Record Information
Version1.0
Creation date2010-04-08 22:04:50 UTC
Update date2018-05-28 23:04:38 UTC
Primary IDFDB001089
Secondary Accession NumbersNot Available
Chemical Information
FooDB Name(S)-N-Acetylmethionine
DescriptionN-Acetyl-L-methionine, also known as acmet or L-(N-acetyl)methionine, belongs to the class of organic compounds known as methionine and derivatives. Methionine and derivatives are compounds containing methionine or a derivative thereof resulting from reaction of methionine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. N-Acetyl-L-methionine has been detected, but not quantified in, a few different foods, such as anatidaes (Anatidae), chickens (Gallus gallus), and domestic pigs (Sus scrofa domestica). This could make N-acetyl-L-methionine a potential biomarker for the consumption of these foods. Based on a literature review a significant number of articles have been published on N-Acetyl-L-methionine.
CAS Number65-82-7
Structure
Thumb
Synonyms
SynonymSource
(2S)-2-Acetamido-4-(methylsulfanyl)butanoic acidChEBI
Acetyl-L-methionineChEBI
AcetylmethionineChEBI
AcMetChEBI
L-(N-Acetyl)methionineChEBI
MethionamineChEBI
N-Ac-metChEBI
N-AcetylmethionineChEBI
Nalpha-acetyl-L-methionineChEBI
(2S)-2-Acetamido-4-(methylsulfanyl)butanoateGenerator
(2S)-2-Acetamido-4-(methylsulphanyl)butanoateGenerator
(2S)-2-Acetamido-4-(methylsulphanyl)butanoic acidGenerator
N-Ac-L-methionineMeSH, HMDB
N-Acetyl-methionineMeSH, HMDB
N-Acetylmethionine monopotassium saltMeSH, HMDB
N-Acetylmethionine monosodium saltMeSH, HMDB
HepsanMeSH, HMDB
N-Acetylmethionine, (D)-isomerMeSH, HMDB
N-Acetylmethionine, (DL)-isomerMeSH, HMDB
N-Acetyl-L-methionineKEGG
(2S)-2-Acetamido-4-methylsulfanylbutanoic acidHMDB
(S)-2-Acetamido-4-(methylthio)butanoic acidHMDB
MethioninHMDB
Acetyl-L-Methioninebiospider
AcetylmethioninHMDB
DL-N-AcetylmethionineHMDB
L-Methionine, N-acetyl-biospider
L-N-Acetyl-methioninebiospider
Methionine, N-acetyl-biospider
Methionine, N-acetyl-, L- (8CI)biospider
N-Acetyl-S-methylhomocysteinebiospider
N-Acetyl(methyl)homocysteineHMDB
ThiomedonHMDB
Predicted Properties
PropertyValueSource
Water Solubility6.84 g/LALOGPS
logP-0.15ALOGPS
logP-0.11ChemAxon
logS-1.4ALOGPS
pKa (Strongest Acidic)4.02ChemAxon
pKa (Strongest Basic)-1.8ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area66.4 ŲChemAxon
Rotatable Bond Count5ChemAxon
Refractivity47.03 m³·mol⁻¹ChemAxon
Polarizability19.59 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Chemical FormulaC7H13NO3S
IUPAC name(2S)-2-acetamido-4-(methylsulfanyl)butanoic acid
InChI IdentifierInChI=1S/C7H13NO3S/c1-5(9)8-6(7(10)11)3-4-12-2/h6H,3-4H2,1-2H3,(H,8,9)(H,10,11)/t6-/m0/s1
InChI KeyXUYPXLNMDZIRQH-LURJTMIESA-N
Isomeric SMILES[H][C@@](CCSC)(NC(C)=O)C(O)=O
Average Molecular Weight191.248
Monoisotopic Molecular Weight191.061613977
Classification
Description Belongs to the class of organic compounds known as methionine and derivatives. Methionine and derivatives are compounds containing methionine or a derivative thereof resulting from reaction of methionine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentMethionine and derivatives
Alternative Parents
Substituents
  • Methionine or derivatives
  • N-acyl-alpha-amino acid
  • N-acyl-alpha amino acid or derivatives
  • N-acyl-l-alpha-amino acid
  • Thia fatty acid
  • Fatty acid
  • Fatty acyl
  • Acetamide
  • Secondary carboxylic acid amide
  • Carboxamide group
  • Dialkylthioether
  • Sulfenyl compound
  • Thioether
  • Monocarboxylic acid or derivatives
  • Carboxylic acid
  • Hydrocarbon derivative
  • Organic oxygen compound
  • Organosulfur compound
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Organic oxide
  • Organopnictogen compound
  • Organic nitrogen compound
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
OntologyNo ontology term
Physico-Chemical Properties - Experimental
Physico-Chemical Properties - Experimental
PropertyValueReference
Physical stateSolid
Physical DescriptionNot Available
Mass CompositionC 43.96%; H 6.85%; N 7.32%; O 25.10%; S 16.77%DFC
Melting PointMp 104°DFC
Boiling PointNot Available
Experimental Water Solubility307 mg/mL at 25 oCBEILSTEIN
Experimental logP-0.03MEYLAN,WM & HOWARD,PH (1995)
Experimental pKaNot Available
Isoelectric pointNot Available
ChargeNot Available
Optical Rotation[a]25D -20.3DFC
Spectroscopic UV DataNot Available
DensityNot Available
Refractive IndexNot Available
Spectra
Spectra
EI-MS/GC-MS
TypeDescriptionSplash KeyView
GC-MS(S)-N-Acetylmethionine, 2 TMS, GC-MS Spectrumsplash10-0v4j-2920000000-21fd3a4d7b12ac2aca3cSpectrum
GC-MS(S)-N-Acetylmethionine, 1 TMS, GC-MS Spectrumsplash10-0002-6900000000-3e9fc6c1775a4e3d390aSpectrum
Predicted GC-MS(S)-N-Acetylmethionine, non-derivatized, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
MS/MS
TypeDescriptionSplash KeyView
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , negativesplash10-0006-0900000000-08cead5b5b6a03d6ba5a2017-09-14View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , negativesplash10-0005-1900000000-d059fe0be6d1a5b4b0842017-09-14View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , negativesplash10-0002-9100000000-43df5a1503ce3f2cf7582017-09-14View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , negativesplash10-0002-9000000000-b757a5078c71037ef5b62017-09-14View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , negativesplash10-0002-9000000000-275fc8f00e0ba4f1dbea2017-09-14View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , positivesplash10-0006-0900000000-4826c0abe069970d97682017-09-14View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , positivesplash10-0udj-3900000000-947d106e4353bbea54492017-09-14View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , positivesplash10-0k92-9500000000-5171045a6fc50c4963f92017-09-14View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , positivesplash10-08fr-9100000000-2e49b493225ec50c951f2017-09-14View Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , positivesplash10-03di-9000000000-df7f02d0426ee253bc2b2017-09-14View Spectrum
MS/MSLC-MS/MS Spectrum - 30V, Positivesplash10-0006-9000000000-c95070994ff6981f31be2021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 10V, Negativesplash10-0005-8900000000-00ef889f3b4f112d8d2e2021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 40V, Negativesplash10-0002-9000000000-7616747f5e52c0cfcb212021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 30V, Negativesplash10-0002-9000000000-832ee5d6104ffe5e03432021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 20V, Negativesplash10-0002-9000000000-253c94d8794c74656d122021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 10V, Positivesplash10-0k97-9700000000-c475f07ae6596a5bd16c2021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 0V, Positivesplash10-0006-0900000000-3c38449e27fee255c0e62021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 10V, Positivesplash10-0udm-6900000000-8def9e0a4df7dda943182021-09-20View Spectrum
MS/MSLC-MS/MS Spectrum - 30V, Positivesplash10-08fu-9000000000-c048830a23b089c34b542021-09-20View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0006-1900000000-15861132c8b2269198ae2015-09-15View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0udj-2900000000-dfeda97a2049e74815ce2015-09-15View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0w2m-9400000000-6da930234f6033225c782015-09-15View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0005-4900000000-fd1e8a8512a5adc4f78b2015-09-15View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0002-9500000000-ba3c2cf457f39b90d9b02015-09-15View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0002-9000000000-63ccb712a985eedfd16a2015-09-15View Spectrum
NMR
TypeDescriptionView
1D NMR1H NMR Spectrum (1D, 500 MHz, H2O, experimental)Spectrum
1D NMR1H NMR Spectrum (1D, 100 MHz, D2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 100 MHz, D2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 1000 MHz, D2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 1000 MHz, D2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 200 MHz, D2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 200 MHz, D2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 300 MHz, D2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 300 MHz, D2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 400 MHz, D2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 400 MHz, D2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 500 MHz, D2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 500 MHz, D2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 600 MHz, D2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 600 MHz, D2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 700 MHz, D2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 700 MHz, D2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 800 MHz, D2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 800 MHz, D2O, predicted)Spectrum
1D NMR1H NMR Spectrum (1D, 900 MHz, D2O, predicted)Spectrum
1D NMR13C NMR Spectrum (1D, 900 MHz, D2O, predicted)Spectrum
2D NMR[1H, 13C]-HSQC NMR Spectrum (2D, 500 MHz, H2O, experimental)Spectrum
ChemSpider ID5945
ChEMBL IDCHEMBL45002
KEGG Compound IDC02712
Pubchem Compound ID6180
Pubchem Substance IDNot Available
ChEBI IDNot Available
Phenol-Explorer IDNot Available
DrugBank IDDB01646
HMDB IDHMDB11745
CRC / DFC (Dictionary of Food Compounds) IDBSS42-E:BSS44-G
EAFUS ID43
Dr. Duke IDNot Available
BIGG IDNot Available
KNApSAcK IDNot Available
HET IDNot Available
Food Biomarker OntologyNot Available
VMH IDNot Available
Flavornet IDNot Available
GoodScent IDNot Available
SuperScent IDNot Available
Wikipedia IDNot Available
Phenol-Explorer Metabolite IDNot Available
Duplicate IDSNot Available
Old DFC IDSNot Available
Associated Foods
FoodContent Range AverageReference
FoodReference
Biological Effects and Interactions
Health Effects / BioactivitiesNot Available
Enzymes
NameGene NameUniProt ID
Glycine N-acyltransferaseGLYATQ6IB77
Glycine N-acyltransferase-like protein 1GLYATL1Q969I3
Glycine N-acyltransferase-like protein 2GLYATL2Q8WU03
RhodopsinRHOP08100
PathwaysNot Available
MetabolismNot Available
BiosynthesisNot Available
Organoleptic Properties
FlavoursNot Available
Files
MSDSshow
References
Synthesis ReferenceNot Available
General ReferenceNot Available
Content Reference