1.02010-04-08 22:10:13 UTC2019-11-26 03:06:57 UTCFDB012523DicoumarolIsolated from Melilotus alba (white melilot)
Dicoumarol (INN) or dicumarol (USAN) is an anticoagulant that functions as a Vitamin K antagonist (similar to warfarin). It is also used in biochemical experiments as an inhibitor of reductases.; Dicumarol is an coumarin-like compound found in sweet clover. It is used as an oral anticoagulant and acts by inhibiting the hepatic synthesis of vitamin K-dependent coagulation factors (prothrombin and factors VII, IX, and X). It is also used in biochemical experiments as an inhibitor of reductases.; It is a derivative of coumarin.; Mechanism of action : it is a competitive inhibitor of Vitamin K preventing the formation of prothrombin , Administration of Vitamin K is the antidote for dicumarol toxicity; also that Dicumarol is a chemical subsrance of plant origin given only orally and acts within two days.2H-1-Benzopyran-2-one, 3,3'-methylenebis(4-hydroxy-2H-1-Benzopyran-2-one, 3,3'-methylenebis(4-hydroxy)-2H-1-Benzopyran-2-one, 3,3'-methylenebis[4-hydroxy-2H-1-Benzopyran-2-one, 3,3'-methylenebis[4-hydroxy- (9CI)2H-1-Benzopyran-2-one), 3,3'-methylenebis(4-hydroxy-2H-1-Benzopyran-2-one], 3,3'-methylenebis[4-hydroxy-3, 3'-Methylen-bis(4-hydroxy-cumarin) (GERMAN)3,3 -Methylene-bis[4-hydroxycoumarin]3,3'-methanediylbis(4-hydroxy-2H-chromen-2-one)3,3'-Methyleen-bis(4-hydroxy-cumarine)3,3'-Methylen-bis(4-hydroxy-cumarin)3,3'-Methylene-bis(4-hydroxycoumarin)3,3'-Methylene-bis(4-hydroxycoumarine)3,3'-Methylenebis-4-hydroxycoumarin, 8CI3,3'-Methylenebis(4-hydroxy-1,2-benzopyrone)3,3'-Methylenebis(4-hydroxy-2H-1-benzopyran-2-one)3,3'-methylenebis(4-hydroxy-2H-chromen-2-one)3,3'-Methylenebis(4-hydroxycoumarin)3,3'-Methylenebis[4-hydroxy-1,2-benzopyrone]3,3'-Methylenebis[4-hydroxy-2H-1-benzopyran-2-one]3,3'-Methylenebis[4-hydroxy-2H-1-benzopyran-2-one], 9CI3,3'-Methylenebis[4-hydroxycoumarin]3,3'-Metilen-bis(4-idrossi-cumarina)4,4'-Dihydroxy-3,3'-methylene bis coumarinAcadylAcavylAnathrombaseAntitrombosinApekumarolBaracouminBis-3, 3'-(4-hydroxycoumarinyl)methaneBis-3,3'-(4-hydroxycoumarinyl)methaneBis-3,3'-(4-oxycoumarinyl)ethylacetateBis-hydroxycoumarinBis(4-hydroxycoumarin-3-yl)methaneBishydroxycoumarinCoumarin, 3,3'-methylenebis(4-hydroxy-Coumarin, 3,3'-methylenebis[4-hydroxy-Coumarin, 3,3'-methylenebis[4-hydroxy- (8CI)CUMACumidDi-(4-hydroxy-3-coumarinyl)methaneDi-4-hydroxy-3, 3'-methylenedicoumarinDi-4-hydroxy-3,3'-methylenedicoumarinDicoumalDicoumarinDicoumarol (inn)DicoumarolumDicoumerolDicumanDicumaol rDicumarineDicumarinumDicumarolDicumarol (TN)Dicumarol (usan)Dicumarol [usan]Dicumarol(usan)DicumaroloDicumarolo [dcit]DicumarolumDicumolDikumarolDTCDufaloneDwukumarolKumoranMelitoxinTemparinTrombosanUncoupler of oxidative respirationC19H12O6336.295336.0633881164-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl]-2H-chromen-2-onedicoumarol66-76-2OC1=C(CC2=C(O)C3=C(OC2=O)C=CC=C3)C(=O)OC2=C1C=CC=C2InChI=1S/C19H12O6/c20-16-10-5-1-3-7-14(10)24-18(22)12(16)9-13-17(21)11-6-2-4-8-15(11)25-19(13)23/h1-8,20-21H,9H2DOBMPNYZJYQDGZ-UHFFFAOYSA-N belongs to the class of organic compounds known as 4-hydroxycoumarins. These are coumarins that contain one or more hydroxyl groups attached to C4-position the coumarin skeleton.4-hydroxycoumarinsOrganic compoundsPhenylpropanoids and polyketidesCoumarins and derivativesHydroxycoumarinsAromatic heteropolycyclic compounds1-benzopyransBenzenoidsHeteroaromatic compoundsHydrocarbon derivativesLactonesOrganic oxidesOrganooxygen compoundsOxacyclic compoundsPyranones and derivativesVinylogous acids1-benzopyran4-hydroxycoumarinAromatic heteropolycyclic compoundBenzenoidBenzopyranHeteroaromatic compoundHydrocarbon derivativeLactoneOrganic oxideOrganic oxygen compoundOrganoheterocyclic compoundOrganooxygen compoundOxacyclePyranPyranoneVinylogous acidcoumarinshydroxycoumarinSolidlogp1.54logs-3.71solubility6.62e-02 g/lmelting_pointMp 288-289°logp-1.6pka_strongest_acidic-12pka_strongest_basic-3.1iupac4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl]-2H-chromen-2-oneaverage_mass336.295mono_mass336.063388116smilesOC1=C(CC2=C(O)C3=C(OC2=O)C=CC=C3)C(=O)OC2=C1C=CC=C2formulaC19H12O6inchiInChI=1S/C19H12O6/c20-16-10-5-1-3-7-14(10)24-18(22)12(16)9-13-17(21)11-6-2-4-8-15(11)25-19(13)23/h1-8,20-21H,9H2inchikeyDOBMPNYZJYQDGZ-UHFFFAOYSA-Npolar_surface_area93.06refractivity89.19polarizability32.32rotatable_bond_count2acceptor_count4donor_count2physiological_charge-1formal_charge0Dicumarol PathwaySMP00270Specdb::CMs14944Specdb::CMs29927Specdb::CMs40308Specdb::CMs100092Specdb::CMs151563Specdb::NmrOneD100758Specdb::NmrOneD100759Specdb::NmrOneD100760Specdb::NmrOneD100761Specdb::NmrOneD100762Specdb::NmrOneD100763Specdb::NmrOneD100764Specdb::NmrOneD100765Specdb::NmrOneD100766Specdb::NmrOneD100767Specdb::NmrOneD100768Specdb::NmrOneD100769Specdb::NmrOneD100770Specdb::NmrOneD100771Specdb::NmrOneD100772Specdb::NmrOneD100773Specdb::NmrOneD100774Specdb::NmrOneD100775Specdb::NmrOneD100776Specdb::NmrOneD100777Specdb::MsMs94890Specdb::MsMs94891Specdb::MsMs94892Specdb::MsMs159021Specdb::MsMs159022Specdb::MsMs159023Specdb::MsMs2392537Specdb::MsMs2392538Specdb::MsMs2392539Specdb::MsMs2570030Specdb::MsMs2570031Specdb::MsMs2570032HMDB14411#<Reference:0x00005556741acaa0>#<Reference:0x00005556741ac870>#<Reference:0x00005556741ac550>#<Reference:0x00005556741ac280>Herbs and SpicesUnknowngenericPulsesUnknowngenericbitterVitamin K epoxide reductase complex subunit 1Q9BQB6VKORC1