1.0 2011-09-21 00:04:56 UTC 2025-11-19 02:40:21 UTC FDB021905 Methylmalonic acid A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA. [HMDB] 1,1-Ethanedicarboxylate 1,1-Ethanedicarboxylic acid 2-Methylmalonate 2-Methylmalonic acid a-Methylmalonate a-Methylmalonic acid alpha-Methylmalonate alpha-Methylmalonic acid Isosuccinate Isosuccinic acid methyl-Malonate methyl-Malonic acid methyl-Propanedioate methyl-Propanedioic acid Methylmalonate Methylmalonic acid Methylpropanedioate Methylpropanedioic acid α-methylmalonate α-methylmalonic acid C4H6O4 118.088 118.02660868 2-methylpropanedioic acid methylmalonic acid 516-05-2 CC(C(O)=O)C(O)=O InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) ZIYVHBGGAOATLY-UHFFFAOYSA-N belongs to the class of organic compounds known as dicarboxylic acids and derivatives. These are organic compounds containing exactly two carboxylic acid groups. Dicarboxylic acids and derivatives Organic compounds Organic acids and derivatives Carboxylic acids and derivatives Dicarboxylic acids and derivatives Aliphatic acyclic compounds 1,3-dicarbonyl compounds Carboxylic acids Hydrocarbon derivatives Organic oxides 1,3-dicarbonyl compound Aliphatic acyclic compound Carbonyl group Carboxylic acid Dicarboxylic acid or derivatives Hydrocarbon derivative Organic oxide Organic oxygen compound Organooxygen compound C4-dicarboxylic acid Dicarboxylic acids Solid logp 0.17 ALOGPS logs 0.10 ALOGPS solubility 1.49e+02 g/l ALOGPS logp 0.21 ChemAxon pka_strongest_acidic 2.48 ChemAxon iupac 2-methylpropanedioic acid ChemAxon average_mass 118.088 ChemAxon mono_mass 118.02660868 ChemAxon smiles CC(C(O)=O)C(O)=O ChemAxon formula C4H6O4 ChemAxon inchi InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) ChemAxon inchikey ZIYVHBGGAOATLY-UHFFFAOYSA-N ChemAxon polar_surface_area 74.6 ChemAxon refractivity 23.56 ChemAxon polarizability 10.06 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 4 ChemAxon donor_count 2 ChemAxon physiological_charge -2 ChemAxon formal_charge 0 ChemAxon Propanoate Metabolism SMP00016 map00640 Valine, Leucine and Isoleucine Degradation SMP00032 map00280 Specdb::NmrTwoD 1203 Specdb::EiMs 476 Specdb::NmrOneD 1183 Specdb::NmrOneD 1201 Specdb::NmrOneD 2429 Specdb::NmrOneD 3116 Specdb::NmrOneD 5057 Specdb::NmrOneD 5058 Specdb::NmrOneD 166478 Specdb::MsIr 287 Specdb::MsIr 288 Specdb::MsIr 289 Specdb::CMs 456 Specdb::CMs 457 Specdb::CMs 969 Specdb::CMs 1101 Specdb::CMs 3366 Specdb::CMs 29830 Specdb::CMs 30218 Specdb::CMs 30834 Specdb::CMs 31066 Specdb::CMs 31067 Specdb::CMs 31868 Specdb::CMs 37353 Specdb::CMs 156464 Specdb::CMs 1054021 Specdb::CMs 1054023 Specdb::CMs 1054024 Specdb::MsMs 325 Specdb::MsMs 326 Specdb::MsMs 327 Specdb::MsMs 3590 Specdb::MsMs 3591 Specdb::MsMs 3592 Specdb::MsMs 3593 Specdb::MsMs 3594 Specdb::MsMs 180024 Specdb::MsMs 180025 Specdb::MsMs 180026 Specdb::MsMs 182358 Specdb::MsMs 182359 Specdb::MsMs 182360 Specdb::MsMs 438075 Specdb::MsMs 438076 Specdb::MsMs 438077 Specdb::MsMs 438078 Specdb::MsMs 438079 Specdb::MsMs 2235969 Specdb::MsMs 2236625 Specdb::MsMs 2236726 Specdb::MsMs 2238140 Specdb::MsMs 2238778 Specdb::MsMs 2238826 HMDB00202 17453 DXX #<Reference:0x000055ce319c1800> #<Reference:0x000055ce319c1648> #<Reference:0x000055ce319c1490> #<Reference:0x000055ce319c12d8> #<Reference:0x000055ce319c1120> #<Reference:0x000055ce319c0f68> #<Reference:0x000055ce319c0db0> #<Reference:0x000055ce319c0bf8> #<Reference:0x000055ce319c0a40> #<Reference:0x000055ce319c0888> #<Reference:0x000055ce319c06d0> #<Reference:0x000055ce319c0518> #<Reference:0x000055ce319c0360> #<Reference:0x000055ce319c01a8> #<Reference:0x000055ce319c1cb0> Anatidae Type 1 specific Anatidae 8830 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Mallard duck Type 1 specific Anas platyrhynchos 8839 Milk (Cow) Type 2 specific Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 Wild boar Type 1 specific Sus scrofa 9823