1.02011-09-21 00:12:03 UTC2018-05-28 18:32:27 UTCFDB02231811alpha-HydroxyprogesteroneProgesterone is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy (supports gestation) and embryogenesis of humans and other species. Progesterone belongs to a class of hormones called progestagens, and is the major naturally occurring human progestagen. -- Wikipedia; Progesterone's reproductive function serves to convert the endometrium to its secretory stage to prepare the uterus for implantation. If pregnancy does not occur, progesterone levels will decrease leading to menstruation in the human. Normal menstrual bleeding is a progesterone withdrawal bleeding. -- Wikipedia; During implantation and gestation, progesterone appears to decrease the maternal immune response to allow for the acceptance of the pregnancy. Progesterone decreases contractility of the uterine musculature. The fetus metabolizes placental progesterone in the production of adrenal mineralo- and glucosteroids. A drop in progesterone levels is possibly one step that facilitates the onset of labor. In addition progesterone inhibits lactation during pregnancy. The fall in progesterone levels following delivery is one of the triggers for milk production. Progesterone has an effect upon vaginal epithelium and cervical mucus. -- Wikipedia [HMDB]11-Hydroxyprogesterone11a-Hydroxy-pregn-4-ene-3,20-dione11a-Hydroxy-progesterone11a-Hydroxypregn-4-ene-3,20-dione11a-Hydroxyprogesterone4-Pregnene-11a-ol-3,20-dionePregn-4-en-11a-ol-3,20-dioneC21H30O3330.4611330.219494826(1S,2R,10S,11S,15S,17R)-14-acetyl-17-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one(1S,2R,10S,11S,15S,17R)-14-acetyl-17-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one312-90-3[H][C@@]12CCC(C(C)=O)[C@@]1(C)C[C@@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12CInChI=1S/C21H30O3/c1-12(22)16-6-7-17-15-5-4-13-10-14(23)8-9-20(13,2)19(15)18(24)11-21(16,17)3/h10,15-19,24H,4-9,11H2,1-3H3/t15-,16?,17-,18+,19+,20-,21+/m0/s1BFZHCUBIASXHPK-ODYOLWGQSA-N belongs to the class of organic compounds known as gluco/mineralocorticoids, progestogins and derivatives. These are steroids with a structure based on a hydroxylated prostane moiety.Gluco/mineralocorticoids, progestogins and derivativesOrganic compoundsLipids and lipid-like moleculesSteroids and steroid derivativesPregnane steroidsAliphatic homopolycyclic compounds11-alpha-hydroxysteroids20-oxosteroids3-oxo delta-4-steroidsCyclic alcohols and derivativesCyclohexenonesDelta-4-steroidsHydrocarbon derivativesOrganic oxidesSecondary alcohols11-alpha-hydroxysteroid11-hydroxysteroid20-oxosteroid3-oxo-delta-4-steroid3-oxosteroidAlcoholAliphatic homopolycyclic compoundCarbonyl groupCyclic alcoholCyclic ketoneCyclohexenoneDelta-4-steroidHydrocarbon derivativeHydroxysteroidKetoneOrganic oxideOrganic oxygen compoundOrganooxygen compoundOxosteroidProgestogin-skeletonSecondary alcoholSolidlogp2.65logs-3.97solubility3.56e-02 g/llogp2.84pka_strongest_acidic18.88pka_strongest_basic-0.26iupac(1S,2R,10S,11S,15S,17R)-14-acetyl-17-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-oneaverage_mass330.4611mono_mass330.219494826smiles[H][C@@]12CCC(C(C)=O)[C@@]1(C)C[C@@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12CformulaC21H30O3inchiInChI=1S/C21H30O3/c1-12(22)16-6-7-17-15-5-4-13-10-14(23)8-9-20(13,2)19(15)18(24)11-21(16,17)3/h10,15-19,24H,4-9,11H2,1-3H3/t15-,16?,17-,18+,19+,20-,21+/m0/s1inchikeyBFZHCUBIASXHPK-ODYOLWGQSA-Npolar_surface_area54.37refractivity94.3polarizability38.02rotatable_bond_count1acceptor_count3donor_count1physiological_charge0formal_charge0Specdb::NmrOneD1603Specdb::NmrTwoD1544Specdb::MsMs1306Specdb::MsMs1307Specdb::MsMs1308Specdb::MsMs313909Specdb::MsMs313910Specdb::MsMs313911Specdb::MsMs359509Specdb::MsMs359510Specdb::MsMs359511Specdb::MsMs2817789Specdb::MsMs2817790Specdb::MsMs2817791Specdb::MsMs2887547Specdb::MsMs2887548Specdb::MsMs2887549Specdb::CMs21552Specdb::CMs37843Specdb::CMs131290Specdb::CMs139024Specdb::CMs1081669Specdb::CMs1081671Specdb::CMs1081673Specdb::CMs1081675Specdb::CMs1081677Specdb::CMs1081679Specdb::CMs1081681HMDB0092016076#<Reference:0x0000555675b4abd8>#<Reference:0x0000555675b4a9f8>#<Reference:0x0000555675b4a778>AnatidaeType 1specificAnatidae8830BeefaloType 1specificBos taurus X Bison bison297284BisonType 1specificBison bison9901BuffaloType 1specificBubalus bubalis89462Cattle (Beef, Veal)Type 1specificBos taurus9913ChickenType 1specificGallus gallus9031Columbidae (Dove, Pigeon)Type 1specificColumbidae8930DeerType 1specificCervidae9850Domestic goatType 1specificCapra aegagrus hircus9925Domestic pigType 1specificSus scrofa domestica9825ElkType 1specificCervus canadensis1574408EmuType 1specificDromaius novaehollandiae8790European rabbitType 1specificOryctolagus9984Greylag gooseType 1specificAnser anser8843Guinea henType 1specificNumida meleagris8996HorseType 1specificEquus caballus9796Mallard duckType 1specificAnas platyrhynchos8839Mountain hareType 1specificLepus timidus62621Mule deerType 1specificOdocoileus9871OstrichType 1specificStruthio camelus8801PheasantType 1specificPhasianus colchicus9054QuailType 1specificPhasianidae9005RabbitType 1specificLeporidae9979Rock ptarmiganType 1specificLagopus muta64668Sheep (Mutton, Lamb)Type 1specificOvis aries9940SquabType 1specificColumba8931TurkeyType 1specificMeleagris gallopavo9103Velvet duckType 1specificMelanitta fusca371864Wild boarType 1specificSus scrofa9823