1.02011-09-21 01:45:14 UTC2015-07-21 06:59:32 UTCFDB0288072-Keto-6-acetamidocaproate2-Keto-6-acetamidocaproate is an intermediate in lysine degradation. It can be generated from N6-acetyl-L-lysine. N-acetyl-lysine is an acetylated amino acid. Post-translational lysine-acetylation is one of two major modifications of lysine residues in various proteins. Acetylation of specific lysine residues in the N-terminal domains of core histones is a biochemical marker of active genes. Acetylation is now known to play a major role in eukaryotic transcription. Specifically, acetyltransferase enzymes that act on particular lysine side chains of histones and other proteins are intimately involved in transcriptional activation. N6-acetyl-L-lysine can be converted to 2-Keto-6-acetamidocaproate via the enzyme N6-acetyllysine aminotransferase and then 2-keto-6-acetamidocaproate can be reduced enzymatically to 5-acetamidovalerate. [HMDB]2-Keto-6-acetamidocaproate2-Keto-6-acetamidocaproic acid2-keto-6-acetamidohexanoate2-keto-6-acetamidohexanoic acid2-oxo-6-acetamidocaproate2-oxo-6-acetamidocaproic acid6-acetamido-2-oxohexanoate6-acetamido-2-oxohexanoic acidC8H13NO4187.1931187.0844579096-acetamido-2-oxohexanoic acid6-acetamido-2-oxohexanoic acid59403-50-8CC(=O)NCCCCC(=O)C(O)=OInChI=1S/C8H13NO4/c1-6(10)9-5-3-2-4-7(11)8(12)13/h2-5H2,1H3,(H,9,10)(H,12,13)NGCXIFFZXAZRAF-UHFFFAOYSA-N belongs to the class of organic compounds known as medium-chain keto acids and derivatives. These are keto acids with a 6 to 12 carbon atoms long side chain.Medium-chain keto acids and derivativesOrganic compoundsOrganic acids and derivativesKeto acids and derivativesMedium-chain keto acids and derivativesAliphatic acyclic compoundsAcetamidesAlpha-hydroxy ketonesAlpha-keto acids and derivativesAmino fatty acidsCarboxylic acidsHydrocarbon derivativesMonocarboxylic acids and derivativesOrganic oxidesOrganonitrogen compoundsOrganopnictogen compoundsSecondary carboxylic acid amidesAcetamideAliphatic acyclic compoundAlpha-hydroxy ketoneAlpha-keto acidAmino fatty acidCarbonyl groupCarboxamide groupCarboxylic acidCarboxylic acid derivativeFatty acylHydrocarbon derivativeKetoneMedium-chain keto acidMonocarboxylic acid or derivativesOrganic nitrogen compoundOrganic oxideOrganic oxygen compoundOrganonitrogen compoundOrganooxygen compoundOrganopnictogen compoundSecondary carboxylic acid amide2-oxo monocarboxylic acidacetamidesSolidlogp-0.10logs-1.83solubility2.75e+00 g/llogp-0.069pka_strongest_acidic3.36pka_strongest_basic-0.63iupac6-acetamido-2-oxohexanoic acidaverage_mass187.1931mono_mass187.084457909smilesCC(=O)NCCCCC(=O)C(O)=OformulaC8H13NO4inchiInChI=1S/C8H13NO4/c1-6(10)9-5-3-2-4-7(11)8(12)13/h2-5H2,1H3,(H,9,10)(H,12,13)inchikeyNGCXIFFZXAZRAF-UHFFFAOYSA-Npolar_surface_area83.47refractivity44.85polarizability18.88rotatable_bond_count6acceptor_count4donor_count2physiological_charge-1formal_charge0Specdb::CMs12166Specdb::CMs39834Specdb::CMs134221Specdb::CMs141955Specdb::MsIr2663Specdb::MsIr2664Specdb::MsIr2665Specdb::NmrOneD151290Specdb::NmrOneD151291Specdb::NmrOneD151292Specdb::NmrOneD151293Specdb::NmrOneD151294Specdb::NmrOneD151295Specdb::NmrOneD151296Specdb::NmrOneD151297Specdb::NmrOneD151298Specdb::NmrOneD151299Specdb::NmrOneD151300Specdb::NmrOneD151301Specdb::NmrOneD151302Specdb::NmrOneD151303Specdb::NmrOneD151304Specdb::NmrOneD151305Specdb::NmrOneD151306Specdb::NmrOneD151307Specdb::NmrOneD151308Specdb::NmrOneD151309Specdb::MsMs292762Specdb::MsMs292763Specdb::MsMs292764Specdb::MsMs333055Specdb::MsMs333056Specdb::MsMs333057Specdb::MsMs2462712Specdb::MsMs2462713Specdb::MsMs2462714Specdb::MsMs2498999Specdb::MsMs2499000Specdb::MsMs2499001HMDB12150AnatidaeType 1specificAnatidae8830BeefaloType 1specificBos taurus X Bison bison297284BisonType 1specificBison bison9901BuffaloType 1specificBubalus bubalis89462Cattle (Beef, Veal)Type 1specificBos taurus9913ChickenType 1specificGallus gallus9031Columbidae (Dove, Pigeon)Type 1specificColumbidae8930DeerType 1specificCervidae9850Domestic goatType 1specificCapra aegagrus hircus9925Domestic pigType 1specificSus scrofa domestica9825ElkType 1specificCervus canadensis1574408EmuType 1specificDromaius novaehollandiae8790European rabbitType 1specificOryctolagus9984Greylag gooseType 1specificAnser anser8843Guinea henType 1specificNumida meleagris8996HorseType 1specificEquus caballus9796Mallard duckType 1specificAnas platyrhynchos8839Mountain hareType 1specificLepus timidus62621Mule deerType 1specificOdocoileus9871OstrichType 1specificStruthio camelus8801PheasantType 1specificPhasianus colchicus9054QuailType 1specificPhasianidae9005RabbitType 1specificLeporidae9979Rock ptarmiganType 1specificLagopus muta64668Sheep (Mutton, Lamb)Type 1specificOvis aries9940SquabType 1specificColumba8931TurkeyType 1specificMeleagris gallopavo9103Velvet duckType 1specificMelanitta fusca371864Wild boarType 1specificSus scrofa9823