Record Information
Version1.0
Creation date2010-04-08 22:04:46 UTC
Update date2020-02-24 19:10:18 UTC
Primary IDFDB000958
Secondary Accession NumbersNot Available
Chemical Information
FooDB NameProcyanidin B1
DescriptionProcyanidin B1, also known as ec-(4b,8)-C or endotelon, belongs to the class of organic compounds known as biflavonoids and polyflavonoids. These are organic compounds containing at least two flavan/flavone units. These units are usually linked through CC or C-O-C bonds. Some examples include C2-O-C3, C2-O-C4, C3'-C3''', and C6-C8''. Thus, procyanidin B1 is considered to be a flavonoid. Procyanidin B1 is found, on average, in the highest concentration within a few different foods, such as cocoa powder, peach (var.), and nectarines (Prunus persica var. nucipersica) and in a lower concentration in custard apples (Annona reticulata), teas (Camellia sinensis), and common grapes (Vitis vinifera). Procyanidin B1 has also been detected, but not quantified in, several different foods, such as eggplants (Solanum melongena), bananas (Musa acuminata), cocoa beans (Theobroma cacao), lettuces (Lactuca sativa), and apple cider. This could make procyanidin B1 a potential biomarker for the consumption of these foods. Based on a literature review a significant number of articles have been published on Procyanidin B1.
CAS Number20315-25-7
Structure
Thumb
Synonyms
SynonymSource
EC-(4b,8)-CChEBI
EndotelonChEBI
Epicatechin(4beta->8)catechinChEBI
Epicatechin-(4beta->8)-ent-epicatechinChEBI
Proanthocyanidin b1ChEBI
Procyanidin dimer b1ChEBI
Epicatechin(4b->8)catechinGenerator
Epicatechin(4β->8)catechinGenerator
Epicatechin-(4b->8)-ent-epicatechinGenerator
Epicatechin-(4β->8)-ent-epicatechinGenerator
Procyanidin bHMDB
Procyanidin DHMDB
Procyanidol DHMDB
Procyanidol oligomerHMDB
Proanthocyanidin B1db_source
Procyanidin B1db_source
Procyanidin dbiospider
Procyanidin dimer B1db_source
Procyanidol dbiospider
Predicted Properties
PropertyValueSource
Water Solubility0.14 g/LALOGPS
logP2.29ALOGPS
logP3.12ChemAxon
logS-3.6ALOGPS
pKa (Strongest Acidic)8.69ChemAxon
pKa (Strongest Basic)-5.2ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count12ChemAxon
Hydrogen Donor Count10ChemAxon
Polar Surface Area220.76 ŲChemAxon
Rotatable Bond Count3ChemAxon
Refractivity146.51 m³·mol⁻¹ChemAxon
Polarizability57.12 ųChemAxon
Number of Rings6ChemAxon
BioavailabilityNoChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Chemical FormulaC30H26O12
IUPAC name(2R,3S)-2-(3,4-dihydroxyphenyl)-8-[(2R,3R,4R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-1-benzopyran-4-yl]-3,4-dihydro-2H-1-benzopyran-3,5,7-triol
InChI IdentifierInChI=1S/C30H26O12/c31-13-7-20(37)24-23(8-13)41-29(12-2-4-16(33)19(36)6-12)27(40)26(24)25-21(38)10-17(34)14-9-22(39)28(42-30(14)25)11-1-3-15(32)18(35)5-11/h1-8,10,22,26-29,31-40H,9H2/t22-,26+,27+,28+,29+/m0/s1
InChI KeyXFZJEEAOWLFHDH-UKWJTHFESA-N
Isomeric SMILESO[C@H]1CC2=C(O)C=C(O)C([C@@H]3[C@@H](O)[C@H](OC4=CC(O)=CC(O)=C34)C3=CC=C(O)C(O)=C3)=C2O[C@@H]1C1=CC=C(O)C(O)=C1
Average Molecular Weight578.526
Monoisotopic Molecular Weight578.142426277
Classification
Description Belongs to the class of organic compounds known as biflavonoids and polyflavonoids. These are organic compounds containing at least two flavan/flavone units. These units are usually linked through CC or C-O-C bonds. Some examples include C2-O-C3, C2-O-C4, C3'-C3''', and C6-C8''.
KingdomOrganic compounds
Super ClassPhenylpropanoids and polyketides
ClassFlavonoids
Sub ClassBiflavonoids and polyflavonoids
Direct ParentBiflavonoids and polyflavonoids
Alternative Parents
Substituents
  • B-type proanthocyanidin
  • Bi- and polyflavonoid skeleton
  • Proanthocyanidin
  • Catechin
  • Flavan-3-ol
  • Hydroxyflavonoid
  • 3'-hydroxyflavonoid
  • 7-hydroxyflavonoid
  • 5-hydroxyflavonoid
  • 4'-hydroxyflavonoid
  • 3-hydroxyflavonoid
  • Flavan
  • Chromane
  • 1-benzopyran
  • Benzopyran
  • Catechol
  • Phenol
  • 1-hydroxy-2-unsubstituted benzenoid
  • Alkyl aryl ether
  • 1-hydroxy-4-unsubstituted benzenoid
  • Benzenoid
  • Monocyclic benzene moiety
  • Secondary alcohol
  • Polyol
  • Organoheterocyclic compound
  • Oxacycle
  • Ether
  • Hydrocarbon derivative
  • Alcohol
  • Organic oxygen compound
  • Organooxygen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
Disposition

Route of exposure:

Source:

Biological location:

Physico-Chemical Properties - Experimental
Physico-Chemical Properties - Experimental
PropertyValueReference
Physical stateNot Available
Physical DescriptionNot Available
Mass CompositionC 62.28%; H 4.53%; O 33.19%DFC
Melting PointMp 231-232° (deca-Ac)DFC
Boiling PointNot Available
Experimental Water SolubilityNot Available
Experimental logPNot Available
Experimental pKaNot Available
Isoelectric pointNot Available
ChargeNot Available
Optical Rotation[a]25D +110.9 (c, 2 in Me2CO) (deca-Ac)DFC
Spectroscopic UV DataNot Available
DensityNot Available
Refractive IndexNot Available
Spectra
Spectra
EI-MS/GC-MS
TypeDescriptionSplash KeyView
Predicted GC-MSProcyanidin B1, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positivesplash10-03mj-0510690000-115aeaaab9de9537434cSpectrum
Predicted GC-MSProcyanidin B1, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positivesplash10-00dr-2301229000-34e0d16a3e8eb63a692aSpectrum
Predicted GC-MSProcyanidin B1, "Procyanidin B1,1TMS,#1" TMS, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSProcyanidin B1, TMS_1_2, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSProcyanidin B1, TMS_1_3, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSProcyanidin B1, TMS_1_4, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSProcyanidin B1, TMS_1_5, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSProcyanidin B1, TMS_1_6, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSProcyanidin B1, TMS_1_7, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSProcyanidin B1, TMS_1_8, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSProcyanidin B1, TMS_1_9, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSProcyanidin B1, TMS_1_10, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSProcyanidin B1, TMS_2_1, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSProcyanidin B1, TMS_2_2, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSProcyanidin B1, TMS_2_3, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSProcyanidin B1, TMS_2_4, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSProcyanidin B1, TMS_2_5, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSProcyanidin B1, TMS_2_6, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSProcyanidin B1, TMS_2_7, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSProcyanidin B1, TMS_2_8, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSProcyanidin B1, TMS_2_9, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSProcyanidin B1, TMS_2_10, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSProcyanidin B1, TMS_2_11, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSProcyanidin B1, TMS_2_12, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSProcyanidin B1, TMS_2_13, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
MS/MS
TypeDescriptionSplash KeyView
MS/MSLC-MS/MS Spectrum - ESI-TOF 40V, Negativesplash10-052r-0390200000-9f1e13b0bba9785308a3Spectrum
MS/MSLC-MS/MS Spectrum - ESI-TOF , Negativesplash10-004i-0100090000-6fdf4ab81dd423c4334dSpectrum
MS/MSLC-MS/MS Spectrum - ESI-TOF 10V, Negativesplash10-004i-0000190000-136d2e8bbb6419a5dcb7Spectrum
MS/MSLC-MS/MS Spectrum - ESI-TOF 30V, Negativesplash10-052r-0191600000-fe7651fd7e7097baa30aSpectrum
MS/MSLC-MS/MS Spectrum - ESI-TOF 20V, Negativesplash10-004i-0050960000-456238d05a29305098bbSpectrum
MS/MSLC-MS/MS Spectrum - ESI-TOF 50V, Negativesplash10-0551-0690000000-0de917967e41c73de31bSpectrum
MS/MSLC-MS/MS Spectrum - ESI-TOF 40V, Negativesplash10-052r-0390200000-9f1e13b0bba9785308a3Spectrum
MS/MSLC-MS/MS Spectrum - ESI-TOF , Negativesplash10-004i-0100090000-6fdf4ab81dd423c4334dSpectrum
MS/MSLC-MS/MS Spectrum - ESI-TOF 10V, Negativesplash10-004i-0000190000-136d2e8bbb6419a5dcb7Spectrum
MS/MSLC-MS/MS Spectrum - ESI-TOF 30V, Negativesplash10-052r-0191600000-fe7651fd7e7097baa30aSpectrum
MS/MSLC-MS/MS Spectrum - ESI-TOF 20V, Negativesplash10-004i-0050960000-456238d05a29305098bbSpectrum
MS/MSLC-MS/MS Spectrum - ESI-TOF 50V, Negativesplash10-0551-0690000000-0de917967e41c73de31bSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , negativesplash10-004r-0960640000-4a8afc17f0a82219e1c6Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF , positivesplash10-004i-0910120000-904b693b4080a3b311f0Spectrum
MS/MSLC-MS/MS Spectrum - 6V, Positivesplash10-004i-0020690000-f8b67d5f019fb672880bSpectrum
MS/MSLC-MS/MS Spectrum - 6V, Positivesplash10-0570-0891300000-4b7ae7a8937f478478a9Spectrum
MS/MSLC-MS/MS Spectrum - 6V, Positivesplash10-004i-0940000000-d82f8b13868ad872d04bSpectrum
MS/MSLC-MS/MS Spectrum - 6V, Positivesplash10-01t9-0930000000-e22414604be4795a3b5bSpectrum
MS/MSLC-MS/MS Spectrum - 6V, Positivesplash10-0570-0591730000-e2fd4fa16cc5af16e65aSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-004i-0110980000-5100aeb456b72604bfbeSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0a4i-0334920000-f9222e1bae7f0bca6417Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0076-0491110000-c8af712677eef1677727Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-004i-0000290000-ae7911e8a6b7e2e8867eSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0kbr-0920440000-53d4ef58d673c17bbbb2Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-004i-0910000000-851c43689a6c620aa704Spectrum
NMRNot Available
ChemSpider ID9425166
ChEMBL IDNot Available
KEGG Compound IDNot Available
Pubchem Compound ID11250133
Pubchem Substance IDNot Available
ChEBI IDNot Available
Phenol-Explorer ID150
DrugBank IDNot Available
HMDB IDHMDB29754
CRC / DFC (Dictionary of Food Compounds) IDHGT19-P:BNP85-V
EAFUS IDNot Available
Dr. Duke IDPROANTHOCYANIDIN-B1|PROCYANIDIN-B-1
BIGG IDNot Available
KNApSAcK IDC00009075
HET IDNot Available
Food Biomarker OntologyNot Available
VMH IDNot Available
Flavornet IDNot Available
GoodScent IDNot Available
SuperScent IDNot Available
Wikipedia IDNot Available
Phenol-Explorer Metabolite ID150
Duplicate IDSNot Available
Old DFC IDSNot Available
Associated Foods
FoodContent Range AverageReference
FoodReference
Biological Effects and Interactions
Health Effects / Bioactivities
DescriptorIDDefinitionReference
angiotensin converting enzyme inhibitor35457 An EC 3.4.15.* (peptidyl-dipeptidase) inhibitor that interferes with the action of peptidyl-dipeptidase A (EC 3.4.15.1).DUKE
EnzymesNot Available
PathwaysNot Available
MetabolismNot Available
BiosynthesisNot Available
Organoleptic Properties
FlavoursNot Available
Files
MSDSNot Available
References
Synthesis ReferenceNot Available
General ReferenceNot Available
Content Reference— Rothwell JA, Pérez-Jiménez J, Neveu V, Medina-Ramon A, M'Hiri N, Garcia Lobato P, Manach C, Knox K, Eisner R, Wishart D, Scalbert A. (2013) Phenol-Explorer 3.0: a major update of the Phenol-Explorer database to incorporate data on the effects of food processing on polyphenol content. Database, 10.1093/database/bat070.
— Shinbo, Y., et al. 'KNApSAcK: a comprehensive species-metabolite relationship database.' Plant Metabolomics. Springer Berlin Heidelberg, 2006. 165-181.
— Duke, James. 'Dr. Duke's Phytochemical and Ethnobotanical Databases. United States Department of Agriculture.' Agricultural Research Service, Accessed April 27 (2004).