1.02011-09-21 00:35:20 UTC2019-11-26 03:21:10 UTCFDB023822o-Tyrosineo-Tyrosine is a normal human metabolite. Its presence is possible due to the hydroxylation of l-phenylalanine by hydroxyl radical (*OH), and is proposed as an hydroxy radical biomarker of oxidative damage to proteins. o-Tyrosine might also be included in the diet and absorbed. It has been associated with disease such as Kwashiorkor, a severe form of protein-energy malnutrition. However, many publications mention that the results are inconclusive, and o-tyrosine is not selectively altered by antioxidant intervention, exercise training or age. (PMID: 14670743, 10969271, 9887186) [HMDB]2-hydroxy-DL-Phenylalanine2-hydroxy-Phenylalanine2-Hydroxyphenylalanine2-Tyrosine3-(o-hydroxyphenyl)DL-AlanineDL- O-tyrosineDL-3-(o-Hydroxyphenyl)alanineDL-o-tyrosineOrtho-tyrosineC9H11NO3181.1885181.0738932232-amino-3-(2-hydroxyphenyl)propanoic acid2-tyrosine2370-61-8NC(CC1=CC=CC=C1O)C(O)=OInChI=1S/C9H11NO3/c10-7(9(12)13)5-6-3-1-2-4-8(6)11/h1-4,7,11H,5,10H2,(H,12,13)WRFPVMFCRNYQNR-UHFFFAOYSA-N belongs to the class of organic compounds known as phenylalanine and derivatives. Phenylalanine and derivatives are compounds containing phenylalanine or a derivative thereof resulting from reaction of phenylalanine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.Phenylalanine and derivativesOrganic compoundsOrganic acids and derivativesCarboxylic acids and derivativesAmino acids, peptides, and analoguesAromatic homomonocyclic compounds1-hydroxy-2-unsubstituted benzenoids1-hydroxy-4-unsubstituted benzenoidsAlpha amino acidsAmino acidsAmphetamines and derivativesAralkylaminesCarbonyl compoundsCarboxylic acidsHydrocarbon derivativesMonoalkylaminesMonocarboxylic acids and derivativesOrganic oxidesOrganopnictogen compoundsPhenylpropanoic acids1-hydroxy-2-unsubstituted benzenoid1-hydroxy-4-unsubstituted benzenoid3-phenylpropanoic-acidAlpha-amino acidAmineAmino acidAmphetamine or derivativesAralkylamineAromatic homomonocyclic compoundBenzenoidCarbonyl groupCarboxylic acidHydrocarbon derivativeMonocarboxylic acid or derivativesMonocyclic benzene moietyOrganic nitrogen compoundOrganic oxideOrganic oxygen compoundOrganonitrogen compoundOrganooxygen compoundOrganopnictogen compoundPhenolPhenylalanine or derivativesPrimary aliphatic aminePrimary aminean amino acid derivativeSolidlogp-2.34logs-1.51solubility5.57e+00 g/llogp-1.5pka_strongest_acidic2.01pka_strongest_basic8.88iupac2-amino-3-(2-hydroxyphenyl)propanoic acidaverage_mass181.1885mono_mass181.073893223smilesNC(CC1=CC=CC=C1O)C(O)=OformulaC9H11NO3inchiInChI=1S/C9H11NO3/c10-7(9(12)13)5-6-3-1-2-4-8(6)11/h1-4,7,11H,5,10H2,(H,12,13)inchikeyWRFPVMFCRNYQNR-UHFFFAOYSA-Npolar_surface_area83.55refractivity47.1polarizability17.76rotatable_bond_count3acceptor_count4donor_count3physiological_charge0formal_charge0Specdb::NmrTwoD1969Specdb::MsIr2359Specdb::MsIr2360Specdb::MsIr2361Specdb::NmrOneD2035Specdb::NmrOneD61632Specdb::NmrOneD61633Specdb::NmrOneD61634Specdb::NmrOneD61635Specdb::NmrOneD61636Specdb::NmrOneD61637Specdb::NmrOneD61638Specdb::NmrOneD61639Specdb::NmrOneD61640Specdb::NmrOneD61641Specdb::NmrOneD61642Specdb::NmrOneD61643Specdb::NmrOneD61644Specdb::NmrOneD61645Specdb::NmrOneD61646Specdb::NmrOneD61647Specdb::NmrOneD61648Specdb::NmrOneD61649Specdb::NmrOneD61650Specdb::NmrOneD61651Specdb::NmrOneD166565Specdb::MsMs2466Specdb::MsMs2467Specdb::MsMs2468Specdb::MsMs296221Specdb::MsMs296222Specdb::MsMs296223Specdb::MsMs337465Specdb::MsMs337466Specdb::MsMs337467Specdb::MsMs2391610Specdb::MsMs2391611Specdb::MsMs2391612Specdb::MsMs2570597Specdb::MsMs2570598Specdb::MsMs2570599Specdb::CMs13709Specdb::CMs38950Specdb::CMs127933Specdb::CMs135828Specdb::CMs143562Specdb::CMs831120Specdb::CMs831121Specdb::CMs831122Specdb::CMs831123Specdb::CMs831124Specdb::CMs831125Specdb::CMs831126Specdb::CMs831127Specdb::CMs831128Specdb::CMs831129Specdb::CMs831130Specdb::CMs831131Specdb::CMs831132HMDB06050#<Reference:0x00005556745184c8>#<Reference:0x00005556745182c0>#<Reference:0x000055567451a3e0>AnatidaeType 1specificAnatidae8830BeefaloType 1specificBos taurus X Bison bison297284BisonType 1specificBison bison9901BuffaloType 1specificBubalus bubalis89462Cattle (Beef, Veal)Type 1specificBos taurus9913ChickenType 1specificGallus gallus9031Columbidae (Dove, Pigeon)Type 1specificColumbidae8930DeerType 1specificCervidae9850Domestic goatType 1specificCapra aegagrus hircus9925Domestic pigType 1specificSus scrofa domestica9825ElkType 1specificCervus canadensis1574408EmuType 1specificDromaius novaehollandiae8790European rabbitType 1specificOryctolagus9984Greylag gooseType 1specificAnser anser8843Guinea henType 1specificNumida meleagris8996HorseType 1specificEquus caballus9796Mallard duckType 1specificAnas platyrhynchos8839Milk (Cow)Type 2specificMountain hareType 1specificLepus timidus62621Mule deerType 1specificOdocoileus9871OstrichType 1specificStruthio camelus8801PheasantType 1specificPhasianus colchicus9054QuailType 1specificPhasianidae9005RabbitType 1specificLeporidae9979Rock ptarmiganType 1specificLagopus muta64668Sheep (Mutton, Lamb)Type 1specificOvis aries9940SquabType 1specificColumba8931TurkeyType 1specificMeleagris gallopavo9103Velvet duckType 1specificMelanitta fusca371864Wild boarType 1specificSus scrofa9823