Record Information
Version1.0
Creation date2010-04-08 22:04:42 UTC
Update date2020-02-24 19:10:13 UTC
Primary IDFDB000760
Secondary Accession NumbersNot Available
Chemical Information
FooDB NameChloroform
DescriptionIndirect food additive arising from adhesives and polymers Chloroform is a common solvent in the laboratory because it is relatively unreactive, miscible with most organic liquids, and conveniently volatile. Chloroform is used as a solvent in the pharmaceutical industry and for producing dyes and pesticides. Chloroform is an effective solvent for alkaloids in their base form and thus plant material is commonly extracted with chloroform for pharmaceutical processing. For example, it is commercially used to extract morphine from poppies and scopolamine from Datura plants. Chloroform containing deuterium (heavy hydrogen), CDCl3, is a common solvent used in NMR spectroscopy. It can be used to bond pieces of acrylic glass (also known under the trade names Perspex and Plexiglas). A solvent of phenol:chloroform:isoamyl alcohol 25:24:1 is used to dissolve non-nucleic acid biomolecules in DNA and RNA extractions.; Chloroform is the organic compound with formula CHCl3. It does not undergo combustion in air, although it will burn when mixed with more flammable substances. It is a member of a group of compounds known as trihalomethanes. Chloroform has myriad uses as a reagent and a solvent. It is also considered an environmental hazard. Several million tons are produced annually.; The output of this process is a mixture of the four chloromethanes: chloromethane, dichloromethane, chloroform (trichloromethane), and carbon tetrachloride, which are then separated by distillation. Chloroform is found in spearmint.
CAS Number67-66-3
Structure
Thumb
Synonyms
SynonymSource
1,1,1-Trichloromethanebiospider
CFbiospider
CHCl3biospider
Chloroform [NF xvII]biospider
Chloroform [UN1888] [Poison]biospider
Chloroform, acsbiospider
Chloroformebiospider
Chloroformium pro narcosiChEBI
Chloroformwith amylenebiospider
Chloroformwith ethanolbiospider
Cloroformiobiospider
Formyl trichloridebiospider
Freon 20biospider
HSDB 56biospider
Methane trichloridebiospider
Methane, trichloro-biospider
Methenyl chloridebiospider
Methenyl trichloridebiospider
Methyl trichloridebiospider
Methylidyne trichloridebiospider
R 20HMDB
R 20 (refrigerant)biospider
R 20 (VAN)biospider
R20db_source
Refrigerant R20biospider
TCMbiospider
Trichloormethaanbiospider
Trichlormethanbiospider
Trichloro-methaneHMDB
Trichloroformbiospider
Trichloromethanebiospider
Trichloromethane, 9CIdb_source
Trichloromethyl radicalbiospider
Triclorometanobiospider
Predicted PropertiesNot Available
Chemical FormulaCHCl3
IUPAC name
InChI IdentifierInChI=1S/CHCl3/c2-1(3)4/h1H
InChI KeyHEDRZPFGACZZDS-UHFFFAOYSA-N
Isomeric SMILESClC(Cl)Cl
Average Molecular Weight119.378
Monoisotopic Molecular Weight117.914383153
Classification
ClassificationNot classified
Ontology
Physiological effect

Health effect:

Disposition

Route of exposure:

Source:

Biological location:

Process

Industrial process:

Role

Indirect biological role:

Environmental role:

Industrial application:

Physico-Chemical Properties - Experimental
Physico-Chemical Properties - Experimental
PropertyValueReference
Physical stateNot Available
Physical DescriptionNot Available
Mass CompositionC 10.06%; H 0.84%; Cl 89.09%DFC
Melting PointMp -63.2°DFC
Boiling PointBp 61.3°DFC
Experimental Water Solubility7.95 mg/mL at 25 oCMACKAY,D et al. (1980)
Experimental logP1.97HANSCH,C ET AL. (1995)
Experimental pKaNot Available
Isoelectric pointNot Available
ChargeNot Available
Optical RotationNot Available
Spectroscopic UV DataNot Available
Densityd254 1.48DFC
Refractive Indexn20D 1.4467DFC
Spectra
Spectra
EI-MS/GC-MSNot Available
MS/MSNot Available
NMRNot Available
ChemSpider ID5977
ChEMBL IDCHEMBL44618
KEGG Compound IDC13827
Pubchem Compound ID6212
Pubchem Substance IDNot Available
ChEBI ID35255
Phenol-Explorer IDNot Available
DrugBank IDNot Available
HMDB IDHMDB29596
CRC / DFC (Dictionary of Food Compounds) IDBGW06-K:BGW06-K
EAFUS ID624
Dr. Duke IDCHLOROFORM
BIGG IDNot Available
KNApSAcK IDNot Available
HET IDMCH
Food Biomarker OntologyNot Available
VMH IDNot Available
Flavornet IDNot Available
GoodScent IDNot Available
SuperScent IDNot Available
Wikipedia IDChloroform
Phenol-Explorer Metabolite IDNot Available
Duplicate IDSNot Available
Old DFC IDSNot Available
Associated Foods
FoodContent Range AverageReference
FoodReference
Biological Effects and Interactions
Health Effects / BioactivitiesNot Available
EnzymesNot Available
PathwaysNot Available
MetabolismNot Available
BiosynthesisNot Available
Organoleptic Properties
FlavoursNot Available
Files
MSDSshow
References
Synthesis ReferenceNot Available
General ReferenceNot Available
Content Reference— Duke, James. 'Dr. Duke's Phytochemical and Ethnobotanical Databases. United States Department of Agriculture.' Agricultural Research Service, Accessed April 27 (2004).