1.02011-09-21 00:18:21 UTC2019-11-26 03:21:06 UTCFDB022713AcetaminophenThe excellent tolerability of therapeutic doses of paracetamol (acetaminophen) is a major factor in the very wide use of the drug. The major problem in the use of paracetamol is its hepatotoxicity after an overdose. Hepatotoxicity has also been reported after therapeutic doses, but critical analysis indicates that most patients with alleged toxicity from therapeutic doses have taken overdoses. Importantly, prospective studies indicate that therapeutic doses of paracetamol are an unlikely cause of hepatotoxicity in patients who ingest moderate to large amounts of alcohol. (PMID 15733027)
Single doses of paracetamol are effective analgesics for acute postoperative pain and give rise to few adverse effects. (PMID 14974073)
Acetaminophen (AAP) overdose and the resulting hepatotoxicity is an important clinical problem. In addition, AAP is widely used as a prototype hepatotoxin to study mechanisms of chemical-induced cell injury and to test the hepatoprotective potential of new drugs and herbal medicines. Because of its importance, the mechanisms of AAP-induced liver cell injury have been extensively investigated and controversially discussed for many years. (PMID 16863451) [HMDB]4-(Acetylamino)phenol4-Acetamidophenol4-Acetaminophenol4-Hydroxyacetanilide4-Hydroxyanilid kyseliny octove4'-HydroxyacetanilideA-PerA.F. AnacinAbenolAbensanilAbrolAbroletAcamolAccu-TapAcenolAcephenAcertolAceta ElixirAceta TabletsAcetagesicAcetalginAcetaminofenAcetaminophenAcetaminophen UnisertsAcetaminopheneAcetamolAcetofenActaminActamin ExtraActamin SuperActifed PlusActimol Chewable TabletsActimol Children's SuspensionActimol Infants' SuspensionActimol Junior Strength CapletsActronAfebrinAfebrylAferadolAlgesidalAlginaAlgomolAlgotropylAllayalpha-PerAlpinyAlpinylAlvedonAmadilAminofenAminofen MaxAnacin-3Anacin-3 Extra StrengthAnadin dla dzieciAnaflonAnalterAnapapAndoxAnelixAnexsiaAnexsia 10/660Anexsia 5/325Anexsia 7.5/325Anexsia 7.5/650AnhibaAnoquanAnti-AlgosAntidolApacetApacet CapsulesApacet ElixirApacet Extra Strength CapletsApacet Extra Strength TabletsApacet Regular Strength TabletsApadonApamidApamideAPAPApitrelalApo-AcetaminophenArfenAsetamAsomalAspacAspirin Free Anacin Maximum Strength CapletsAspirin Free Anacin Maximum Strength Gel CapletsAspirin Free Anacin Maximum Strength TabletsAspirin-Free AnacinAspirin-Free Excedrin CapletsAsplinAtasol CapletsAtasol DropsAtasol Forte CapletsAtasol Forte TabletsAtasol Oral SolutionAtasol TabletsAtralidonBabikanBacetamolBancapBancap HcBanesinBayer Select Allergy-SinusBayer Select Head ColdBayer Select Headache PainBayer Select Maximum Strength Headache Pain Relief FormulaBayer Select Menstrual Multi-SymptomBayer Select Sinus Pain ReliefBen-u-ronBenmyoBickie-molBiocetamolBucetButalbitalButapapCadafenCalapolCalmanticoldCalpolCapital with CodeineCaptinCausalonCefalexCetadolChildren's Acetaminophen Elixir DropsChildren's Acetaminophen Oral SolutionChildren's Tylenol ChewableClaradol CodeineClixodyneCo-GesicCod-Acamol ForteCodabrolCodalginCodapaneCodicetCodisalCodisal ForteCodolipraneCodral Pain ReliefCofamolConacetolContac Cough & Sore Throat FormulaContra-Schmerz PCoricidinCoricidin DCoricidin SinusCosutoneCroix BlancheCuponolCuradonCurpolCustodialDapa X-SDarocetDarvocetDarvocet-N 50DatrilDatril Extra-StrengthDaygripDemiletsDeminofenDemocylDemogripalDesfebreDhamolDhc PlusDial-a-gesicDial-alpha-gesicDimindolDiroxDisprolDol-StopDolcorDolefinDolegrippinDolene Ap-65DolgesicDolipraneDolkoDolofuginDoloreductDolorfugDolorol ForteDolorstopDolotecDolproneDorocoffDresanDristan Cold No DrowsinessDristancitoDuracetamolDuradyne DhcDurapanDymadonDymadon CoDymadon ForteDypapEcosetolElixodyneEmpracetEndeconEnelfaEnerilEsgicEsgic-PlusEu-MedExcedrinExcedrin CapletsExcedrin Extra Strength CapletsExcipainExdolExdol StrongFanalgicFarmadolFebranineFebrectalFebrectolFebrexFebricetFebridolFebrilixFebrinFebrinolFebro-GesicFebrolinFemcetFendonFensumFepanilFeverall Junior StrengthFeverall Sprinkle Caps Junior StrengthFevorFinimalFiniwehFioricetFluparmolFortalidon PFreka-cetamolGattaphen TGelocatilGelupraneGenapap Children's ElixirGenapap Children's TabletsGenapap Extra Strength CapletsGenapap Extra Strength TabletsGenapap Regular Strength TabletsGenebs Extra Strength CapletsGenebs Regular Strength TabletsGenebs X-TraGeralgine-PGripin BebeGrippostadGynospasmineHedexHelon NHomoolanHy-PhenHycomine CompoundHydrocetIldamolInalgexInfadropsInfants' FeverallInflubene NInjectapapIntensinJanupapJunior DisprolKataprinKinder FinimalKorumKratofin simplexLabamolLekadolLemgripLemsipLestempLiquagesicLiquigesic CoLiquiprinLiquiprin Children's ElixirLiquiprin Infants" DropsLonaridLonarid MonoLorcet-HdLortabLupocetLytecaLyteca SyrupMagnidolMalex NMalgisMalidensMaxadolMedigesic PlusMedinol PaediatricMedocodeneMelabon InfantilMexalenMidol Maximum StrengthMidol PM Night Time FormulaMidol Regular StrengthMidol Teen FormulaMigraleve YellowMinafenMinosetMiralginMomentumMono PraecimedMultinN-(4-Hydroxyphenyl)acetamideN-Acetyl-4-aminophenolN-Acetyl-p-aminophenolNaldegesicNAPANapafenNapapNaprinolNealgylNebsNeo-FepramolNeoCitranNeodolNeodolitoNeopapNeotrendNeuridonNew Cortal for ChildrenNilnOcenNinaNo-FebrilNobedonNodolexNoralNorcetNorcoo-AcetaminophenolOltylOralganOraphen-PDOrtensanOxycetOxycocetOxycodone 2.5/Apap 500Oxycodone 5/Apap 500p-(Acetylamino)phenolp-Acetamidophenolp-Acetaminophenolp-Acetylaminophenolp-Hydroxyacetanilidep-HydroxyphenolacetamidePacecoPacemoPacemolPacetPacimolPaedialgonPaedolPainexPaldesicPamolPanacetePanadeinePanadeine CoPanadienePanado-CoPanado-Co CapletsPanadolPanadol Extra StrengthPanadol Junior Strength CapletsPanadol Maximum Strength CapletsPanadol Maximum Strength TabletsPanalevePanamaxPanasorbPanasorbePanetsPanexPanodilPanofenPantalginPapa-Deine #3Papa-Deine #4Para-SuppoPara-TabsParacemolParacenolParacetParacetamolParacetamol ALParacetamol Antipanin PParacetamol BasicsParacetamol BCParacetamol DCParacetamol Dr. SchmidgallParacetamol FecofarParacetamol GenericonParacetamol HanselerParacetamol HarkleyParacetamol HeumannParacetamol HexalParacetamol ItalfarmacoParacetamol NycomedParacetamol PBParacetamol RaffoParacetamol RatiopharmParacetamol RoschParacetamol SaarParacetamol SmithKline BeechamParacetamol StadaParacetamol von ctParacetamol WinthropParacetamoleParacetamoloParacetamolumParacetanolParacetolParacinParacodParacodolParadorParadropsParakaptonParakeParalenParaliefParalinkParalyocParamolParamolanParanoxParapanParasedolParasinParaspenParcetolParelanParmolParogalParomaPasolindPasolind NPCM Paracetamol LichtensteinPe-TamPediapirinPediatrixPedricPercocetPercocet-5Percocet-DemiPercogesic with CodeinePerdolan MonoPhenaphenPhenaphen CapletsPhenaphen W/CodeinePhendonPhenipirinPhogoglandinPhrenilinPhrenilin FortePinexPiraminPirinasolPlicetPolmofenPredimolPredualitoPrestwick_13ProdolPromptProntinaPropacetPropacet 100Proval #3PuernolPulmofenPyregesic-CPyrigesicPyrinazinePyromedQuiet WorldRedutempRelivRemedolRhinex D-Lay TabletsRivalgylRobigesicRobitussin Night ReliefRockamol PlusRounoxRoxicetRoxicet 5/500RoxiloxRubieMolRubophenRupemolSalzoneSanicetSanicopyrineScanolScentalgylScherzatabletten Rezeptur 534SchmerzexSedalitoSedapapSemolacinServigesicSeskamolSetakopSetamolSetolSifenolSinasprilSine-Off Sinus Medicine CapletsSinedolSinmolSinubidSK-ApapSnaplets-FRSpalt fur die nachtSpalt NSt Joseph Aspirin-FreeSt Joseph Aspirin-Free for ChildrenSt. Joseph Cold Tablets for ChildrenSt. Joseph Fever ReducerStanbackStopainSudafed Severe Cold FormulaSudafed SinusSunethetonSupacSupadol monoSupofenSuppapSuppap-120Suppap-325Suppap-650Supramol-MSynalgos-Dc-ATabalginTachiprinaTalacenTapanol Extra Strength CapletsTapanol Extra Strength TabletsTaparTavist Allergy/Sinus/HeadacheTazamolTemloTempanalTempraTempra CapletsTempra Chewable TabletsTempra D.STempra DropsTempra SyrupTenconTermacetTermalginTermalgineTermofrenTheraFluTibinideTibizideTiffyTisinTisiodrazidaTitralganTizideTocris-1706Toximer PTralgonTreupel monTreupel NTreuphadolTriadTriaminic Sore Throat FormulaTriaprinTricotonTussapapTycoletTYLTylenolTylenol Allergy SinusTylenol Arthritis Extended ReliefTylenol CapletsTylenol Children's Chewable TabletsTylenol Children's ElixirTylenol Children's Suspension LiquidTylenol DropsTylenol ElixirTylenol Extra Strength Adult Liquid Pain RelieverTylenol Extra Strength CapletsTylenol Extra Strength GelcapsTylenol Extra Strength TabletsTylenol GelcapsTylenol Infants DropsTylenol Infants" Suspension DropsTylenol Junior Strength CapletsTylenol Junior Strength Chewable TabletsTylenol Regular Strength CapletsTylenol Regular Strength TabletsTylenol TabletsTylexTylex CDTylolTyloxTylox-325TymolUltracetUpsanolUtraginValadolValgesicValorinValorin ExtraVanquishVeralginaVermidonVerpolViclor RichetVicodinVicodin EsVicodin HpVipsVirufluVivimedVolpanWygesicZatinolZolbenC8H9NO2151.1626151.063328537103-90-2CC(=O)NC1=CC=C(O)C=C1InChI=1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)RZVAJINKPMORJF-UHFFFAOYSA-N belongs to the class of organic compounds known as 1-hydroxy-2-unsubstituted benzenoids. These are phenols that are unsubstituted at the 2-position.1-hydroxy-2-unsubstituted benzenoidsOrganic compoundsBenzenoidsPhenols1-hydroxy-2-unsubstituted benzenoidsAromatic homomonocyclic compoundsBenzene and substituted derivativesCarboximidic acidsHydrocarbon derivativesOrganonitrogen compoundsOrganooxygen compoundsOrganopnictogen compoundsPropargyl-type 1,3-dipolar organic compounds1-hydroxy-2-unsubstituted benzenoidAromatic homomonocyclic compoundCarboximidic acidCarboximidic acid derivativeHydrocarbon derivativeMonocyclic benzene moietyOrganic 1,3-dipolar compoundOrganic nitrogen compoundOrganic oxygen compoundOrganonitrogen compoundOrganooxygen compoundOrganopnictogen compoundPropargyl-type 1,3-dipolar organic compounda small moleculeacetamidesphenolsSolidaverage_mass151.1626mono_mass151.063328537smilesCC(=O)NC1=CC=C(O)C=C1formulaC8H9NO2inchiInChI=1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)inchikeyRZVAJINKPMORJF-UHFFFAOYSA-NSpecdb::EiMs731Specdb::NmrTwoD1701Specdb::MsIr1381Specdb::MsIr1382Specdb::MsIr1383Specdb::CMs1301Specdb::CMs8768Specdb::CMs26864Specdb::CMs27405Specdb::CMs27419Specdb::CMs31356Specdb::CMs38150Specdb::CMs165569Specdb::NmrOneD1761Specdb::NmrOneD2079Specdb::NmrOneD2773Specdb::NmrOneD9702Specdb::NmrOneD9703Specdb::NmrOneD9704Specdb::NmrOneD9705Specdb::NmrOneD9706Specdb::NmrOneD9707Specdb::NmrOneD9708Specdb::NmrOneD9709Specdb::NmrOneD9710Specdb::NmrOneD9711Specdb::NmrOneD9712Specdb::NmrOneD9713Specdb::NmrOneD9714Specdb::NmrOneD9715Specdb::NmrOneD9716Specdb::NmrOneD9717Specdb::NmrOneD9718Specdb::NmrOneD9719Specdb::NmrOneD9720Specdb::NmrOneD9721Specdb::MsMs435677Specdb::MsMs435678Specdb::MsMs435679Specdb::MsMs435680Specdb::MsMs435681Specdb::MsMs435682Specdb::MsMs435683Specdb::MsMs435684Specdb::MsMs435685Specdb::MsMs435686Specdb::MsMs435687Specdb::MsMs435688Specdb::MsMs435689Specdb::MsMs2231162Specdb::MsMs2233013Specdb::MsMs2235817Specdb::MsMs2237575Specdb::MsMs2237884Specdb::MsMs2239678Specdb::MsMs2240039Specdb::MsMs2241687Specdb::MsMs2242129Specdb::MsMs2243728Specdb::MsMs2246379Specdb::MsMs2247925HMDB018592386TYL#<Reference:0x0000555676423ca0>#<Reference:0x00005556764236b0>#<Reference:0x0000555676423160>#<Reference:0x0000555676422d78>#<Reference:0x00005556764225f8>#<Reference:0x0000555676422350>#<Reference:0x0000555676421f90>#<Reference:0x0000555676421b80>#<Reference:0x00005556764215e0>#<Reference:0x0000555676421360>#<Reference:0x0000555676420fa0>#<Reference:0x00005556764204d8>#<Reference:0x000055567641fe70>#<Reference:0x000055567641f948>#<Reference:0x000055567641f588>#<Reference:0x000055567641f088>#<Reference:0x000055567641e908>#<Reference:0x000055567641e610>#<Reference:0x000055567641e390>Milk (Cow)Type 2specificbitter