1.0 2010-04-08 22:04:58 UTC 2019-11-26 02:56:28 UTC FDB001434 5-HETE 5-Hydroxyeicosatetraenoic acid (5-HETE) is an endogenous eicosanoid. 5-HETE is an intermediate in the pathway of leukotriene synthesis. In addition, it is a modulator of tubuloglomerular feedback.; 5-hydroxyeicosatetraenoic acid (5-HETE) is an endogenous eicosanoid. 5-HETE is an intermediate in Arachidonic acid metabolism. It is converted from 5(S)-HPETE via the enzyme glutathione peroxidase (EC 1.11.1.9)and then it is converted to 5-OxoETE. It is also involved in the pathway of leukotriene synthesis. In addition, it is a modulator of tubuloglomerular feedback. 5-HETE is found in corn. (5S,6e,8Z,11Z,14Z)-5-Hydroxyeicosa-6,8,11,14-tetraenoate (5S,6e,8Z,11Z,14Z)-5-Hydroxyeicosa-6,8,11,14-tetraenoic acid (5S,6E,8Z,11Z,14Z)-5-hydroxyicosa-6,8,11,14-tetraenoic acid (6e,8Z,11Z,14Z)-(5S)-5-Hydroxyicosa-6,8,11,14-tetraenoate (6e,8Z,11Z,14Z)-(5S)-5-Hydroxyicosa-6,8,11,14-tetraenoic acid (S)-(e,Z,Z,Z)-5-Hydroxyeicosa-6,8,11,14-tetraenoate (S)-(e,Z,Z,Z)-5-Hydroxyeicosa-6,8,11,14-tetraenoic acid 5-Hydroxy-6,8,11,14-eicosatetraenoate 5-Hydroxy-6,8,11,14-eicosatetraenoic acid 5-Hydroxyarachidonic acid 5-Hydroxyeicosatetraenoate 5-Hydroxyeicosatetraenoic acid 5-L-Hydroxy-6,8,11,14-eicosatetraenoate 5-L-Hydroxy-6,8,11,14-eicosatetraenoic acid 5(S)-HETE 5(S)-Hydroxy-6-trans-8,11,14-cis-eicosatetraenoate 5(S)-Hydroxy-6-trans-8,11,14-cis-eicosatetraenoic acid 5(S)-Hydroxy-6(e),8(Z),11(Z),14(Z)-eicosatetraenoate 5(S)-Hydroxy-6(e),8(Z),11(Z),14(Z)-eicosatetraenoic acid 5(S)-Hydroxyeicosatetraenoate 5(S)-Hydroxyeicosatetraenoic acid 5S-HETE 5S-Hydroxy-6,8,11,14-eicosatetraenoate 5S-Hydroxy-6,8,11,14-eicosatetraenoic acid 6,8,11,14-Eicosatetraenoic acid, 5-hydroxy-, (S-(E,Z,Z,Z))- C20H32O3 320.4663 320.23514489 (5S,6E,8Z,11Z,14Z)-5-hydroxyicosa-6,8,11,14-tetraenoic acid 5-hydroxyeicosatetraenoic acid 70608-72-9 CCCCC\C=C/C\C=C/C\C=C/C=C/[C@@H](O)CCCC(O)=O InChI=1S/C20H32O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(21)17-15-18-20(22)23/h6-7,9-10,12-14,16,19,21H,2-5,8,11,15,17-18H2,1H3,(H,22,23)/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1 KGIJOOYOSFUGPC-JGKLHWIESA-N belongs to the class of organic compounds known as hydroxyeicosatetraenoic acids. These are eicosanoic acids with an attached hydroxyl group and four CC double bonds. Hydroxyeicosatetraenoic acids Organic compounds Lipids and lipid-like molecules Fatty Acyls Eicosanoids Aliphatic acyclic compounds Carbonyl compounds Carboxylic acids Hydrocarbon derivatives Hydroxy fatty acids Long-chain fatty acids Monocarboxylic acids and derivatives Organic oxides Secondary alcohols Unsaturated fatty acids Alcohol Aliphatic acyclic compound Carbonyl group Carboxylic acid Carboxylic acid derivative Fatty acid Hydrocarbon derivative Hydroxy fatty acid Hydroxyeicosatetraenoic acid Long-chain fatty acid Monocarboxylic acid or derivatives Organic oxide Organic oxygen compound Organooxygen compound Secondary alcohol Unsaturated fatty acid HETE Hydroxy/hydroperoxyeicosatetraenoic acids Hydroxy/hydroperoxyeicosatetraenoic acids Solid logp 5.88 ALOGPS logs -5.32 ALOGPS solubility 1.55e-03 g/l ALOGPS logp 5.36 ChemAxon pka_strongest_acidic 4.58 ChemAxon pka_strongest_basic -1.5 ChemAxon iupac (5S,6E,8Z,11Z,14Z)-5-hydroxyicosa-6,8,11,14-tetraenoic acid ChemAxon average_mass 320.4663 ChemAxon mono_mass 320.23514489 ChemAxon smiles CCCCC\C=C/C\C=C/C\C=C/C=C/[C@@H](O)CCCC(O)=O ChemAxon formula C20H32O3 ChemAxon inchi InChI=1S/C20H32O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(21)17-15-18-20(22)23/h6-7,9-10,12-14,16,19,21H,2-5,8,11,15,17-18H2,1H3,(H,22,23)/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1 ChemAxon inchikey KGIJOOYOSFUGPC-JGKLHWIESA-N ChemAxon polar_surface_area 57.53 ChemAxon refractivity 101.47 ChemAxon polarizability 38.13 ChemAxon rotatable_bond_count 14 ChemAxon acceptor_count 3 ChemAxon donor_count 2 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon Arachidonic Acid Metabolism SMP00075 map00590 Specdb::CMs 10783 Specdb::CMs 39556 Specdb::CMs 156865 Specdb::NmrOneD 270738 Specdb::NmrOneD 270739 Specdb::NmrOneD 270740 Specdb::NmrOneD 270741 Specdb::NmrOneD 270742 Specdb::NmrOneD 270743 Specdb::NmrOneD 270744 Specdb::NmrOneD 270745 Specdb::NmrOneD 270746 Specdb::NmrOneD 270747 Specdb::NmrOneD 270748 Specdb::NmrOneD 270749 Specdb::NmrOneD 270750 Specdb::NmrOneD 270751 Specdb::NmrOneD 270752 Specdb::NmrOneD 270753 Specdb::NmrOneD 270754 Specdb::NmrOneD 270755 Specdb::NmrOneD 270756 Specdb::NmrOneD 270757 Specdb::MsMs 94239 Specdb::MsMs 94240 Specdb::MsMs 94241 Specdb::MsMs 158256 Specdb::MsMs 158257 Specdb::MsMs 158258 Specdb::MsMs 435467 Specdb::MsMs 435468 Specdb::MsMs 435469 Specdb::MsMs 435470 Specdb::MsMs 435471 Specdb::MsMs 435472 Specdb::MsMs 435473 Specdb::MsMs 435474 Specdb::MsMs 435475 Specdb::MsMs 2792864 Specdb::MsMs 2792865 Specdb::MsMs 2792866 Specdb::MsMs 2916458 Specdb::MsMs 2916459 Specdb::MsMs 2916460 HMDB11134 28209 #<Reference:0x000055ce30ba83e0> #<Reference:0x000055ce30ba81d8> #<Reference:0x000055ce30bbbfa8> #<Reference:0x000055ce30bbbcd8> #<Reference:0x000055ce30bbbaa8> #<Reference:0x000055ce30bbb8c8> #<Reference:0x000055ce30bbb5a8> #<Reference:0x000055ce30bbb030> #<Reference:0x000055ce30bbad38> #<Reference:0x000055ce30bba928> #<Reference:0x000055ce30bba2c0> #<Reference:0x000055ce30bba0b8> #<Reference:0x000055ce30bb9f00> #<Reference:0x000055ce30bb9c58> #<Reference:0x000055ce30bb9910> #<Reference:0x000055ce30bb9690> Anatidae Type 1 specific Anatidae 8830 Beefalo Type 1 specific Bos taurus X Bison bison 297284 Bison Type 1 specific Bison bison 9901 Buffalo Type 1 specific Bubalus bubalis 89462 Cattle (Beef, Veal) Type 1 specific Bos taurus 9913 Chicken Type 1 specific Gallus gallus 9031 Columbidae (Dove, Pigeon) Type 1 specific Columbidae 8930 Corn Type 1 specific Zea mays 4577 Deer Type 1 specific Cervidae 9850 Domestic goat Type 1 specific Capra aegagrus hircus 9925 Domestic pig Type 1 specific Sus scrofa domestica 9825 Elk Type 1 specific Cervus canadensis 1574408 Emu Type 1 specific Dromaius novaehollandiae 8790 European rabbit Type 1 specific Oryctolagus 9984 Greylag goose Type 1 specific Anser anser 8843 Guinea hen Type 1 specific Numida meleagris 8996 Horse Type 1 specific Equus caballus 9796 Mallard duck Type 1 specific Anas platyrhynchos 8839 Mountain hare Type 1 specific Lepus timidus 62621 Mule deer Type 1 specific Odocoileus 9871 Ostrich Type 1 specific Struthio camelus 8801 Pheasant Type 1 specific Phasianus colchicus 9054 Quail Type 1 specific Phasianidae 9005 Rabbit Type 1 specific Leporidae 9979 Rock ptarmigan Type 1 specific Lagopus muta 64668 Sheep (Mutton, Lamb) Type 1 specific Ovis aries 9940 Squab Type 1 specific Columba 8931 Turkey Type 1 specific Meleagris gallopavo 9103 Velvet duck Type 1 specific Melanitta fusca 371864 Wild boar Type 1 specific Sus scrofa 9823 Epididymal secretory glutathione peroxidase O75715 GPX5 Glutathione peroxidase 1 P07203 GPX1 Glutathione peroxidase 2 P18283 GPX2 Glutathione peroxidase 3 P22352 GPX3 Glutathione peroxidase 6 P59796 GPX6 Glutathione peroxidase 7 Q96SL4 GPX7 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial P36969 GPX4