1.0 2010-04-08 22:04:59 UTC 2025-11-18 22:31:30 UTC FDB001473 6-Methylscutellarein 6-methylscutellarein, also known as 4',5,7-trihydroxy-6-methoxyflavone or dinatin, is a member of the class of compounds known as 6-o-methylated flavonoids. 6-o-methylated flavonoids are flavonoids with methoxy groups attached to the C6 atom of the flavonoid backbone. Thus, 6-methylscutellarein is considered to be a flavonoid lipid molecule. 6-methylscutellarein is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). 6-methylscutellarein can be found in a number of food items such as italian oregano, common sage, sunflower, and common thyme, which makes 6-methylscutellarein a potential biomarker for the consumption of these food products. 4',5,7-Trihydroxy-6-methoxyflavone 6-Methylscutellarein 6-O-Methylapigenin Dinatin Hispidulin Scutellarein 6-methyl ether C16H12O6 300.2629 300.063388116 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-chromen-4-one hispidulin 1447-88-7 COC1=C(O)C2=C(OC(=CC2=O)C2=CC=C(O)C=C2)C=C1O InChI=1S/C16H12O6/c1-21-16-11(19)7-13-14(15(16)20)10(18)6-12(22-13)8-2-4-9(17)5-3-8/h2-7,17,19-20H,1H3 IHFBPDAQLQOCBX-UHFFFAOYSA-N belongs to the class of organic compounds known as 6-o-methylated flavonoids. These are flavonoids with methoxy groups attached to the C6 atom of the flavonoid backbone. 6-O-methylated flavonoids Organic compounds Phenylpropanoids and polyketides Flavonoids O-methylated flavonoids Aromatic heteropolycyclic compounds 1-hydroxy-2-unsubstituted benzenoids 1-hydroxy-4-unsubstituted benzenoids 4'-hydroxyflavonoids 5-hydroxyflavonoids 7-hydroxyflavonoids Alkyl aryl ethers Anisoles Benzene and substituted derivatives Chromones Flavones Heteroaromatic compounds Hydrocarbon derivatives Organic oxides Oxacyclic compounds Pyranones and derivatives Vinylogous acids 1-benzopyran 1-hydroxy-2-unsubstituted benzenoid 1-hydroxy-4-unsubstituted benzenoid 4'-hydroxyflavonoid 5-hydroxyflavonoid 6-methoxyflavonoid-skeleton 7-hydroxyflavonoid Alkyl aryl ether Anisole Aromatic heteropolycyclic compound Benzenoid Benzopyran Chromone Ether Flavone Heteroaromatic compound Hydrocarbon derivative Hydroxyflavonoid Monocyclic benzene moiety Organic oxide Organic oxygen compound Organoheterocyclic compound Organooxygen compound Oxacycle Phenol Pyran Pyranone Vinylogous acid Flavones and Flavonols Flavones and Flavonols flavones monomethoxyflavone trihydroxyflavone logp 3.09 ALOGPS logs -3.58 ALOGPS solubility 7.91e-02 g/l ALOGPS logp 2.55 ChemAxon pka_strongest_acidic 7.09 ChemAxon pka_strongest_basic -4.8 ChemAxon iupac 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-chromen-4-one ChemAxon average_mass 300.2629 ChemAxon mono_mass 300.063388116 ChemAxon smiles COC1=C(O)C2=C(OC(=CC2=O)C2=CC=C(O)C=C2)C=C1O ChemAxon formula C16H12O6 ChemAxon inchi InChI=1S/C16H12O6/c1-21-16-11(19)7-13-14(15(16)20)10(18)6-12(22-13)8-2-4-9(17)5-3-8/h2-7,17,19-20H,1H3 ChemAxon inchikey IHFBPDAQLQOCBX-UHFFFAOYSA-N ChemAxon polar_surface_area 96.22 ChemAxon refractivity 79.38 ChemAxon polarizability 29.85 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 6 ChemAxon donor_count 3 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon Specdb::CMs 5595 Specdb::CMs 52980 Specdb::CMs 152736 Specdb::MsMs 109467 Specdb::MsMs 109468 Specdb::MsMs 109469 Specdb::MsMs 176910 Specdb::MsMs 176911 Specdb::MsMs 176912 Specdb::MsMs 285969 Specdb::MsMs 285970 Specdb::MsMs 285971 Specdb::MsMs 285972 Specdb::MsMs 285973 Specdb::MsMs 285974 Specdb::MsMs 2722020 Specdb::MsMs 2722021 Specdb::MsMs 2722022 Specdb::MsMs 2959395 Specdb::MsMs 2959396 Specdb::MsMs 2959397 Common sage Type 1 specific Salvia officinalis 38868 16.299999 16.299999237 16.299999237 mg/100 g Common thyme Type 1 specific Thymus vulgaris 49992 20.799999 20.799999237 20.799999237 mg/100 g Italian oregano Type 1 specific Origanum X majoricum 1384207 48.700001 48.700000763 48.700000763 mg/100 g Lemon verbena Type 1 specific Aloysia triphylla 542672 29.1375 29.137500014 29.137500014 mg/100 g Mexican oregano Type 1 specific Lippia graveolens 105.594406 105.594406128 105.594406128 mg/100 g Rosemary Type 1 specific Rosmarinus officinalis 39367 10.85 10.850000381 10.850000381 mg/100 g Sunflower Type 1 specific Helianthus annuus 4232 Tarragon Type 1 specific Artemisia dracunculus 72341 Anti hepatotoxic 328 Any compound that is able to prevent damage to the liver. Anti peroxidant 519 Anti radicular 572 Anti-aggregant 94 Anti-oxidant 502 A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides. In European countries, E-numbers for permitted antioxidant food additives are from E 300 to E 324. Antitumor 672 A substance that inhibits or prevents the proliferation of neoplasms. Cancer preventive 754 A substance that inhibits or prevents the proliferation of neoplasms.