1.0 2011-09-21 00:11:22 UTC 2018-05-29 01:52:47 UTC FDB022274 N-Acetylgalactosamine 6-sulfate N-Acetylgalactosamine 6-sulfate is found in keratan sulfate and chondroitin 6-sulfate. PMID: 12489154 Morquio syndrome is caused by an abnormal accumulation of mucopolysaccharides - in this case, keratan sulfate - in the body. Keratan sulfate is excreted in urine. The symptoms vary from patient to patient, and may include hearing loss, cataracts, skeletal dysplasia, spinal instability, and minor respiratory issues, among others. Two forms are recognized, type A and type B. Type A is a deficiency of the enzyme N-acetylgalactosamine-6-sulfate sulfatase. [HMDB] N-acetyl-Chondrosamine 6-(hydrogen sulfate) N-Acetyl-chondrosamine 6-(hydrogen sulphate) N-Acetylgalactosamine 6-sulfate N-Acetylgalactosamine 6-sulfic acid N-Acetylgalactosamine 6-sulphate Nag-6-S C8H15NO9S 301.271 301.046751773 {[(2R,3R,4R,5R)-5-acetamido-2,3,4-trihydroxy-6-oxohexyl]oxy}sulfonic acid [(2R,3R,4R,5R)-5-acetamido-2,3,4-trihydroxy-6-oxohexyl]oxysulfonic acid 10357-00-3 CC(=O)N[C@@H](C=O)[C@@H](O)[C@@H](O)[C@H](O)COS(O)(=O)=O InChI=1S/C8H15NO9S/c1-4(11)9-5(2-10)7(13)8(14)6(12)3-18-19(15,16)17/h2,5-8,12-14H,3H2,1H3,(H,9,11)(H,15,16,17)/t5-,6+,7+,8-/m0/s1 NHZWETQZLORZIR-OSMVPFSASA-N belongs to the class of organic compounds known as monosaccharide sulfates. These are monosaccharides that contain a sulfate group linked to the sugar moiety. Monosaccharide sulfates Organic compounds Organic oxygen compounds Organooxygen compounds Carbohydrates and carbohydrate conjugates Aliphatic acyclic compounds Acetamides Alkyl sulfates Aminosaccharides Beta-hydroxy aldehydes Hydrocarbon derivatives Organic oxides Organonitrogen compounds Organopnictogen compounds Polyols Secondary alcohols Secondary carboxylic acid amides Sulfuric acid monoesters Acetamide Alcohol Aldehyde Aliphatic acyclic compound Alkyl sulfate Amino saccharide Beta-hydroxy aldehyde Carbonyl group Carboxamide group Carboxylic acid derivative Hydrocarbon derivative Monosaccharide sulfate Organic nitrogen compound Organic oxide Organic sulfuric acid or derivatives Organonitrogen compound Organopnictogen compound Polyol Secondary alcohol Secondary carboxylic acid amide Sulfate-ester Sulfuric acid ester Sulfuric acid monoester Solid logp -1.90 ALOGPS logs -1.20 ALOGPS solubility 1.89e+01 g/l ALOGPS logp -5.7 ChemAxon pka_strongest_acidic -2 ChemAxon pka_strongest_basic -1.1 ChemAxon iupac {[(2R,3R,4R,5R)-5-acetamido-2,3,4-trihydroxy-6-oxohexyl]oxy}sulfonic acid ChemAxon average_mass 301.271 ChemAxon mono_mass 301.046751773 ChemAxon smiles CC(=O)N[C@@H](C=O)[C@@H](O)[C@@H](O)[C@H](O)COS(O)(=O)=O ChemAxon formula C8H15NO9S ChemAxon inchi InChI=1S/C8H15NO9S/c1-4(11)9-5(2-10)7(13)8(14)6(12)3-18-19(15,16)17/h2,5-8,12-14H,3H2,1H3,(H,9,11)(H,15,16,17)/t5-,6+,7+,8-/m0/s1 ChemAxon inchikey NHZWETQZLORZIR-OSMVPFSASA-N ChemAxon polar_surface_area 170.46 ChemAxon refractivity 58.44 ChemAxon polarizability 26.16 ChemAxon rotatable_bond_count 8 ChemAxon acceptor_count 8 ChemAxon donor_count 5 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon Specdb::NmrOneD 145510 Specdb::NmrOneD 145511 Specdb::NmrOneD 145512 Specdb::NmrOneD 145513 Specdb::NmrOneD 145514 Specdb::NmrOneD 145515 Specdb::NmrOneD 145516 Specdb::NmrOneD 145517 Specdb::NmrOneD 145518 Specdb::NmrOneD 145519 Specdb::NmrOneD 145520 Specdb::NmrOneD 145521 Specdb::NmrOneD 145522 Specdb::NmrOneD 145523 Specdb::NmrOneD 145524 Specdb::NmrOneD 145525 Specdb::NmrOneD 145526 Specdb::NmrOneD 145527 Specdb::NmrOneD 145528 Specdb::NmrOneD 145529 Specdb::CMs 21708 Specdb::CMs 37796 Specdb::CMs 169089 Specdb::CMs 1079256 Specdb::CMs 1079258 Specdb::CMs 1079260 Specdb::CMs 1079261 Specdb::CMs 1079263 Specdb::CMs 1079265 Specdb::CMs 1079267 Specdb::CMs 1079269 Specdb::CMs 1079271 Specdb::CMs 1079273 Specdb::CMs 1079275 Specdb::CMs 1079277 Specdb::CMs 1079279 Specdb::CMs 1079281 Specdb::CMs 1079283 Specdb::CMs 1079285 Specdb::CMs 1079287 Specdb::CMs 1079288 Specdb::CMs 1079290 Specdb::CMs 1079292 Specdb::CMs 1079294 Specdb::CMs 1079295 Specdb::MsMs 314275 Specdb::MsMs 314276 Specdb::MsMs 314277 Specdb::MsMs 360001 Specdb::MsMs 360002 Specdb::MsMs 360003 Specdb::MsMs 2292399 Specdb::MsMs 2292400 Specdb::MsMs 2292401 Specdb::MsMs 2646291 Specdb::MsMs 2646292 Specdb::MsMs 2646293 HMDB00841 #<Reference:0x000055ce316343e0> #<Reference:0x000055ce31634200> #<Reference:0x000055ce31635178> #<Reference:0x000055ce31634b88> #<Reference:0x000055ce31633d78> #<Reference:0x000055ce31633bc0> Anatidae Type 1 specific Anatidae 8830 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Mallard duck Type 1 specific Anas platyrhynchos 8839 Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 Wild boar Type 1 specific Sus scrofa 9823