1.02011-09-21 00:24:33 UTC2015-10-09 22:31:57 UTCFDB023091CysteamineCysteamine is a product of the constitutive degradation of coenzyme A, a process that occurs in all tissues, although some tissues such as brain and heart may have exceptionally high coenzyme A turnover rates. Cysteamine has only one known function, and that is as a precursor for the formation of hypotaurine, which is subsequently oxidized to taurine. The rate of cysteamine production as a result of coenzyme A breakdown is not well understood but it is clear that cysteamine levels are not as dramatically affected by dietary habits as are cysteine levels. Cysteamine is generated from hypotaurine by cysteamine dioxygenase (EC:1.13.11.19), an enzyme that was recently identified in mammals (PMID: 17581819). Cysteamine is the simplest stable aminothiol found in the body. It is used in the treatment of disorders of cystine excretion. Cysteamine cleaves the disulfide bond with cysteine to produce molecules that can escape the metabolic defect in cystinosis and cystinuria. Cyst(e)amine may also serve as an endogenous regulator of immune system activity as well as a potential therapeutic agent for the treatment of Huntington disease. Cysteamine is also used as a radiation-protective agent that oxidizes in air to form cystamine. It can be given intravenously or orally to treat radiation sickness. -- Wikipedia [HMDB](2-Mercaptoethyl)amine2-Amino-1-ethanethiol2-amino-ETHANETHIOL2-Aminoethanethiol2-Aminoethyl mercaptan2-MercaptoethanamineAminoethyl mercaptanb-Aminoethanethiolb-Aminoethylthiolb-MEAb-MercaptoethylamineBecaptanbeta-Aminoethanethiolbeta-Aminoethylthiolbeta-MEAbeta-MercaptoethylamineCASHCisteaminaCysteamideCysteaminCysteamineCysteaminiumCysteinamineDecarboxycysteineEthanethiolamineLambratenLambrateneMecramineMercaminMercamineMercaptaminMercaptaminaMercaptamineMercaptaminumMerkaminRiaconThioethanolamineβ-aminoethanethiolβ-aminoethylthiolβ-meaβ-mercaptoethylamineC2H7NS77.14977.0299199192-aminoethane-1-thiolcysteamine60-23-1NCCSInChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2UFULAYFCSOUIOV-UHFFFAOYSA-N belongs to the class of organic compounds known as alkylthiols. These are organic compounds containing the thiol functional group linked to an alkyl chain.AlkylthiolsOrganic compoundsOrganosulfur compoundsThiolsAlkylthiolsAliphatic acyclic compoundsHydrocarbon derivativesMonoalkylaminesOrganopnictogen compoundsAliphatic acyclic compoundAlkylthiolAmineHydrocarbon derivativeOrganic nitrogen compoundOrganonitrogen compoundOrganopnictogen compoundPrimary aliphatic aminePrimary amineBiogenic aminesa thiolaminethiolSolidlogp0.01logs-0.52solubility2.35e+01 g/llogp-0.42pka_strongest_acidic9.42pka_strongest_basic10.4iupac2-aminoethane-1-thiolaverage_mass77.149mono_mass77.029919919smilesNCCSformulaC2H7NSinchiInChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2inchikeyUFULAYFCSOUIOV-UHFFFAOYSA-Npolar_surface_area26.02refractivity22.39polarizability8.65rotatable_bond_count1acceptor_count1donor_count2physiological_charge1formal_charge0Taurine and Hypotaurine MetabolismSMP00021map00430Specdb::NmrTwoD1854Specdb::MsIr1852Specdb::MsIr1853Specdb::MsIr1854Specdb::CMs825Specdb::CMs826Specdb::CMs827Specdb::CMs1137Specdb::CMs9234Specdb::CMs30179Specdb::CMs30271Specdb::CMs30924Specdb::CMs31435Specdb::CMs31679Specdb::CMs31739Specdb::CMs160424Specdb::NmrOneD1919Specdb::NmrOneD149380Specdb::NmrOneD149381Specdb::NmrOneD149382Specdb::NmrOneD149383Specdb::NmrOneD149384Specdb::NmrOneD149385Specdb::NmrOneD149386Specdb::NmrOneD149387Specdb::NmrOneD149388Specdb::NmrOneD149389Specdb::NmrOneD149390Specdb::NmrOneD149391Specdb::NmrOneD149392Specdb::NmrOneD149393Specdb::NmrOneD149394Specdb::NmrOneD149395Specdb::NmrOneD149396Specdb::NmrOneD149397Specdb::NmrOneD149398Specdb::NmrOneD149399Specdb::MsMs2176Specdb::MsMs2177Specdb::MsMs2178Specdb::MsMs264549Specdb::MsMs264550Specdb::MsMs264551Specdb::MsMs284478Specdb::MsMs284479Specdb::MsMs284480Specdb::MsMs2233837Specdb::MsMs2352859Specdb::MsMs2352860Specdb::MsMs2352861Specdb::MsMs2585446Specdb::MsMs2585447Specdb::MsMs2585448HMDB0299117141DHL#<Reference:0x00005556755f2b68>#<Reference:0x00005556755f2988>#<Reference:0x00005556755f2730>#<Reference:0x00005556755f2578>#<Reference:0x00005556755f2398>#<Reference:0x00005556755f2190>#<Reference:0x00005556755f1fd8>#<Reference:0x00005556755f1dd0>#<Reference:0x00005556755f1b28>#<Reference:0x00005556755f1970>#<Reference:0x00005556755f1768>#<Reference:0x00005556755f1510>#<Reference:0x00005556755f1358>#<Reference:0x00005556755f1178>#<Reference:0x00005556755f0f70>#<Reference:0x00005556755f0db8>#<Reference:0x00005556755f0b60>#<Reference:0x00005556755f08e0>#<Reference:0x00005556755f0660>AnatidaeType 1specificAnatidae8830BeefaloType 1specificBos taurus X Bison bison297284BisonType 1specificBison bison9901BuffaloType 1specificBubalus bubalis89462Cattle (Beef, Veal)Type 1specificBos taurus9913ChickenType 1specificGallus gallus9031Columbidae (Dove, Pigeon)Type 1specificColumbidae8930DeerType 1specificCervidae9850Domestic goatType 1specificCapra aegagrus hircus9925Domestic pigType 1specificSus scrofa domestica9825ElkType 1specificCervus canadensis1574408EmuType 1specificDromaius novaehollandiae8790European rabbitType 1specificOryctolagus9984Greylag gooseType 1specificAnser anser8843Guinea henType 1specificNumida meleagris8996HorseType 1specificEquus caballus9796Mallard duckType 1specificAnas platyrhynchos8839Mountain hareType 1specificLepus timidus62621Mule deerType 1specificOdocoileus9871OstrichType 1specificStruthio camelus8801PheasantType 1specificPhasianus colchicus9054QuailType 1specificPhasianidae9005RabbitType 1specificLeporidae9979Rock ptarmiganType 1specificLagopus muta64668Sheep (Mutton, Lamb)Type 1specificOvis aries9940SquabType 1specificColumba8931TurkeyType 1specificMeleagris gallopavo9103Velvet duckType 1specificMelanitta fusca371864Wild boarType 1specificSus scrofa9823PantetheinaseO95497VNN1SomatostatinP61278SST