1.0 2010-04-08 22:04:46 UTC 2015-10-09 22:31:19 UTC FDB000956 Frusemide Potential contaminant in cow's milk arising from its use in dairy cattle for the treatment of physiological parturient edema Additionally, furosemide is a noncompetitive subtype-specific blocker of GABA-A receptors. Furosemide has been reported to reversibly antagonize GABA-evoked currents of alpha6 beta2 gamma2 receptors at microM concentrations, but not alpha1 beta2 gamma2 receptors. During development, the alpha6 beta2 gamma2 receptor increases in expression in cerebellar granule neurons, corresponding to increased sensitivity to furosemide.; An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed) It acts by inhibiting translocation during protein synthesis.; Furosemide (INN) or frusemide (former BAN) is a loop diuretic used in the treatment of congestive heart failure and edema. It is most commonly marketed by Sanofi-Aventis under the brand name Lasix. It has also been used to prevent thoroughbred and standardbred race horses from bleeding through the nose during races.; Furosemide or frusemide is a loop diuretic used in the treatment of congestive heart failure and edema. It is most commonly marketed by Aventis Pharma under the brand name Lasix. It has also been used to prevent thoroughbred race horses from bleeding through the nose during races.; Furosemide, a sulfonamide-type loop diuretic structurally related to bumetanide, is used to manage hypertension and edema associated with congestive heart failure, cirrhosis, and renal disease, including the nephrotic syndrome. 2-Furfurylamino-4-chloro-5-sulfamoylbenzoate 2-Furfurylamino-4-chloro-5-sulfamoylbenzoic acid 2-Furfurylamino-4-chloro-5-sulphamoylbenzoate 2-Furfurylamino-4-chloro-5-sulphamoylbenzoic acid 4-chloro-5-Sulfamoyl-N-furfuryl-anthranilate 4-Chloro-5-sulfamoyl-N-furfuryl-anthranilic acid 4-chloro-5-Sulphamoyl-N-furfuryl-anthranilate 4-chloro-5-Sulphamoyl-N-furfuryl-anthranilic acid 4-chloro-N-(2-Furylmethyl)-5-sulfamoylanthranilate 4-Chloro-N-(2-furylmethyl)-5-sulfamoylanthranilic acid 4-chloro-N-(2-Furylmethyl)-5-sulphamoylanthranilate 4-chloro-N-(2-Furylmethyl)-5-sulphamoylanthranilic acid 4-chloro-N-Furfuryl-5-sulfamoylanthranilate 4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid 4-chloro-N-Furfuryl-5-sulphamoylanthranilate 4-chloro-N-Furfuryl-5-sulphamoylanthranilic acid 5-(Aminosulfonyl)-4-chloro-2-[2-(furanylmethyl)amino]benzoic acid, 9CI Acetic acid potassium salt Aisemide Aldalix Aldic Aluzine Anfuramaide Anthranilic acid, 4-chloro-N-furfuryl-5-sulfamoyl- Apo-frusemide Apo-furosemide Aquarid Aquasin Arasemide Beronald Bio-furosemide Bioretic Cetasix Depix Desal Desdemin Dirine Disal Discoid Disemide Diural Diurapid Diuretic salt Diurin Diurolasa Diusemide Diusil Diuzol Dom-furosemide Dranex Dryptal Durafurid Edemid Edenol Eliur Endural Errolon Eutensin Farsix Fluidrol Fluss Franyl Froop Frumax Frumex Frumide Frumil Frusedan Frusema Frusemid Frusemide Frusemide, BAN Frusemin Frusenex Frusetic Frusid Frusol Fulsix Fuluvamide Fuluvamine Furanthril Furanthryl Furantril Furanturil Furesis Furetic Furex Furfan Furix Furmid Furo-basan Furo-puren Furobeta Furocot Furodiurol Furodrix Furomen Furomex Furomide m.d. Furorese Furosan Furose Furosedon Furosemid Furosemida Furosemide "mita" Furosemide 40mg Furosemide special Furosemide(usan) Furosemidu Furosemidum Furosemix Furoside Furosifar Furosix Furoter Furovite Fursemid Fursemida Fursemide Fursol Fusid Fusidic acid Golan Hissuflux Hydrex Hydro hydro-Rapid Hydroled Impugan Jenafusid Katlex Kofuzon Kolkin Kutrix Lasemid Lasex Lasiletten Lasilix Lasix Lasix retard Lasix special Laxur Lazix Less diur Liside Logirene Lowpston Lowpstron Luscek Macasirool Marsemide Mirfat MITA Moilarorin Nadis Nelsix Neo-renal Nephron Nicorol Novosemide Octan draselny Odemase Odemex Oedemex Osyrol PMS-furosemide Polysquall a Prefemin Profemin Promedes Promide Protargen Puresis Radisemide Radonna Radouna Retep Rosemide Rosis Rusyde Sal diureticum Salinex Salix Salurex Salurid Seguril Selectofur Sigasalur Spirofur Synephron Tenkafruse Transit Trofurit Uremide Uresix Urex Urex-m Urian Uridon Uritol Urosemide Vesix Yidoli Zafimida C12H11ClN2O5S 330.744 330.007719869 4-chloro-2-{[(furan-2-yl)methyl]amino}-5-sulfamoylbenzoic acid furosemide 54-31-9 NS(=O)(=O)C1=C(Cl)C=C(NCC2=CC=CO2)C(=C1)C(O)=O InChI=1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19) ZZUFCTLCJUWOSV-UHFFFAOYSA-N belongs to the class of organic compounds known as aminobenzenesulfonamides. These are organic compounds containing a benzenesulfonamide moiety with an amine group attached to the benzene ring. Aminobenzenesulfonamides Organic compounds Benzenoids Benzene and substituted derivatives Benzenesulfonamides Aromatic heteromonocyclic compounds 4-halobenzoic acids Amino acids Aminobenzoic acids Aminosulfonyl compounds Aniline and substituted anilines Aryl chlorides Benzenesulfonyl compounds Benzoic acids Benzoyl derivatives Carboxylic acids Chlorobenzenes Furans Halobenzoic acids Heteroaromatic compounds Hydrocarbon derivatives Monocarboxylic acids and derivatives Organic oxides Organochlorides Organooxygen compounds Organopnictogen compounds Organosulfonamides Oxacyclic compounds Phenylalkylamines Secondary alkylarylamines Vinylogous amides 4-halobenzoic acid 4-halobenzoic acid or derivatives Amine Amino acid Amino acid or derivatives Aminobenzenesulfonamide Aminobenzoic acid Aminobenzoic acid or derivatives Aminosulfonyl compound Aniline or substituted anilines Aralkylamine Aromatic heteromonocyclic compound Aryl chloride Aryl halide Benzenesulfonyl group Benzoic acid Benzoic acid or derivatives Benzoyl Carboxylic acid Carboxylic acid derivative Chlorobenzene Furan Halobenzene Halobenzoic acid Halobenzoic acid or derivatives Heteroaromatic compound Hydrocarbon derivative Monocarboxylic acid or derivatives Organic nitrogen compound Organic oxide Organic oxygen compound Organic sulfonic acid or derivatives Organochloride Organohalogen compound Organoheterocyclic compound Organonitrogen compound Organooxygen compound Organopnictogen compound Organosulfonic acid amide Organosulfonic acid or derivatives Organosulfur compound Oxacycle Phenylalkylamine Secondary aliphatic/aromatic amine Secondary amine Sulfonyl Vinylogous amide chlorobenzoic acid furans sulfonamide Solid logp 2.71 ALOGPS logs -3.45 ALOGPS solubility 1.18e-01 g/l ALOGPS melting_point Mp 206° logp 1.75 ChemAxon pka_strongest_acidic 4.25 ChemAxon pka_strongest_basic -1.5 ChemAxon iupac 4-chloro-2-{[(furan-2-yl)methyl]amino}-5-sulfamoylbenzoic acid ChemAxon average_mass 330.744 ChemAxon mono_mass 330.007719869 ChemAxon smiles NS(=O)(=O)C1=C(Cl)C=C(NCC2=CC=CO2)C(=C1)C(O)=O ChemAxon formula C12H11ClN2O5S ChemAxon inchi InChI=1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19) ChemAxon inchikey ZZUFCTLCJUWOSV-UHFFFAOYSA-N ChemAxon polar_surface_area 122.63 ChemAxon refractivity 77.47 ChemAxon polarizability 30.55 ChemAxon rotatable_bond_count 5 ChemAxon acceptor_count 5 ChemAxon donor_count 3 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon Furosemide Pathway SMP00115 Specdb::NmrOneD 1811 Specdb::NmrTwoD 1751 Specdb::CMs 7020 Specdb::CMs 38191 Specdb::CMs 155254 Specdb::MsMs 1875 Specdb::MsMs 1876 Specdb::MsMs 1877 Specdb::MsMs 251280 Specdb::MsMs 251281 Specdb::MsMs 251282 Specdb::MsMs 271221 Specdb::MsMs 271222 Specdb::MsMs 271223 Specdb::MsMs 435890 Specdb::MsMs 435891 Specdb::MsMs 435892 Specdb::MsMs 435893 Specdb::MsMs 435894 Specdb::MsMs 435895 Specdb::MsMs 435896 Specdb::MsMs 435897 Specdb::MsMs 435898 Specdb::MsMs 435899 Specdb::MsMs 435900 Specdb::MsMs 435901 Specdb::MsMs 435902 Specdb::MsMs 435903 Specdb::MsMs 439305 Specdb::MsMs 439306 HMDB01933 5198 FUN #<Reference:0x000055ce325fc570> #<Reference:0x000055ce325fc368> #<Reference:0x000055ce325fc1b0> #<Reference:0x000055ce325fbf80> #<Reference:0x000055ce325fbd78> #<Reference:0x000055ce325fbbc0> #<Reference:0x000055ce325fb9e0> #<Reference:0x000055ce325fb7d8> #<Reference:0x000055ce325fb620> #<Reference:0x000055ce325fb440> #<Reference:0x000055ce325fb238> 6-phosphogluconate dehydrogenase, decarboxylating P52209 PGD