1.02011-09-21 00:36:54 UTC2015-07-21 06:57:56 UTCFDB023924Elaidic carnitineElaidic carnitine is an acylcarnitine. Numerous disorders have been described that lead to disturbances in energy production and in intermediary metabolism in the organism which are characterized by the production and excretion of unusual acylcarnitines. A mutation in the gene coding for carnitine-acylcarnitine translocase or the OCTN2 transporter aetiologically causes a carnitine deficiency that results in poor intestinal absorption of dietary L-carnitine, its impaired reabsorption by the kidney and, consequently, in increased urinary loss of L-carnitine. Determination of the qualitative pattern of acylcarnitines can be of diagnostic and therapeutic importance. The betaine structure of carnitine requires special analytical procedures for recording. The ionic nature of L-carnitine causes a high water solubility which decreases with increasing chain length of the ester group in the acylcarnitines. Therefore, the distribution of L-carnitine and acylcarnitines in various organs is defined by their function and their physico-chemical properties as well. High performance liquid chromatography (HPLC) permits screening for free and total carnitine, as well as complete quantitative acylcarnitine determination, including the long-chain acylcarnitine profile. (PMID: 17508264, Monatshefte fuer Chemie (2005), 136(8), 1279-1291., Int J Mass Spectrom. 1999;188:39-52.) [HMDB]C25H47NO4425.645425.3505089973-[(9E)-octadec-9-enoyloxy]-4-(trimethylazaniumyl)butanoateelaidic carnitineCCCCCCCC\C=C\CCCCCCCC(=O)OC(CC([O-])=O)C[N+](C)(C)CInChI=1S/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/b13-12+IPOLTUVFXFHAHI-OUKQBFOZSA-N belongs to the class of organic compounds known as acyl carnitines. These are organic compounds containing a fatty acid with the carboxylic acid attached to carnitine through an ester bond.Acyl carnitinesOrganic compoundsLipids and lipid-like moleculesFatty AcylsFatty acid estersAliphatic acyclic compoundsAminesCarbonyl compoundsCarboxylic acid estersCarboxylic acid saltsCarboxylic acidsDicarboxylic acids and derivativesHydrocarbon derivativesOrganic oxidesOrganic saltsOrganopnictogen compoundsTetraalkylammonium saltsAcyl-carnitineAliphatic acyclic compoundAmineCarbonyl groupCarboxylic acidCarboxylic acid derivativeCarboxylic acid esterCarboxylic acid saltDicarboxylic acid or derivativesHydrocarbon derivativeOrganic nitrogen compoundOrganic oxideOrganic oxygen compoundOrganic saltOrganonitrogen compoundOrganooxygen compoundOrganopnictogen compoundQuaternary ammonium saltTetraalkylammonium saltO-octadecenoylcarnitineSolidlogp2.02logs-7.87solubility6.51e-06 g/llogp2.56pka_strongest_acidic4.22pka_strongest_basic-7.1iupac3-[(9E)-octadec-9-enoyloxy]-4-(trimethylazaniumyl)butanoateaverage_mass425.645mono_mass425.350508997smilesCCCCCCCC\C=C\CCCCCCCC(=O)OC(CC([O-])=O)C[N+](C)(C)CformulaC25H47NO4inchiInChI=1S/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/b13-12+inchikeyIPOLTUVFXFHAHI-OUKQBFOZSA-Npolar_surface_area66.43refractivity147.4polarizability53.39rotatable_bond_count21acceptor_count3donor_count0physiological_charge0formal_charge0Specdb::CMs13402Specdb::CMs148080Specdb::MsMs295498Specdb::MsMs295499Specdb::MsMs295500Specdb::MsMs336511Specdb::MsMs336512Specdb::MsMs336513Specdb::MsMs3087880Specdb::MsMs3087881Specdb::MsMs3087882HMDB06464#<Reference:0x0000555676040598>AnatidaeType 1specificAnatidae8830BeefaloType 1specificBos taurus X Bison bison297284BisonType 1specificBison bison9901BuffaloType 1specificBubalus bubalis89462Cattle (Beef, Veal)Type 1specificBos taurus9913ChickenType 1specificGallus gallus9031Columbidae (Dove, Pigeon)Type 1specificColumbidae8930DeerType 1specificCervidae9850Domestic goatType 1specificCapra aegagrus hircus9925Domestic pigType 1specificSus scrofa domestica9825ElkType 1specificCervus canadensis1574408EmuType 1specificDromaius novaehollandiae8790European rabbitType 1specificOryctolagus9984Greylag gooseType 1specificAnser anser8843Guinea henType 1specificNumida meleagris8996HorseType 1specificEquus caballus9796Mallard duckType 1specificAnas platyrhynchos8839Mountain hareType 1specificLepus timidus62621Mule deerType 1specificOdocoileus9871OstrichType 1specificStruthio camelus8801PheasantType 1specificPhasianus colchicus9054QuailType 1specificPhasianidae9005RabbitType 1specificLeporidae9979Rock ptarmiganType 1specificLagopus muta64668Sheep (Mutton, Lamb)Type 1specificOvis aries9940SquabType 1specificColumba8931TurkeyType 1specificMeleagris gallopavo9103Velvet duckType 1specificMelanitta fusca371864Wild boarType 1specificSus scrofa9823