbiospider
ICN Brand 2 of Methoxsalenbiospider
ICN Brand 3 of Methoxsalenbiospider
Meladininbiospider
Meladinin (van)biospider
Meladoxenbiospider
Methoxa-Domedb_source
Methoxatenbiospider
MethoxsalenChEBI
Methoxsalen (JP15/USP)biospider
Methoxsalen [ban:jan]biospider
Methoxsalen delta brandbiospider
Methoxsalen plus ultraviolet radiationbiospider
Methoxsalen with ultra-violet a theraphybiospider
Methoxsalen, 8-biospider
Methoxsalen, BANdb_source
Methoxy-8-psoralenbiospider
Mex america brand of methoxsalenbiospider
Mex-america brand of methoxsalenbiospider
New-meladininbiospider
O-methylxanthotoxolbiospider
Oxoralenbiospider
Oxsoralen (TN)biospider
Oxsoralen lotionbiospider
Oxsoralen ul trabiospider
Oxypsoralenbiospider
Proralone-mopbiospider
Psoralen-mopbiospider
Psoralon-mopbiospider
Puvametbiospider
Sanofi synthelabo brand of methoxsalenbiospider
Sanofi-synthelabo brand of methoxsalenbiospider
Predicted Properties
PropertyValueSource
Water Solubility0.16 g/LALOGPS
logP2.1ALOGPS
logP1.78ChemAxon
logS-3.1ALOGPS
pKa (Strongest Basic)-2.9ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area48.67 ŲChemAxon
Rotatable Bond Count1ChemAxon
Refractivity56.85 m³·mol⁻¹ChemAxon
Polarizability20.98 ųChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Chemical FormulaC12H8O4
IUPAC name9-methoxy-7H-furo[3,2-g]chromen-7-one
InChI IdentifierInChI=1S/C12H8O4/c1-14-12-10-8(4-5-15-10)6-7-2-3-9(13)16-11(7)12/h2-6H,1H3
InChI KeyQXKHYNVANLEOEG-UHFFFAOYSA-N
Isomeric SMILESCOC1=C2OC(=O)C=CC2=CC2=C1OC=C2
Average Molecular Weight216.192
Monoisotopic Molecular Weight216.042258738
Classification
Description belongs to the class of organic compounds known as 8-methoxypsoralens. These are psoralens containing a methoxy group attached at the C8 position of the psoralen group.
KingdomOrganic compounds
Super ClassPhenylpropanoids and polyketides
ClassCoumarins and derivatives
Sub ClassFuranocoumarins
Direct Parent8-methoxypsoralens
Alternative Parents
Substituents
  • 8-methoxypsoralen
  • Benzopyran
  • 1-benzopyran
  • Benzofuran
  • Anisole
  • Alkyl aryl ether
  • Pyranone
  • Pyran
  • Benzenoid
  • Furan
  • Heteroaromatic compound
  • Lactone
  • Oxacycle
  • Ether
  • Organoheterocyclic compound
  • Organic oxygen compound
  • Organooxygen compound
  • Hydrocarbon derivative
  • Organic oxide
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Physico-Chemical Properties - Experimental
Physico-Chemical Properties - Experimental
PropertyValueReference
Physical stateSolid
Physical DescriptionNot Available
Mass CompositionC 66.67%; H 3.73%; O 29.60%DFC
Melting PointMp 148°DFC
Boiling PointNot Available
Experimental Water Solubility0.0476 mg/mL at 30 oCYALKOWSKY,SH & DANNENFELSER,RM (1992)
Experimental logPNot Available
Experimental pKaNot Available
Isoelectric pointNot Available
ChargeNot Available
Optical RotationNot Available
Spectroscopic UV Data301 (e 14400) (EtOH) (Berdy)DFC
DensityNot Available
Refractive IndexNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash Key
ChemSpider ID3971
ChEMBL IDCHEMBL416
KEGG Compound IDC01864
Pubchem Compound ID4114
Pubchem Substance IDNot Available
ChEBI IDNot Available
Phenol-Explorer ID719
DrugBank IDDB00553
HMDB IDHMDB14693
CRC / DFC (Dictionary of Food Compounds) IDHHG12-C:HHG12-C
EAFUS IDNot Available
Dr. Duke ID8-METHOXY-PSORALEN|XANTHOTOXIN
BIGG IDNot Available
KNApSAcK IDC00000576
HET ID8MO
Flavornet IDNot Available
GoodScent IDNot Available
SuperScent IDNot Available
Wikipedia IDXanthotoxin
Phenol-Explorer Metabolite IDNot Available
Duplicate IDSNot Available
Old DFC IDSNot Available
Associated Foods
FoodContent Range AverageReference
FoodReference
Biological Effects and Interactions
Health Effects / Bioactivities
DescriptorIDDefinitionReference
anti aflatoxin35222 A substance that diminishes the rate of a chemical reaction.DUKE
anti alopecic52217 Any substance introduced into a living organism with therapeutic or diagnostic purpose.DUKE
anti bacterial33282 A substance that kills or slows the growth of bacteria.DUKE
anti dermatitic50177 A drug used to treat or prevent skin disorders or for the routine care of skin.DUKE
anti feedantDUKE
anti histaminic37956 Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists.DUKE
anti inflammatory35472 A substance that reduces or suppresses inflammation.DUKE
anti keratoticDUKE
anti leucodermicDUKE
anti lymphomicDUKE
anti mitoticDUKE
anti mutagenicDUKE
anti mycoticDUKE
anti pityriasicDUKE
anti pruritic50177 A drug used to treat or prevent skin disorders or for the routine care of skin.DUKE
anti psoriac52217 Any substance introduced into a living organism with therapeutic or diagnostic purpose.DUKE
anti scleromyxoedemic50177 A drug used to treat or prevent skin disorders or for the routine care of skin.DUKE
anti spasmodic52217 Any substance introduced into a living organism with therapeutic or diagnostic purpose.DUKE
anti staphylococcic33282 A substance that kills or slows the growth of bacteria.DUKE
antitumor35610 A substance that inhibits or prevents the proliferation of neoplasms.DUKE
antitumor promoter35610 A substance that inhibits or prevents the proliferation of neoplasms.DUKE
anti viral22587 A substance that destroys or inhibits replication of viruses.DUKE
anti vitiligicDUKE
artemicideDUKE
bufocideDUKE
calcium antagonist48706 Substance that attaches to and blocks cell receptors that normally bind naturally occurring substances.DUKE
cancer preventive35610 A substance that inhibits or prevents the proliferation of neoplasms.DUKE
candidicideDUKE
carcinogenic50903 A role played by a chemical compound which is known to induce a process of carcinogenesis by corrupting normal cellular pathways, leading to the acquistion of tumoral capabilities.DUKE
cytotoxic52209 A role played by the molecular entity or part thereof which causes the development of a pathological process.DUKE
dermatitigenicDUKE
emeticDUKE
fungicide24127 A substance used to destroy fungal pests.DUKE
fungistatDUKE
hepatoprotective62868 Any compound that is able to prevent damage to the liver.DUKE
herbicide24527 A substance used to destroy plant pests.DUKE
hypertrichoticDUKE
immunosuppressant35705 An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.DUKE
insecticide24852 Strictly, a substance intended to kill members of the class Insecta. In common usage, any substance used for preventing, destroying, repelling or controlling insects.DUKE
lipolyticDUKE
lymphocytogenicDUKE
melaninogenicDUKE
mitogenicDUKE
molluscicide33904 A substance used to destroy pests of the phylum Mollusca.DUKE
mutagenicDUKE
pesticide25944 Strictly, a substance intended to kill pests. In common usage, any substance used for controlling, preventing, or destroying animal, microbiological or plant pests.DUKE
photodermatitigenicDUKE
phototoxicDUKE
phytoalexin26115 A toxin made by a plant that acts against an organism attacking it.DUKE
piscicideDUKE
EnzymesNot Available
PathwaysNot Available
MetabolismNot Available
BiosynthesisNot Available
Organoleptic Properties
Flavours
FlavorCitations
bitter
  1. Ayana Wiener, Marina Shudler, Anat Levit, Masha Y. Niv. BitterDB: a database of bitter compounds. Nucleic Acids Res 2012, 40(Database issue):D413-419. DOI:10.1093/nar/gkr755
Files
MSDSshow
References
Synthesis ReferenceNot Available
General ReferenceNot Available
Content Reference— Shinbo, Y., et al. 'KNApSAcK: a comprehensive species-metabolite relationship database.' Plant Metabolomics. Springer Berlin Heidelberg, 2006. 165-181.
— Duke, James. 'Dr. Duke's Phytochemical and Ethnobotanical Databases. United States Department of Agriculture.' Agricultural Research Service, Accessed April 27 (2004).
— Rothwell JA, Pérez-Jiménez J, Neveu V, Medina-Ramon A, M'Hiri N, Garcia Lobato P, Manach C, Knox K, Eisner R, Wishart D, Scalbert A. (2013) Phenol-Explorer 3.0: a major update of the Phenol-Explorer database to incorporate data on the effects of food processing on polyphenol content. Database, 10.1093/database/bat070.