1.02011-09-21 00:04:29 UTC2019-11-26 03:21:00 UTCFDB021883AldosteroneAldosterone is a steroid hormone produced by the adrenal cortex in the adrenal gland to regulate sodium and potassium balance in the blood. Specifically it regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium. It is synthesized from cholesterol by aldosterone synthase, which is absent in other sections of the adrenal gland. It is the sole endogenous member of the class of mineralocorticoids. Aldosterone increases the permeability of the apical (luminal) membrane of the kidney's collecting ducts to potassium and sodium and activates their basolateral Na+/K+ pumps, stimulating ATP hydrolysis, reabsorbing sodium (Na+) ions and water into the blood, and excreting potassium (K+) ions into the urine. [HMDB](+)-Aldosterone(11b)-11,21-dihydroxy-3,20-dioxo-pregn-4-en-18-al(11beta)-11,21-dihydroxy-3,20-dioxo-Pregn-4-en-18-al11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-13-carbaldehyde11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al11b,21-dihydroxy-3,20-dioxo-pregn-4-en-18-al11beta,21-Dihydroxy-3,20-diketo-4-pregnen-18-al11beta,21-Dihydroxy-3,20-diketopregn-4-ene-18-al11beta,21-Dihydroxy-3,20-dioxo-pregn-4-en-18-al11beta,21-Dihydroxypregn-4-ene-3,18,20-trione18-Formyl-11beta,21-dihydroxy-4-pregnene-3,20-dione18-OxocorticosteroneAldocortenAldocorteneAldocortinaldosteroneAldosteronumd-Aldosteronedelta-AldosteroneElectrocortinElektrocortinReichstein XC21H28O5360.444360.193674006(2R,14S,15R,17S)-17-hydroxy-14-(2-hydroxyacetyl)-2-methyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-ene-15-carbaldehyde(2R,14S,15R,17S)-17-hydroxy-14-(2-hydroxyacetyl)-2-methyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-ene-15-carbaldehyde52-39-1C[C@]12CCC(=O)C=C1CCC1C3CC[C@H](C(=O)CO)[C@]3(C[C@H](O)C21)C=OInChI=1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14?,15?,16-,17+,19?,20+,21-/m1/s1PQSUYGKTWSAVDQ-SRPWZAMTSA-N belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone.21-hydroxysteroidsOrganic compoundsLipids and lipid-like moleculesSteroids and steroid derivativesHydroxysteroidsAliphatic homopolycyclic compounds11-beta-hydroxysteroids20-oxosteroids3-oxo delta-4-steroidsAldehydesAlpha-hydroxy ketonesCyclic alcohols and derivativesCyclohexenonesDelta-4-steroidsGluco/mineralocorticoids, progestogins and derivativesHydrocarbon derivativesOrganic oxidesPrimary alcoholsSecondary alcohols11-beta-hydroxysteroid11-hydroxysteroid18-oxosteroid20-oxosteroid21-hydroxysteroid3-oxo-delta-4-steroid3-oxosteroidAlcoholAldehydeAliphatic homopolycyclic compoundAlpha-hydroxy ketoneCarbonyl groupCyclic alcoholCyclic ketoneCyclohexenoneDelta-4-steroidHydrocarbon derivativeKetoneOrganic oxideOrganic oxygen compoundOrganooxygen compoundOxosteroidPregnane-skeletonPrimary alcoholProgestogin-skeletonSecondary alcoholSolidlogp1.54logs-3.39solubility1.48e-01 g/llogp1.06pka_strongest_acidic13.82pka_strongest_basic-2.9iupac(2R,14S,15R,17S)-17-hydroxy-14-(2-hydroxyacetyl)-2-methyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-ene-15-carbaldehydeaverage_mass360.444mono_mass360.193674006smilesC[C@]12CCC(=O)C=C1CCC1C3CC[C@H](C(=O)CO)[C@]3(C[C@H](O)C21)C=OformulaC21H28O5inchiInChI=1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14?,15?,16-,17+,19?,20+,21-/m1/s1inchikeyPQSUYGKTWSAVDQ-SRPWZAMTSA-Npolar_surface_area91.67refractivity96.79polarizability38.77rotatable_bond_count3acceptor_count5donor_count2physiological_charge0formal_charge0SteroidogenesisSMP00130map00140Specdb::NmrOneD1045Specdb::NmrTwoD1103Specdb::MsMs27122Specdb::MsMs27123Specdb::MsMs27124Specdb::MsMs33680Specdb::MsMs33681Specdb::MsMs33682Specdb::CMs17836Specdb::CMs37259HMDB0003727584#<Reference:0x00005556763b7528>#<Reference:0x00005556763b7370>#<Reference:0x00005556763b7050>#<Reference:0x00005556763b6d80>#<Reference:0x00005556763b6bc8>#<Reference:0x00005556763b6a10>#<Reference:0x00005556763b6830>#<Reference:0x00005556763b6628>#<Reference:0x00005556763b6420>#<Reference:0x00005556763b6268>#<Reference:0x00005556763b5cf0>#<Reference:0x00005556763b5a20>#<Reference:0x00005556763b5750>#<Reference:0x00005556763b5598>#<Reference:0x00005556763b53b8>#<Reference:0x00005556763b51d8>#<Reference:0x00005556763b4fa8>#<Reference:0x00005556763b4df0>#<Reference:0x00005556763b4c38>#<Reference:0x00005556763b4a80>AnatidaeType 1specificAnatidae8830BeefaloType 1specificBos taurus X Bison bison297284BisonType 1specificBison bison9901BuffaloType 1specificBubalus bubalis89462Cattle (Beef, Veal)Type 1specificBos taurus9913ChickenType 1specificGallus gallus9031Columbidae (Dove, Pigeon)Type 1specificColumbidae8930DeerType 1specificCervidae9850Domestic goatType 1specificCapra aegagrus hircus9925Domestic pigType 1specificSus scrofa domestica9825ElkType 1specificCervus canadensis1574408EmuType 1specificDromaius novaehollandiae8790European rabbitType 1specificOryctolagus9984Greylag gooseType 1specificAnser anser8843Guinea henType 1specificNumida meleagris8996HorseType 1specificEquus caballus9796Mallard duckType 1specificAnas platyrhynchos8839Milk (Cow)Type 2specificMountain hareType 1specificLepus timidus62621Mule deerType 1specificOdocoileus9871OstrichType 1specificStruthio camelus8801PheasantType 1specificPhasianus colchicus9054QuailType 1specificPhasianidae9005RabbitType 1specificLeporidae9979Rock ptarmiganType 1specificLagopus muta64668Sheep (Mutton, Lamb)Type 1specificOvis aries9940SquabType 1specificColumba8931TurkeyType 1specificMeleagris gallopavo9103Velvet duckType 1specificMelanitta fusca371864Wild boarType 1specificSus scrofa98233-oxo-5-beta-steroid 4-dehydrogenaseP51857AKR1D1ADMP35318ADMConnective tissue growth factorP29279CTGFEpidermal growth factor receptorP00533EGFRFibronectinP02751FN1Natriuretic peptides BP16860NPPBProstaglandin E2 receptor EP4 subtypeP35408PTGER4