1.02011-09-21 00:29:15 UTC2015-07-21 06:57:41 UTCFDB0233928-Isoprostane8-isoprostane concentrations are elevated in asthma and increase with the clinical severity and during acute asthma episodes. Isoprostane is formed in the airways of asthmatic patients from peroxidation of poly-unsaturated fatty acids in cell membranes, the effect of reactive oxygen species resulting of the NADPH oxidase of eosinophils, neutrophils and alveolar macrophages, which produces superoxide anion which undergoes dismutation to H2O2. (PMID 16354413)
8-isoprostane is also elevated in Bronchopulmonary dysplasia, which remains an important cause of morbidity and mortality in extremely premature newborn infants receiving intensive care and is the most common contributing factor to severe respiratory morbidity and mortality in early childhood. (PMID 14980283)
8-Isoprostaglandin F(2a) is a marker of oxidative stress in the aqueous humour of patients with exfoliation syndrome (XFS) (PubMed ID 12598453) [HMDB](1R,2S)-1-Heptyl-2-octylcyclopentane(8b)-Prostane(8beta)-Prostane(8β)-prostane8-beta-prostane8-IsoprostaneC20H40280.5316280.31300128(1R,2S)-1-heptyl-2-octylcyclopentane8β-prostane155976-51-5[H][C@@]1(CCCCCCC)CCC[C@]1([H])CCCCCCCCInChI=1S/C20H40/c1-3-5-7-9-11-13-16-20-18-14-17-19(20)15-12-10-8-6-4-2/h19-20H,3-18H2,1-2H3/t19-,20+/m1/s1UKVVPDHLUHAJNZ-UXHICEINSA-N belongs to the class of organic compounds known as cycloalkanes. These are saturated monocyclic hydrocarbons (with or without side chains).CycloalkanesOrganic compoundsHydrocarbonsSaturated hydrocarbonsCycloalkanesAliphatic homomonocyclic compoundsAliphatic homomonocyclic compoundCycloalkane1-heptyl-2-octylcyclopentaneSolidlogp9.29logs-7.56solubility7.76e-06 g/llogp8.58iupac(1R,2S)-1-heptyl-2-octylcyclopentaneaverage_mass280.5316mono_mass280.31300128smiles[H][C@@]1(CCCCCCC)CCC[C@]1([H])CCCCCCCCformulaC20H40inchiInChI=1S/C20H40/c1-3-5-7-9-11-13-16-20-18-14-17-19(20)15-12-10-8-6-4-2/h19-20H,3-18H2,1-2H3/t19-,20+/m1/s1inchikeyUKVVPDHLUHAJNZ-UXHICEINSA-Npolar_surface_area0refractivity91.92polarizability40.05rotatable_bond_count13acceptor_count0donor_count0physiological_charge0formal_charge0Arachidonic Acid MetabolismSMP00075map00590Specdb::CMs21612Specdb::CMs135175Specdb::CMs142909Specdb::MsMs69711Specdb::MsMs69712Specdb::MsMs69713Specdb::MsMs128043Specdb::MsMs128044Specdb::MsMs128045Specdb::MsMs2421492Specdb::MsMs2421493Specdb::MsMs2421494Specdb::MsMs2544892Specdb::MsMs2544893Specdb::MsMs2544894HMDB04659#<Reference:0x000055567614aa10>#<Reference:0x000055567614a6c8>#<Reference:0x000055567614a3f8>#<Reference:0x000055567614a150>#<Reference:0x0000555676149e08>#<Reference:0x0000555676149b88>#<Reference:0x0000555676149908>#<Reference:0x0000555676149700>#<Reference:0x00005556761494d0>#<Reference:0x0000555676149318>#<Reference:0x0000555676149048>#<Reference:0x0000555676148d50>#<Reference:0x0000555676148a58>#<Reference:0x0000555676148800>#<Reference:0x0000555676148620>#<Reference:0x0000555676148418>#<Reference:0x0000555676148008>#<Reference:0x0000555676147ae0>#<Reference:0x0000555676147630>#<Reference:0x0000555676146f00>#<Reference:0x00005556761466e0>AnatidaeType 1specificAnatidae8830BeefaloType 1specificBos taurus X Bison bison297284BisonType 1specificBison bison9901BuffaloType 1specificBubalus bubalis89462Cattle (Beef, Veal)Type 1specificBos taurus9913ChickenType 1specificGallus gallus9031Columbidae (Dove, Pigeon)Type 1specificColumbidae8930DeerType 1specificCervidae9850Domestic goatType 1specificCapra aegagrus hircus9925Domestic pigType 1specificSus scrofa domestica9825ElkType 1specificCervus canadensis1574408EmuType 1specificDromaius novaehollandiae8790European rabbitType 1specificOryctolagus9984Greylag gooseType 1specificAnser anser8843Guinea henType 1specificNumida meleagris8996HorseType 1specificEquus caballus9796Mallard duckType 1specificAnas platyrhynchos8839Mountain hareType 1specificLepus timidus62621Mule deerType 1specificOdocoileus9871OstrichType 1specificStruthio camelus8801PheasantType 1specificPhasianus colchicus9054QuailType 1specificPhasianidae9005RabbitType 1specificLeporidae9979Rock ptarmiganType 1specificLagopus muta64668Sheep (Mutton, Lamb)Type 1specificOvis aries9940SquabType 1specificColumba8931TurkeyType 1specificMeleagris gallopavo9103Velvet duckType 1specificMelanitta fusca371864Wild boarType 1specificSus scrofa9823