1.0 2011-09-21 00:29:05 UTC 2024-11-29 22:26:49 UTC FDB023383 N-alpha-Acetyl-L-arginine N-alpha-Acetylarginine is one of the guanidino compounds found elevated in the serum of an hemodialyzed renal insufficient (uremic) pediatric population. (PMID 7777105) N-alpha-acetylarginine serum levels (and other guanidino compounds) were elevated of all the hyperargininemic patients are higher than the normal range. Untreated hyperargininemic patients have the highest guanidino compound levels in cerebrospinal fluid. (PMID 1690873) N-alpha-acetylarginine increases in urine hyperargininemic patients. During a low-arginine diet, together with sodium benzoate therapy, there was a marked decrease in plasma N-alpha-acetylarginine. (PMID 3987036) [HMDB]. N-alpha-Acetyl-L-arginine is found in loquat and apple. N-a-Acetyl-L-arginine N-Ac-L-arg-OH N-Acetyl-L-arginine N-alpha-Acetyl-L-arginine N-alpha-L-Acetyl-arginine N(2)-Acetyl-L-arginine N2-Acetyl-L-arginine C8H16N4O3 216.2376 216.122240398 (2S)-5-carbamimidamido-2-acetamidopentanoic acid N~2~-acetyl-L-arginine 155-84-0 CC(=O)N[C@@H](CCCNC(N)=N)C(O)=O InChI=1S/C8H16N4O3/c1-5(13)12-6(7(14)15)3-2-4-11-8(9)10/h6H,2-4H2,1H3,(H,12,13)(H,14,15)(H4,9,10,11)/t6-/m0/s1 SNEIUMQYRCDYCH-LURJTMIESA-N belongs to the class of organic compounds known as n-acyl-l-alpha-amino acids. These are n-acylated alpha amino acids which have the L-configuration of the alpha-carbon atom. N-acyl-L-alpha-amino acids Organic compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Aliphatic acyclic compounds Acetamides Carbonyl compounds Carboximidamides Carboxylic acids Fatty acids and conjugates Guanidines Hydrocarbon derivatives Monocarboxylic acids and derivatives Organic oxides Organopnictogen compounds Propargyl-type 1,3-dipolar organic compounds Secondary carboxylic acid amides Acetamide Aliphatic acyclic compound Carbonyl group Carboxamide group Carboximidamide Carboxylic acid Fatty acid Guanidine Hydrocarbon derivative Monocarboxylic acid or derivatives N-acyl-l-alpha-amino acid Organic 1,3-dipolar compound Organic nitrogen compound Organic oxide Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Propargyl-type 1,3-dipolar organic compound Secondary carboxylic acid amide N-acetyl-L-amino acid Solid logp -1.73 ALOGPS logs -2.45 ALOGPS solubility 7.67e-01 g/l ALOGPS logp -3.3 ChemAxon pka_strongest_acidic 3.68 ChemAxon pka_strongest_basic 12.24 ChemAxon iupac (2S)-5-carbamimidamido-2-acetamidopentanoic acid ChemAxon average_mass 216.2376 ChemAxon mono_mass 216.122240398 ChemAxon smiles CC(=O)N[C@@H](CCCNC(N)=N)C(O)=O ChemAxon formula C8H16N4O3 ChemAxon inchi InChI=1S/C8H16N4O3/c1-5(13)12-6(7(14)15)3-2-4-11-8(9)10/h6H,2-4H2,1H3,(H,12,13)(H,14,15)(H4,9,10,11)/t6-/m0/s1 ChemAxon inchikey SNEIUMQYRCDYCH-LURJTMIESA-N ChemAxon polar_surface_area 128.3 ChemAxon refractivity 63.37 ChemAxon polarizability 22.04 ChemAxon rotatable_bond_count 6 ChemAxon acceptor_count 6 ChemAxon donor_count 5 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Metabolism and Physiological Effects of N-alpha-Acetyl-L-arginine SMP0125530 Specdb::CMs 22571 Specdb::CMs 38770 Specdb::CMs 150679 Specdb::MsMs 63897 Specdb::MsMs 63898 Specdb::MsMs 63899 Specdb::MsMs 120930 Specdb::MsMs 120931 Specdb::MsMs 120932 Specdb::MsMs 2240402 Specdb::MsMs 2241322 Specdb::MsMs 2242419 Specdb::MsMs 2243417 Specdb::MsMs 2375117 Specdb::MsMs 2375118 Specdb::MsMs 2375119 Specdb::MsMs 2560977 Specdb::MsMs 2560978 Specdb::MsMs 2560979 Specdb::NmrOneD 48382 Specdb::NmrOneD 48383 Specdb::NmrOneD 48384 Specdb::NmrOneD 48385 Specdb::NmrOneD 48386 Specdb::NmrOneD 48387 Specdb::NmrOneD 48388 Specdb::NmrOneD 48389 Specdb::NmrOneD 48390 Specdb::NmrOneD 48391 Specdb::NmrOneD 48392 Specdb::NmrOneD 48393 Specdb::NmrOneD 48394 Specdb::NmrOneD 48395 Specdb::NmrOneD 48396 Specdb::NmrOneD 48397 Specdb::NmrOneD 48398 Specdb::NmrOneD 48399 Specdb::NmrOneD 48400 Specdb::NmrOneD 48401 HMDB04620 AAG #<Reference:0x000055ce3252eb70> #<Reference:0x000055ce3252e9b8> #<Reference:0x000055ce3252e800> #<Reference:0x000055ce3252e648> Anatidae Type 1 specific Anatidae 8830 Apple Type 1 specific Malus pumila 283210 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Loquat Type 1 specific Eriobotrya japonica 32224 Mallard duck Type 1 specific Anas platyrhynchos 8839 Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 Wild boar Type 1 specific Sus scrofa 9823