Record Information
Version1.0
Creation date2011-04-11 17:01:43 UTC
Update date2015-10-09 22:29:05 UTC
Primary IDFDB021813
Secondary Accession NumbersNot Available
Chemical Information
FooDB NameAdenosine triphosphate
DescriptionAdenosine triphosphate (ATP) is a nucleotide consisting of a purine base (adenine) attached to the first carbon atom of ribose (a pentose sugar). Three phosphate groups are esterified at the fifth carbon atom of the ribose. ATP is incorporated into nucleic acids by polymerases in the processes of DNA replication and transcription. ATP contributes to cellular energy charge and participates in overall energy balance, maintaining cellular homeostasis. ATP can act as an extracellular signaling molecule via interactions with specific purinergic receptors to mediate a wide variety of processes as diverse as neurotransmission, inflammation, apoptosis, and bone remodelling. Extracellular ATP and its metabolite adenosine have also been shown to exert a variety of effects on nearly every cell type in human skin, and ATP seems to play a direct role in triggering skin inflammatory, regenerative, and fibrotic responses to mechanical injury, an indirect role in melanocyte proliferation and apoptosis, and a complex role in Langerhans cell-directed adaptive immunity. During exercise, intracellular homeostasis depends on the matching of adenosine triphosphate (ATP) supply and ATP demand. Metabolites play a useful role in communicating the extent of ATP demand to the metabolic supply pathways Effects as different as proliferation or differentiation, chemotaxis, release of cytokines or lysosomal constituents, and generation of reactive oxygen or nitrogen species are elicited upon stimulation of blood cells with extracellular ATP. The increased concentration of adenosine triphosphate (ATP) in erythrocytes from patients with chronic renal failure (CRF) has been observed in many studies but the mechanism leading to these abnormalities still is controversial. (PMID: 15490415, 15129319, 14707763, 14696970, 11157473) [HMDB]
CAS Number56-65-5
Structure
Thumb
Synonyms
SynonymSource
5'-(Tetrahydrogen triate) adenosineHMDB
5'-ATPHMDB
Adenosine 5'-triateChEBI
Adenosine 5'-triic acidGenerator
Adenosine 5'-triorateHMDB
Adenosine 5'-trioric acidHMDB
Adenosine triateChEBI
Adenosine triic acidGenerator
ADENOSINE-5'-triATEChEBI
ADENOSINE-5'-triic acidGenerator
AdenylpyroorateHMDB
Adenylpyrooric acidHMDB
AdephosChEBI
AdetolChEBI
AdynolChEBI
AtipiChEBI
ATPHMDB
AtriphosChEBI
CardenosineChEBI
FosfobionChEBI
GlucobasinChEBI
H4ATPChEBI
MyotriphosChEBI
ObionHMDB
StriadyneHMDB
TriadenChEBI
TriadenylChEBI
Trioric acid adenosine esterHMDB
Predicted Properties
PropertyValueSource
Water Solubility4.49 g/LALOGPS
logP-0.84ALOGPS
logP-6.2ChemAxon
logS-2ALOGPS
pKa (Strongest Acidic)0.9ChemAxon
pKa (Strongest Basic)5ChemAxon
Physiological Charge-3ChemAxon
Hydrogen Acceptor Count14ChemAxon
Hydrogen Donor Count7ChemAxon
Polar Surface Area279.13 ŲChemAxon
Rotatable Bond Count8ChemAxon
Refractivity95.81 m³·mol⁻¹ChemAxon
Polarizability39.53 ųChemAxon
Number of Rings3ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Chemical FormulaC10H16N5O13P3
IUPAC name({[({[5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid
InChI IdentifierInChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)
InChI KeyInChIKey=ZKHQWZAMYRWXGA-UHFFFAOYSA-N
Isomeric SMILESNC1=C2N=CN(C3OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C3O)C2=NC=N1
Average Molecular Weight507
Monoisotopic Molecular Weight507
Classification
DescriptionThis compound belongs to the class of chemical entities known as purine ribonucleoside triphosphates. These are purine ribobucleotides with a triphosphate group linked to the ribose moiety.
KingdomChemical entities
Super ClassOrganic compounds
ClassNucleosides, nucleotides, and analogues
Sub ClassPurine nucleotides
Direct ParentPurine ribonucleoside triphosphates
Alternative Parents
Substituents
  • Purine ribonucleoside triphosphate
  • Purine ribonucleoside monophosphate
  • Pentose phosphate
  • Pentose-5-phosphate
  • Glycosyl compound
  • N-glycosyl compound
  • 6-aminopurine
  • Monosaccharide phosphate
  • Pentose monosaccharide
  • Imidazopyrimidine
  • Purine
  • Aminopyrimidine
  • Monoalkyl phosphate
  • Pyrimidine
  • Alkyl phosphate
  • Imidolactam
  • Primary aromatic amine
  • Phosphoric acid ester
  • Monosaccharide
  • N-substituted imidazole
  • Organic phosphoric acid derivative
  • Imidazole
  • Tetrahydrofuran
  • Heteroaromatic compound
  • Azole
  • Secondary alcohol
  • 1,2-diol
  • Oxacycle
  • Azacycle
  • Organoheterocyclic compound
  • Organic nitrogen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Organopnictogen compound
  • Organic oxygen compound
  • Organonitrogen compound
  • Organooxygen compound
  • Amine
  • Alcohol
  • Primary amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External DescriptorsNot Available
Physico-Chemical Properties - Experimental
Physico-Chemical Properties - Experimental
PropertyValueReference
Physical stateSolid
Physical DescriptionNot Available
Mass CompositionNot Available
Melting PointNot Available
Boiling PointNot Available
Experimental Water SolubilityNot Available
Experimental logPNot Available
Experimental pKaNot Available
Isoelectric pointNot Available
ChargeNot Available
Optical RotationNot Available
Spectroscopic UV DataNot Available
DensityNot Available
Refractive IndexNot Available
Spectra
SpectraNot Available
ChemSpider ID5742
ChEMBL IDCHEMBL14249
KEGG Compound IDC00002
Pubchem Compound ID5957
Pubchem Substance IDNot Available
ChEBI IDNot Available
Phenol-Explorer IDNot Available
DrugBank IDNot Available
HMDB IDHMDB00538
CRC / DFC (Dictionary of Food Compounds) IDHCH56-O:HCH56-O
EAFUS IDNot Available
Dr. Duke IDNot Available
BIGG ID33477
KNApSAcK IDNot Available
HET IDATP
Flavornet IDNot Available
GoodScent IDNot Available
SuperScent IDNot Available
Wikipedia IDNot Available
Phenol-Explorer Metabolite IDNot Available
Duplicate IDSNot Available
Old DFC IDSNot Available
Associated Foods
FoodContent Range AverageReference
FoodReference
Biological Effects and Interactions
Health Effects / BioactivitiesNot Available
Enzymes
NameGene NameUniProt ID
SedoheptulokinaseSHPKQ9UHJ6
Inositol-pentakisphosphate 2-kinaseIPPKQ9H8X2
Inositol hexakisphosphate kinase 3IHPK3Q5TAQ4
Putative uncharacterized protein IP6K1IP6K1Q92551
Tyrosine--tRNA ligase, cytoplasmicYARSP54577
Tyrosine--tRNA ligase, mitochondrialYARS2Q9Y2Z4
Epidermal growth factor receptorEGFRP00533
Propionyl-CoA carboxylase beta chain, mitochondrialPCCBP05166
Valine--tRNA ligaseVARSP26640
Valine--tRNA ligase, mitochondrialVARS2Q5ST30
Lysine--tRNA ligaseKARSQ15046
Trifunctional purine biosynthetic protein adenosine-3GARTP22102
Glycine--tRNA ligaseGARSP41250
Glutathione synthetaseGSSP48637
Heat shock 70 kDa protein 1A/1BHSPA1AP08107
Alanine--tRNA ligase, cytoplasmicAARSP49588
Alanine--tRNA ligase, mitochondrialAARS2Q5JTZ9
Glutamate--cysteine ligase catalytic subunitGCLCP48506
Bifunctional glutamate/proline--tRNA ligaseEPRSP07814
Probable proline--tRNA ligase, mitochondrialPARS2Q7L3T8
Choline/ethanolamine kinaseCHKBQ9Y259
Choline kinase alphaCHKAP35790
Serum paraoxonase/lactonase 3PON3Q15166
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1PAPSS1O43252
Glycerol kinase 2GK2Q14410
Glycerol kinaseGKP32189
Putative glycerol kinase 3GK3PQ14409
Putative glycerol kinase 5GK5Q6ZS86
Ethanolamine kinase 1ETNK1Q9HBU6
Ethanolamine kinase 2ETNK2Q9NVF9
Asparagine synthetase [glutamine-hydrolyzing]ASNSP08243
Asparagine--tRNA ligase, cytoplasmicNARSO43776
Probable asparagine--tRNA ligase, mitochondrialNARS2Q96I59
V-type proton ATPase catalytic subunit AATP6V1AP38606
V-type proton ATPase subunit C 1ATP6V1C1P21283
N-acetylgalactosamine kinaseGALK2Q01415
GalactokinaseGALK1P51570
GlucokinaseGCKP35557
Hexokinase-3HK3P52790
Hexokinase-2HK2P52789
Hexokinase-1HK1P19367
Insulin-like growth factor 1 receptorIGF1RP08069
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinaseGNEQ9Y223
ATP-citrate synthaseACLYP53396
Probable leucine--tRNA ligase, mitochondrialLARS2Q15031
Leucine--tRNA ligase, cytoplasmicLARSQ9P2J5
Deoxycytidine kinaseDCKP27707
Probable gluconokinaseIDNKQ5T6J7
Tryptophan--tRNA ligase, cytoplasmicWARSP23381
Tryptophan--tRNA ligase, mitochondrialWARS2Q9UGM6
Arginine--tRNA ligase, cytoplasmicRARSP54136
Argininosuccinate synthaseASS1P00966
Probable arginine--tRNA ligase, mitochondrialRARS2Q5T160
Selenide, water dikinase 2SEPHS2Q99611
Homeodomain-interacting protein kinase 1HIPK1Q86Z02
Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrialMMABQ96EY8
Proto-oncogene tyrosine-protein kinase SrcSRCP12931
Inositol-trisphosphate 3-kinase AITPKAP23677
Myosin light chain kinase 2, skeletal/cardiac muscleMYLK2Q9H1R3
Calcium/calmodulin-dependent protein kinase type II subunit deltaCAMK2DQ13557
Calcium/calmodulin-dependent protein kinase IDCAMK1DQ5SQQ7
Calcium/calmodulin-dependent protein kinase (CaM kinase) II betaCAMK2BA4D2J9
Putative uncharacterized protein DKFZp686I0955DKFZp686I0955Q5HYC3
Calcium/calmodulin-dependent protein kinase I, isoform CRA_aCAMK1B0YIY3
Sodium/potassium-transporting ATPase subunit beta-3ATP1B3P54709
Sodium/potassium-transporting ATPase subunit beta-2ATP1B2P14415
Potassium-transporting ATPase alpha chain 2ATP12AP54707
Potassium-transporting ATPase subunit betaATP4BP51164
Potassium-transporting ATPase alpha chain 1ATP4AP20648
Delta-1-pyrroline-5-carboxylate synthaseALDH18A1P54886
Beta-adrenergic receptor kinase 1ADRBK1P25098
Beta-adrenergic receptor kinase 2ADRBK2P35626
Rhodopsin kinaseGRK1Q15835
G protein-coupled receptor kinase 7GRK7Q8WTQ7
Carbamoyl-phosphate synthase [ammonia], mitochondrialCPS1P31327
Glutamine synthetaseGLULP15104
CTP synthase 2CTPS2Q9NRF8
Glycogen synthase kinase-3 betaGSK3BP49841
KetohexokinaseKHKP50053
Mevalonate kinaseMVKQ03426
Creatine kinase S-type, mitochondrialCKMT2P17540
Creatine kinase B-typeCKBP12277
Creatine kinase U-type, mitochondrialCKMT1AP12532
Creatine kinase M-typeCKMP06732
Uridine-cytidine kinase-like 1UCKL1Q9NWZ5
UMP-CMP kinase 2, mitochondrialCMPK2Q5EBM0
Ribonucleoside-diphosphate reductase large subunitRRM1P23921
N-acylglucosamine 2-epimeraseRENBPP51606
N-acetyl-D-glucosamine kinaseNAGKQ9UJ70
Spliceosome RNA helicase DDX39BDDX39BQ13838
Acetyl-coenzyme A synthetase, cytoplasmicACSS2Q9NR19
Acetyl-coenzyme A synthetase 2-like, mitochondrialACSS1Q9NUB1
Thiamin pyrophosphokinase 1TPK1Q9H3S4
Probable glutamate--tRNA ligase, mitochondrialEARS2Q5JPH6
Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)DAKQ3LXA3
Ubiquitin-conjugating enzyme E2 D2UBE2D2P62837
RibokinaseRBKSQ9H477
Long-chain-fatty-acid--CoA ligase ACSBG2ACSBG2Q5FVE4
Long-chain-fatty-acid--CoA ligase ACSBG1ACSBG1Q96GR2
Pantothenate kinase 4PANK4Q9NVE7
Pantothenate kinase 1PANK1Q8TE04
Pantothenate kinase 3PANK3Q9H999
Probable histidine--tRNA ligase, mitochondrialHARS2P49590
Histidine--tRNA ligase, cytoplasmicHARSP12081
Phosphopantothenate--cysteine ligasePPCSQ9HAB8
Threonine--tRNA ligase, cytoplasmicTARSP26639
Probable threonine--tRNA ligase 2, cytoplasmicTARSL2A2RTX5
Threonine--tRNA ligase, mitochondrialTARS2Q9BW92
Propionyl-CoA carboxylase alpha chain, mitochondrialPCCAP05165
Deoxyguanosine kinase, mitochondrialDGUOKQ16854
Methionine--tRNA ligase, cytoplasmicMARSP56192
Methionine--tRNA ligase, mitochondrialMARS2Q96GW9
Glutamine--tRNA ligaseQARSP47897
Phosphoribosylformylglycinamidine synthasePFASO15067
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrialPET112O75879
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrialQRSL1Q9H0R6
Glycerate kinaseGLYCTKQ8IVS8
Adenylate kinase 2, mitochondrialAK2P54819
Guanylate kinaseGUK1Q16774
Isoleucine--tRNA ligase, cytoplasmicIARSP41252
Isoleucine--tRNA ligase, mitochondrialIARS2Q9NSE4
Folylpolyglutamate synthase, mitochondrialFPGSQ05932
5-oxoprolinaseOPLAHO14841
Aspartate--tRNA ligase, cytoplasmicDARSP14868
Multifunctional protein ADE2PAICSP22234
Aspartate--tRNA ligase, mitochondrialDARS2Q6PI48
Cysteine--tRNA ligase, cytoplasmicCARSP49589
Serine--tRNA ligase, mitochondrialSARS2Q9NP81
Serine--tRNA ligase, cytoplasmicSARSP49591
Thymidine kinase, cytosolicTK1P04183
Thymidine kinase 2, mitochondrialTK2O00142
C-1-tetrahydrofolate synthase, cytoplasmicMTHFD1P11586
Monofunctional C1-tetrahydrofolate synthase, mitochondrialMTHFD1LQ6UB35
Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolaseMTHFD2Q7Z650
Bile acyl-CoA synthetaseSLC27A5Q9Y2P5
DNA-directed RNA polymerase III subunit RPC4POLR3DP05423
DNA-directed RNA polymerase, mitochondrialPOLRMTO00411
DNA-directed RNA polymerase I subunit RPA2POLR1BQ9H9Y6
DNA-directed RNA polymerase III subunit RPC7POLR3GO15318
DNA-directed RNA polymerase III subunit RPC2POLR3BQ9NW08
DNA-directed RNA polymerase I subunit RPA49POLR1EQ9GZS1
DNA-directed RNA polymerase III subunit RPC8POLR3HQ9Y535
DNA-directed RNA polymerase III subunit RPC1POLR3AO14802
DNA-directed RNA polymerase I subunit RPA1POLR1AO95602
Zinc ribbon domain containing 1ZNRD1Q2L6J2
DNA-directed RNA polymerases I and III subunit RPAC2POLR1DQ9Y2S0
DNA-directed RNA polymeraseDKFZp686D10173Q7Z3R8
DNA-directed RNA polymerase III subunit RPC7-likePOLR3GLQ9BT43
POLR1C proteinPOLR1CQ96HT3
Phenylalanine--tRNA ligase, mitochondrialFARS2O95363
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2PAPSS2O95340
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrialMCCC2Q9HCC0
Biotin--protein ligaseHLCSP50747
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrialMCCC1Q96RQ3
Phenylalanine--tRNA ligase beta subunitFARSBQ9NSD9
Ubiquitin-conjugating enzyme E2 AUBE2AP49459
NEDD8-conjugating enzyme Ubc12UBE2MP61081
Ubiquitin/ISG15-conjugating enzyme E2 L6UBE2L6O14933
Ubiquitin-conjugating enzyme E2 G1UBE2G1P62253
Ubiquitin-conjugating enzyme E2 E2UBE2E2Q96LR5
DNA ligase 4LIG4P49917
Ubiquitin-conjugating enzyme E2 BUBE2BP63146
Ubiquitin-conjugating enzyme E2 J2UBE2J2Q8N2K1
Ubiquitin-conjugating enzyme E2 L3UBE2L3P68036
RNA 3'-terminal phosphate cyclaseRTCAO00442
Ubiquitin-conjugating enzyme E2 D3UBE2D3P61077
Ubiquitin-like modifier-activating enzyme 1UBA1P22314
Ubiquitin-conjugating enzyme E2 E1UBE2E1P51965
SUMO-conjugating enzyme UBC9UBE2IP63279
Ubiquitin-conjugating enzyme E2 J1UBE2J1Q9Y385
Ubiquitin-conjugating enzyme E2 CUBE2CO00762
Selenide, water dikinase 1SEPHS1P49903
Ubiquitin-conjugating enzyme E2 NUBE2NP61088
DNA ligase 1LIG1P18858
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3PFKFB3Q16875
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4PFKFB4Q16877
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1PFKFB1P16118
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2PFKFB2O60825
Diphosphomevalonate decarboxylaseMVDP53602
Poly(A) polymerase alphaPAPOLAP51003
Poly(A) polymerase gammaPAPOLGQ9BWT3
Katanin p60 ATPase-containing subunit A1KATNA1O75449
Bifunctional polynucleotide phosphatase/kinasePNKPQ96T60
Bifunctional coenzyme A synthaseCOASYQ13057
E3 ubiquitin-protein ligase NEDD4-likeNEDD4LQ96PU5
Acetoacetyl-CoA synthetaseAACSQ86V21
3-hydroxyisobutyryl-CoA hydrolase, mitochondrialHIBCHQ6NVY1
RuvB-like 2RUVBL2Q9Y230
Acyl-CoA synthetase family member 4AASDHQ4L235
FARSLA proteinFARSLAQ6IBR2
SUMO-activating enzyme subunit 2UBA2Q9UBT2
E3 ubiquitin-protein ligase HUWE1HUWE1Q7Z6Z7
E3 ubiquitin-protein ligase ToporsTOPORSQ9NS56
STIP1 homology and U-box containing protein 1 (STIP1 homology and U- box containing protein 1, isoform CRA_c)STUB1Q9UNE7
Ubiquitin conjugation factor E4 BUBE4BO95155
Membrane-associated ring finger (C3HC4) 6 (Membrane-associated ring finger (C3HC4) 6, isoform CRA_a)MARCH6O60337
NEDD4-like E3 ubiquitin-protein ligase WWP2WWP2O00308
E3 ubiquitin-protein ligase MARCH3MARCH3Q86UD3
NEDD8-conjugating enzyme UBE2FUBE2FQ969M7
Ubiquitin-conjugating enzyme E2 UUBE2UQ5VVX9
Probable E3 ubiquitin-protein ligase MARCH10MARCH10Q8NA82
E3 ubiquitin-protein ligase UBR1UBR1Q8IWV7
E3 ubiquitin-protein ligase MARCH8MARCH8Q5T0T0
E3 ubiquitin-protein ligase ZNRF2ZNRF2Q8NHG8
E3 ubiquitin-protein ligase TRIM32TRIM32Q13049
Probable E3 ubiquitin-protein ligase MYCBP2MYCBP2O75592
E3 ubiquitin-protein ligase MGRN1MGRN1O60291
E3 ubiquitin-protein ligase UBR2UBR2Q8IWV8
E3 ubiquitin-protein ligase UBR4UBR4Q5T4S7
E3 ubiquitin-protein ligase AMFRAMFRQ9UKV5
Ubiquitin-conjugating enzyme E2 SUBE2SQ16763
Pre-mRNA-processing factor 19PRPF19Q9UMS4
Myosin regulatory light chain interacting protein (Myosin regulatory light chain interacting protein, isoform CRA_a)MYLIPQ8WY64
HNP95hNp95Q96T88
Putative ubiquitin-conjugating enzyme E2 N-likeUBE2NLQ5JXB2
Midline-1MID1O15344
E3 ubiquitin-protein ligase NEDD4NEDD4P46934
CCR4-NOT transcription complex subunit 4CNOT4O95628
E3 ubiquitin-protein ligase MARCH2MARCH2Q9P0N8
E3 ubiquitin-protein ligase UBR5UBR5O95071
E3 ubiquitin-protein ligase TRIM33TRIM33Q9UPN9
E3 ubiquitin-protein ligase MARCH5MARCH5Q9NX47
Ubiquitin-conjugating enzyme E2 R2UBE2R2Q712K3
E3 ubiquitin-protein ligase MARCH1MARCH1Q8TCQ1
E3 ubiquitin-protein ligase FANCLFANCLQ9NW38
Ubiquitin-like modifier-activating enzyme 6UBA6A0AVT1
Ubiquitin-conjugating enzyme E2 WUBE2WQ96B02
Galactosyl transferase-associated proteinGTAPQ29SN7
E3 ubiquitin-protein ligase CHFRCHFRQ96EP1
Ring finger protein 20RNF20Q5VTR2
E3 ubiquitin-protein ligase RAD18RAD18Q9NS91
E3 ubiquitin ligase SMURF1SMURF1Q9HCE7
Baculoviral IAP repeat-containing protein 6BIRC6Q9NR09
E3 ubiquitin-protein ligase MARCH4MARCH4Q9P2E8
E3 ubiquitin-protein ligase CCNB1IP1CCNB1IP1Q9NPC3
E3 ubiquitin-protein ligase RNF5RNF5Q99942
Ubiquitin-conjugating enzyme E2 OUBE2OQ9C0C9
Praja 1PJA1A2A322
RFWD2 proteinRFWD2Q05CT6
E3 ubiquitin-protein ligase SMURF2SMURF2Q9HAU4
E3 ubiquitin-protein ligase SIAH1SIAH1Q8IUQ4
E3 ubiquitin-protein ligase SIAH2SIAH2O43255
E3 ubiquitin-protein ligase MARCH7MARCH7Q9H992
Ubiquitin-conjugating enzyme E2 ZUBE2ZQ9H832
Ubiquitin-like modifier-activating enzyme 7UBA7P41226
Ubiquitin carrier proteinUBE2HA4D1L5
Ubiquitin-protein ligase E3AUBE3AQ05086
E3 ubiquitin-protein ligase RNF128RNF128Q8TEB7
E3 ubiquitin-protein ligase TRIM11TRIM11Q96F44
E3 ubiquitin-protein ligase synoviolinSYVN1Q86TM6
E3 ubiquitin-protein ligase TRIM63TRIM63Q969Q1
E3 ubiquitin-protein ligase LNXLNX1Q8TBB1
E3 ubiquitin-protein ligase ZNRF1ZNRF1Q8ND25
Tripartite motif-containing protein 5TRIM5Q9C035
Ubiquitin-protein ligase E3BUBE3BQ7Z3V4
E3 ubiquitin-protein ligase RNF8RNF8O76064
E3 ubiquitin-protein ligase LRSAM1LRSAM1Q6UWE0
Ubiquitin-conjugating enzyme E2 Q2UBE2Q2Q8WVN8
E3 ubiquitin-protein ligase MARCH9MARCH9Q86YJ5
Probable E3 ubiquitin-protein ligase TRIP12TRIP12Q14669
E3 ubiquitin-protein ligase DZIP3DZIP3Q86Y13
Ubiquitin-protein ligase E3CUBE3CQ15386
Poly(A) polymerase beta (Testis specific)PAPOLBA4D1Z6
Cancer-related nucleoside-triphosphataseNTPCRQ9BSD7
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16DHX16O60231
E3 ubiquitin-protein ligase MIB1MIB1Q86YT6
E3 ubiquitin-protein ligase RNF138RNF138Q8WVD3
E3 ubiquitin-protein ligase RING2RNF2Q99496
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferaseAASDHPPTQ9NRN7
SUMO-activating enzyme subunit 1SAE1Q9UBE0
Ubiquitin-conjugating enzyme E2 D4UBE2D4Q9Y2X8
Ubiquitin conjugation factor E4 AUBE4AQ14139
E3 ubiquitin-protein ligase RNF144BRNF144BQ7Z419
V-type proton ATPase subunit G 3ATP6V1G3Q96LB4
V-type proton ATPase subunit G 1ATP6V1G1O75348
ATP synthase subunit epsilon, mitochondrialATP5EP56381
ATP synthase subunit delta, mitochondrialATP5DP30049
V-type proton ATPase subunit G 2ATP6V1G2O95670
ATP synthase subunit O, mitochondrialATP5OP48047
ATP synthase-coupling factor 6, mitochondrialATP5JP18859
ATP synthase protein 8MT-ATP8P03928
ATP synthase subunit e, mitochondrialATP5IP56385
ATP synthase subunit gamma, mitochondrialATP5C1P36542
V-type proton ATPase subunit d 1ATP6V0D1P61421
V-type proton ATPase subunit B, brain isoformATP6V1B2P21281
ATP synthase subunit b, mitochondrialATP5F1P24539
ATP synthase subunit alpha, mitochondrialATP5A1P25705
Probable phospholipid-transporting ATPase IIBATP9BO43861
V-type proton ATPase 16 kDa proteolipid subunitATP6V0CP27449
V-type proton ATPase subunit e 1ATP6V0E1O15342
ATP synthase subunit d, mitochondrialATP5HO75947
ATP synthase subunit f, mitochondrialATP5J2P56134
V-type proton ATPase 116 kDa subunit a isoform 2ATP6V0A2Q9Y487
ATP synthase lipid-binding protein, mitochondrialATP5G3P48201
V-type proton ATPase subunit HATP6V1HQ9UI12
V-type proton ATPase subunit DATP6V1DQ9Y5K8
V-type proton ATPase subunit d 2ATP6V0D2Q8N8Y2
V-ATPase subunit E 2ATP6V1E2Q96A05
V-type proton ATPase subunit C 2ATP6V1C2Q8NEY4
T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 (T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3, isoform CRA_c)TCIRG1Q13488
V-type proton ATPase subunit e 2ATP6V0E2Q8NHE4
Putative uncharacterized protein ATP6V1E1ATP6V1E1P36543
ATPase, H+ transporting, lysosomal accessory protein 1 (ATPase, H+ transporting, lysosomal accessory protein 1, isoform CRA_d) (cDNA FLJ78461, highly similar to Homo sapiens ATPase, H+ transporting, lysosomal accessory protein 1 (ATP6AP1), mRNA) (FragmentATP6AP1Q15904
ATPase, H+ transporting, lysosomal 14kDa, V1 subunit FATP6V1FA4D1K0
Cell division protein kinase 5CDK5Q00535
Phenylalanine--tRNA ligase alpha subunitFARSAQ9Y285
L-fucose kinaseFUKQ8N0W3
Adenylate kinase isoenzyme 1AK1P00568
Adenylate kinase isoenzyme 4, mitochondrialAK4P27144
Adenylate kinase 7AK7Q96M32
Very long-chain acyl-CoA synthetaseSLC27A2O14975
Adenylyltransferase and sulfurtransferase MOCS3MOCS3O95396
Thymidylate kinaseDTYMKP23919
Phosphomevalonate kinasePMVKQ15126
cGMP-dependent protein kinase 1PRKG1Q13976
cGMP-dependent protein kinase 2PRKG2Q13237
Serine/threonine-protein kinase RIO2RIOK2Q9BVS4
Cell division protein kinase 3CDK3Q00526
Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gammaPIK3C2GO75747
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoformPIK3CDO00329
Tyrosine-protein kinase TXKTXKP42681
Epithelial discoidin domain-containing receptor 1DDR1Q08345
Receptor-interacting serine/threonine-protein kinase 3RIPK3Q9Y572
BDNF/NT-3 growth factors receptorNTRK2Q16620
Myosin-IIIaMYO3AQ8NEV4
Macrophage-stimulating protein receptorMST1RQ04912
Vascular endothelial growth factor receptor 3FLT4P35916
Dual specificity protein kinase CLK4CLK4Q9HAZ1
Receptor tyrosine-protein kinase erbB-3ERBB3P21860
Ephrin type-A receptor 5EPHA5P54756
[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrialPDK1Q15118
Cell division protein kinase 10CDK10Q15131
Mitogen-activated protein kinase kinase kinase 14MAP3K14Q99558
Tyrosine-protein kinase transmembrane receptor ROR2ROR2Q01974
MAP/microtubule affinity-regulating kinase 3MARK3P27448
Tyrosine-protein kinase-like 7PTK7Q13308
Mitotic checkpoint serine/threonine-protein kinase BUB1BUB1O43683
Ephrin type-B receptor 1EPHB1P54762
FL cytokine receptorFLT3P36888
Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoformPHKG1Q16816
Tyrosine-protein kinase JAK2JAK2O60674
Serine/threonine-protein kinase N2PKN2Q16513
Maternal embryonic leucine zipper kinaseMELKQ14680
Phosphatidylinositol-5-phosphate 4-kinase type-2 alphaPIP4K2AP48426
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoformPIK3CBP42338
Cyclin-dependent kinase-like 5CDKL5O76039
Cell division protein kinase 17CDK17Q00537
Protein-tyrosine kinase 6PTK6Q13882
Tyrosine-protein kinase receptor TYRO3TYRO3Q06418
ALK tyrosine kinase receptorALKQ9UM73
Proto-oncogene tyrosine-protein kinase YesYES1P07947
Serine-protein kinase ATMATMQ13315
Dual specificity tyrosine-phosphorylation-regulated kinase 1BDYRK1BQ9Y463
Fibroblast growth factor receptor 4FGFR4P22455
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoformPIK3CAP42336
Serine/threonine-protein kinase pim-3PIM3Q86V86
Hormonally up-regulated neu tumor-associated kinaseHUNKP57058
MAP/microtubule affinity-regulating kinase 4MARK4Q96L34
Insulin receptor-related proteinINSRRP14616
Ephrin type-A receptor 2EPHA2P29317
Dual specificity protein kinase CLK1CLK1P49759
Tyrosine-protein kinase HCKHCKP08631
Homeodomain-interacting protein kinase 3HIPK3Q9H422
Discoidin domain-containing receptor 2DDR2Q16832
Serine/threonine-protein kinase 10STK10O94804
Cell division protein kinase 13CDK13Q14004
Serine/threonine-protein kinase VRK1VRK1Q99986
Vascular endothelial growth factor receptor 2KDRP35968
Serine/threonine-protein kinase pim-2PIM2Q9P1W9
Focal adhesion kinase 1PTK2Q05397
Serine/threonine-protein kinase 35STK35Q8TDR2
Inositol polyphosphate multikinaseIPMKQ8NFU5
Serine/threonine-protein kinase PRP4 homologPRPF4BQ13523
Serine/threonine-protein kinase PLK4PLK4O00444
Non-receptor tyrosine-protein kinase TNK1TNK1Q13470
Cell division protein kinase 12CDK12Q9NYV4
Ephrin type-B receptor 4EPHB4P54760
Dual specificity protein kinase CLK2CLK2P49760
Inhibitor of nuclear factor kappa-B kinase subunit betaIKBKBO14920
Fibroblast growth factor receptor 2FGFR2P21802
Tyrosine-protein kinase JAK1JAK1P23458
Macrophage colony-stimulating factor 1 receptorCSF1RP07333
Serine/threonine-protein kinase 6AURKAO14965
Proto-oncogene serine/threonine-protein kinase mosMOSP00540
RAC-beta serine/threonine-protein kinaseAKT2P31751
Serine/threonine-protein kinase VRK2VRK2Q86Y07
DNA-dependent protein kinase catalytic subunitPRKDCP78527
Ephrin type-A receptor 7EPHA7Q15375
Serine/threonine-protein kinase ULK1ULK1O75385
Tyrosine-protein kinase MerMERTKQ12866
Serine/threonine-protein kinase Sgk2SGK2Q9HBY8
TP53-regulating kinaseTP53RKQ96S44
Serine/threonine-protein kinase MAKMAKP20794
Ephrin type-A receptor 1EPHA1P21709
Phosphatidylinositol-5-phosphate 4-kinase type-2 betaPIP4K2BP78356
Alpha-type platelet-derived growth factor receptorPDGFRAP16234
Tyrosine-protein kinase LckLCKP06239
Tyrosine-protein kinase JAK3JAK3P52333
Cell division protein kinase 9CDK9P50750
Muscle, skeletal receptor tyrosine-protein kinaseMUSKO15146
Fibroblast growth factor receptor 3FGFR3P22607
RAC-gamma serine/threonine-protein kinaseAKT3Q9Y243
Dual specificity mitogen-activated protein kinase kinase 4MAP2K4P45985
Ephrin type-A receptor 3EPHA3P29320
Non-receptor tyrosine-protein kinase TYK2TYK2P29597
Receptor tyrosine-protein kinase erbB-4ERBB4Q15303
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinasePKMYT1Q99640
Glycogen synthase kinase-3 alphaGSK3AP49840
Cell division protein kinase 7CDK7P50613
Tyrosine-protein kinase FgrFGRP09769
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoformPIK3CGP48736
Phosphorylase b kinase gamma catalytic chain, testis/liver isoformPHKG2P15735
Cell division protein kinase 4CDK4P11802
Phosphatidylinositol 4-kinase alphaPI4KAP42356
Serine/threonine-protein kinase RIO1RIOK1Q9BRS2
Serine/threonine-protein kinase 16STK16O75716
Ribosomal protein S6 kinase beta-1RPS6KB1P23443
Ephrin type-A receptor 4EPHA4P54764
3-phosphoinositide-dependent protein kinase 1PDPK1O15530
STE20/SPS1-related proline-alanine-rich protein kinaseSTK39Q9UEW8
Casein kinase II subunit alphaCSNK2A1P68400
Serine/threonine-protein kinase PLK2PLK2Q9NYY3
Beta-type platelet-derived growth factor receptorPDGFRBP09619
Tyrosine-protein kinase BlkBLKP51451
Cyclin-dependent kinase-like 1CDKL1Q00532
Tyrosine-protein kinase receptor Tie-1TIE1P35590
Mitotic checkpoint serine/threonine-protein kinase BUB1 betaBUB1BO60566
Tyrosine-protein kinase RYKRYKP34925
Integrin-linked protein kinaseILKQ13418
Vascular endothelial growth factor receptor 1FLT1P17948
ATP synthase subunit beta, mitochondrialATP5BP06576
Receptor tyrosine-protein kinase erbB-2ERBB2P04626
Serine/threonine-protein kinase Chk1CHEK1O14757
Casein kinase II subunit alpha'CSNK2A2P19784
Tyrosine-protein kinase FRKFRKP42685
Proto-oncogene tyrosine-protein kinase ROSROS1P08922
Cell division protein kinase 19CDK19Q9BWU1
Cell division protein kinase 18CDK18Q07002
Tyrosine-protein kinase Fes/FpsFESP07332
Tyrosine-protein kinase FerFERP16591
Tyrosine-protein kinase STYK1STYK1Q6J9G0
Phosphoglycerate kinase 2PGK2P07205
Receptor-interacting serine/threonine-protein kinase 2RIPK2O43353
Ephrin type-B receptor 3EPHB3P54753
[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrialPDK3Q15120
Tyrosine-protein kinase SrmsSRMSQ9H3Y6
Mast/stem cell growth factor receptorKITP10721
Serine/threonine-protein kinase PLK1PLK1P53350
Tyrosine-protein kinase ZAP-70ZAP70P43403
Serine/threonine-protein kinase 17BSTK17BO94768
Insulin receptorINSRP06213
Serine/threonine-protein kinase DCLK2DCLK2Q8N568
Proto-oncogene tyrosine-protein kinase receptor RetRETP07949
Phosphoglycerate kinase 1PGK1P00558
Serine/threonine-protein kinase 17ASTK17AQ9UEE5
Serine/threonine-protein kinase N1PKN1Q16512
Ephrin type-B receptor 2EPHB2P29323
Serine/threonine-protein kinase H1PSKH1P11801
Inhibitor of nuclear factor kappa-B kinase subunit alphaCHUKO15111
Xylulose kinaseXYLBO75191
Dual specificity mitogen-activated protein kinase kinase 3MAP2K3P46734
MAP kinase-activated protein kinase 2MAPKAPK2P49137
Phosphatidylinositol-4-phosphate 5-kinase type-1 gammaPIP5K1CO60331
Phosphatidylinositol 4-kinase, catalytic, beta polypeptidePIK4CBQ9UBF8
Phosphatidylinositol-5-phosphate 4-kinase type-2 gammaPIP4K2CQ8TBX8
Sphingosine kinase 1SPHK1Q96GK1
Diacylglycerol kinase, epsilon 64kDaDGKEA1L4Q0
Multiple substrate lipid kinase, isoform CRA_aFLJ10842A4D1U5
Phosphoinositide-3-kinase, class 2, beta polypeptidePIK3C2BA2RUF7
EPH receptor A8EPHA8P29322
Ephrin type-B receptor 6EPHB6O15197
Ephrin type-A receptor 10EPHA10Q5JZY3
Met proto-oncogene (Hepatocyte growth factor receptor)METP08581
Neurotrophic tyrosine kinase, receptor, type 3NTRK3Q96CY4
ROR1 proteinROR1Q01973
AXL receptor tyrosine kinaseAXLP30530
LYN proteinLYNQ6NUK7
Leucine-rich repeat serine/threonine-protein kinase 2LRRK2Q5S007
Myosin-IIIbMYO3BQ8WXR4
CSNK1A1 proteinCSNK1A1Q6PJ06
Casein kinase I isoform deltaCSNK1DP48730
Casein kinase I isoform epsilonCSNK1EP49674
Casein kinase I isoform gamma-3CSNK1G3Q9Y6M4
Mixed lineage kinase domain-like proteinMLKLQ8NB16
AP2-associated protein kinase 1AAK1Q2M2I8
TRAF2 and NCK interacting kinase (TRAF2 and NCK interacting kinase, isoform CRA_g)TNIKQ9UKE5
PASK proteinPASKQ96RG2
HCG1641087TSSK2A0ZT99
Dual serine/threonine and tyrosine protein kinaseDSTYKQ6XUX3
Cyclin-G-associated kinaseGAKO14976
Serine/threonine-protein kinase ULK3ULK3Q6PHR2
SFRS protein kinase 3SRPK3Q9UPE1
Homeodomain-interacting protein kinase 2HIPK2Q9H2X6
Myosin light chain kinase family member 4MYLK4Q86YV6
Interleukin-1 receptor-associated kinase-like 2IRAK2O43187
Serine/threonine-protein kinase SBK1SBK1Q52WX2
LIM domain kinase 2LIMK2P53671
Eukaryotic translation initiation factor 2-alpha kinase 4EIF2AK4Q9P2K8
Interleukin-1 receptor associated kinase-4IRAK4Q69FE3
Putative uncharacterized protein VRK3VRK3Q8IV63
Serine/threonine-protein kinase TAO3TAOK3Q9H2K8
Putative uncharacterized protein DKFZp547K1617 (Casein kinase 1, gamma 1) (HCG2004507, isoform CRA_a)DKFZp547K1617Q9HCP0
Protein kinasedikQ9H4D1
E3 ubiquitin-protein ligase RFWD3RFWD3Q6PCD5
Putative uncharacterized protein BMP2KBMP2KQ4W5H2
TAO kinase 1 (TAO kinase 1, isoform CRA_a)TAOK1Q7L7X3
Putative uncharacterized protein RPS6KA1RPS6KA1A6NND1
Putative uncharacterized protein WNK2WNK2A8MQ23
Aurora/Ipl1-related kinase 3 transcript variant 1AURKCQ9UQB9
Cell division cycle 7-related protein kinaseCDC7O00311
Testis-specific serine kinase 1TSSK1A0ZT98
Serine/threonine kinase 24 (STE20 homolog, yeast)STK24Q5U0E6
Microtubule-associated serine/threonine-protein kinase-likeMASTLQ96GX5
Serine/threonine-protein kinase H2PSKH2Q96QS6
Receptor-interacting serine/threonine-protein kinase 1RIPK1Q13546
U4/U6 small nuclear ribonucleoprotein Prp4PRPF4O43172
TAOK2 proteinTAOK2A0PJ48
Eukaryotic translation initiation factor 2-alpha kinase 3EIF2AK3Q9NZJ5
Serine/threonine-protein kinase ULK2ULK2Q8IYT8
STE20-like serine/threonine-protein kinaseSLKQ9H2G2
Pyruvate dehydrogenase kinase, isoenzyme 4PDK4A4D1H4
Inhibitor of nuclear factor kappa-B kinase subunit epsilonIKBKEQ14164
Serine/threonine-protein kinase N3PKN3Q6P5Z2
Cyclin-dependent kinase 6CDK6A4D1G0
Cell division protein kinase 20CDK20Q8IZL9
Cyclin-dependent kinase-like 4CDKL4Q5MAI5
Cyclin-dependent kinase-like 3CDKL3Q8IVW4
PFTAIRE protein kinase 1 (PFTAIRE protein kinase 1, isoform CRA_c) (cDNA FLJ75582, highly similar to Homo sapiens PFTAIRE protein kinase 1 (PFTK1), mRNA)PFTK1O94921
MAPK/MAK/MRK overlapping kinaseRAGEQ9UQ07
Mitogen-activated protein kinase 15MAPK15Q8TD08
Mitogen-activated protein kinase 4MAPK4A1A4C4
Tau-tubulin kinase 2TTBK2Q6IQ55
Dual specificity tyrosine-phosphorylation-regulated kinase 1ADYRK1AQ13627
Lymphokine-activated killer T-cell-originated protein kinasePBKQ96KB5
Mitogen-activated protein kinase kinase 1MAP2K1A4QPA9
Dual specificity mitogen-activated protein kinase kinase 2MAP2K2P36507
Casein kinase 2 beta polypeptideCSNK2BP67870
V-akt murine thymoma viral oncogene homolog 1AKT1B0LPE5
WNK lysine deficient protein kinase 4WNK4B0LPI0
Protein kinase, cAMP-dependent, catalytic, beta, isoform CRA_aPRKACBB2RB89
Cyclin-dependent kinase-like 2CDKL2Q92772
Serine/threonine-protein kinase LMTK2LMTK2Q8IWU2
Ribosomal protein S6 kinase beta-2RPS6KB2Q9UBS0
Casein kinase I isoform gamma-2CSNK1G2P78368
MAP kinase-activated protein kinase 3MAPKAPK3Q16644
Pathways
NameSMPDB LinkKEGG Link
Amino Sugar MetabolismSMP00045 map00520
Ammonia RecyclingSMP00009 map00910
Citric Acid CycleSMP00057 map00020
DNA Replication ForkSMP00477 Not Available
Ethanol DegradationSMP00449 Not Available
Folate MetabolismSMP00053 map00670
GluconeogenesisSMP00128 map00010
Glycerolipid MetabolismSMP00039 map00561
Glycine and Serine MetabolismSMP00004 map00260
GlycolysisSMP00040 map00010
Histidine MetabolismSMP00044 map00340
Inositol Phosphate MetabolismSMP00462 map00562
Lactose DegradationSMP00457 Not Available
Lactose SynthesisSMP00444 Not Available
Methionine MetabolismSMP00033 map00270
Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty AcidsSMP00482 Not Available
Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty AcidsSMP00481 Not Available
Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty AcidsSMP00480 Not Available
Mitochondrial Electron Transport ChainSMP00355 map00190
Phosphatidylinositol Phosphate MetabolismSMP00463 map00562
Phytanic Acid Peroxisomal OxidationSMP00450 Not Available
Purine MetabolismSMP00050 map00230
Spermidine and Spermine BiosynthesisSMP00445 Not Available
Threonine and 2-Oxobutanoate DegradationSMP00452 Not Available
Transcription/TranslationSMP00019 Not Available
Transfer of Acetyl Groups into MitochondriaSMP00466 Not Available
Trehalose DegradationSMP00467 Not Available
Urea CycleSMP00059 map00330
MetabolismNot Available
BiosynthesisNot Available
Organoleptic Properties
FlavoursNot Available
Files
MSDSNot Available
References
Synthesis ReferenceNot Available
General ReferenceNot Available
Content Reference