1.02011-09-21 00:19:01 UTC2018-05-28 18:33:54 UTCFDB022749MetoprololMetoprolol is a selective beta1 receptor blocker used in treatment of several diseases of the cardiovascular system. It is marketed under the brand name Lopressor by Novartis, and Toprol (in the USA); Seleken or Selokeen (elsewhere); A selective adrenergic beta-1-blocking agent with no stimulatory action. It's binding to plasma albumin is weaker than alprenolol and it may be useful in the treatment of several diseases of the cardiovascular system; Metoprolol is a selective beta1 receptor blocker used in treatment of several diseases of the cardiovascular system. It is marketed under the brand name Lopressor by Novartis, and Toprol (in the USA); Seleken or Selokeen (elsewhere); as Minax by Alphapharm (in Australia), as Betaloc by AstraZeneca and as Corvitol by Berlin-Chemie AG; A selective adrenergic beta-1-blocking agent with no stimulatory action. It's binding to plasma albumin is weaker than alprenolol and it may be useful in angina pectoris, hypertension, or cardiac arrhythmias; as Minax by Alphapharm (in Australia), as Betaloc by AstraZeneca and as Corvitol by Berlin-Chemie AG. [HMDB](+/-)-Metoprolol(RS)-Metoprolol1-(Isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-olBeatrololdl-MetoprololLopresorLopresoreticLopressorMeijoprololMetohexalMetoprololMetoprolol succinateMetoprolol tartrateMetoprololumPreblokPresololSelokenSerokenSpesicorToprol-XLC15H25NO3267.3639267.1834436711-[4-(2-methoxyethyl)phenoxy]-3-[(propan-2-yl)amino]propan-2-olmetoprolol37350-58-6COCCC1=CC=C(OCC(O)CNC(C)C)C=C1InChI=1S/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/h4-7,12,14,16-17H,8-11H2,1-3H3IUBSYMUCCVWXPE-UHFFFAOYSA-N belongs to the class of organic compounds known as tyrosols and derivatives. Tyrosols and derivatives are compounds containing a hydroxyethyl group attached to the C4 carbon of a phenol group.Tyrosols and derivativesOrganic compoundsBenzenoidsPhenolsTyrosols and derivativesAromatic homomonocyclic compounds1,2-aminoalcoholsAlkyl aryl ethersDialkyl ethersDialkylaminesHydrocarbon derivativesOrganopnictogen compoundsPhenol ethersPhenoxy compoundsSecondary alcohols1,2-aminoalcoholAlcoholAlkyl aryl etherAmineAromatic homomonocyclic compoundDialkyl etherEtherHydrocarbon derivativeMonocyclic benzene moietyOrganic nitrogen compoundOrganic oxygen compoundOrganonitrogen compoundOrganooxygen compoundOrganopnictogen compoundPhenol etherPhenoxy compoundSecondary alcoholSecondary aliphatic amineSecondary amineTyrosol derivativearomatic etherpropanolaminesecondary alcoholsecondary amino compoundSolidlogp1.80logs-2.82solubility4.02e-01 g/llogp1.76pka_strongest_acidic14.09pka_strongest_basic9.67iupac1-[4-(2-methoxyethyl)phenoxy]-3-[(propan-2-yl)amino]propan-2-olaverage_mass267.3639mono_mass267.183443671smilesCOCCC1=CC=C(OCC(O)CNC(C)C)C=C1formulaC15H25NO3inchiInChI=1S/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/h4-7,12,14,16-17H,8-11H2,1-3H3inchikeyIUBSYMUCCVWXPE-UHFFFAOYSA-Npolar_surface_area50.72refractivity76.7polarizability31.9rotatable_bond_count9acceptor_count4donor_count2physiological_charge1formal_charge0Specdb::NmrTwoD1750Specdb::NmrOneD1810Specdb::CMs8773Specdb::CMs38190Specdb::CMs117906Specdb::CMs123897Specdb::CMs152903Specdb::CMs806621Specdb::CMs806622Specdb::MsMs1872Specdb::MsMs1873Specdb::MsMs1874Specdb::MsMs261720Specdb::MsMs261721Specdb::MsMs261722Specdb::MsMs281652Specdb::MsMs281653Specdb::MsMs281654Specdb::MsMs440891Specdb::MsMs441601Specdb::MsMs441602Specdb::MsMs441603Specdb::MsMs441604Specdb::MsMs441605Specdb::MsMs441606Specdb::MsMs441607Specdb::MsMs441608Specdb::MsMs441609Specdb::MsMs441610Specdb::MsMs441611Specdb::MsMs441612Specdb::MsMs441613Specdb::MsMs441614Specdb::MsMs444872HMDB019326904#<Reference:0x00005556755ed208>#<Reference:0x00005556755ecfd8>#<Reference:0x00005556755ecdd0>Beta-1 adrenergic receptorP08588ADRB1