1.02011-09-21 00:29:00 UTC2015-07-21 06:57:39 UTCFDB0233781D-Myo-inositol 1,4,5,6-tetrakisphosphate1D-Myo-inositol 1,4,5,6-tetrakisphosphate has been shown to regulate Cl- transport, to be a phosphoinositide 3-kinase antagonist, and to bind tightly to some pleckstrin homology domains, and finally, it may contribute to transcriptional regulation. Inositol phosphates comprise a large family of intracellular signals which play many important roles in cell biology. These biological actions can be quite specific to one particular inositol phosphate. 1D-myo-Inositol 1,4,5,6-tetrakisphosphate (Ins(1,4,5,6)P4) is phosphorylated by inositolphosphate-multikinase (IPMK; this enzyme has the capacity to regulate the cellular levels of Ins(1,4,5,6)P4 in mammalian cells. (PMID: 16376887, 10720331, 8809047, 9405634) [HMDB]1D-myo-Inositol 1,4,5,6-tetrakisate1D-myo-Inositol 1,4,5,6-tetrakisic acid1D-myo-Inositol 1,4,5,6-tetrakisphosphic acidD-myo-Inositol 1,4,5,6-tetrakisateD-myo-Inositol 1,4,5,6-tetrakisic acidD-myo-Inositol 1,4,5,6-tetrakisphosphateInositol 1,4,5,6-tetrakisateInositol 1,4,5,6-tetrakisic acidInositol 1,4,5,6-tetrakisphosphateC6H16O18P4500.0755499.928709756{[(1S,2R,3S,4R,5R,6S)-3,4-dihydroxy-2,5,6-tris(phosphonooxy)cyclohexyl]oxy}phosphonic acid[(1S,2R,3S,4R,5R,6S)-3,4-dihydroxy-2,5,6-tris(phosphonooxy)cyclohexyl]oxyphosphonic acid121010-58-0O[C@H]1[C@@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=OInChI=1S/C6H16O18P4/c7-1-2(8)4(22-26(12,13)14)6(24-28(18,19)20)5(23-27(15,16)17)3(1)21-25(9,10)11/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/t1-,2+,3-,4-,5+,6+/m1/s1MRVYFOANPDTYBY-YORTWTKJSA-N belongs to the class of organic compounds known as inositol phosphates. Inositol phosphates are compounds containing a phosphate group attached to an inositol (or cyclohexanehexol) moiety.Inositol phosphatesOrganic compoundsOrganic oxygen compoundsOrganooxygen compoundsAlcohols and polyolsAliphatic homomonocyclic compounds1,2-diolsCyclohexanolsHydrocarbon derivativesMonoalkyl phosphatesOrganic oxides1,2-diolAliphatic homomonocyclic compoundAlkyl phosphateCyclohexanolHydrocarbon derivativeInositol phosphateMonoalkyl phosphateOrganic oxideOrganic phosphoric acid derivativePhosphoric acid esterSecondary alcoholmyo-inositol tetrakisphosphateSolidlogp-0.45logs-1.64solubility1.15e+01 g/llogp-4.3pka_strongest_acidic0.24iupac{[(1S,2R,3S,4R,5R,6S)-3,4-dihydroxy-2,5,6-tris(phosphonooxy)cyclohexyl]oxy}phosphonic acidaverage_mass500.0755mono_mass499.928709756smilesO[C@H]1[C@@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=OformulaC6H16O18P4inchiInChI=1S/C6H16O18P4/c7-1-2(8)4(22-26(12,13)14)6(24-28(18,19)20)5(23-27(15,16)17)3(1)21-25(9,10)11/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/t1-,2+,3-,4-,5+,6+/m1/s1inchikeyMRVYFOANPDTYBY-YORTWTKJSA-Npolar_surface_area307.5refractivity79.27polarizability34.03rotatable_bond_count8acceptor_count14donor_count10physiological_charge-8formal_charge0Inositol MetabolismSMP00011map00562Inositol Phosphate MetabolismSMP00462map00562Specdb::CMs2395Specdb::CMs38765Specdb::CMs166582Specdb::MsMs178065Specdb::MsMs178066Specdb::MsMs178067Specdb::MsMs180378Specdb::MsMs180379Specdb::MsMs180380Specdb::MsMs2696592Specdb::MsMs2696593Specdb::MsMs2696594Specdb::MsMs2982866Specdb::MsMs2982867Specdb::MsMs2982868Specdb::NmrOneD149880Specdb::NmrOneD149881Specdb::NmrOneD149882Specdb::NmrOneD149883Specdb::NmrOneD149884Specdb::NmrOneD149885Specdb::NmrOneD149886Specdb::NmrOneD149887Specdb::NmrOneD149888Specdb::NmrOneD149889Specdb::NmrOneD149890Specdb::NmrOneD149891Specdb::NmrOneD149892Specdb::NmrOneD149893Specdb::NmrOneD149894Specdb::NmrOneD149895Specdb::NmrOneD149896Specdb::NmrOneD149897Specdb::NmrOneD149898Specdb::NmrOneD149899HMDB0452716067#<Reference:0x000055567418f5b8>#<Reference:0x000055567418f400>#<Reference:0x000055567418f248>#<Reference:0x000055567418f090>AnatidaeType 1specificAnatidae8830BeefaloType 1specificBos taurus X Bison bison297284BisonType 1specificBison bison9901BuffaloType 1specificBubalus bubalis89462Cattle (Beef, Veal)Type 1specificBos taurus9913ChickenType 1specificGallus gallus9031Columbidae (Dove, Pigeon)Type 1specificColumbidae8930DeerType 1specificCervidae9850Domestic goatType 1specificCapra aegagrus hircus9925Domestic pigType 1specificSus scrofa domestica9825ElkType 1specificCervus canadensis1574408EmuType 1specificDromaius novaehollandiae8790European rabbitType 1specificOryctolagus9984Greylag gooseType 1specificAnser anser8843Guinea henType 1specificNumida meleagris8996HorseType 1specificEquus caballus9796Mallard duckType 1specificAnas platyrhynchos8839Mountain hareType 1specificLepus timidus62621Mule deerType 1specificOdocoileus9871OstrichType 1specificStruthio camelus8801PheasantType 1specificPhasianus colchicus9054QuailType 1specificPhasianidae9005RabbitType 1specificLeporidae9979Rock ptarmiganType 1specificLagopus muta64668Sheep (Mutton, Lamb)Type 1specificOvis aries9940SquabType 1specificColumba8931TurkeyType 1specificMeleagris gallopavo9103Velvet duckType 1specificMelanitta fusca371864Wild boarType 1specificSus scrofa9823Inositol polyphosphate multikinaseQ8NFU5IPMK