1.02011-09-21 01:31:57 UTC2015-07-21 06:59:16 UTCFDB027916HypusineHypusine is formed in eIF-5A by post-translational modification of one of the lysyl residues. There are two reactions and two enzymes involved:; Hypusine is an unusual amino acid found in all eukaryotes and in some archaea, but not in bacteria. The only known protein containing hypusine is eukaryotic translation initiation factor 5A (eIF-5A) and a similar protein found in archaebacteria. In human, two isoforms of eIF-5A have been described: eIF-5A-1 and eIF-5A-2. They are coded by two different genes. This protein is involved in protein biosynthesis and promotes the formation of the first peptide bond. The region surrounding the hypusine residue is highly conserved among the eukaryotes and is essential to the function of eIF-5A. Thus, hypusine and eIF-5A appear to be vital for the viability and proliferation of eukaryotic cells. [HMDB]N(6)-(4-Amino-2-hydroxybutyl)-L-lysineC10H23N3O3233.3079233.173941617(2S)-2-amino-6-{[(2S)-4-amino-2-hydroxybutyl]amino}hexanoic acidhypusine34994-11-1NCC[C@H](O)CNCCCC[C@H](N)C(O)=OInChI=1S/C10H23N3O3/c11-5-4-8(14)7-13-6-2-1-3-9(12)10(15)16/h8-9,13-14H,1-7,11-12H2,(H,15,16)/t8-,9-/m0/s1BZUIJMCJNWUGKQ-IUCAKERBSA-N belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.L-alpha-amino acidsOrganic compoundsOrganic acids and derivativesCarboxylic acids and derivativesAmino acids, peptides, and analoguesAliphatic acyclic compounds1,2-aminoalcohols1,3-aminoalcoholsAmino acidsAmino fatty acidsCarbonyl compoundsCarboxylic acidsDialkylaminesHydrocarbon derivativesHydroxy fatty acidsMedium-chain fatty acidsMonoalkylaminesMonocarboxylic acids and derivativesOrganic oxidesOrganopnictogen compoundsSecondary alcohols1,2-aminoalcohol1,3-aminoalcoholAlcoholAliphatic acyclic compoundAmineAmino acidAmino fatty acidCarbonyl groupCarboxylic acidFatty acidFatty acylHydrocarbon derivativeHydroxy fatty acidL-alpha-amino acidMedium-chain fatty acidMonocarboxylic acid or derivativesOrganic nitrogen compoundOrganic oxideOrganic oxygen compoundOrganonitrogen compoundOrganooxygen compoundOrganopnictogen compoundPrimary aliphatic aminePrimary amineSecondary alcoholSecondary aliphatic amineSecondary amineSolidlogp-3.23logs-1.01solubility2.27e+01 g/llogp-4.4pka_strongest_acidic2.3pka_strongest_basic10.39iupac(2S)-2-amino-6-{[(2S)-4-amino-2-hydroxybutyl]amino}hexanoic acidaverage_mass233.3079mono_mass233.173941617smilesNCC[C@H](O)CNCCCC[C@H](N)C(O)=OformulaC10H23N3O3inchiInChI=1S/C10H23N3O3/c11-5-4-8(14)7-13-6-2-1-3-9(12)10(15)16/h8-9,13-14H,1-7,11-12H2,(H,15,16)/t8-,9-/m0/s1inchikeyBZUIJMCJNWUGKQ-IUCAKERBSA-Npolar_surface_area121.6refractivity61.36polarizability26.12rotatable_bond_count10acceptor_count6donor_count5physiological_charge2formal_charge0Specdb::CMs13016Specdb::CMs39560Specdb::CMs134862Specdb::CMs142596Specdb::NmrOneD92832Specdb::NmrOneD92833Specdb::NmrOneD92834Specdb::NmrOneD92835Specdb::NmrOneD92836Specdb::NmrOneD92837Specdb::NmrOneD92838Specdb::NmrOneD92839Specdb::NmrOneD92840Specdb::NmrOneD92841Specdb::NmrOneD92842Specdb::NmrOneD92843Specdb::NmrOneD92844Specdb::NmrOneD92845Specdb::NmrOneD92846Specdb::NmrOneD92847Specdb::NmrOneD92848Specdb::NmrOneD92849Specdb::NmrOneD92850Specdb::NmrOneD92851Specdb::MsMs294601Specdb::MsMs294602Specdb::MsMs294603Specdb::MsMs335365Specdb::MsMs335366Specdb::MsMs335367Specdb::MsMs2807324Specdb::MsMs2807325Specdb::MsMs2807326Specdb::MsMs2898495Specdb::MsMs2898496Specdb::MsMs2898497HMDB11140AnatidaeType 1specificAnatidae8830BeefaloType 1specificBos taurus X Bison bison297284BisonType 1specificBison bison9901BuffaloType 1specificBubalus bubalis89462Cattle (Beef, Veal)Type 1specificBos taurus9913ChickenType 1specificGallus gallus9031Columbidae (Dove, Pigeon)Type 1specificColumbidae8930DeerType 1specificCervidae9850Domestic goatType 1specificCapra aegagrus hircus9925Domestic pigType 1specificSus scrofa domestica9825ElkType 1specificCervus canadensis1574408EmuType 1specificDromaius novaehollandiae8790European rabbitType 1specificOryctolagus9984Greylag gooseType 1specificAnser anser8843Guinea henType 1specificNumida meleagris8996HorseType 1specificEquus caballus9796Mallard duckType 1specificAnas platyrhynchos8839Mountain hareType 1specificLepus timidus62621Mule deerType 1specificOdocoileus9871OstrichType 1specificStruthio camelus8801PheasantType 1specificPhasianus colchicus9054QuailType 1specificPhasianidae9005RabbitType 1specificLeporidae9979Rock ptarmiganType 1specificLagopus muta64668Sheep (Mutton, Lamb)Type 1specificOvis aries9940SquabType 1specificColumba8931TurkeyType 1specificMeleagris gallopavo9103Velvet duckType 1specificMelanitta fusca371864Wild boarType 1specificSus scrofa9823Eukaryotic translation initiation factor 5A-1P63241EIF5A