1.0 2011-09-21 00:22:25 UTC 2015-07-21 06:57:26 UTC FDB022961 11,12-DiHETrE 11,12-DiHETrE is a Cytochrome P450 (P450) eicosanoid. Arachidonic acid may be oxygenated by cytochrome P450 in several ways. Epoxidation of the double bonds leads to the regio- and enantioselective formation of four epoxyeicosatrienoic acids (EETs), which are hydrolyzed by epoxide hydrolase to vicinal diols (DHETs). 11,12-DiHETrE excretion is increased in healthy pregnant women compared with nonpregnant female volunteers, and increased even further in patients with pregnancy-induced hypertension (PIH). The physiological significance of arachidonic acid epoxides has been debated and it is unknown whether they play a role in pregnancy and parturition. Vasodilative effects, inhibition of cyclooxygenase, or inhibition of platelet aggregation by EETs have been observed only at micromolar concentrations. On the other hand, effects on the stimulus-secretion coupling during hormone release have been found in the nanomolar and picomolar range. (PMID: 9440131, 2198572) [HMDB] (+/-)-11,12-dihydroxy-5Z,8Z,14Z,17Z-eicosatetraenoate (+/-)-11,12-dihydroxy-5Z,8Z,14Z,17Z-eicosatetraenoic acid (+/-)11,12-dihetre (5Z,8Z,14Z)-11,12-Dihydroxyeicosa-5,8,14-trienoate (5Z,8Z,14Z)-11,12-Dihydroxyeicosa-5,8,14-trienoic acid (5Z,8Z,14Z)-11,12-Dihydroxyicosa-5,8,14-trienoate (5Z,8Z,14Z)-11,12-Dihydroxyicosa-5,8,14-trienoic acid 11,12-DHET 11,12-dihydroxy-5Z,8Z,14Z-eicosatrienoate 11,12-dihydroxy-5Z,8Z,14Z-eicosatrienoic acid 11,12-Dihydroxyeicosatrienoate 11,12-Dihydroxyeicosatrienoic acid 12-Dihydroxyicosa-5,8,14-trienoate 12-Dihydroxyicosa-5,8,14-trienoic acid C20H34O4 338.4816 338.245709576 11,12-dihydroxyicosa-5,8,14-trienoic acid 11,12-dihydroxyicosa-5,8,14-trienoic acid 192461-95-3 CCCCCC=CCC(O)C(O)CC=CCC=CCCCC(O)=O InChI=1S/C20H34O4/c1-2-3-4-5-9-12-15-18(21)19(22)16-13-10-7-6-8-11-14-17-20(23)24/h6,8-10,12-13,18-19,21-22H,2-5,7,11,14-17H2,1H3,(H,23,24) LRPPQRCHCPFBPE-UHFFFAOYSA-N belongs to the class of organic compounds known as hydroxyeicosatrienoic acids. These are eicosanoic acids with an attached hydroxyl group and three CC double bonds. Hydroxyeicosatrienoic acids Organic compounds Lipids and lipid-like molecules Fatty Acyls Eicosanoids Aliphatic acyclic compounds 1,2-diols Carbonyl compounds Carboxylic acids Hydrocarbon derivatives Hydroxy fatty acids Long-chain fatty acids Monocarboxylic acids and derivatives Organic oxides Secondary alcohols Unsaturated fatty acids 1,2-diol Alcohol Aliphatic acyclic compound Carbonyl group Carboxylic acid Carboxylic acid derivative Fatty acid Hydrocarbon derivative Hydroxy fatty acid Hydroxyeicosatrienoic acid Long-chain fatty acid Monocarboxylic acid or derivatives Organic oxide Organic oxygen compound Organooxygen compound Secondary alcohol Unsaturated fatty acid Solid logp 5.41 ALOGPS logs -4.41 ALOGPS solubility 1.30e-02 g/l ALOGPS logp 4.49 ChemAxon pka_strongest_acidic 4.82 ChemAxon pka_strongest_basic -3.2 ChemAxon iupac 11,12-dihydroxyicosa-5,8,14-trienoic acid ChemAxon average_mass 338.4816 ChemAxon mono_mass 338.245709576 ChemAxon smiles CCCCCC=CCC(O)C(O)CC=CCC=CCCCC(O)=O ChemAxon formula C20H34O4 ChemAxon inchi InChI=1S/C20H34O4/c1-2-3-4-5-9-12-15-18(21)19(22)16-13-10-7-6-8-11-14-17-20(23)24/h6,8-10,12-13,18-19,21-22H,2-5,7,11,14-17H2,1H3,(H,23,24) ChemAxon inchikey LRPPQRCHCPFBPE-UHFFFAOYSA-N ChemAxon polar_surface_area 77.76 ChemAxon refractivity 101.87 ChemAxon polarizability 40.48 ChemAxon rotatable_bond_count 15 ChemAxon acceptor_count 4 ChemAxon donor_count 3 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon Arachidonic Acid Metabolism SMP00075 map00590 HMDB02314 #<Reference:0x000055ce3192f338> #<Reference:0x000055ce3192f108> Anatidae Type 1 specific Anatidae 8830 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Mallard duck Type 1 specific Anas platyrhynchos 8839 Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 Wild boar Type 1 specific Sus scrofa 9823