1.02010-04-08 22:04:56 UTC2018-05-28 23:05:47 UTCFDB001355DexamethasoneGlucocorticoid with potent antiinflammatory props. Not FDA approved for use in food-producing animals, but may be used illegally
Dexamethasone and its derivatives, dexamethasone sodium phosphate and dexamethasone acetate, are synthetic glucocorticoids. It is used for its antiinflammatory or immunosuppressive properties and ability to penetrate the CNS, dexamethasone is used alone to manage cerebral edema and with tobramycin to treat corticosteroid-responsive inflammatory ocular conditions.; Dexamethasone can be used in the context of congenital adrenal hyperplasia, to prevent virilisation of a female fetus. If one or both parents are carriers of mutations to the CYP21 (CYP21A2) gene, the mother may start dexamethasone treatment within 7 weeks of conception. At the 12th week, a chorionic villus sample will determine whether the fetus is male (in which case the dexamethasone is stopped) or female. Subsequent DNA analysis can then reveal whether the female fetus is a carrier of the mutation, in which case dexamethasone treatment must continue until birth. The side-effects for the mother can be severe and the long-term impact on the child is not clear.; Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid hormones. It acts as an anti-inflammatory and immunosuppressant. Its potency is about 20-30 times that of hydrocortisone and 4-5 times of prednisone.α-Fluoro-16-α-methylcortisolα-fluoro-16α-methyl-1-Dehydro-16α-methyl-9α-fluorohydrocortisone1-dehydro-16a-Methyl-9a-fluorohydrocortisone1-dehydro-16alpha -Methyl-9alpha -fluorohydrocortisone1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone1-dehydro-16α-methyl-9α-fluorohydrocortisone16-alpha-Methyl-9-alpha-fluoro-1-dehydrocortisol16-alpha-Methyl-9-alpha-fluoro-delta(sup 1)-hydrocortisone16-alpha-Methyl-9-alpha-fluoro-delta1-hydrocortisone16-alpha-Methyl-9-alpha-fluoroprednisolone16α-Methyl-9α-fluoro-1-dehydrocortisol16α-Methyl-9α-fluoroprednisolone16a-Methyl-9a-fluoro-1-dehydrocortisol16alpha -Methyl-9alpha -fluoro-1-dehydrocortisol16alpha -Methyl-9alpha -fluoroprednisolone16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol16alpha-Methyl-9alpha-fluoro-delta(sup 1)-hydrocortisone16alpha-Methyl-9alpha-fluoroprednisolone16α-methyl-9α-fluoro-1-dehydrocortisol9-alpha-Fluoro-16-alpha-methylprednisolone9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione9-Fluoro-11α-methylpregna-1,4-diene-3,20-dione9-Fluoro-11alpha -methylpregna-1,4-diene-3,20-dione9-Fluoro-16-methylprednisolone9α-Fluoro-16α-methylprednisolone9a-Fluoro-16a-methylprednisolone9A-FLUORO-16BETA-METHYLPREDNISOLONE9alpha -Fluoro-16alpha -methylprednisolone9alpha-Fluoro-16alpha-methyl-prednisolone9alpha-Fluoro-16alpha-methylprednisolone9α-fluoro-16α-methylprednisoloneAeroseb-dAeroseb-dexAk Dex Oph Otic Soln 0.1%alpha -Fluoro-16-alpha -methylcortisolAnaflogisticoAphtasolonApo-dexamethasoneAuxironAzimycin (veterinary)AziumAzium (veterinary)Bisu DSCalonatCorsonCorsoneCortisummanDecacortinDecadermDecadronDecagelDecalixDecasoneDecasprayDectancylDekacortdelta(sup 1)-9-alpha-Fluoro-16-alpha-methylcortisoldelta1-9alpha-Fluoro-16alpha-methylcortisolDeltafluoreneDergraminDeronilDesadreneDesametasoneDesametasone [dcit]DesamethasoneDesametonDeseronilDEXDex-ideDEXADexa mamalletDexa-cortideltDexa-cortisylDexa-scherosonDexa-sineDexacidinDexacortDexacortalDexacortinDexadeltoneDexafarmaDexalonaDexametasonaDexametasoneDexamethDexamethansoneDexamethasone (from sample)Dexamethasone [inn:ban:jan]Dexamethasone acetateDexamethasone alcoholDexamethasone baseDexamethasone intensolDexamethasone sodium ateDexamethasone sodium phosphateDexamethasone-omegaDexamethasonumDexamethazoneDexapolcortDexaposDexaprolDexasonDexasoneDexasone 0.5mgDexasone 0.75mgDexasone 4mgDexasporinDexinolonDexinoralDexoneDEXONE 0.5DEXONE 0.75DEXONE 1.5DEXONE 4DextelanDezoneDinormonDXMDXMSFluormethylprednisoloneFortecortinGammacortenHexadecadrolHexadrolHexadrol elixirHL-dexIsopto-dexLokalison fLoverineLuxazoneMaxidexMaxidex Ont 0.1%Maxidex Sus 0.1%MaxitrolMediamethasoneMethylfluorprednisoloneMexidexMillicortenMK 125MymethasoneNaquasone (veterinary)Neomycin and polymyxin b sulfates and dexamethasoneNeomycin and polymyxin b sulphates and dexamethasoneNSC 34521Ocu-trolOradexonPet derm IIIPHL-dexamethasonePms Dexamethasone Elixir 0.5mg/5mlPMS-dexamethasonePolicortPrednisolon fPrednisolone fPrednisolone, 9α-fluoro-16α-methyl-Prednisolone, 9alpha-fluoro-16alpha-methyl-Pregna-1,4-diene-3,20-dione, 9-fluoro-11α-methyl-ProdexSandoz dexamethasoneSK-dexamethasoneSpolovenSunia sol dSuperprednolTobradexTobramycin and dexamethasoneTresaderm (veterinary)TurbinaireVisumetazoneC22H29FO5392.4611392.1999022431-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one50-02-2CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)COInChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3UREBDLICKHMUKA-UHFFFAOYSA-N belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone.21-hydroxysteroidsOrganic compoundsLipids and lipid-like moleculesSteroids and steroid derivativesHydroxysteroidsAliphatic homopolycyclic compounds11-hydroxysteroids17-hydroxysteroids20-oxosteroids3-oxo delta-1,4-steroidsAlkyl fluoridesAlpha-hydroxy ketonesCyclic alcohols and derivativesCyclic ketonesDelta-1,4-steroidsFluorohydrinsGluco/mineralocorticoids, progestogins and derivativesHalogenated steroidsHydrocarbon derivativesOrganic oxidesOrganofluoridesPrimary alcoholsSecondary alcoholsTertiary alcohols11-hydroxysteroid17-hydroxysteroid20-oxosteroid21-hydroxysteroid3-oxo-delta-1,4-steroid3-oxosteroid9-halo-steroidAlcoholAliphatic homopolycyclic compoundAlkyl fluorideAlkyl halideAlpha-hydroxy ketoneCarbonyl groupCyclic alcoholCyclic ketoneDelta-1,4-steroidFluorohydrinHalo-steroidHalohydrinHydrocarbon derivativeKetoneOrganic oxideOrganic oxygen compoundOrganofluorideOrganohalogen compoundOrganooxygen compoundOxosteroidPregnane-skeletonPrimary alcoholProgestogin-skeletonSecondary alcoholTertiary alcohola steroidSolidlogp1.93logs-3.89solubility5.05e-02 g/lmelting_pointMp 262-264°logp1.68pka_strongest_acidic12.42pka_strongest_basic-3.3iupac1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-oneaverage_mass392.4611mono_mass392.199902243smilesCC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)COformulaC22H29FO5inchiInChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3inchikeyUREBDLICKHMUKA-UHFFFAOYSA-Npolar_surface_area94.83refractivity102.49polarizability41rotatable_bond_count2acceptor_count5donor_count3physiological_charge0formal_charge0Specdb::MsMs2236621Specdb::MsMs2236770Specdb::MsMs2238690Specdb::MsMs2238877Specdb::MsMs2242908Specdb::MsMs2242927Specdb::MsMs3422144Specdb::MsMs3422145Specdb::MsMs3422146Specdb::MsMs3422147Specdb::MsMs3422148Specdb::MsMs3422149Specdb::CMs113736Specdb::CMs127572Specdb::CMs860240Specdb::CMs860241Specdb::CMs860242Specdb::CMs860243Specdb::CMs860244Specdb::CMs860245Specdb::CMs860246Specdb::CMs860247Specdb::CMs860248Specdb::CMs860249Specdb::CMs860250Specdb::CMs860251Specdb::CMs860252Specdb::CMs860253Specdb::CMs860254Specdb::CMs860255Specdb::CMs860256Specdb::CMs860257Specdb::CMs860258Specdb::CMs860259Specdb::CMs860260Specdb::CMs860261Specdb::CMs860262HMDB1536441879DEX#<Reference:0x0000555676418990>#<Reference:0x0000555676418620>#<Reference:0x0000555676418328>#<Reference:0x0000555676418030>#<Reference:0x000055567641bb90>#<Reference:0x0000555676417dd8>bitterNuclear receptor subfamily 0 group B member 1P51843NR0B1