1.0 2011-09-21 00:31:57 UTC 2015-07-21 06:57:46 UTC FDB023583 Sertraline A selective serotonin uptake inhibitor that is used in the treatment of depression.; Sertraline hydrochloride (also labeled under numerous brand names: Zoloft, Sertralin, Lustral, Apo-Sertral, Asentra, Gladem, Serlift, Stimuloton, Xydep, Serlain, Concorz) is an orally administered antidepressant of the selective serotonin reuptake inhibitor (SSRI) type. It was first approved by the Food and Drug Administration (FDA) in 1991.; Sertraline is an odorless, white, sparingly soluble crystalline solid. The minimum effective dose is usually 50 mg per day (it can be still effective at 25 mg or 37.5 mg), but lower doses may be used in the initial weeks of treatment to acclimate the patient's body, especially the liver, to the drug and to minimize the severity of any side effects. Patients who do not experience relief of symptoms at 50 mg a day may have their dose increased, up to 200 mg a day.; Sertraline (HCl) is used medically mainly to treat the symptoms of depression and anxiety. It is also prescribed for the treatment of obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder (PD) and social phobia/social anxiety disorder.; A study has shown that sertraline is an effective treatment for impulsive aggressive behavior in personality disordered patients. [HMDB] (+)-Sertraline (1S-cis)-1,2,3,4-Tetrahydro-4-(3,4-dichlorophenyl)-N-methyl-1-naphthalenamine (1S,4S)-Sertraline cis-(+)-Sertraline CP 51974 Sertralina Sertraline hydrochloride Sertralinum Zoloft C17H17Cl2N 306.23 305.073804963 (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine sertraline 79617-96-2 CN[C@H]1CC[C@@H](C2=CC(Cl)=C(Cl)C=C2)C2=CC=CC=C12 InChI=1S/C17H17Cl2N/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11/h2-6,8,10,12,17,20H,7,9H2,1H3/t12-,17-/m0/s1 VGKDLMBJGBXTGI-SJCJKPOMSA-N belongs to the class of organic compounds known as tametralines. Tametralines are compounds containing a tametraline moiety, which consists of a tetrahydronaphthalene linked to a phenyl group to form N-methyl-4-phenyl-1,2,3,4-tetrahydronaphthalen-1-amine skeleton. Tametralines Organic compounds Benzenoids Tetralins Tametralines Aromatic homopolycyclic compounds Aralkylamines Aryl chlorides Dialkylamines Dichlorobenzenes Hydrocarbon derivatives Organochlorides Organopnictogen compounds 1,2-dichlorobenzene Amine Aralkylamine Aromatic homopolycyclic compound Aryl chloride Aryl halide Chlorobenzene Halobenzene Hydrocarbon derivative Monocyclic benzene moiety Organic nitrogen compound Organochloride Organohalogen compound Organonitrogen compound Organopnictogen compound Secondary aliphatic amine Secondary amine Tametraline dichlorobenzene secondary amino compound tetralins Solid logp 5.06 ALOGPS logs -6.32 ALOGPS solubility 1.45e-04 g/l ALOGPS logp 5.15 ChemAxon pka_strongest_basic 9.85 ChemAxon iupac (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine ChemAxon average_mass 306.23 ChemAxon mono_mass 305.073804963 ChemAxon smiles CN[C@H]1CC[C@@H](C2=CC(Cl)=C(Cl)C=C2)C2=CC=CC=C12 ChemAxon formula C17H17Cl2N ChemAxon inchi InChI=1S/C17H17Cl2N/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11/h2-6,8,10,12,17,20H,7,9H2,1H3/t12-,17-/m0/s1 ChemAxon inchikey VGKDLMBJGBXTGI-SJCJKPOMSA-N ChemAxon polar_surface_area 12.03 ChemAxon refractivity 85.74 ChemAxon polarizability 32.44 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 1 ChemAxon donor_count 1 ChemAxon physiological_charge 1 ChemAxon formal_charge 0 ChemAxon Specdb::CMs 20845 Specdb::CMs 150331 Specdb::EiMs 684 Specdb::MsMs 71244 Specdb::MsMs 71245 Specdb::MsMs 71246 Specdb::MsMs 129879 Specdb::MsMs 129880 Specdb::MsMs 129881 Specdb::MsMs 441039 Specdb::MsMs 441040 Specdb::MsMs 441041 Specdb::MsMs 441042 Specdb::MsMs 450563 Specdb::MsMs 450564 Specdb::MsMs 450985 Specdb::MsMs 451376 Specdb::MsMs 452414 Specdb::MsMs 2230786 Specdb::MsMs 2233339 Specdb::MsMs 2236601 Specdb::MsMs 2236757 Specdb::MsMs 2238703 Specdb::MsMs 2238892 Specdb::MsMs 2240801 Specdb::MsMs 2240880 Specdb::MsMs 2242919 Specdb::MsMs 2242942 HMDB05010 SRE #<Reference:0x000055ce32125510> #<Reference:0x000055ce32125358> #<Reference:0x000055ce32125178> #<Reference:0x000055ce32124f98> #<Reference:0x000055ce32124de0> #<Reference:0x000055ce32124c28> #<Reference:0x000055ce32124a70> #<Reference:0x000055ce321248b8> #<Reference:0x000055ce32124700> #<Reference:0x000055ce32124548> 5-hydroxytryptamine receptor 1A P08908 HTR1A