Record Information
Version1.0
Creation date2015-05-07 20:35:58 UTC
Update date2019-11-27 17:45:42 UTC
Primary IDFDB030952
Secondary Accession NumbersNot Available
Chemical Information
FooDB NameL-1-glycero-3-phosphocholine
DescriptionCholine alfoscerate, also known as glycerophosphocholine or choline glycerophosphate, is a member of the class of compounds known as glycerophosphocholines. Glycerophosphocholines are lipids containing a glycerol moiety carrying a phosphocholine at the 3-position. Choline alfoscerate is slightly soluble (in water) and a moderately acidic compound (based on its pKa). Choline alfoscerate can be found in a number of food items such as radish, strawberry guava, yellow pond-lily, and pepper (c. baccatum), which makes choline alfoscerate a potential biomarker for the consumption of these food products. L-Alpha glycerylphosphorylcholine (alpha-GPC, choline alfoscerate) is a natural choline compound found in the brain. It is also a parasympathomimetic acetylcholine precursor which may have potential for the treatment of Alzheimer's disease and other dementias .
CAS Number28319-77-9
Structure
Thumb
Synonyms
SynonymSource
(2R)-2,3-Dihydroxypropyl 2-(trimethylammonio)ethyl phosphateChEBI
Alfoscerate de cholineChEBI
Alfoscerato de colinaChEBI
alpha-GlycerophosphorylcholineChEBI
Choline alphoscerateChEBI
Choline glycerophosphateChEBI
Cholini alfoscerasChEBI
Cholini glycerophosphasChEBI
Glicerofosfato de colinaChEBI
Glycerol phosphorylcholineChEBI
Glycerol-3-phosphatidylcholineChEBI
Glycerol-3-phosphocholineChEBI
Glycerophosphate de cholineChEBI
GlycerophosphorylcholineChEBI
GPChoChEBI
L-alpha-GlycerophosphocholineChEBI
L-alpha-GlycerophosphorylcholineChEBI
L-Choline hydroxide 2,3-dihydroxypropyl hydrogen phosphate inner saltChEBI
sn-3-GPCChEBI
sn-Glycero-3-phosphocholineChEBI
sn-Glycerol 3-phosphocholineChEBI
GliatilinKegg
(2R)-2,3-Dihydroxypropyl 2-(trimethylammonio)ethyl phosphoric acidGenerator
Alfosceric acid de cholineGenerator
a-GlycerophosphorylcholineGenerator
Α-glycerophosphorylcholineGenerator
Choline alphosceric acidGenerator
Choline glycerophosphoric acidGenerator
Glycerophosphoric acid de cholineGenerator
L-a-GlycerophosphocholineGenerator
L-Α-glycerophosphocholineGenerator
L-a-GlycerophosphorylcholineGenerator
L-Α-glycerophosphorylcholineGenerator
L-Choline hydroxide 2,3-dihydroxypropyl hydrogen phosphoric acid inner saltGenerator
Choline alfosceric acidHMDB
Glycerol 3 phosphocholineHMDB
GlycerylphosphorylcholineHMDB
Alphoscerate, cholineHMDB
L alpha GlycerylphosphorylcholineHMDB
3-Phosphocholine, glycerolHMDB
Glycerol 3-phosphocholineHMDB
L-alpha-GlycerylphosphorylcholineHMDB
Alfoscerate, cholineHMDB
Glycerophosphate, cholineHMDB
2-[[(2,3-Dihydroxypropoxy)hydroxyphosphinyl]oxy]-N,N,N-trimethyl-ethanaminium inner saltHMDB
a-GlycerylphosphorylcholineHMDB
alpha-GlycerylphosphorylcholineHMDB
Choline alfoscerateHMDB
GlycerophosphatidylcholineHMDB
GPCHMDB
Hydrogen glycerophosphate cholineHMDB
CeretonHMDB
CholicerinHMDB
CholitilineHMDB
DelecitHMDB
Glycerol 3-phosphorylcholineHMDB
Glycerophosphoric acid choline esterHMDB
Glyceryl 3-phosphorylcholineHMDB
GlycerylphosphocholineHMDB
L-alpha-GPCHMDB
L-Α-GPCHMDB
L-Α-glycerylphosphorylcholineHMDB
O-(sn-Glycero-3-phosphoryl)-cholineHMDB
sn-Glycero-3-phosphorylcholineHMDB
Α-glycerylphosphorylcholineHMDB
GlycerophosphocholineChEBI
Predicted Properties
PropertyValueSource
Water Solubility8.96 g/LALOGPS
logP-2.6ALOGPS
logP-5.7ChemAxon
logS-1.5ALOGPS
pKa (Strongest Acidic)1.86ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area99.05 ŲChemAxon
Rotatable Bond Count8ChemAxon
Refractivity68.68 m³·mol⁻¹ChemAxon
Polarizability24.77 ųChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Chemical FormulaC8H20NO6P
IUPAC name(2-{[(2R)-2,3-dihydroxypropyl phosphono]oxy}ethyl)trimethylazanium
InChI IdentifierInChI=1S/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/t8-/m1/s1
InChI KeySUHOQUVVVLNYQR-MRVPVSSYSA-N
Isomeric SMILES[H][C@@](O)(CO)COP([O-])(=O)OCC[N+](C)(C)C
Average Molecular Weight257.223
Monoisotopic Molecular Weight257.102824366
Classification
Description belongs to the class of organic compounds known as glycerophosphocholines. These are lipids containing a glycerol moiety carrying a phosphocholine at the 3-position.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassGlycerophospholipids
Sub ClassGlycerophosphocholines
Direct ParentGlycerophosphocholines
Alternative Parents
Substituents
  • Glycero-3-phosphocholine
  • Phosphocholine
  • Dialkyl phosphate
  • Organic phosphoric acid derivative
  • Phosphoric acid ester
  • Alkyl phosphate
  • Tetraalkylammonium salt
  • Quaternary ammonium salt
  • 1,2-diol
  • Secondary alcohol
  • Organic nitrogen compound
  • Organic salt
  • Hydrocarbon derivative
  • Primary alcohol
  • Organic oxide
  • Organopnictogen compound
  • Organooxygen compound
  • Organonitrogen compound
  • Organic oxygen compound
  • Amine
  • Alcohol
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Physiological effect

Organoleptic effect:

Health effect:

Disposition

Route of exposure:

Source:

Biological location:

Process

Naturally occurring process:

Role

Industrial application:

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Physico-Chemical Properties - Experimental
Physico-Chemical Properties - Experimental
PropertyValueReference
Physical stateNot Available
Physical DescriptionNot Available
Mass CompositionNot Available
Melting PointNot Available
Boiling PointNot Available
Experimental Water SolubilityNot Available
Experimental logPNot Available
Experimental pKaNot Available
Isoelectric pointNot Available
ChargeNot Available
Optical RotationNot Available
Spectroscopic UV DataNot Available
DensityNot Available
Refractive IndexNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash Key
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positivesplash10-001j-7910000000-79a0f6ec434740d09410View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-052r-9140000000-3347b58fbc5fe0b0a201View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0a7r-9210000000-60118aed826a14bb4cb1View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0a4r-9000000000-b6ac875e42841f04bcfcView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0a4i-0390000000-9adc870a20cd016e3aa2View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0kor-2920000000-b31eb4ca99ba45d9f931View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-004i-9100000000-dec05a487d7ae73f1d27View in MoNA
1D NMR1H NMR SpectrumNot AvailableView in JSpectraViewer
2D NMR[1H,13C] 2D NMR SpectrumNot AvailableView in JSpectraViewer
ChemSpider IDNot Available
ChEMBL IDNot Available
KEGG Compound IDNot Available
Pubchem Compound IDNot Available
Pubchem Substance IDNot Available
ChEBI IDNot Available
Phenol-Explorer IDNot Available
DrugBank IDNot Available
HMDB IDNot Available
CRC / DFC (Dictionary of Food Compounds) IDNot Available
EAFUS IDNot Available
Dr. Duke IDNot Available
BIGG IDNot Available
KNApSAcK IDNot Available
HET IDNot Available
Food Biomarker OntologyNot Available
VMH IDNot Available
Flavornet IDNot Available
GoodScent IDNot Available
SuperScent IDNot Available
Wikipedia IDNot Available
Phenol-Explorer Metabolite IDNot Available
Duplicate IDSNot Available
Old DFC IDSNot Available
Associated Foods
FoodContent Range AverageReference
FoodReference
Biological Effects and Interactions
Health Effects / BioactivitiesNot Available
EnzymesNot Available
PathwaysNot Available
MetabolismNot Available
BiosynthesisNot Available
Organoleptic Properties
FlavoursNot Available
Files
MSDSNot Available
References
Synthesis ReferenceNot Available
General ReferenceNot Available
Content Reference