1.0 2011-09-21 00:35:25 UTC 2015-10-09 22:32:42 UTC FDB023828 Scyllitol Scyllitol is an isomer of cyclohexanehexol or inositol. It was first isolated from the kidneys of fish in 1858 by Staedeler and Freierchs. Scyllitol is a naturally occurring plant sugar alcohol found most abundantly in the coconut palm. It appears to accumulate in a number of human tissues and biofluids through dietary consumption. It has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379). Results reported by Viola et al (PMID: 15340856) suggest that high CSF concentrations of scyllo-inositol can be induced by chronic alcoholism. scyllo-Inositol (also called "scyllitol") when fed to transgenic mice that exhibit a memory disease very similar to human Alzheimer's disease, can block the accumulation of soluble amyloid-beta (A&#946;) plaques in the brain. Scyllitol was found to reverse memory deficits in the mice, reduce the amount of A&#946; plaque in the brains of the mice, and reversed other symptoms associated with the presence of A&#946; in the brain (PMID: 16767098). [HMDB] (1r,2r,3r,4r,5r,6r)-cyclohexane-1,2,3,4,5,6-hexol (1R,2R,3R,4S,5S,6S)-Cyclohexane-1,2,3,4,5,6-hexol 1,2,3,4,5/6-cyclohexanehexol 1,3,5/2,4,6-cyclohexanehexol Cocositol cyclohexane-1,2,3,4,5,6-hexol epi-inositol Quercinitol scyllo-Inositol C6H12O6 180.1559 180.063388116 (1R,2S,3r,4R,5S,6s)-cyclohexane-1,2,3,4,5,6-hexol (+)-inositol 488-59-5 O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](O)[C@H]1O InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6+ CDAISMWEOUEBRE-NIPYSYMMSA-N belongs to the class of organic compounds known as cyclohexanols. Cyclohexanols are compounds containing an alcohol group attached to a cyclohexane ring. Cyclohexanols Organic compounds Organic oxygen compounds Organooxygen compounds Alcohols and polyols Aliphatic homomonocyclic compounds Cyclitols and derivatives Hydrocarbon derivatives Polyols Sugar alcohols Aliphatic homomonocyclic compound Cyclic alcohol Cyclitol or derivatives Cyclohexanol Hydrocarbon derivative Polyol Sugar alcohol inositol Solid logp -2.59 ALOGPS logs 0.43 ALOGPS solubility 4.85e+02 g/l ALOGPS logp -3.8 ChemAxon pka_strongest_acidic 12.29 ChemAxon pka_strongest_basic -3.6 ChemAxon iupac (1R,2S,3r,4R,5S,6s)-cyclohexane-1,2,3,4,5,6-hexol ChemAxon average_mass 180.1559 ChemAxon mono_mass 180.063388116 ChemAxon smiles O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](O)[C@H]1O ChemAxon formula C6H12O6 ChemAxon inchi InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6+ ChemAxon inchikey CDAISMWEOUEBRE-NIPYSYMMSA-N ChemAxon polar_surface_area 121.38 ChemAxon refractivity 35.78 ChemAxon polarizability 16.05 ChemAxon rotatable_bond_count 0 ChemAxon acceptor_count 6 ChemAxon donor_count 6 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Specdb::MsMs 2469 Specdb::MsMs 2470 Specdb::MsMs 2471 Specdb::MsMs 324019 Specdb::MsMs 324020 Specdb::MsMs 324021 Specdb::MsMs 372331 Specdb::MsMs 372332 Specdb::MsMs 372333 Specdb::MsMs 2799031 Specdb::MsMs 2799032 Specdb::MsMs 2799033 Specdb::MsMs 2883791 Specdb::MsMs 2883792 Specdb::MsMs 2883793 Specdb::CMs 26189 Specdb::CMs 38956 Specdb::CMs 167248 Specdb::NmrOneD 72052 Specdb::NmrOneD 72053 Specdb::NmrOneD 72054 Specdb::NmrOneD 72055 Specdb::NmrOneD 72056 Specdb::NmrOneD 72057 Specdb::NmrOneD 72058 Specdb::NmrOneD 72059 Specdb::NmrOneD 72060 Specdb::NmrOneD 72061 Specdb::NmrOneD 72062 Specdb::NmrOneD 72063 Specdb::NmrOneD 72064 Specdb::NmrOneD 72065 Specdb::NmrOneD 72066 Specdb::NmrOneD 72067 Specdb::NmrOneD 72068 Specdb::NmrOneD 72069 Specdb::NmrOneD 72070 Specdb::NmrOneD 72071 HMDB06088 10642 #<Reference:0x000055ce31c76118> #<Reference:0x000055ce31c75f38>