1.0 2010-04-08 22:04:56 UTC 2018-05-28 23:05:47 UTC FDB001355 Dexamethasone Glucocorticoid with potent antiinflammatory props. Not FDA approved for use in food-producing animals, but may be used illegally Dexamethasone and its derivatives, dexamethasone sodium phosphate and dexamethasone acetate, are synthetic glucocorticoids. It is used for its antiinflammatory or immunosuppressive properties and ability to penetrate the CNS, dexamethasone is used alone to manage cerebral edema and with tobramycin to treat corticosteroid-responsive inflammatory ocular conditions.; Dexamethasone can be used in the context of congenital adrenal hyperplasia, to prevent virilisation of a female fetus. If one or both parents are carriers of mutations to the CYP21 (CYP21A2) gene, the mother may start dexamethasone treatment within 7 weeks of conception. At the 12th week, a chorionic villus sample will determine whether the fetus is male (in which case the dexamethasone is stopped) or female. Subsequent DNA analysis can then reveal whether the female fetus is a carrier of the mutation, in which case dexamethasone treatment must continue until birth. The side-effects for the mother can be severe and the long-term impact on the child is not clear.; Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid hormones. It acts as an anti-inflammatory and immunosuppressant. Its potency is about 20-30 times that of hydrocortisone and 4-5 times of prednisone. α-Fluoro-16-α-methylcortisol α-fluoro-16α-methyl- 1-Dehydro-16α-methyl-9α-fluorohydrocortisone 1-dehydro-16a-Methyl-9a-fluorohydrocortisone 1-dehydro-16alpha -Methyl-9alpha -fluorohydrocortisone 1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone 1-dehydro-16α-methyl-9α-fluorohydrocortisone 16-alpha-Methyl-9-alpha-fluoro-1-dehydrocortisol 16-alpha-Methyl-9-alpha-fluoro-delta(sup 1)-hydrocortisone 16-alpha-Methyl-9-alpha-fluoro-delta1-hydrocortisone 16-alpha-Methyl-9-alpha-fluoroprednisolone 16α-Methyl-9α-fluoro-1-dehydrocortisol 16α-Methyl-9α-fluoroprednisolone 16a-Methyl-9a-fluoro-1-dehydrocortisol 16alpha -Methyl-9alpha -fluoro-1-dehydrocortisol 16alpha -Methyl-9alpha -fluoroprednisolone 16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol 16alpha-Methyl-9alpha-fluoro-delta(sup 1)-hydrocortisone 16alpha-Methyl-9alpha-fluoroprednisolone 16α-methyl-9α-fluoro-1-dehydrocortisol 9-alpha-Fluoro-16-alpha-methylprednisolone 9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 9-Fluoro-11α-methylpregna-1,4-diene-3,20-dione 9-Fluoro-11alpha -methylpregna-1,4-diene-3,20-dione 9-Fluoro-16-methylprednisolone 9α-Fluoro-16α-methylprednisolone 9a-Fluoro-16a-methylprednisolone 9A-FLUORO-16BETA-METHYLPREDNISOLONE 9alpha -Fluoro-16alpha -methylprednisolone 9alpha-Fluoro-16alpha-methyl-prednisolone 9alpha-Fluoro-16alpha-methylprednisolone 9α-fluoro-16α-methylprednisolone Aeroseb-d Aeroseb-dex Ak Dex Oph Otic Soln 0.1% alpha -Fluoro-16-alpha -methylcortisol Anaflogistico Aphtasolon Apo-dexamethasone Auxiron Azimycin (veterinary) Azium Azium (veterinary) Bisu DS Calonat Corson Corsone Cortisumman Decacortin Decaderm Decadron Decagel Decalix Decasone Decaspray Dectancyl Dekacort delta(sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol delta1-9alpha-Fluoro-16alpha-methylcortisol Deltafluorene Dergramin Deronil Desadrene Desametasone Desametasone [dcit] Desamethasone Desameton Deseronil DEX Dex-ide DEXA Dexa mamallet Dexa-cortidelt Dexa-cortisyl Dexa-scheroson Dexa-sine Dexacidin Dexacort Dexacortal Dexacortin Dexadeltone Dexafarma Dexalona Dexametasona Dexametasone Dexameth Dexamethansone Dexamethasone (from sample) Dexamethasone [inn:ban:jan] Dexamethasone acetate Dexamethasone alcohol Dexamethasone base Dexamethasone intensol Dexamethasone sodium ate Dexamethasone sodium phosphate Dexamethasone-omega Dexamethasonum Dexamethazone Dexapolcort Dexapos Dexaprol Dexason Dexasone Dexasone 0.5mg Dexasone 0.75mg Dexasone 4mg Dexasporin Dexinolon Dexinoral Dexone DEXONE 0.5 DEXONE 0.75 DEXONE 1.5 DEXONE 4 Dextelan Dezone Dinormon DXM DXMS Fluormethylprednisolone Fortecortin Gammacorten Hexadecadrol Hexadrol Hexadrol elixir HL-dex Isopto-dex Lokalison f Loverine Luxazone Maxidex Maxidex Ont 0.1% Maxidex Sus 0.1% Maxitrol Mediamethasone Methylfluorprednisolone Mexidex Millicorten MK 125 Mymethasone Naquasone (veterinary) Neomycin and polymyxin b sulfates and dexamethasone Neomycin and polymyxin b sulphates and dexamethasone NSC 34521 Ocu-trol Oradexon Pet derm III PHL-dexamethasone Pms Dexamethasone Elixir 0.5mg/5ml PMS-dexamethasone Policort Prednisolon f Prednisolone f Prednisolone, 9α-fluoro-16α-methyl- Prednisolone, 9alpha-fluoro-16alpha-methyl- Pregna-1,4-diene-3,20-dione, 9-fluoro-11α-methyl- Prodex Sandoz dexamethasone SK-dexamethasone Spoloven Sunia sol d Superprednol Tobradex Tobramycin and dexamethasone Tresaderm (veterinary) Turbinaire Visumetazone C22H29FO5 392.4611 392.199902243 1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one 1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one 50-02-2 CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)CO InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3 UREBDLICKHMUKA-UHFFFAOYSA-N belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone. 21-hydroxysteroids Organic compounds Lipids and lipid-like molecules Steroids and steroid derivatives Hydroxysteroids Aliphatic homopolycyclic compounds 11-hydroxysteroids 17-hydroxysteroids 20-oxosteroids 3-oxo delta-1,4-steroids Alkyl fluorides Alpha-hydroxy ketones Cyclic alcohols and derivatives Cyclic ketones Delta-1,4-steroids Fluorohydrins Gluco/mineralocorticoids, progestogins and derivatives Halogenated steroids Hydrocarbon derivatives Organic oxides Organofluorides Primary alcohols Secondary alcohols Tertiary alcohols 11-hydroxysteroid 17-hydroxysteroid 20-oxosteroid 21-hydroxysteroid 3-oxo-delta-1,4-steroid 3-oxosteroid 9-halo-steroid Alcohol Aliphatic homopolycyclic compound Alkyl fluoride Alkyl halide Alpha-hydroxy ketone Carbonyl group Cyclic alcohol Cyclic ketone Delta-1,4-steroid Fluorohydrin Halo-steroid Halohydrin Hydrocarbon derivative Ketone Organic oxide Organic oxygen compound Organofluoride Organohalogen compound Organooxygen compound Oxosteroid Pregnane-skeleton Primary alcohol Progestogin-skeleton Secondary alcohol Tertiary alcohol a steroid Solid logp 1.93 ALOGPS logs -3.89 ALOGPS solubility 5.05e-02 g/l ALOGPS melting_point Mp 262-264° logp 1.68 ChemAxon pka_strongest_acidic 12.42 ChemAxon pka_strongest_basic -3.3 ChemAxon iupac 1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one ChemAxon average_mass 392.4611 ChemAxon mono_mass 392.199902243 ChemAxon smiles CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)CO ChemAxon formula C22H29FO5 ChemAxon inchi InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3 ChemAxon inchikey UREBDLICKHMUKA-UHFFFAOYSA-N ChemAxon polar_surface_area 94.83 ChemAxon refractivity 102.49 ChemAxon polarizability 41 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 5 ChemAxon donor_count 3 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Specdb::MsMs 2236621 Specdb::MsMs 2236770 Specdb::MsMs 2238690 Specdb::MsMs 2238877 Specdb::MsMs 2242908 Specdb::MsMs 2242927 Specdb::MsMs 3422144 Specdb::MsMs 3422145 Specdb::MsMs 3422146 Specdb::MsMs 3422147 Specdb::MsMs 3422148 Specdb::MsMs 3422149 Specdb::CMs 113736 Specdb::CMs 127572 Specdb::CMs 860240 Specdb::CMs 860241 Specdb::CMs 860242 Specdb::CMs 860243 Specdb::CMs 860244 Specdb::CMs 860245 Specdb::CMs 860246 Specdb::CMs 860247 Specdb::CMs 860248 Specdb::CMs 860249 Specdb::CMs 860250 Specdb::CMs 860251 Specdb::CMs 860252 Specdb::CMs 860253 Specdb::CMs 860254 Specdb::CMs 860255 Specdb::CMs 860256 Specdb::CMs 860257 Specdb::CMs 860258 Specdb::CMs 860259 Specdb::CMs 860260 Specdb::CMs 860261 Specdb::CMs 860262 HMDB15364 41879 DEX #<Reference:0x000055ce31fe92c8> #<Reference:0x000055ce31fe90c0> #<Reference:0x000055ce31fe8ee0> #<Reference:0x000055ce31fe8d28> #<Reference:0x000055ce31fe8b70> #<Reference:0x000055ce31fe89b8> bitter Nuclear receptor subfamily 0 group B member 1 P51843 NR0B1