1.02011-09-21 00:32:16 UTC2015-10-09 22:33:06 UTCFDB023602OndansetronOndansetron is a well tolerated drug with few side effects. Headache, constipation, and dizziness are the most commonly reported side effects associated with its use. There have been no significant drug interactions reported with this drugs use. It is broken down by the hepatic cytochrome P450 system and it has little effect on the metabolism of other drugs broken down by this system; Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly to treat nausea and vomiting following chemotherapy. Its effects are thought to be on both peripheral and central nerves. One part is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata, the other is a blockage of serotonin receptors in the chemoreceptor trigger zone. It does not have much effect on vomiting due to motion sickness. This drug does not have any effect on dopamine receptors or muscarinic receptors; A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties; Ondansetron (INN) is a serotonin 5-HT3 receptor antagonist used mainly to treat nausea and vomiting following chemotherapy. Its effects are thought to be on both peripheral and central nerves. One part is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata, the other is a blockage of serotonin receptors in the chemoreceptor trigger zone. It does not have much effect on vomiting due to motion sickness. This drug does not have any effect on dopamine receptors or muscarinic receptors. [HMDB]OndansetronZofranZofran odtZophrenZudanC18H19N3O293.363293.1528122459-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-2,3,4,9-tetrahydro-1H-carbazol-4-oneondansetron99614-02-5CN1C2=C(C3=CC=CC=C13)C(=O)C(CN1C=CN=C1C)CC2InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3FELGMEQIXOGIFQ-UHFFFAOYSA-N belongs to the class of organic compounds known as carbazoles. Carbazoles are compounds containing a three ring system containing a pyrrole ring fused on either side to a benzene ring.CarbazolesOrganic compoundsOrganoheterocyclic compoundsIndoles and derivativesCarbazolesAromatic heteropolycyclic compoundsAryl alkyl ketonesAzacyclic compoundsBenzenoidsHeteroaromatic compoundsHydrocarbon derivativesIndolesN-alkylindolesN-methylpyrrolesN-substituted imidazolesOrganic oxidesOrganonitrogen compoundsOrganopnictogen compoundsVinylogous amidesAromatic heteropolycyclic compoundAryl alkyl ketoneAryl ketoneAzacycleAzoleBenzenoidCarbazoleHeteroaromatic compoundHydrocarbon derivativeImidazoleIndoleKetoneN-alkylindoleN-methylpyrroleN-substituted imidazoleOrganic nitrogen compoundOrganic oxideOrganic oxygen compoundOrganonitrogen compoundOrganooxygen compoundOrganopnictogen compoundPyrroleSubstituted pyrroleVinylogous amidecarbazolesSolidlogp2.56logs-3.07solubility2.48e-01 g/llogp2.35pka_strongest_acidic15.39pka_strongest_basic7.34iupac9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-2,3,4,9-tetrahydro-1H-carbazol-4-oneaverage_mass293.363mono_mass293.152812245smilesCN1C2=C(C3=CC=CC=C13)C(=O)C(CN1C=CN=C1C)CC2formulaC18H19N3OinchiInChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3inchikeyFELGMEQIXOGIFQ-UHFFFAOYSA-Npolar_surface_area39.82refractivity86.78polarizability33.16rotatable_bond_count2acceptor_count2donor_count0physiological_charge1formal_charge0Specdb::CMs23367Specdb::CMs147166Specdb::NmrOneD2021Specdb::NmrTwoD1956Specdb::MsMs89406Specdb::MsMs89407Specdb::MsMs89408Specdb::MsMs152334Specdb::MsMs152335Specdb::MsMs152336Specdb::MsMs451031Specdb::MsMs452363Specdb::MsMs2228064Specdb::MsMs2229005Specdb::MsMs2230456Specdb::MsMs2231438Specdb::MsMs2232745Specdb::MsMs2233870Specdb::MsMs2235087Specdb::MsMs2237306Specdb::MsMs2316419Specdb::MsMs2316420Specdb::MsMs2316421Specdb::MsMs2621783Specdb::MsMs2621784Specdb::MsMs2621785HMDB05035#<Reference:0x0000555675ea3ed8>#<Reference:0x0000555675ea3d20>5-hydroxytryptamine receptor 3AP46098HTR3A5-hydroxytryptamine receptor 6P50406HTR6