1.02011-09-21 00:04:49 UTC2019-11-26 03:21:00 UTCFDB021897beta-D-Glucuronic acidGlucuronic acid is a carboxylic acid that has the structure of a glucose molecule that has had its sixth carbon atom (of six total) oxidized. The salts of glucuronic acid are known as glucuronates. Glucuronic acid is highly soluble in water. In the animal body, glucuronic acid is often linked to poisonous substances to allow for subsequent elimination, and to hormones to allow for easier transport. These linkages involve O-glycosidic bonds. The process is known as glucuronidation, and the resulting substances are known as glucuronides (or glucuronosides). Glucuronidation uses UDP-glucuronic acid (glucuronic acid linked via a glycosidic bond to uridine diphosphate) as an intermediate. UDP-glucuronic acid is formed in the liver of all animals. [HMDB]
Widely distributed in plants, where it occurs in gums, mucilages, saponins and flavone glycosides and in animals as a constituent of mucopolysaccharides. Glycosides are formed in the liver to detoxify poisonous hydroxyl-containing substances. Phenyl, cresyl and indoxyl glycosides are present in normal urine. [CCD]. beta-D-Glucuronic acid is found in many foods, some of which are cashew nut, american cranberry, sour cherry, and soy bean.alpha-D-Glucopyranuronic acidalpha-D-Glucuronic acidalpha-delta-Glucopyranuronic acidalpha-delta-Glucuronic acidD-(+)-GlucuronateD-(+)-Glucuronic acidD-GlucuronateD-GLUCURONIC ACIDdelta-(+)-Glucuronatedelta-(+)-Glucuronic aciddelta-GlucuronateGCUGlcAaGlcAalphaGlucosiduronateGlucosiduronic acidGlucuronateGlucuronic acidC6H10O7194.1394194.042652674(2S,3S,4S,5R,6S)-3,4,5,6-tetrahydroxyoxane-2-carboxylic acidglucuronic acid6556-12-3O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=OInChI=1S/C6H10O7/c7-1-2(8)4(5(10)11)13-6(12)3(1)9/h1-4,6-9,12H,(H,10,11)/t1-,2-,3+,4-,6-/m0/s1AEMOLEFTQBMNLQ-WAXACMCWSA-N belongs to the class of organic compounds known as glucuronic acid derivatives. Glucuronic acid derivatives are compounds containing a glucuronic acid moiety (or a derivative), which consists of a glucose moiety with the C6 carbon oxidized to a carboxylic acid.Glucuronic acid derivativesOrganic compoundsOrganic oxygen compoundsOrganooxygen compoundsCarbohydrates and carbohydrate conjugatesAliphatic heteromonocyclic compoundsBeta hydroxy acids and derivativesCarbonyl compoundsCarboxylic acidsHemiacetalsHydrocarbon derivativesMonocarboxylic acids and derivativesMonosaccharidesOrganic oxidesOxacyclic compoundsOxanesPolyolsPyransSecondary alcoholsAlcoholAliphatic heteromonocyclic compoundBeta-hydroxy acidCarbonyl groupCarboxylic acidCarboxylic acid derivativeGlucuronic acid or derivativesHemiacetalHydrocarbon derivativeHydroxy acidMonocarboxylic acid or derivativesMonosaccharideOrganic oxideOrganoheterocyclic compoundOxacycleOxanePolyolPyranSecondary alcoholD-glucopyranuronic acidSolidlogp-2.30logs0.18solubility2.95e+02 g/llogp-2.6pka_strongest_acidic3.21pka_strongest_basic-3.7iupac(2S,3S,4S,5R,6S)-3,4,5,6-tetrahydroxyoxane-2-carboxylic acidaverage_mass194.1394mono_mass194.042652674smilesO[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=OformulaC6H10O7inchiInChI=1S/C6H10O7/c7-1-2(8)4(5(10)11)13-6(12)3(1)9/h1-4,6-9,12H,(H,10,11)/t1-,2-,3+,4-,6-/m0/s1inchikeyAEMOLEFTQBMNLQ-WAXACMCWSA-Npolar_surface_area127.45refractivity35.79polarizability16.32rotatable_bond_count1acceptor_count7donor_count5physiological_charge-1formal_charge0Inositol MetabolismSMP00011map00562Starch and Sucrose MetabolismSMP00058map00500Specdb::NmrTwoD1156Specdb::MsIr195Specdb::MsIr196Specdb::MsIr197Specdb::NmrOneD1098Specdb::NmrOneD1156Specdb::NmrOneD142390Specdb::NmrOneD142391Specdb::NmrOneD142392Specdb::NmrOneD142393Specdb::NmrOneD142394Specdb::NmrOneD142395Specdb::NmrOneD142396Specdb::NmrOneD142397Specdb::NmrOneD142398Specdb::NmrOneD142399Specdb::NmrOneD142400Specdb::NmrOneD142401Specdb::NmrOneD142402Specdb::NmrOneD142403Specdb::NmrOneD142404Specdb::NmrOneD142405Specdb::NmrOneD142406Specdb::NmrOneD142407Specdb::NmrOneD142408Specdb::NmrOneD142409Specdb::NmrOneD166527Specdb::CMs24385Specdb::CMs37309Specdb::CMs172924Specdb::CMs1051028Specdb::CMs1051030Specdb::CMs1051032Specdb::CMs1051034Specdb::CMs1051036Specdb::CMs1051037Specdb::CMs1051039Specdb::CMs1051041Specdb::CMs1051043Specdb::CMs1051045Specdb::CMs1051047Specdb::CMs1051049Specdb::CMs1051050Specdb::CMs1051052Specdb::CMs1051054Specdb::CMs1051056Specdb::CMs1051058Specdb::CMs1051060Specdb::CMs1051062Specdb::CMs1051064Specdb::CMs1051066Specdb::CMs1051067Specdb::MsMs192Specdb::MsMs193Specdb::MsMs319990Specdb::MsMs319991Specdb::MsMs319992Specdb::MsMs367270Specdb::MsMs367271Specdb::MsMs367272Specdb::MsMs2236268Specdb::MsMs2237099Specdb::MsMs2238362Specdb::MsMs2239234Specdb::MsMs2242475Specdb::MsMs2243401Specdb::MsMs2413042Specdb::MsMs2413043Specdb::MsMs2413044Specdb::MsMs2552132Specdb::MsMs2552133Specdb::MsMs2552134HMDB0012728860GCU#<Reference:0x0000555674112518>#<Reference:0x0000555674112310>#<Reference:0x0000555674112158>#<Reference:0x0000555674111e60>#<Reference:0x0000555674111be0>#<Reference:0x0000555674111938>#<Reference:0x00005556741116b8>#<Reference:0x0000555674111500>#<Reference:0x00005556741112d0>#<Reference:0x0000555674111078>#<Reference:0x0000555674110e48>#<Reference:0x0000555674110c90>American cranberryType 1specificVaccinium macrocarpon13750AnatidaeType 1specificAnatidae8830BeefaloType 1specificBos taurus X Bison bison297284BisonType 1specificBison bison9901BuffaloType 1specificBubalus bubalis89462CapersType 1specificCapparis spinosa65558Cashew nutType 1specificAnacardium occidentale171929Cattle (Beef, Veal)Type 1specificBos taurus9913ChickenType 1specificGallus gallus9031Columbidae (Dove, Pigeon)Type 1specificColumbidae8930DeerType 1specificCervidae9850Domestic goatType 1specificCapra aegagrus hircus9925Domestic pigType 1specificSus scrofa domestica9825ElkType 1specificCervus canadensis1574408EmuType 1specificDromaius novaehollandiae8790European rabbitType 1specificOryctolagus9984FlaxseedType 1specificLinum usitatissimum4006Greylag gooseType 1specificAnser anser8843GuavaType 1specificPsidium guajava120290Guinea henType 1specificNumida meleagris8996HorseType 1specificEquus caballus9796Mallard duckType 1specificAnas platyrhynchos8839Mountain hareType 1specificLepus timidus62621Mule deerType 1specificOdocoileus9871OstrichType 1specificStruthio camelus8801PheasantType 1specificPhasianus colchicus9054QuailType 1specificPhasianidae9005RabbitType 1specificLeporidae9979Red wineType 2105.105210.00.21mg/100 gRock ptarmiganType 1specificLagopus muta64668Sheep (Mutton, Lamb)Type 1specificOvis aries9940Sour cherryType 1specificPrunus cerasus140311Soy beanType 1specificGlycine max3847SquabType 1specificColumba8931TurkeyType 1specificMeleagris gallopavo9103Velvet duckType 1specificMelanitta fusca371864White mustardType 1specificSinapis alba3728White wineType 2120.12240.00.24mg/100 gWild boarType 1specificSus scrofa9823Beta-glucuronidaseP08236GUSBDermatan-sulfate epimeraseQ9UL01DSEUDP-glucuronosyltransferase 1-1P22309UGT1A1UDP-glucuronosyltransferase 1-10Q9HAW8UGT1A10UDP-glucuronosyltransferase 1-3P35503UGT1A3UDP-glucuronosyltransferase 1-4P22310UGT1A4UDP-glucuronosyltransferase 1-5P35504UGT1A5UDP-glucuronosyltransferase 1-6P19224UGT1A6UDP-glucuronosyltransferase 1-7Q9HAW7UGT1A7UDP-glucuronosyltransferase 1-8Q9HAW9UGT1A8UDP-glucuronosyltransferase 1-9O60656UGT1A9UDP-glucuronosyltransferase 2A1Q9Y4X1UGT2A1UDP-glucuronosyltransferase 2A3Q6UWM9UGT2A3UDP-glucuronosyltransferase 2B10P36537UGT2B10UDP-glucuronosyltransferase 2B11O75310UGT2B11UDP-glucuronosyltransferase 2B15P54855UGT2B15UDP-glucuronosyltransferase 2B17O75795UGT2B17UDP-glucuronosyltransferase 2B28Q9BY64UGT2B28UDP-glucuronosyltransferase 2B4P06133UGT2B4UDP-glucuronosyltransferase 2B7P16662UGT2B7anti hepatotoxic328Any compound that is able to prevent damage to the liver.antidote236Any protective agent counteracting or neutralizing the action of poisons.detoxicant877Any protective agent counteracting or neutralizing the action of poisons.