1.02011-09-21 00:31:50 UTC2015-10-09 22:33:02 UTCFDB023575GuaifenesinGuaifenesin (INN) or guaiphenesin (former BAN) is an expectorant drug usually taken orally to assist the expectoration ('bringing up') of phlegm from the airways in acute respiratory tract infections. It is a common ingredient in many over-the-counter cough/cold medications. Guaifenesin is also used in the experimental guaifenesin protocol in the treatment of fibromyalgia. It was first approved by the Food and Drug Administration (FDA) in 1952. Guaifenesin works by drawing water into the bronchi. The water both thins mucus and lubricates the airway, facilitating the removal of mucus by coughing. [HMDB]3-(2-Methoxyphenoxy)-1,2-propanediol3-(o-Methoxyphenoxy)-1,2-propanediol3-(o-Methoxyphenoxy)-propanediol-1,23-o-Methoxyphenoxypropane 1:2-diola-Glyceryl guaiacol ethera-Glyceryl guaiacolate etherActifed CAeronesinalpha-Glyceryl guaiacol etheralpha-Glyceryl guaiacolate etherAmonidrenAmonidrinAresolBenylin-EBroncholglycerin etherGlycerin guaiacolateGlycero-guaiacol etherGlycerol a-(2-methoxyphenyl) etherGlycerol a-(o-methoxyphenyl)etherGlycerol a-guaiacyl etherGlycerol a-guiacyl etherGlycerol a-monoguaiacol etherGlycerol guaiacolateGlycerol mono(2-methoxyphenyl) etherGlycerol-a-guajakoletherGlycerol-alpha-guajakoletherGlyceryl guaiacolGlyceryl guaiacol etherGlyceryl guaiacolateGlyceryl guaiacolate etherGlyceryl guaiacyl etherGlyceryl guaicolateGlyceryl guiacolateGlycerylguaiacolGuaiacol glycerol etherGuaiacol glyceryl etherGuaiacolglicerinetereGuaiacuranGuaiacuraneGuaiacyl glyceryl etherGuaiamarGuaianesinGuaicol glycerine etherGuaicol glyceryl etherGuaifenesinGuaifenesineGuaiphenesinGuaiphenesineGuaiphesinHustosilMethoxypropanediolMethphenoxydiolMetossipropandioloo-Methoxyphenyl glyceryl etherOrganidin NRPneumomistPropanosedylRedutonRobitussinC10H14O4198.2158198.0892089363-(2-methoxyphenoxy)propane-1,2-diolguaifenesin93-14-1COC1=CC=CC=C1OCC(O)COInChI=1S/C10H14O4/c1-13-9-4-2-3-5-10(9)14-7-8(12)6-11/h2-5,8,11-12H,6-7H2,1H3HSRJKNPTNIJEKV-UHFFFAOYSA-N belongs to the class of organic compounds known as anisoles. These are organic compounds containing a methoxybenzene or a derivative thereof.AnisolesOrganic compoundsBenzenoidsPhenol ethersAnisolesAromatic homomonocyclic compounds1,2-diolsAlkyl aryl ethersHydrocarbon derivativesMethoxybenzenesPhenoxy compoundsPrimary alcoholsSecondary alcohols1,2-diolAlcoholAlkyl aryl etherAnisoleAromatic homomonocyclic compoundEtherHydrocarbon derivativeMethoxybenzeneMonocyclic benzene moietyOrganic oxygen compoundOrganooxygen compoundPhenoxy compoundPrimary alcoholSecondary alcoholSolidlogp0.76logs-1.12solubility1.49e+01 g/llogp0.34pka_strongest_acidic13.62pka_strongest_basic-3iupac3-(2-methoxyphenoxy)propane-1,2-diolaverage_mass198.2158mono_mass198.089208936smilesCOC1=CC=CC=C1OCC(O)COformulaC10H14O4inchiInChI=1S/C10H14O4/c1-13-9-4-2-3-5-10(9)14-7-8(12)6-11/h2-5,8,11-12H,6-7H2,1H3inchikeyHSRJKNPTNIJEKV-UHFFFAOYSA-Npolar_surface_area58.92refractivity51.24polarizability20.59rotatable_bond_count5acceptor_count4donor_count2physiological_charge0formal_charge0Specdb::EiMs379Specdb::MsIr2276Specdb::MsIr2277Specdb::MsIr2278Specdb::NmrTwoD1948Specdb::CMs22869Specdb::CMs38831Specdb::CMs121187Specdb::CMs146327Specdb::CMs829061Specdb::CMs829062Specdb::CMs829063Specdb::CMs829064Specdb::CMs829065Specdb::NmrOneD2013Specdb::NmrOneD2705Specdb::NmrOneD3396Specdb::NmrOneD54882Specdb::NmrOneD54883Specdb::NmrOneD54884Specdb::NmrOneD54885Specdb::NmrOneD54886Specdb::NmrOneD54887Specdb::NmrOneD54888Specdb::NmrOneD54889Specdb::NmrOneD54890Specdb::NmrOneD54891Specdb::NmrOneD54892Specdb::NmrOneD54893Specdb::NmrOneD54894Specdb::NmrOneD54895Specdb::NmrOneD54896Specdb::NmrOneD54897Specdb::NmrOneD54898Specdb::NmrOneD54899Specdb::NmrOneD54900Specdb::NmrOneD54901Specdb::MsMs374268Specdb::MsMs450731Specdb::MsMs171276Specdb::MsMs171277Specdb::MsMs171278Specdb::MsMs2512035Specdb::MsMs2512036Specdb::MsMs2512037Specdb::MsMs104907Specdb::MsMs104908Specdb::MsMs104909Specdb::MsMs2427106Specdb::MsMs2427107Specdb::MsMs2427108HMDB04998#<Reference:0x00005556741481b8>bitter