1.0 2011-09-21 00:04:49 UTC 2019-11-26 03:21:00 UTC FDB021897 beta-D-Glucuronic acid Glucuronic acid is a carboxylic acid that has the structure of a glucose molecule that has had its sixth carbon atom (of six total) oxidized. The salts of glucuronic acid are known as glucuronates. Glucuronic acid is highly soluble in water. In the animal body, glucuronic acid is often linked to poisonous substances to allow for subsequent elimination, and to hormones to allow for easier transport. These linkages involve O-glycosidic bonds. The process is known as glucuronidation, and the resulting substances are known as glucuronides (or glucuronosides). Glucuronidation uses UDP-glucuronic acid (glucuronic acid linked via a glycosidic bond to uridine diphosphate) as an intermediate. UDP-glucuronic acid is formed in the liver of all animals. [HMDB] Widely distributed in plants, where it occurs in gums, mucilages, saponins and flavone glycosides and in animals as a constituent of mucopolysaccharides. Glycosides are formed in the liver to detoxify poisonous hydroxyl-containing substances. Phenyl, cresyl and indoxyl glycosides are present in normal urine. [CCD]. beta-D-Glucuronic acid is found in many foods, some of which are cashew nut, american cranberry, sour cherry, and soy bean. alpha-D-Glucopyranuronic acid alpha-D-Glucuronic acid alpha-delta-Glucopyranuronic acid alpha-delta-Glucuronic acid D-(+)-Glucuronate D-(+)-Glucuronic acid D-Glucuronate D-GLUCURONIC ACID delta-(+)-Glucuronate delta-(+)-Glucuronic acid delta-Glucuronate GCU GlcAa GlcAalpha Glucosiduronate Glucosiduronic acid Glucuronate Glucuronic acid C6H10O7 194.1394 194.042652674 (2S,3S,4S,5R,6S)-3,4,5,6-tetrahydroxyoxane-2-carboxylic acid glucuronic acid 6556-12-3 O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O InChI=1S/C6H10O7/c7-1-2(8)4(5(10)11)13-6(12)3(1)9/h1-4,6-9,12H,(H,10,11)/t1-,2-,3+,4-,6-/m0/s1 AEMOLEFTQBMNLQ-WAXACMCWSA-N belongs to the class of organic compounds known as glucuronic acid derivatives. Glucuronic acid derivatives are compounds containing a glucuronic acid moiety (or a derivative), which consists of a glucose moiety with the C6 carbon oxidized to a carboxylic acid. Glucuronic acid derivatives Organic compounds Organic oxygen compounds Organooxygen compounds Carbohydrates and carbohydrate conjugates Aliphatic heteromonocyclic compounds Beta hydroxy acids and derivatives Carbonyl compounds Carboxylic acids Hemiacetals Hydrocarbon derivatives Monocarboxylic acids and derivatives Monosaccharides Organic oxides Oxacyclic compounds Oxanes Polyols Pyrans Secondary alcohols Alcohol Aliphatic heteromonocyclic compound Beta-hydroxy acid Carbonyl group Carboxylic acid Carboxylic acid derivative Glucuronic acid or derivatives Hemiacetal Hydrocarbon derivative Hydroxy acid Monocarboxylic acid or derivatives Monosaccharide Organic oxide Organoheterocyclic compound Oxacycle Oxane Polyol Pyran Secondary alcohol D-glucopyranuronic acid Solid logp -2.30 ALOGPS logs 0.18 ALOGPS solubility 2.95e+02 g/l ALOGPS logp -2.6 ChemAxon pka_strongest_acidic 3.21 ChemAxon pka_strongest_basic -3.7 ChemAxon iupac (2S,3S,4S,5R,6S)-3,4,5,6-tetrahydroxyoxane-2-carboxylic acid ChemAxon average_mass 194.1394 ChemAxon mono_mass 194.042652674 ChemAxon smiles O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O ChemAxon formula C6H10O7 ChemAxon inchi InChI=1S/C6H10O7/c7-1-2(8)4(5(10)11)13-6(12)3(1)9/h1-4,6-9,12H,(H,10,11)/t1-,2-,3+,4-,6-/m0/s1 ChemAxon inchikey AEMOLEFTQBMNLQ-WAXACMCWSA-N ChemAxon polar_surface_area 127.45 ChemAxon refractivity 35.79 ChemAxon polarizability 16.32 ChemAxon rotatable_bond_count 1 ChemAxon acceptor_count 7 ChemAxon donor_count 5 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon Inositol Metabolism SMP00011 map00562 Starch and Sucrose Metabolism SMP00058 map00500 Specdb::MsIr 195 Specdb::MsIr 196 Specdb::MsIr 197 Specdb::NmrTwoD 1156 Specdb::NmrOneD 1098 Specdb::NmrOneD 1156 Specdb::NmrOneD 142390 Specdb::NmrOneD 142391 Specdb::NmrOneD 142392 Specdb::NmrOneD 142393 Specdb::NmrOneD 142394 Specdb::NmrOneD 142395 Specdb::NmrOneD 142396 Specdb::NmrOneD 142397 Specdb::NmrOneD 142398 Specdb::NmrOneD 142399 Specdb::NmrOneD 142400 Specdb::NmrOneD 142401 Specdb::NmrOneD 142402 Specdb::NmrOneD 142403 Specdb::NmrOneD 142404 Specdb::NmrOneD 142405 Specdb::NmrOneD 142406 Specdb::NmrOneD 142407 Specdb::NmrOneD 142408 Specdb::NmrOneD 142409 Specdb::NmrOneD 166527 Specdb::CMs 24385 Specdb::CMs 37309 Specdb::CMs 172924 Specdb::CMs 1051028 Specdb::CMs 1051030 Specdb::CMs 1051032 Specdb::CMs 1051034 Specdb::CMs 1051036 Specdb::CMs 1051037 Specdb::CMs 1051039 Specdb::CMs 1051041 Specdb::CMs 1051043 Specdb::CMs 1051045 Specdb::CMs 1051047 Specdb::CMs 1051049 Specdb::CMs 1051050 Specdb::CMs 1051052 Specdb::CMs 1051054 Specdb::CMs 1051056 Specdb::CMs 1051058 Specdb::CMs 1051060 Specdb::CMs 1051062 Specdb::CMs 1051064 Specdb::CMs 1051066 Specdb::CMs 1051067 Specdb::MsMs 192 Specdb::MsMs 193 Specdb::MsMs 319990 Specdb::MsMs 319991 Specdb::MsMs 319992 Specdb::MsMs 367270 Specdb::MsMs 367271 Specdb::MsMs 367272 Specdb::MsMs 2236268 Specdb::MsMs 2237099 Specdb::MsMs 2238362 Specdb::MsMs 2239234 Specdb::MsMs 2242475 Specdb::MsMs 2243401 Specdb::MsMs 2413042 Specdb::MsMs 2413043 Specdb::MsMs 2413044 Specdb::MsMs 2552132 Specdb::MsMs 2552133 Specdb::MsMs 2552134 HMDB00127 28860 GCU #<Reference:0x000055ce32b9ced0> #<Reference:0x000055ce32b9cd18> #<Reference:0x000055ce32b9cac0> #<Reference:0x000055ce32b9c8b8> #<Reference:0x000055ce32b9c5e8> #<Reference:0x000055ce32b9c390> #<Reference:0x000055ce32b9c1d8> #<Reference:0x000055ce32b9c020> #<Reference:0x000055ce32b97e08> #<Reference:0x000055ce32b978e0> #<Reference:0x000055ce32b976d8> #<Reference:0x000055ce32b974a8> American cranberry Type 1 specific Vaccinium macrocarpon 13750 Anatidae Type 1 specific Anatidae 8830 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Capers Type 1 specific Capparis spinosa 65558 Cashew nut Type 1 specific Anacardium occidentale 171929 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Flaxseed Type 1 specific Linum usitatissimum 4006 Greylag goose Type 1 specific Anser anser 8843 Guava Type 1 specific Psidium guajava 120290 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Mallard duck Type 1 specific Anas platyrhynchos 8839 Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Red wine Type 2 105.105 210.0 0.21 mg/100 g Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Sour cherry Type 1 specific Prunus cerasus 140311 Soy bean Type 1 specific Glycine max 3847 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 White mustard Type 1 specific Sinapis alba 3728 White wine Type 2 120.12 240.0 0.24 mg/100 g Wild boar Type 1 specific Sus scrofa 9823 Beta-glucuronidase P08236 GUSB Dermatan-sulfate epimerase Q9UL01 DSE UDP-glucuronosyltransferase 1-1 P22309 UGT1A1 UDP-glucuronosyltransferase 1-10 Q9HAW8 UGT1A10 UDP-glucuronosyltransferase 1-3 P35503 UGT1A3 UDP-glucuronosyltransferase 1-4 P22310 UGT1A4 UDP-glucuronosyltransferase 1-5 P35504 UGT1A5 UDP-glucuronosyltransferase 1-6 P19224 UGT1A6 UDP-glucuronosyltransferase 1-7 Q9HAW7 UGT1A7 UDP-glucuronosyltransferase 1-8 Q9HAW9 UGT1A8 UDP-glucuronosyltransferase 1-9 O60656 UGT1A9 UDP-glucuronosyltransferase 2A1 Q9Y4X1 UGT2A1 UDP-glucuronosyltransferase 2A3 Q6UWM9 UGT2A3 UDP-glucuronosyltransferase 2B10 P36537 UGT2B10 UDP-glucuronosyltransferase 2B11 O75310 UGT2B11 UDP-glucuronosyltransferase 2B15 P54855 UGT2B15 UDP-glucuronosyltransferase 2B17 O75795 UGT2B17 UDP-glucuronosyltransferase 2B28 Q9BY64 UGT2B28 UDP-glucuronosyltransferase 2B4 P06133 UGT2B4 UDP-glucuronosyltransferase 2B7 P16662 UGT2B7 Anti hepatotoxic 328 Any compound that is able to prevent damage to the liver. Antidote 236 Any protective agent counteracting or neutralizing the action of poisons. Detoxicant 877 Any protective agent counteracting or neutralizing the action of poisons.