1.0 2011-09-21 00:35:19 UTC 2015-07-21 06:57:53 UTC FDB023821 O-Phosphotyrosine O-Phosphotyrosine is a phosphorylated amino acid that occurs in a number of proteins. Tyrosine phosphorylation and dephosphorylation plays a role in cellular signal transduction and possibly in cell growth control and carcinogenesis. Small amounts of free phosphotyrosine can be found in urine (PMID: 7693088). Levels of this amino acid appear to be elevated in mammalian urine during liver regeneration (PMID: 7516161). Phosphotyrosine is also able to induce platelet aggregation in vitro and it has been suggested that free phosphotyrosine in blood could be meaningful for in vivo platelet activation (PMID: 1282059). [HMDB] L-3-(4-Hydroxyphenyl)alanine 4'-ate L-3-(4-Hydroxyphenyl)alanine 4'-phosphate L-Otyrosine L-Phosphotyrosine L-Tyrosine-O-ate L-Tyrosine-O-phosphate O-L-Tyrosine O-O-L-Tyrosine O-ONO-L-Tyrosine O-Otyrosine O-Phospho-L-tyrosine O-Phosphotyrosine Onotyrosine Otyrosine Otyrosine (py) Phospho-L-tyrosine Phosphonotyrosine Phosphotyrosine Phosphotyrosine (pY) Tyrosine ate Tyrosine ic acid Tyrosine O-ate Tyrosine O-phosphate C9H12NO6P 261.1684 261.040223633 (2S)-2-amino-3-[4-(phosphonooxy)phenyl]propanoic acid phosphonotyrosine 21820-51-9 N[C@@H](CC1=CC=C(OP(O)(O)=O)C=C1)C(O)=O InChI=1S/C9H12NO6P/c10-8(9(11)12)5-6-1-3-7(4-2-6)16-17(13,14)15/h1-4,8H,5,10H2,(H,11,12)(H2,13,14,15)/t8-/m0/s1 DCWXELXMIBXGTH-QMMMGPOBSA-N belongs to the class of organic compounds known as phenylalanine and derivatives. Phenylalanine and derivatives are compounds containing phenylalanine or a derivative thereof resulting from reaction of phenylalanine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. Phenylalanine and derivatives Organic compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Aromatic homomonocyclic compounds Amino acids Amphetamines and derivatives Aralkylamines Carbonyl compounds Carboxylic acids Hydrocarbon derivatives L-alpha-amino acids Monoalkylamines Monocarboxylic acids and derivatives Organic oxides Organopnictogen compounds Phenoxy compounds Phenyl phosphates Phenylpropanoic acids 3-phenylpropanoic-acid Alpha-amino acid Amine Amino acid Amphetamine or derivatives Aralkylamine Aromatic homomonocyclic compound Aryl phosphate Aryl phosphomonoester Benzenoid Carbonyl group Carboxylic acid Hydrocarbon derivative L-alpha-amino acid Monocarboxylic acid or derivatives Monocyclic benzene moiety Organic nitrogen compound Organic oxide Organic oxygen compound Organic phosphoric acid derivative Organonitrogen compound Organooxygen compound Organopnictogen compound Phenoxy compound Phenyl phosphate Phenylalanine or derivatives Phosphoric acid ester Primary aliphatic amine Primary amine L-tyrosine derivative O(4)-phosphotyrosine non-proteinogenic L-alpha-amino acid Solid logp -0.76 ALOGPS logs -2.13 ALOGPS solubility 1.93e+00 g/l ALOGPS logp -1.5 ChemAxon pka_strongest_acidic 1.38 ChemAxon pka_strongest_basic 9.46 ChemAxon iupac (2S)-2-amino-3-[4-(phosphonooxy)phenyl]propanoic acid ChemAxon average_mass 261.1684 ChemAxon mono_mass 261.040223633 ChemAxon smiles N[C@@H](CC1=CC=C(OP(O)(O)=O)C=C1)C(O)=O ChemAxon formula C9H12NO6P ChemAxon inchi InChI=1S/C9H12NO6P/c10-8(9(11)12)5-6-1-3-7(4-2-6)16-17(13,14)15/h1-4,8H,5,10H2,(H,11,12)(H2,13,14,15)/t8-/m0/s1 ChemAxon inchikey DCWXELXMIBXGTH-QMMMGPOBSA-N ChemAxon polar_surface_area 130.08 ChemAxon refractivity 57.97 ChemAxon polarizability 22.7 ChemAxon rotatable_bond_count 5 ChemAxon acceptor_count 6 ChemAxon donor_count 4 ChemAxon physiological_charge -2 ChemAxon formal_charge 0 ChemAxon Specdb::CMs 19420 Specdb::CMs 38949 Specdb::CMs 131361 Specdb::CMs 139095 Specdb::MsMs 23204 Specdb::MsMs 23205 Specdb::MsMs 23206 Specdb::MsMs 30002 Specdb::MsMs 30003 Specdb::MsMs 30004 Specdb::MsMs 2351341 Specdb::MsMs 2351342 Specdb::MsMs 2351343 Specdb::MsMs 2583956 Specdb::MsMs 2583957 Specdb::MsMs 2583958 Specdb::NmrOneD 61612 Specdb::NmrOneD 61613 Specdb::NmrOneD 61614 Specdb::NmrOneD 61615 Specdb::NmrOneD 61616 Specdb::NmrOneD 61617 Specdb::NmrOneD 61618 Specdb::NmrOneD 61619 Specdb::NmrOneD 61620 Specdb::NmrOneD 61621 Specdb::NmrOneD 61622 Specdb::NmrOneD 61623 Specdb::NmrOneD 61624 Specdb::NmrOneD 61625 Specdb::NmrOneD 61626 Specdb::NmrOneD 61627 Specdb::NmrOneD 61628 Specdb::NmrOneD 61629 Specdb::NmrOneD 61630 Specdb::NmrOneD 61631 HMDB06049 PTR #<Reference:0x000055ce307c0e80> #<Reference:0x000055ce307c0c28> #<Reference:0x000055ce307c0a70> Anatidae Type 1 specific Anatidae 8830 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Mallard duck Type 1 specific Anas platyrhynchos 8839 Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 Wild boar Type 1 specific Sus scrofa 9823