1.02011-09-21 01:58:23 UTC2015-07-21 06:59:46 UTCFDB02960912-KETE12-keto-eicosatetraenoic acid is a biologically active eicosanoid in the nervous system of Aplysia.It is a metabolite of 12-HPETE formed by Aplysia nervous tissue. 12-KETE was identified in incubations of the tissue with arachidonic acid using HPLC, UV spectrometry, and gas-chromatography/mass spectrometry. [3H]12-KETE is formed from endogenous lipid stores in nervous tissue, labeled with [3H]arachidonic acid upon stimulation by application of histamine. In L14 and L10 cells, identified neurons in the abdominal ganglion, applications of 12-KETE elicit changes in membrane potential similar to those evoked by histamine.[PMID:2774398] [HMDB](5Z,8Z,10E,14Z)-12-Oxoeicosa-5,8,10,14-tetraenoate(5Z,8Z,10E,14Z)-12-Oxoeicosa-5,8,10,14-tetraenoic acid(5Z,8Z,10E,14Z)-12-Oxoicosa-5,8,10,14-tetraenoate(5Z,8Z,10E,14Z)-12-Oxoicosa-5,8,10,14-tetraenoic acid12-keto-ETE12-Ketoeicosatetraenoate12-Ketoeicosatetraenoic acid12-oxo-ETE12-oxo, 5c,8c,10t,14c-20:412-OxoETEC20H30O3318.4504318.219494826(5Z,8Z,10E,14Z)-12-oxoicosa-5,8,10,14-tetraenoic acid12-oxo-ETE108437-64-5CCCCC\C=C/CC(=O)\C=C\C=C/C\C=C/CCCC(O)=OInChI=1S/C20H30O3/c1-2-3-4-5-10-13-16-19(21)17-14-11-8-6-7-9-12-15-18-20(22)23/h7-11,13-14,17H,2-6,12,15-16,18H2,1H3,(H,22,23)/b9-7-,11-8-,13-10-,17-14+GURBRQGDZZKITB-VXBMJZGYSA-N belongs to the class of organic compounds known as long-chain fatty acids. These are fatty acids with an aliphatic tail that contains between 13 and 21 carbon atoms.Long-chain fatty acidsOrganic compoundsLipids and lipid-like moleculesFatty AcylsFatty acids and conjugatesAliphatic acyclic compoundsAcryloyl compoundsCarboxylic acidsEnonesHydrocarbon derivativesKetonesMonocarboxylic acids and derivativesOrganic oxidesUnsaturated fatty acidsAcryloyl-groupAliphatic acyclic compoundAlpha,beta-unsaturated ketoneCarbonyl groupCarboxylic acidCarboxylic acid derivativeEnoneHydrocarbon derivativeKetoneLong-chain fatty acidMonocarboxylic acid or derivativesOrganic oxideOrganic oxygen compoundOrganooxygen compoundUnsaturated fatty acidHydroxy/hydroperoxyeicosatetraenoic acidsHydroxy/hydroperoxyeicosatetraenoic acidsoxoicosatetraenoic acidSolidlogp5.79logs-5.62solubility7.59e-04 g/llogp5.77pka_strongest_acidic4.89pka_strongest_basic-4.7iupac(5Z,8Z,10E,14Z)-12-oxoicosa-5,8,10,14-tetraenoic acidaverage_mass318.4504mono_mass318.219494826smilesCCCCC\C=C/CC(=O)\C=C\C=C/C\C=C/CCCC(O)=OformulaC20H30O3inchiInChI=1S/C20H30O3/c1-2-3-4-5-10-13-16-19(21)17-14-11-8-6-7-9-12-15-18-20(22)23/h7-11,13-14,17H,2-6,12,15-16,18H2,1H3,(H,22,23)/b9-7-,11-8-,13-10-,17-14+inchikeyGURBRQGDZZKITB-VXBMJZGYSA-Npolar_surface_area54.37refractivity100.57polarizability37.42rotatable_bond_count14acceptor_count3donor_count1physiological_charge-1formal_charge0Arachidonic Acid MetabolismSMP00075map00590Specdb::CMs10585Specdb::CMs40143Specdb::CMs161749Specdb::MsMs328711Specdb::MsMs328712Specdb::MsMs328713Specdb::MsMs3063262Specdb::MsMs3063263Specdb::MsMs3063264Specdb::MsMs289321Specdb::MsMs289322Specdb::MsMs289323Specdb::MsMs2305968Specdb::MsMs2305969Specdb::MsMs2305970HMDB1363334151#<Reference:0x000055567490fec8>