1.0 2010-04-08 22:10:13 UTC 2015-07-20 22:51:31 UTC FDB012540 Hygromycin B FDA approved antibiotic food additive for swine and poultry Hygromycin B is an antibiotic produced by the bacterium Streptomyces hygroscopicus. It is an aminoglycoside that kills bacteria, fungi and higher eukaryotic cells by inhibiting protein synthesis.; In the laboratory it is used for the selection and maintenance of prokaryotic and eukaryotic cells that contain the hygromycin resistance gene. The resistance gene is a kinase that inactivates hygromycin B through phosphorylation. Since the discovery of hygromycin-resistance genes, hygromycin B has become a standard selection antibiotic in gene transfer experiments in many prokaryotic and eukaryotic cells. Antibiotic A-396-II Antihelmycin Hyanthelmix Hydromycin b Hygromix 2.4 Hygromix-8 Hygromycin B Hygrovectine Hygrovetine C20H37N3O13 527.5201 527.232638285 4-{[3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy}-6'-(1-amino-2-hydroxyethyl)-6-(hydroxymethyl)-tetrahydro-3aH-spiro[[1,3]dioxolo[4,5-c]pyran-2,2'-oxane]-3',4',5',7-tetrol 4-{[3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy}-6'-(1-amino-2-hydroxyethyl)-6-(hydroxymethyl)-tetrahydro-3aH-spiro[[1,3]dioxolo[4,5-c]pyran-2,2'-oxane]-3',4',5',7-tetrol 31282-04-9 CNC1CC(N)C(O)C(OC2OC(CO)C(O)C3OC4(OC23)OC(C(N)CO)C(O)C(O)C4O)C1O InChI=1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3 GRRNUXAQVGOGFE-UHFFFAOYSA-N belongs to the class of organic compounds known as 2-deoxystreptamine aminoglycosides. These are aminoglycosides containing the 2-deoxystreptamine (1,3-diaminocyclohexane-4,5,6-triol) core. 2-deoxystreptamine aminoglycosides Organic compounds Organic oxygen compounds Organooxygen compounds Carbohydrates and carbohydrate conjugates Aliphatic heteropolycyclic compounds 1,2-aminoalcohols 1,3-dioxolanes Acetals Aminocyclitols and derivatives Carboxylic acid orthoesters Cyclohexanols Cyclohexylamines Dialkylamines Dioxolopyrans Disaccharides Hydrocarbon derivatives Monoalkylamines O-glycosyl compounds Organopnictogen compounds Ortho esters Oxacyclic compounds Oxanes Polyols Primary alcohols 1,2-aminoalcohol 2-deoxystreptamine aminoglycoside Acetal Alcohol Aliphatic heteropolycyclic compound Amine Aminocyclitol or derivatives Carboxylic acid orthoester Cyclic alcohol Cyclitol or derivatives Cyclohexanol Cyclohexylamine Dioxolopyran Disaccharide Glycosyl compound Hydrocarbon derivative Meta-dioxolane O-glycosyl compound Organic nitrogen compound Organoheterocyclic compound Organonitrogen compound Organopnictogen compound Ortho ester Orthocarboxylic acid derivative Oxacycle Oxane Polyol Primary alcohol Primary aliphatic amine Primary amine Secondary alcohol Secondary aliphatic amine Secondary amine amino cyclitol logp -2.92 ALOGPS logs -0.39 ALOGPS solubility 2.13e+02 g/l ALOGPS melting_point Mp 160-180° dec. logp -6.5 ChemAxon pka_strongest_acidic 11.41 ChemAxon pka_strongest_basic 9.83 ChemAxon iupac 4-{[3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy}-6'-(1-amino-2-hydroxyethyl)-6-(hydroxymethyl)-tetrahydro-3aH-spiro[[1,3]dioxolo[4,5-c]pyran-2,2'-oxane]-3',4',5',7-tetrol ChemAxon average_mass 527.5201 ChemAxon mono_mass 527.232638285 ChemAxon smiles CNC1CC(N)C(O)C(OC2OC(CO)C(O)C3OC4(OC23)OC(C(N)CO)C(O)C(O)C4O)C1O ChemAxon formula C20H37N3O13 ChemAxon inchi InChI=1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3 ChemAxon inchikey GRRNUXAQVGOGFE-UHFFFAOYSA-N ChemAxon polar_surface_area 272.06 ChemAxon refractivity 114.05 ChemAxon polarizability 51.86 ChemAxon rotatable_bond_count 6 ChemAxon acceptor_count 16 ChemAxon donor_count 11 ChemAxon physiological_charge 3 ChemAxon formal_charge 0 ChemAxon Specdb::NmrOneD 124998 Specdb::NmrOneD 124999 Specdb::NmrOneD 125000 Specdb::NmrOneD 125001 Specdb::NmrOneD 125002 Specdb::NmrOneD 125003 Specdb::NmrOneD 125004 Specdb::NmrOneD 125005 Specdb::NmrOneD 125006 Specdb::NmrOneD 125007 Specdb::NmrOneD 125008 Specdb::NmrOneD 125009 Specdb::NmrOneD 125010 Specdb::NmrOneD 125011 Specdb::NmrOneD 125012 Specdb::NmrOneD 125013 Specdb::NmrOneD 125014 Specdb::NmrOneD 125015 Specdb::NmrOneD 125016 Specdb::NmrOneD 125017 Specdb::CMs 11959 Specdb::CMs 43773 Specdb::CMs 179047 Specdb::CMs 179048 Specdb::CMs 179049 Specdb::CMs 179050 Specdb::CMs 179051 Specdb::CMs 179052 Specdb::CMs 179053 Specdb::CMs 179054 Specdb::CMs 179055 Specdb::CMs 280941 Specdb::CMs 912450 Specdb::CMs 912451 Specdb::CMs 912452 Specdb::CMs 912453 Specdb::CMs 912454 Specdb::CMs 912455 Specdb::CMs 912456 Specdb::CMs 912457 Specdb::CMs 912458 Specdb::CMs 912459 Specdb::CMs 912460 Specdb::CMs 912461 Specdb::CMs 912462 Specdb::MsMs 95094 Specdb::MsMs 95095 Specdb::MsMs 95096 Specdb::MsMs 159273 Specdb::MsMs 159274 Specdb::MsMs 159275 Specdb::MsMs 2392261 Specdb::MsMs 2392262 Specdb::MsMs 2392263 Specdb::MsMs 2569550 Specdb::MsMs 2569551 Specdb::MsMs 2569552 HMDB34229 16976 #<Reference:0x000055ce31a9c680>