1.02011-09-21 00:18:17 UTC2015-10-09 22:30:55 UTCFDB022708VerapamilA calcium channel blocker that is a class IV anti-arrhythmia agent. -- Pubchem;
Calcium channel antagonists can be quite toxic. In the management of poisoning, early recognition is critical. Calcium channel antagonists are frequently prescribed, and the potential for serious morbidity and mortality with over dosage is significant. Ingestion of these agents should be suspected in any patient who presents in an overdose situation with unexplained hypotension and conduction abnormalities. The potential for toxicity should be noted in patients with underlying hepatic or renal dysfunction who are receiving therapeutic doses. (PMID 8213877) [HMDB]AkilenAnpecApo-VerapArpamyl LPBerkatensCalanCalan SRCalaptinCalaptin 240 SRCalcanCardiabeltinCardiaguttCardibeltinCardioprotectCaverilCivicorCivicor RetardCoraverCordiloxCordilox SRCorpamilCovera-HsD-365delta-365DignoverDilacoranDilacoran HTADurasoptinElthonFalicardFinoptinFlamonGeanginHartezeHexasoptinHexasoptin RetardHormitolIkacorIkapressInselonIproveratrilIsoptinIsoptin RetardIsoptin SRIsoptineIsoptinoIsotopinIzoptinJenapamilLekoptinLodixalMagotironManidonManidon RetardNovapamyl LPNovo-VeramilNu-VerapOrmilPraecicorQuasarRapamRobatelanSecuronTarkaUniverUnivexVasolanVasomilVasoptenVera-SanoraniaVerabetaVeracaps SRVeracorVerahexalVeralocVeramexVeramilVerapamilVerapamil AcisVerapamil ALVerapamil AtidVerapamil BasicsVerapamil EbeweVerapamil hclVerapamil HenningVerapamil InjectionVerapamil MSDVerapamil NMVerapamil NM PharmaVerapamil NordicVerapamil PBVerapamil RikerVerapamil SRVerapamil VerlaVerapamil-AbZVerapamiloVerapamilumVerapinVerapress 240 SRVerasalVerasifarVeratensinVerdilacVerelanVerelan PMVerelan SRVeroptinstadaVerpamilVetrimilVortacC27H38N2O4454.6016454.2831577142-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrileveraβ52-53-9COC1=C(OC)C=C(CCN(C)CCCC(C#N)(C(C)C)C2=CC(OC)=C(OC)C=C2)C=C1InChI=1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3SGTNSNPWRIOYBX-UHFFFAOYSA-N belongs to the class of organic compounds known as phenylbutylamines. Phenylbutylamines are compounds containing a phenylbutylamine moiety, which consists of a phenyl group substituted at the fourth carbon by an butan-1-amine.PhenylbutylaminesOrganic compoundsBenzenoidsBenzene and substituted derivativesPhenylbutylaminesAromatic homomonocyclic compoundsAlkyl aryl ethersAnisolesAralkylaminesDimethoxybenzenesHydrocarbon derivativesNitrilesOrganopnictogen compoundsPhenethylaminesPhenoxy compoundsPhenylpropanesTrialkylaminesAlkyl aryl etherAmineAnisoleAralkylamineAromatic homomonocyclic compoundCarbonitrileDimethoxybenzeneEtherHydrocarbon derivativeMethoxybenzeneNitrileO-dimethoxybenzeneOrganic nitrogen compoundOrganic oxygen compoundOrganonitrogen compoundOrganooxygen compoundOrganopnictogen compoundPhenethylaminePhenol etherPhenoxy compoundPhenylbutylaminePhenylpropaneTertiary aliphatic amineTertiary aminearomatic ethernitrilepolyethertertiary amino compoundSolidlogp5.23logs-5.06solubility3.94e-03 g/llogp5.04pka_strongest_basic9.68iupac2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrileaverage_mass454.6016mono_mass454.283157714smilesCOC1=C(OC)C=C(CCN(C)CCCC(C#N)(C(C)C)C2=CC(OC)=C(OC)C=C2)C=C1formulaC27H38N2O4inchiInChI=1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3inchikeySGTNSNPWRIOYBX-UHFFFAOYSA-Npolar_surface_area63.95refractivity132.65polarizability51.7rotatable_bond_count13acceptor_count6donor_count0physiological_charge1formal_charge0Specdb::NmrTwoD1694Specdb::NmrOneD1754Specdb::EiMs640Specdb::CMs25919Specdb::CMs122410Specdb::CMs126312Specdb::CMs133613Specdb::CMs141347Specdb::MsMs1711Specdb::MsMs1712Specdb::MsMs1713Specdb::MsMs5476Specdb::MsMs5477Specdb::MsMs5478Specdb::MsMs5479Specdb::MsMs5480Specdb::MsMs5481Specdb::MsMs5482Specdb::MsMs5483Specdb::MsMs5484Specdb::MsMs5485Specdb::MsMs264744Specdb::MsMs264745Specdb::MsMs264746Specdb::MsMs284673Specdb::MsMs284674Specdb::MsMs284675Specdb::MsMs441374Specdb::MsMs441375Specdb::MsMs441376Specdb::MsMs441377Specdb::MsMs441378Specdb::MsMs442323HMDB01850#<Reference:0x0000555676380190>#<Reference:0x000055567637ff60>#<Reference:0x000055567637fd30>#<Reference:0x000055567637fa88>#<Reference:0x000055567637f7b8>#<Reference:0x000055567637f538>#<Reference:0x000055567637f218>#<Reference:0x000055567637f038>#<Reference:0x000055567637ee80>#<Reference:0x000055567637ec78>#<Reference:0x000055567637ea98>#<Reference:0x000055567637e890>#<Reference:0x000055567637e6d8>#<Reference:0x000055567637e520>#<Reference:0x000055567637e368>#<Reference:0x000055567637e1b0>#<Reference:0x000055567637dff8>#<Reference:0x000055567637de18>#<Reference:0x000055567637dbc0>#<Reference:0x000055567637d9b8>#<Reference:0x000055567637d738>#<Reference:0x000055567637d4e0>