1.0 2010-04-08 22:04:44 UTC 2020-02-24 19:10:15 UTC FDB000861 Diosmetin Isolated from peel of lemon (Citrus limon) and others. Diosmetin is found in many foods, some of which are spearmint, citrus, rosemary, and common thyme. 3',5,7-Trihydroxy-4'-methoxyflavone 4'-Methylluteolin 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone 5,7,3'-Trihydroxy-4'-methoxyflavone Diosmetin Luteolin 4'-methyl ether Salinigricoflavonol Vitamin P C16H12O6 300.2629 300.063388116 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one diosmetin 520-34-3 COC1=C(O)C=C(C=C1)C1=CC(=O)C2=C(O1)C=C(O)C=C2O InChI=1S/C16H12O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-7,17-19H,1H3 MBNGWHIJMBWFHU-UHFFFAOYSA-N belongs to the class of organic compounds known as 4'-o-methylated flavonoids. These are flavonoids with methoxy groups attached to the C4' atom of the flavonoid backbone. 4'-O-methylated flavonoids Organic compounds Phenylpropanoids and polyketides Flavonoids O-methylated flavonoids Aromatic heteropolycyclic compounds 1-hydroxy-2-unsubstituted benzenoids 1-hydroxy-4-unsubstituted benzenoids 3'-hydroxyflavonoids 5-hydroxyflavonoids 7-hydroxyflavonoids Alkyl aryl ethers Anisoles Chromones Flavones Heteroaromatic compounds Hydrocarbon derivatives Methoxybenzenes Methoxyphenols Organic oxides Oxacyclic compounds Phenoxy compounds Pyranones and derivatives Vinylogous acids 1-benzopyran 1-hydroxy-2-unsubstituted benzenoid 1-hydroxy-4-unsubstituted benzenoid 3'-hydroxyflavonoid 4p-methoxyflavonoid-skeleton 5-hydroxyflavonoid 7-hydroxyflavonoid Alkyl aryl ether Anisole Aromatic heteropolycyclic compound Benzenoid Benzopyran Chromone Ether Flavone Heteroaromatic compound Hydrocarbon derivative Hydroxyflavonoid Methoxybenzene Methoxyphenol Monocyclic benzene moiety Organic oxide Organic oxygen compound Organoheterocyclic compound Organooxygen compound Oxacycle Phenol Phenol ether Phenoxy compound Pyran Pyranone Vinylogous acid 3'-hydroxyflavonoid Flavones and Flavonols Flavones and Flavonols flavones monomethoxyflavone trihydroxyflavone logp 3.06 ALOGPS logs -3.60 ALOGPS solubility 7.54e-02 g/l ALOGPS melting_point Mp 228-230° logp 2.55 ChemAxon pka_strongest_acidic 6.64 ChemAxon pka_strongest_basic -4.8 ChemAxon iupac 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one ChemAxon average_mass 300.2629 ChemAxon mono_mass 300.063388116 ChemAxon smiles COC1=C(O)C=C(C=C1)C1=CC(=O)C2=C(O1)C=C(O)C=C2O ChemAxon formula C16H12O6 ChemAxon inchi InChI=1S/C16H12O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-7,17-19H,1H3 ChemAxon inchikey MBNGWHIJMBWFHU-UHFFFAOYSA-N ChemAxon polar_surface_area 96.22 ChemAxon refractivity 79.38 ChemAxon polarizability 29.84 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 6 ChemAxon donor_count 3 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon Specdb::CMs 5958 Specdb::CMs 41510 Specdb::CMs 157793 Specdb::MsMs 12974 Specdb::MsMs 12975 Specdb::MsMs 12976 Specdb::MsMs 19646 Specdb::MsMs 19647 Specdb::MsMs 19648 Specdb::MsMs 285659 Specdb::MsMs 285660 Specdb::MsMs 285661 Specdb::MsMs 285662 Specdb::MsMs 373712 Specdb::MsMs 373713 Specdb::MsMs 373714 Specdb::MsMs 373715 Specdb::MsMs 439391 Specdb::MsMs 439909 Specdb::MsMs 439910 Specdb::MsMs 440234 Specdb::MsMs 440235 Specdb::MsMs 440236 Specdb::MsMs 450157 Specdb::MsMs 1479264 Specdb::MsMs 1479362 Specdb::MsMs 2236596 Specdb::MsMs 2236763 HMDB29676 4630 #<Reference:0x000055ce31dd6530> Citrus Unknown generic Common oregano Type 1 specific Origanum vulgare 39352 Common sage Type 1 specific Salvia officinalis 38868 Common thyme Type 1 specific Thymus vulgaris 49992 Dill Type 1 specific Anethum graveolens 40922 Hyssop Type 1 specific Hyssopus officinalis 39324 Lemon Type 1 specific Citrus limon 2708 Lemon verbena Type 1 specific Aloysia triphylla 542672 Rosemary Type 1 specific Rosmarinus officinalis 39367 Spearmint Type 1 specific Mentha spicata 29719 Sweet marjoram Type 1 specific Origanum majorana 268884 Aldose reductase inhibitor 40 An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of aldehyde reductase (EC 1.1.1.21). Anti-Alzheimeran 105 Any substance introduced into a living organism with therapeutic or diagnostic purpose. Anti-dementia 222 Any substance introduced into a living organism with therapeutic or diagnostic purpose. Anti-mutagenic 451 Anti-oxidant 502 A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides. In European countries, E-numbers for permitted antioxidant food additives are from E 300 to E 324. Anti-rhinoviral 588 A substance that destroys or inhibits replication of viruses. Anti-viral 689 A substance that destroys or inhibits replication of viruses. Cancer preventive 754 A substance that inhibits or prevents the proliferation of neoplasms. Estrogenic 922 Nitric-oxide inhibitor 1167 A substance that diminishes the rate of a chemical reaction. Osteoblastogenic 1177 Peroxisome proliferator activated receptor gamma antagonist 1239 Substance that attaches to and blocks cell receptors that normally bind naturally occurring substances. TNF-alpha inhibitor 1363 A substance that diminishes the rate of a chemical reaction.