1.0 2011-09-21 00:28:12 UTC 2025-11-19 02:43:47 UTC FDB023330 N1-Methyl-2-pyridone-5-carboxamide N-methyl-2-pyridone-5-carboxamide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Increased serum 2PY concentrations are observed in chronic renal failure (CRF) patients, which along with the deterioration of kidney function and its toxic properties (significant inhibition of PARP-1), suggests that 2PY is an uremic toxin. (PMID 12694300) [HMDB] 1-Methyl-5-carboxylamide-2-pyridone N-Methyl-2-pyridone-5-carboxamide N'-Methyl-2-pyridone-5-carboxamide N'methyl-2-pyridone-5-carboxamide N(1)-methyl-2-pyridone-5-carboxamide C7H8N2O2 152.1506 152.05857751 1-methyl-6-oxo-1,6-dihydropyridine-3-carboxamide 1-methyl-6-oxopyridine-3-carboxamide 701-44-0 CN1C=C(C=CC1=O)C(N)=O InChI=1S/C7H8N2O2/c1-9-4-5(7(8)11)2-3-6(9)10/h2-4H,1H3,(H2,8,11) JLQSXXWTCJPCBC-UHFFFAOYSA-N belongs to the class of organic compounds known as nicotinamides. These are heterocyclic aromatic compounds containing a pyridine ring substituted at position 3 by a carboxamide group. Nicotinamides Organic compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids and derivatives Aromatic heteromonocyclic compounds Azacyclic compounds Carboximidic acids Dihydropyridinecarboxylic acids and derivatives Heteroaromatic compounds Hydrocarbon derivatives Lactams Organic oxides Organonitrogen compounds Organooxygen compounds Organopnictogen compounds Pyridinones Aromatic heteromonocyclic compound Azacycle Carboximidic acid Carboximidic acid derivative Dihydropyridine Dihydropyridinecarboxylic acid derivative Heteroaromatic compound Hydrocarbon derivative Hydropyridine Lactam Nicotinamide Organic nitrogen compound Organic oxide Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Pyridinone methylpyridines pyridinecarboxamide pyridone Solid logp -0.96 ALOGPS logs -0.57 ALOGPS solubility 4.14e+01 g/l ALOGPS logp -1.1 ChemAxon pka_strongest_acidic 15.93 ChemAxon pka_strongest_basic 1.36 ChemAxon iupac 1-methyl-6-oxo-1,6-dihydropyridine-3-carboxamide ChemAxon average_mass 152.1506 ChemAxon mono_mass 152.05857751 ChemAxon smiles CN1C=C(C=CC1=O)C(N)=O ChemAxon formula C7H8N2O2 ChemAxon inchi InChI=1S/C7H8N2O2/c1-9-4-5(7(8)11)2-3-6(9)10/h2-4H,1H3,(H2,8,11) ChemAxon inchikey JLQSXXWTCJPCBC-UHFFFAOYSA-N ChemAxon polar_surface_area 63.4 ChemAxon refractivity 40.76 ChemAxon polarizability 14.71 ChemAxon rotatable_bond_count 1 ChemAxon acceptor_count 2 ChemAxon donor_count 1 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Nicotinate and Nicotinamide Metabolism SMP00048 map00760 Specdb::CMs 16654 Specdb::CMs 148498 Specdb::MsIr 2158 Specdb::MsIr 2159 Specdb::MsIr 2160 Specdb::NmrOneD 41822 Specdb::NmrOneD 41823 Specdb::NmrOneD 41824 Specdb::NmrOneD 41825 Specdb::NmrOneD 41826 Specdb::NmrOneD 41827 Specdb::NmrOneD 41828 Specdb::NmrOneD 41829 Specdb::NmrOneD 41830 Specdb::NmrOneD 41831 Specdb::NmrOneD 41832 Specdb::NmrOneD 41833 Specdb::NmrOneD 41834 Specdb::NmrOneD 41835 Specdb::NmrOneD 41836 Specdb::NmrOneD 41837 Specdb::NmrOneD 41838 Specdb::NmrOneD 41839 Specdb::NmrOneD 41840 Specdb::NmrOneD 41841 Specdb::MsMs 27173 Specdb::MsMs 27174 Specdb::MsMs 27175 Specdb::MsMs 33731 Specdb::MsMs 33732 Specdb::MsMs 33733 Specdb::MsMs 2236977 Specdb::MsMs 2238490 Specdb::MsMs 2239076 Specdb::MsMs 2240491 Specdb::MsMs 2241230 Specdb::MsMs 2242579 Specdb::MsMs 2243252 Specdb::MsMs 2344274 Specdb::MsMs 2344275 Specdb::MsMs 2344276 Specdb::MsMs 2590594 Specdb::MsMs 2590595 Specdb::MsMs 2590596 HMDB04193 #<Reference:0x000055ce32d174e0> #<Reference:0x000055ce32d16e28> #<Reference:0x000055ce32d16c70> Anatidae Type 1 specific Anatidae 8830 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Mallard duck Type 1 specific Anas platyrhynchos 8839 Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 Wild boar Type 1 specific Sus scrofa 9823