1.0 2011-09-21 00:23:50 UTC 2025-11-19 02:43:06 UTC FDB023050 1,5-Anhydrosorbitol 1,5-Anhydrosorbitol or 1,5-anhydroglucitol (1,5-AG) is a validated marker of short-term glycemic control. This substance is derived mainly from food, is well absorbed in the intestine, and is distributed to all organs and tissues. It is metabolically stable, being excreted in the urine when its level exceeds the renal threshold. It is reabsorbed in the renal tubules, and is competitively inhibited by glucosuria, which leads to a reduction in its level in serum. The correlation between this reduction and the amount of glucose present in urine is so close that 1,5 AG can be used as a sensitive, day-to-day, real-time marker of glycemic control. It provides useful information on current glycemic control and is superior to both hemoglobin A1C and fructosamine in detecting near-normoglycemia. 1,5-AG in human plasma has been proposed for several years as a short-term, retrospective marker of glycaemic control and seems to be the most suitable parameter for monitoring glucose excursions. The decrease in serum 1,5-AG is very sensitive to urinary glucose excretion. It is a metabolically inert polyol that competes with glucose for reabsorption in the kidneys. Otherwise stable levels of 1,5-AG are rapidly depleted as blood glucose levels exceed the renal threshold for glucosuria. 1,5-AG is also more tightly associated with glucose fluctuations and postprandial glucose. (PMID: 18088226, 12166605, 7783360, 8940824) [HMDB] 1,5-AG 1,5-anhydro-D-glucitol 1,5-Anhydro-D-sorbitol 1,5-Anhydroglucitol C6H12O5 164.1565 164.068473494 (2R,3S,4R,5S)-2-(hydroxymethyl)oxane-3,4,5-triol 1,5-anhydroglucitol 154-58-5 OC[C@H]1OC[C@H](O)[C@@H](O)[C@@H]1O InChI=1S/C6H12O5/c7-1-4-6(10)5(9)3(8)2-11-4/h3-10H,1-2H2/t3-,4+,5+,6+/m0/s1 MPCAJMNYNOGXPB-SLPGGIOYSA-N belongs to the class of organic compounds known as monosaccharides. Monosaccharides are compounds containing one carbohydrate unit not glycosidically linked to another such unit, and no set of two or more glycosidically linked carbohydrate units. Monosaccharides have the general formula CnH2nOn. Monosaccharides Organic compounds Organic oxygen compounds Organooxygen compounds Carbohydrates and carbohydrate conjugates Aliphatic heteromonocyclic compounds Dialkyl ethers Hydrocarbon derivatives Oxacyclic compounds Oxanes Polyols Primary alcohols Secondary alcohols Alcohol Aliphatic heteromonocyclic compound Dialkyl ether Ether Hydrocarbon derivative Monosaccharide Organoheterocyclic compound Oxacycle Oxane Polyol Primary alcohol Secondary alcohol anhydro sugar Solid logp -2.62 ALOGPS logs 0.80 ALOGPS solubility 1.04e+03 g/l ALOGPS logp -2.6 ChemAxon pka_strongest_acidic 12.66 ChemAxon pka_strongest_basic -3 ChemAxon iupac (2R,3S,4R,5S)-2-(hydroxymethyl)oxane-3,4,5-triol ChemAxon average_mass 164.1565 ChemAxon mono_mass 164.068473494 ChemAxon smiles OC[C@H]1OC[C@H](O)[C@@H](O)[C@@H]1O ChemAxon formula C6H12O5 ChemAxon inchi InChI=1S/C6H12O5/c7-1-4-6(10)5(9)3(8)2-11-4/h3-10H,1-2H2/t3-,4+,5+,6+/m0/s1 ChemAxon inchikey MPCAJMNYNOGXPB-SLPGGIOYSA-N ChemAxon polar_surface_area 90.15 ChemAxon refractivity 34.89 ChemAxon polarizability 15.19 ChemAxon rotatable_bond_count 1 ChemAxon acceptor_count 5 ChemAxon donor_count 4 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Specdb::CMs 823 Specdb::CMs 18462 Specdb::CMs 30411 Specdb::CMs 32005 Specdb::CMs 32274 Specdb::CMs 38466 Specdb::CMs 146355 Specdb::MsIr 1820 Specdb::MsIr 1821 Specdb::MsIr 1822 Specdb::NmrOneD 1901 Specdb::NmrOneD 128868 Specdb::NmrOneD 128869 Specdb::NmrOneD 128870 Specdb::NmrOneD 128871 Specdb::NmrOneD 128872 Specdb::NmrOneD 128873 Specdb::NmrOneD 128874 Specdb::NmrOneD 128875 Specdb::NmrOneD 128876 Specdb::NmrOneD 128877 Specdb::NmrOneD 128878 Specdb::NmrOneD 128879 Specdb::NmrOneD 128880 Specdb::NmrOneD 128881 Specdb::NmrOneD 128882 Specdb::NmrOneD 128883 Specdb::NmrOneD 128884 Specdb::NmrOneD 128885 Specdb::NmrOneD 128886 Specdb::NmrOneD 128887 Specdb::MsMs 2125 Specdb::MsMs 2126 Specdb::MsMs 2127 Specdb::MsMs 306940 Specdb::MsMs 306941 Specdb::MsMs 306942 Specdb::MsMs 350746 Specdb::MsMs 350747 Specdb::MsMs 350748 Specdb::MsMs 438638 Specdb::MsMs 2692442 Specdb::MsMs 2692443 Specdb::MsMs 2692444 Specdb::MsMs 2990357 Specdb::MsMs 2990358 Specdb::MsMs 2990359 HMDB02712 16070 ASO #<Reference:0x000055ce30e5ec88> #<Reference:0x000055ce30e5ea80> #<Reference:0x000055ce30e5e800> #<Reference:0x000055ce30e5e3a0> #<Reference:0x000055ce30e5df90> #<Reference:0x000055ce30e5ddb0> #<Reference:0x000055ce30e5da68> #<Reference:0x000055ce30e5d748> #<Reference:0x000055ce30e5d1a8> #<Reference:0x000055ce30e5cfa0> #<Reference:0x000055ce30e5cd20> #<Reference:0x000055ce30e5c988> Anatidae Type 1 specific Anatidae 8830 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Mallard duck Type 1 specific Anas platyrhynchos 8839 Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 Wild boar Type 1 specific Sus scrofa 9823