1.0 2011-09-21 00:04:29 UTC 2019-11-26 03:21:00 UTC FDB021883 Aldosterone Aldosterone is a steroid hormone produced by the adrenal cortex in the adrenal gland to regulate sodium and potassium balance in the blood. Specifically it regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium. It is synthesized from cholesterol by aldosterone synthase, which is absent in other sections of the adrenal gland. It is the sole endogenous member of the class of mineralocorticoids. Aldosterone increases the permeability of the apical (luminal) membrane of the kidney's collecting ducts to potassium and sodium and activates their basolateral Na+/K+ pumps, stimulating ATP hydrolysis, reabsorbing sodium (Na+) ions and water into the blood, and excreting potassium (K+) ions into the urine. [HMDB] (+)-Aldosterone (11b)-11,21-dihydroxy-3,20-dioxo-pregn-4-en-18-al (11beta)-11,21-dihydroxy-3,20-dioxo-Pregn-4-en-18-al 11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-13-carbaldehyde 11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al 11b,21-dihydroxy-3,20-dioxo-pregn-4-en-18-al 11beta,21-Dihydroxy-3,20-diketo-4-pregnen-18-al 11beta,21-Dihydroxy-3,20-diketopregn-4-ene-18-al 11beta,21-Dihydroxy-3,20-dioxo-pregn-4-en-18-al 11beta,21-Dihydroxypregn-4-ene-3,18,20-trione 18-Formyl-11beta,21-dihydroxy-4-pregnene-3,20-dione 18-Oxocorticosterone Aldocorten Aldocortene Aldocortin aldosterone Aldosteronum d-Aldosterone delta-Aldosterone Electrocortin Elektrocortin Reichstein X C21H28O5 360.444 360.193674006 (2R,14S,15R,17S)-17-hydroxy-14-(2-hydroxyacetyl)-2-methyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-ene-15-carbaldehyde (2R,14S,15R,17S)-17-hydroxy-14-(2-hydroxyacetyl)-2-methyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-ene-15-carbaldehyde 52-39-1 C[C@]12CCC(=O)C=C1CCC1C3CC[C@H](C(=O)CO)[C@]3(C[C@H](O)C21)C=O InChI=1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14?,15?,16-,17+,19?,20+,21-/m1/s1 PQSUYGKTWSAVDQ-SRPWZAMTSA-N belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone. 21-hydroxysteroids Organic compounds Lipids and lipid-like molecules Steroids and steroid derivatives Hydroxysteroids Aliphatic homopolycyclic compounds 11-beta-hydroxysteroids 20-oxosteroids 3-oxo delta-4-steroids Aldehydes Alpha-hydroxy ketones Cyclic alcohols and derivatives Cyclohexenones Delta-4-steroids Gluco/mineralocorticoids, progestogins and derivatives Hydrocarbon derivatives Organic oxides Primary alcohols Secondary alcohols 11-beta-hydroxysteroid 11-hydroxysteroid 18-oxosteroid 20-oxosteroid 21-hydroxysteroid 3-oxo-delta-4-steroid 3-oxosteroid Alcohol Aldehyde Aliphatic homopolycyclic compound Alpha-hydroxy ketone Carbonyl group Cyclic alcohol Cyclic ketone Cyclohexenone Delta-4-steroid Hydrocarbon derivative Ketone Organic oxide Organic oxygen compound Organooxygen compound Oxosteroid Pregnane-skeleton Primary alcohol Progestogin-skeleton Secondary alcohol Solid logp 1.54 ALOGPS logs -3.39 ALOGPS solubility 1.48e-01 g/l ALOGPS logp 1.06 ChemAxon pka_strongest_acidic 13.82 ChemAxon pka_strongest_basic -2.9 ChemAxon iupac (2R,14S,15R,17S)-17-hydroxy-14-(2-hydroxyacetyl)-2-methyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-ene-15-carbaldehyde ChemAxon average_mass 360.444 ChemAxon mono_mass 360.193674006 ChemAxon smiles C[C@]12CCC(=O)C=C1CCC1C3CC[C@H](C(=O)CO)[C@]3(C[C@H](O)C21)C=O ChemAxon formula C21H28O5 ChemAxon inchi InChI=1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14?,15?,16-,17+,19?,20+,21-/m1/s1 ChemAxon inchikey PQSUYGKTWSAVDQ-SRPWZAMTSA-N ChemAxon polar_surface_area 91.67 ChemAxon refractivity 96.79 ChemAxon polarizability 38.77 ChemAxon rotatable_bond_count 3 ChemAxon acceptor_count 5 ChemAxon donor_count 2 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Steroidogenesis SMP00130 map00140 Specdb::CMs 17836 Specdb::CMs 37259 Specdb::MsMs 27122 Specdb::MsMs 27123 Specdb::MsMs 27124 Specdb::MsMs 33680 Specdb::MsMs 33681 Specdb::MsMs 33682 Specdb::NmrOneD 1045 Specdb::NmrTwoD 1103 HMDB00037 27584 #<Reference:0x000055ce3192af40> #<Reference:0x000055ce3192ad88> #<Reference:0x000055ce3192abd0> #<Reference:0x000055ce3192aa18> #<Reference:0x000055ce3192a860> #<Reference:0x000055ce3192a6a8> #<Reference:0x000055ce3192a4f0> #<Reference:0x000055ce3192a338> #<Reference:0x000055ce3192a180> #<Reference:0x000055ce31929fc8> #<Reference:0x000055ce31929e10> #<Reference:0x000055ce31929c58> #<Reference:0x000055ce31929aa0> #<Reference:0x000055ce319298e8> #<Reference:0x000055ce31929730> #<Reference:0x000055ce31929578> #<Reference:0x000055ce319293c0> #<Reference:0x000055ce31929208> #<Reference:0x000055ce31929050> #<Reference:0x000055ce31928e98> Anatidae Type 1 specific Anatidae 8830 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Mallard duck Type 1 specific Anas platyrhynchos 8839 Milk (Cow) Type 2 specific Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 Wild boar Type 1 specific Sus scrofa 9823 3-oxo-5-beta-steroid 4-dehydrogenase P51857 AKR1D1 ADM P35318 ADM Connective tissue growth factor P29279 CTGF Epidermal growth factor receptor P00533 EGFR Fibronectin P02751 FN1 Natriuretic peptides B P16860 NPPB Prostaglandin E2 receptor EP4 subtype P35408 PTGER4