1.0 2011-09-21 00:25:02 UTC 2015-07-21 06:57:31 UTC FDB023124 Thromboxane Thromboxane is a member of the family of lipids known as eicosanoids. It is produced in platelets by thromboxane synthetase, which is produced from the endoperoxides by the cyclooxygenase (COX) enzyme from arachidonic acid. -- Wikipedia; Thromboxane is a vasoconstrictor, potent hypertensive agent, and facilitates the clumping of platelets. It is in homeostatic balance in the circulatory system with prostacyclin, a related compound. The widely-used drug aspirin acts by inhibiting the ability of the COX enzyme to synthesize the precursors of thromboxane within platelets. -- Wikipedia Thromboxanes are eicosanoids. The eicosanoids consist of the prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs) and lipoxins (LXs). The PGs and TXs are collectively identified as prostanoids. Prostaglandins were originally shown to be synthesized in the prostate gland, thromboxanes from platelets (thrombocytes) and leukotrienes from leukocytes, hence the derivation of their names. All mammalian cells except erythrocytes synthesize eicosanoids. These molecules are extremely potent, able to cause profound physiological effects at very dilute concentrations. All eicosanoids function locally at the site of synthesis, through receptor-mediated G-protein linked signaling pathways. [HMDB] Thromboxane a2 C20H40O 296.531 296.307915902 (2R,3S)-3-heptyl-2-octyloxane (2R,3S)-3-heptyl-2-octyl-oxane 66719-58-2 CCCCCCCC[C@H]1OCCC[C@@H]1CCCCCCC InChI=1S/C20H40O/c1-3-5-7-9-11-13-17-20-19(16-14-18-21-20)15-12-10-8-6-4-2/h19-20H,3-18H2,1-2H3/t19-,20+/m0/s1 RZWIIPASKMUIAC-VQTJNVASSA-N belongs to the class of organic compounds known as thromboxanes. These are eicosanoids structurally characterized by the presence of a 6-member ether containing ring. Thromboxanes Organic compounds Lipids and lipid-like molecules Fatty Acyls Eicosanoids Aliphatic heteromonocyclic compounds Dialkyl ethers Hydrocarbon derivatives Oxacyclic compounds Oxanes Aliphatic heteromonocyclic compound Dialkyl ether Ether Hydrocarbon derivative Organic oxygen compound Organoheterocyclic compound Organooxygen compound Oxacycle Oxane Thromboxane Solid logp 8.56 ALOGPS logs -7.39 ALOGPS solubility 1.22e-05 g/l ALOGPS logp 7.61 ChemAxon pka_strongest_basic -4.1 ChemAxon iupac (2R,3S)-3-heptyl-2-octyloxane ChemAxon average_mass 296.531 ChemAxon mono_mass 296.307915902 ChemAxon smiles CCCCCCCC[C@H]1OCCC[C@@H]1CCCCCCC ChemAxon formula C20H40O ChemAxon inchi InChI=1S/C20H40O/c1-3-5-7-9-11-13-17-20-19(16-14-18-21-20)15-12-10-8-6-4-2/h19-20H,3-18H2,1-2H3/t19-,20+/m0/s1 ChemAxon inchikey RZWIIPASKMUIAC-VQTJNVASSA-N ChemAxon polar_surface_area 9.23 ChemAxon refractivity 93.78 ChemAxon polarizability 41.15 ChemAxon rotatable_bond_count 13 ChemAxon acceptor_count 1 ChemAxon donor_count 0 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Specdb::CMs 23404 Specdb::CMs 136235 Specdb::CMs 143969 Specdb::MsMs 317908 Specdb::MsMs 317909 Specdb::MsMs 317910 Specdb::MsMs 364516 Specdb::MsMs 364517 Specdb::MsMs 364518 Specdb::MsMs 2427103 Specdb::MsMs 2427104 Specdb::MsMs 2427105 Specdb::MsMs 2511999 Specdb::MsMs 2512000 Specdb::MsMs 2512001 HMDB03208 #<Reference:0x000055ce307c2050> #<Reference:0x000055ce307c1e70> #<Reference:0x000055ce307c1c90> #<Reference:0x000055ce307c1ad8> #<Reference:0x000055ce307c1920> #<Reference:0x000055ce307c1768> #<Reference:0x000055ce307c15b0> #<Reference:0x000055ce307c13f8> #<Reference:0x000055ce307c1240> #<Reference:0x000055ce307c1088> #<Reference:0x000055ce307c0ed0> #<Reference:0x000055ce307c0d18> #<Reference:0x000055ce307c0b10> #<Reference:0x000055ce307c0868> #<Reference:0x000055ce307c06b0> #<Reference:0x000055ce307c04f8> #<Reference:0x000055ce307c0318> #<Reference:0x000055ce307c0110> #<Reference:0x000055ce307bff08> Anatidae Type 1 specific Anatidae 8830 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Mallard duck Type 1 specific Anas platyrhynchos 8839 Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 Wild boar Type 1 specific Sus scrofa 9823