1.0 2011-09-21 00:22:57 UTC 2025-11-19 02:42:59 UTC FDB022992 N-Methyl-D-aspartic acid N-Methyl-D-aspartic acid is an amino acid derivative acting as a specific agonist at the NMDA receptor, and therefore mimics the action of the neurotransmitter glutamate on that receptor. In contrast to glutamate, NMDA binds to and regulates the above receptor only, but not other glutamate receptors. NMDA is a water-soluble synthetic substance that is not normally found in biological tissue. It was first synthesized in the 1960's. NMDA is an excitotoxin; this trait has applications in behavioral neuroscience research. The body of work utilizing this technique falls under the term "lesion studies." Researchers apply NMDA to specific regions of an (animal) subject's brain or spinal cord and subsequently test for the behavior of interest, such as operant behavior. If the behavior is compromised, it suggests the destroyed tissue was part of a brain region that made an important contribution to the normal expression of that behavior. Examples of antagonists of the NMDA receptor are APV, dextromethorphan, ketamine, phencyclidine (PCP), riluzole, and memantine. They are commonly referred to as NMDA receptor antagonists. [HMDB] (R)-2-Methylamino-succinate (R)-2-Methylamino-succinic acid 2-Methylamino-succinate 2-Methylamino-succinic acid Methyl aspartate Methyl aspartic acid N-Me-D-Asp-OH N-Methyl aspartate N-Methyl aspartic acid N-methyl D-aspartate N-methyl D-aspartic acid N-Methyl-D-aspartate N-Methylaspartate N-Methylaspartic acid NMDA C5H9NO4 147.1293 147.053157781 (2R)-2-(methylamino)butanedioic acid N methyl D aspartate 6384-92-5 CN[C@H](CC(O)=O)C(O)=O InChI=1S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/t3-/m1/s1 HOKKHZGPKSLGJE-GSVOUGTGSA-N belongs to the class of organic compounds known as aspartic acid and derivatives. Aspartic acid and derivatives are compounds containing an aspartic acid or a derivative thereof resulting from reaction of aspartic acid at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. Aspartic acid and derivatives Organic compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Aliphatic acyclic compounds Amino acids Carbonyl compounds Carboxylic acids D-alpha-amino acids Dialkylamines Dicarboxylic acids and derivatives Fatty acids and conjugates Hydrocarbon derivatives Organic oxides Organopnictogen compounds Aliphatic acyclic compound Alpha-amino acid Amine Amino acid Aspartic acid or derivatives Carbonyl group Carboxylic acid D-alpha-amino acid Dicarboxylic acid or derivatives Fatty acid Hydrocarbon derivative Organic nitrogen compound Organic oxide Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Secondary aliphatic amine Secondary amine D-alpha-amino acid D-aspartic acid derivative amino dicarboxylic acid secondary amino compound Solid logp -2.58 ALOGPS logs -0.56 ALOGPS solubility 4.06e+01 g/l ALOGPS logp -3.3 ChemAxon pka_strongest_acidic 1.46 ChemAxon pka_strongest_basic 10.34 ChemAxon iupac (2R)-2-(methylamino)butanedioic acid ChemAxon average_mass 147.1293 ChemAxon mono_mass 147.053157781 ChemAxon smiles CN[C@H](CC(O)=O)C(O)=O ChemAxon formula C5H9NO4 ChemAxon inchi InChI=1S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/t3-/m1/s1 ChemAxon inchikey HOKKHZGPKSLGJE-GSVOUGTGSA-N ChemAxon polar_surface_area 86.63 ChemAxon refractivity 31.31 ChemAxon polarizability 13.18 ChemAxon rotatable_bond_count 4 ChemAxon acceptor_count 5 ChemAxon donor_count 3 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon Specdb::MsIr 1762 Specdb::MsIr 1763 Specdb::MsIr 1764 Specdb::MsMs 2098 Specdb::MsMs 2099 Specdb::MsMs 2100 Specdb::MsMs 317005 Specdb::MsMs 317006 Specdb::MsMs 317007 Specdb::MsMs 363394 Specdb::MsMs 363395 Specdb::MsMs 363396 Specdb::MsMs 2235953 Specdb::MsMs 2236299 Specdb::MsMs 2237104 Specdb::MsMs 2237449 Specdb::MsMs 2238016 Specdb::MsMs 2238354 Specdb::MsMs 2239207 Specdb::MsMs 2239541 Specdb::MsMs 2240188 Specdb::MsMs 2240371 Specdb::MsMs 2241346 Specdb::MsMs 2241539 Specdb::MsMs 2242272 Specdb::MsMs 2242473 Specdb::MsMs 2243365 Specdb::MsMs 2243575 Specdb::CMs 22970 Specdb::CMs 38408 Specdb::CMs 131561 Specdb::CMs 139295 Specdb::NmrTwoD 1824 Specdb::NmrOneD 1887 Specdb::NmrOneD 122438 Specdb::NmrOneD 122439 Specdb::NmrOneD 122440 Specdb::NmrOneD 122441 Specdb::NmrOneD 122442 Specdb::NmrOneD 122443 Specdb::NmrOneD 122444 Specdb::NmrOneD 122445 Specdb::NmrOneD 122446 Specdb::NmrOneD 122447 Specdb::NmrOneD 122448 Specdb::NmrOneD 122449 Specdb::NmrOneD 122450 Specdb::NmrOneD 122451 Specdb::NmrOneD 122452 Specdb::NmrOneD 122453 Specdb::NmrOneD 122454 Specdb::NmrOneD 122455 Specdb::NmrOneD 122456 Specdb::NmrOneD 122457 Specdb::NmrOneD 166348 Specdb::NmrOneD 166544 HMDB02393 OEM #<Reference:0x000055ce32f3c680> #<Reference:0x000055ce32f3c3d8> #<Reference:0x000055ce32f3c1a8> #<Reference:0x000055ce32f37f40> #<Reference:0x000055ce32f37d88> #<Reference:0x000055ce32f360c8> #<Reference:0x000055ce32f34890> #<Reference:0x000055ce32f34548> #<Reference:0x000055ce32f34390> #<Reference:0x000055ce32f341d8> #<Reference:0x000055ce32f34020> #<Reference:0x000055ce32f2fe08> #<Reference:0x000055ce32f2fc50> #<Reference:0x000055ce32f2fa98> #<Reference:0x000055ce32f2f8e0> #<Reference:0x000055ce32f2f728> #<Reference:0x000055ce32f2f520> Milk (Cow) Type 2 specific A-kinase anchor protein 9 Q99996 AKAP9