1.02011-09-21 00:26:30 UTC2015-07-21 06:57:35 UTCFDB023220MesnaMesna is a chemoprotectant. Chemoprotectants have been developed as a means of ameliorating the toxicity associated with cytotoxic agents by providing site-specific protection for normal tissues, without compromising antitumour efficacy. Mesna eliminates the risk of therapy-limiting urotoxic side effects of oxazaphosphorines. Mesna is widely used for the prevention of cyclophosphamide-related hemorrhagic cystitis. It has been associated with hypersensitivity-like cutaneous and systemic reactions in adult patients. Mesna offers significant uroprotection in patients receiving high dose cyclophosphamide, and is widely used in paediatric oncology practice It is, therefore, important to recognize that it may be associated with a rare but significant systemic adverse reaction. A hypersensitivity-like reaction to mesna was first reported in a young adult receiving treatment for Hodgkin disease over 20 years ago. Oral administration of mesna can facilitate outpatient ifosfamide therapy. Blood and urinary mesna concentrations are more steady and prolonged after oral delivery compared with after intravenous delivery. (PMID: 16333822, 10193684, 1485175) [HMDB]1-THIOETHANEsulfonate1-THIOETHANEsulfonIC ACID1-THIOETHANEsulphonate1-THIOETHANEsulphonic acid2-Mercaptoethanesulfonate2-Mercaptoethanesulfonic acid2-Mercaptoethanesulphonate2-Mercaptoethanesulphonic acid2-Mercaptoethylsulfonate2-Mercaptoethylsulfonic acid2-Mercaptoethylsulphonate2-Mercaptoethylsulphonic acid2-Sulfanylethylsulfonate2-Sulfanylethylsulfonic acid2-Sulphanylethylsulphonate2-Sulphanylethylsulphonic acidb-Mercaptoethanesulfonateb-Mercaptoethanesulfonic acidb-Mercaptoethanesulphonateb-Mercaptoethanesulphonic acidbeta-Mercaptoethanesulfonatebeta-Mercaptoethanesulfonic acidbeta-Mercaptoethanesulphonatebeta-Mercaptoethanesulphonic acidCoenzima mCoenzym mCoenzyme MCoMHS-CoMReduced coenzyme mReduced comβ-mercaptoethanesulfonateβ-mercaptoethanesulfonic acidβ-mercaptoethanesulphonateβ-mercaptoethanesulphonic acidC2H6O3S2142.197141.9758354382-sulfanylethane-1-sulfonic acidHS-CoM3375-50-6OS(=O)(=O)CCSInChI=1S/C2H6O3S2/c3-7(4,5)2-1-6/h6H,1-2H2,(H,3,4,5)ZNEWHQLOPFWXOF-UHFFFAOYSA-N belongs to the class of organic compounds known as organosulfonic acids. Organosulfonic acids are compounds containing the sulfonic acid group, which has the general structure RS(=O)2OH (R is not a hydrogen atom).Organosulfonic acidsOrganic compoundsOrganic acids and derivativesOrganic sulfonic acids and derivativesOrganosulfonic acids and derivativesAliphatic acyclic compoundsAlkanesulfonic acidsAlkylthiolsHydrocarbon derivativesOrganic oxidesSulfonylsAliphatic acyclic compoundAlkanesulfonic acidAlkylthiolHydrocarbon derivativeOrganic oxideOrganic oxygen compoundOrganosulfonic acidOrganosulfur compoundSulfonylorganosulfonic acidthiolSolidlogp-1.53logs-1.05solubility1.27e+01 g/llogp-0.4pka_strongest_acidic-1.2pka_strongest_basic-9.6iupac2-sulfanylethane-1-sulfonic acidaverage_mass142.197mono_mass141.975835438smilesOS(=O)(=O)CCSformulaC2H6O3S2inchiInChI=1S/C2H6O3S2/c3-7(4,5)2-1-6/h6H,1-2H2,(H,3,4,5)inchikeyZNEWHQLOPFWXOF-UHFFFAOYSA-Npolar_surface_area54.37refractivity29.13polarizability12.54rotatable_bond_count2acceptor_count3donor_count2physiological_charge-1formal_charge0Specdb::MsIr2055Specdb::MsIr2056Specdb::MsIr2057Specdb::NmrOneD28642Specdb::NmrOneD28643Specdb::NmrOneD28644Specdb::NmrOneD28645Specdb::NmrOneD28646Specdb::NmrOneD28647Specdb::NmrOneD28648Specdb::NmrOneD28649Specdb::NmrOneD28650Specdb::NmrOneD28651Specdb::NmrOneD28652Specdb::NmrOneD28653Specdb::NmrOneD28654Specdb::NmrOneD28655Specdb::NmrOneD28656Specdb::NmrOneD28657Specdb::NmrOneD28658Specdb::NmrOneD28659Specdb::NmrOneD28660Specdb::NmrOneD28661Specdb::CMs1327Specdb::CMs6649Specdb::CMs31480Specdb::CMs32280Specdb::CMs32281Specdb::CMs147144Specdb::MsMs248919Specdb::MsMs248920Specdb::MsMs248921Specdb::MsMs268860Specdb::MsMs268861Specdb::MsMs268862Specdb::MsMs439193Specdb::MsMs2438362Specdb::MsMs2438363Specdb::MsMs2438364Specdb::MsMs2523417Specdb::MsMs2523418Specdb::MsMs2523419HMDB0374517905COM#<Reference:0x0000555676253178>#<Reference:0x0000555676252f98>#<Reference:0x0000555676252db8>#<Reference:0x0000555676252b88>AnatidaeType 1specificAnatidae8830BeefaloType 1specificBos taurus X Bison bison297284BisonType 1specificBison bison9901BuffaloType 1specificBubalus bubalis89462Cattle (Beef, Veal)Type 1specificBos taurus9913ChickenType 1specificGallus gallus9031Columbidae (Dove, Pigeon)Type 1specificColumbidae8930DeerType 1specificCervidae9850Domestic goatType 1specificCapra aegagrus hircus9925Domestic pigType 1specificSus scrofa domestica9825ElkType 1specificCervus canadensis1574408EmuType 1specificDromaius novaehollandiae8790European rabbitType 1specificOryctolagus9984Greylag gooseType 1specificAnser anser8843Guinea henType 1specificNumida meleagris8996HorseType 1specificEquus caballus9796Mallard duckType 1specificAnas platyrhynchos8839Mountain hareType 1specificLepus timidus62621Mule deerType 1specificOdocoileus9871OstrichType 1specificStruthio camelus8801PheasantType 1specificPhasianus colchicus9054QuailType 1specificPhasianidae9005RabbitType 1specificLeporidae9979Rock ptarmiganType 1specificLagopus muta64668Sheep (Mutton, Lamb)Type 1specificOvis aries9940SquabType 1specificColumba8931TurkeyType 1specificMeleagris gallopavo9103Velvet duckType 1specificMelanitta fusca371864Wild boarType 1specificSus scrofa9823